Actin binding protein 1 (Abp1) encodes an F-actin-binding protein. It plays important roles in cytoskeletal functions of both Scar/WAVE- and wasp-mediated Arp2/3 complex activation during synapse formation, bristle formation and eye development; Belongs to the ABP1 family.

Actin-related protein 2; Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity).

Actin binding protein 1 (Abp1) encodes an F-actin-binding protein. It plays important roles in cytoskeletal functions of both Scar/WAVE- and wasp-mediated Arp2/3 complex activation during synapse formation, bristle formation and eye development; Belongs to the ABP1 family.

Actin-related protein 3; Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks (By similarity). Seems to contact the pointed end of the daughter actin filament (By similarity). Required during embryogenesis for the developmental migration of tail hemocytes anteriorly, along the ventral midline.

Actin binding protein 1 (Abp1) encodes an F-actin-binding protein. It plays important roles in cytoskeletal functions of both Scar/WAVE- and wasp-mediated Arp2/3 complex activation during synapse formation, bristle formation and eye development; Belongs to the ABP1 family.

Capping protein beta (cpb) encodes an actin-binding protein that, together with cpa, binds to the fast growing ends of actin filaments, restricting the addition or loss of actin monomers. It restricts JNK signaling, modulates Hippo signaling, maintains epithelial integrity and neuronal homeostasis, controls proliferation/apoptosis in wing imaginal discs, and promotes oogenesis.

Ankyrin 2, isoform U; Ankyrin 2 (Ank2) encodes a cytoskeletal binding protein required for proper function of the product of beta-Spec via direct interaction. It contributes to the regulation of short-term memory, sound perception, microtubule cytoskeleton and neuromuscular junction development and synapsis.

Transient receptor potential cation channel, mucolipin (Trpml) encodes a ion channel involved in autophagy, lateral inhibition and TOR signalling regulation.

Actin-related protein 2; Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity).

Actin binding protein 1 (Abp1) encodes an F-actin-binding protein. It plays important roles in cytoskeletal functions of both Scar/WAVE- and wasp-mediated Arp2/3 complex activation during synapse formation, bristle formation and eye development; Belongs to the ABP1 family.

Actin-related protein 2; Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity).

Actin-related protein 3; Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks (By similarity). Seems to contact the pointed end of the daughter actin filament (By similarity). Required during embryogenesis for the developmental migration of tail hemocytes anteriorly, along the ventral midline.

Actin-related protein 2; Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity).

P21-activated kinase (Pak) encodes a serine/threonine effector kinase for the small GTPases Rac and the product of Cdc42 involved in cytoskeletal regulation. The product of Pak contributes to growth cone guidance, synaptic development, and epithelial morphogenesis in both the ovary and embryo.

Actin-related protein 2; Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity).

Capping protein beta (cpb) encodes an actin-binding protein that, together with cpa, binds to the fast growing ends of actin filaments, restricting the addition or loss of actin monomers. It restricts JNK signaling, modulates Hippo signaling, maintains epithelial integrity and neuronal homeostasis, controls proliferation/apoptosis in wing imaginal discs, and promotes oogenesis.

Actin-related protein 3; Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks (By similarity). Seems to contact the pointed end of the daughter actin filament (By similarity). Required during embryogenesis for the developmental migration of tail hemocytes anteriorly, along the ventral midline.

Actin binding protein 1 (Abp1) encodes an F-actin-binding protein. It plays important roles in cytoskeletal functions of both Scar/WAVE- and wasp-mediated Arp2/3 complex activation during synapse formation, bristle formation and eye development; Belongs to the ABP1 family.

Actin-related protein 3; Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks (By similarity). Seems to contact the pointed end of the daughter actin filament (By similarity). Required during embryogenesis for the developmental migration of tail hemocytes anteriorly, along the ventral midline.

Actin-related protein 2; Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity).

Actin-related protein 3; Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks (By similarity). Seems to contact the pointed end of the daughter actin filament (By similarity). Required during embryogenesis for the developmental migration of tail hemocytes anteriorly, along the ventral midline.

Capping protein beta (cpb) encodes an actin-binding protein that, together with cpa, binds to the fast growing ends of actin filaments, restricting the addition or loss of actin monomers. It restricts JNK signaling, modulates Hippo signaling, maintains epithelial integrity and neuronal homeostasis, controls proliferation/apoptosis in wing imaginal discs, and promotes oogenesis.

Mothers against dpp (Mad) encodes the primary transcription factor that mediates cellular response to the BMP like ligands encoded by dpp, scw and gbb. Upon phosphorylation by either the products of sax or tkv (type I BMP receptors), it forms a complex with the product of Med and translocates to the nucleus where, together with cofactors, it regulates expression of BMP response target genes; Belongs to the dwarfin/SMAD family.

Mothers against decapentaplegic homolog; Medea (Med) encodes a protein that belongs to the highly conserved Smad family. It can bind its siblings encoded by Mad or Smox to facilitate signal transduction for the product of dpp or Activin ligands in the TGF-beta family. Med-complexes function as transcriptional regulators. Many developmental roles include dorsal-ventral patterning, patterning and proliferation of the wing disc and gene expression in the mushroom body of the larval brain.

Mothers against dpp (Mad) encodes the primary transcription factor that mediates cellular response to the BMP like ligands encoded by dpp, scw and gbb. Upon phosphorylation by either the products of sax or tkv (type I BMP receptors), it forms a complex with the product of Med and translocates to the nucleus where, together with cofactors, it regulates expression of BMP response target genes; Belongs to the dwarfin/SMAD family.

P21-activated kinase (Pak) encodes a serine/threonine effector kinase for the small GTPases Rac and the product of Cdc42 involved in cytoskeletal regulation. The product of Pak contributes to growth cone guidance, synaptic development, and epithelial morphogenesis in both the ovary and embryo.

Mothers against dpp (Mad) encodes the primary transcription factor that mediates cellular response to the BMP like ligands encoded by dpp, scw and gbb. Upon phosphorylation by either the products of sax or tkv (type I BMP receptors), it forms a complex with the product of Med and translocates to the nucleus where, together with cofactors, it regulates expression of BMP response target genes; Belongs to the dwarfin/SMAD family.

Protein 60A; Glass bottom boat (gbb) encodes a BMP ligand in the TGF-beta/BMP family of dimeric signaling molecules. It binds to a receptor complex to transduce signal through phosphorylation of the product of Mad. It contributes to maintain stem cell populations, control cell fate specification, proliferation, synapse growth and neuropeptide release.

Mothers against dpp (Mad) encodes the primary transcription factor that mediates cellular response to the BMP like ligands encoded by dpp, scw and gbb. Upon phosphorylation by either the products of sax or tkv (type I BMP receptors), it forms a complex with the product of Med and translocates to the nucleus where, together with cofactors, it regulates expression of BMP response target genes; Belongs to the dwarfin/SMAD family.

Mitogen-activated protein kinase; Nemo (nmo) encodes an atypical proline-directed serine/threonine kinase with roles in numerous developmental processes, including ommatidial rotation/planar cell polarity, retinal specification and neuronal function, and circadian clock speed. It regulates the activity of several signal transduction pathways, including BMP, Wnt, and Notch, and is implicated in fly models of neurodegenerative diseases; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

Mothers against dpp (Mad) encodes the primary transcription factor that mediates cellular response to the BMP like ligands encoded by dpp, scw and gbb. Upon phosphorylation by either the products of sax or tkv (type I BMP receptors), it forms a complex with the product of Med and translocates to the nucleus where, together with cofactors, it regulates expression of BMP response target genes; Belongs to the dwarfin/SMAD family.

Receptor protein serine/threonine kinase; Saxophone (sax) encodes a type I BMP receptor. Together with the BMP receptors encoded by tkv and put, it transduces signaling of the BMP ligands encoded by dpp, gbb and scw, in a wide variety of developmental processes including embryonic and imaginal disc patterning; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

Mothers against dpp (Mad) encodes the primary transcription factor that mediates cellular response to the BMP like ligands encoded by dpp, scw and gbb. Upon phosphorylation by either the products of sax or tkv (type I BMP receptors), it forms a complex with the product of Med and translocates to the nucleus where, together with cofactors, it regulates expression of BMP response target genes; Belongs to the dwarfin/SMAD family.

Receptor protein serine/threonine kinase; Thickveins (tkv) encodes a transforming growth factor beta type I receptor. Together with the product of put, it functions as a receptor of the product of dpp and therefore contributes to the BMP signaling pathway; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

Mothers against dpp (Mad) encodes the primary transcription factor that mediates cellular response to the BMP like ligands encoded by dpp, scw and gbb. Upon phosphorylation by either the products of sax or tkv (type I BMP receptors), it forms a complex with the product of Med and translocates to the nucleus where, together with cofactors, it regulates expression of BMP response target genes; Belongs to the dwarfin/SMAD family.

Receptor protein serine/threonine kinase; Wishful thinking (wit) encodes a BMP Type II Receptor that, upon binding of the ligand encoded by gbb, makes a complex with either tkv or sax encoding BMP type I receptors. This complex initiates phosphorylation and nuclear translocation of the transcription factor encoded by Mad. wit product controls synaptic homeostasis and neurotransmission at the neuromusclular junction during larval development. It also regulates the peptidergic phenotype of several neurosecretory cells; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase [...]

Mothers against decapentaplegic homolog; Medea (Med) encodes a protein that belongs to the highly conserved Smad family. It can bind its siblings encoded by Mad or Smox to facilitate signal transduction for the product of dpp or Activin ligands in the TGF-beta family. Med-complexes function as transcriptional regulators. Many developmental roles include dorsal-ventral patterning, patterning and proliferation of the wing disc and gene expression in the mushroom body of the larval brain.

Mothers against dpp (Mad) encodes the primary transcription factor that mediates cellular response to the BMP like ligands encoded by dpp, scw and gbb. Upon phosphorylation by either the products of sax or tkv (type I BMP receptors), it forms a complex with the product of Med and translocates to the nucleus where, together with cofactors, it regulates expression of BMP response target genes; Belongs to the dwarfin/SMAD family.

Mothers against decapentaplegic homolog; Medea (Med) encodes a protein that belongs to the highly conserved Smad family. It can bind its siblings encoded by Mad or Smox to facilitate signal transduction for the product of dpp or Activin ligands in the TGF-beta family. Med-complexes function as transcriptional regulators. Many developmental roles include dorsal-ventral patterning, patterning and proliferation of the wing disc and gene expression in the mushroom body of the larval brain.

Phosphoinositide 3-kinase, Dp110; Pi3K92E (Pi3K92E) encodes the catalytic subunit of a class I phosphatidylinositol 3-kinase that functions downstream of the product of InR and other receptors during several processes, including cell and tissue growth; Belongs to the PI3/PI4-kinase family.