ALG-2 interacting protein X (ALiX) encodes an adaptor protein implicated in multiple cellular processes, including positive regulation of mitotic cytokinesis, exosomal secretion and apoptosis.

Apoptosis-linked gene-2; Calcium ion binding. It is involved in the biological process described with: positive regulation of JNK cascade.

ALG-2 interacting protein X (ALiX) encodes an adaptor protein implicated in multiple cellular processes, including positive regulation of mitotic cytokinesis, exosomal secretion and apoptosis.

Plenty of SH3s (POSH) encodes a scaffold protein that regulates TNF-JNK signaling pathway.

Apoptosis-linked gene-2; Calcium ion binding. It is involved in the biological process described with: positive regulation of JNK cascade.

ALG-2 interacting protein X (ALiX) encodes an adaptor protein implicated in multiple cellular processes, including positive regulation of mitotic cytokinesis, exosomal secretion and apoptosis.

Apoptosis-linked gene-2; Calcium ion binding. It is involved in the biological process described with: positive regulation of JNK cascade.

Plenty of SH3s (POSH) encodes a scaffold protein that regulates TNF-JNK signaling pathway.

Apoptotic signal-regulating kinase 1 (Ask1) encodes a serine/threonine kinase that belongs to the MAPK kinase kinase family. In response to various stresses, it phosphorylates MAPK kinases in JNK and p38 MAPK pathways, inducing cellular stress responses including cell death and immune responses.

Mitogen-activated protein kinase kinase kinase 7; Component of a protein kinase signal transduction cascade. Mediator of TGF-beta signal transduction. Responsible for activation of the JNK MAPK pathway (basket, bsk and hemipterous, hep) in response to LPS. Component of the NF-kappa-B pathway; relish-mediated JNK inhibition involves proteasomal degradation of Tak1; certain targets of Relish that are induced during immune responses may facilitate destruction of Tak1 and switch off the JNK cascade. Participates in diverse roles such as control of cell shape and regulation of apoptosis.

Apoptotic signal-regulating kinase 1 (Ask1) encodes a serine/threonine kinase that belongs to the MAPK kinase kinase family. In response to various stresses, it phosphorylates MAPK kinases in JNK and p38 MAPK pathways, inducing cellular stress responses including cell death and immune responses.

TNF-receptor-associated factor-like, isoform A; Protein binding. It is involved in the biological process described with: positive regulation of lipophagy.

Apoptotic signal-regulating kinase 1 (Ask1) encodes a serine/threonine kinase that belongs to the MAPK kinase kinase family. In response to various stresses, it phosphorylates MAPK kinases in JNK and p38 MAPK pathways, inducing cellular stress responses including cell death and immune responses.

TNF-receptor-associated factor 4 (Traf4) encodes an adapter protein thought to bind the TNF receptor and activate downstream signaling. However, it also has TNF independent roles, especially with respect to morphogenesis. The product of Traf4 interacts with and localizes polarity and adherens junction proteins such as the products of baz and arm respectively. It is required for normal embryonic development, cell death, and cell growth.

Apoptotic signal-regulating kinase 1 (Ask1) encodes a serine/threonine kinase that belongs to the MAPK kinase kinase family. In response to various stresses, it phosphorylates MAPK kinases in JNK and p38 MAPK pathways, inducing cellular stress responses including cell death and immune responses.

TNF-receptor-associated factor 6 (Traf6) encodes a protein that belongs to a family of adaptor proteins involved in transducing downstream signaling by interacting with cell surface receptors. It mediates the pro-inflammatory effects of Toll and related receptor signaling, and the cell death induced by JNK activation via the product of egr.

Apoptotic signal-regulating kinase 1 (Ask1) encodes a serine/threonine kinase that belongs to the MAPK kinase kinase family. In response to various stresses, it phosphorylates MAPK kinases in JNK and p38 MAPK pathways, inducing cellular stress responses including cell death and immune responses.

Cell death protein rpr; Reaper (rpr) encodes Reaper, Hid, Grim (RHG) protein. It contributes to the caspase dependent apoptosis by inhibiting the anti-apoptotic protein encoded by Diap1.

Apoptotic signal-regulating kinase 1 (Ask1) encodes a serine/threonine kinase that belongs to the MAPK kinase kinase family. In response to various stresses, it phosphorylates MAPK kinases in JNK and p38 MAPK pathways, inducing cellular stress responses including cell death and immune responses.

Mitogen-activated protein kinase kinase kinase; Activates the JUN N-terminal pathway during dorsal closure.

Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.

TNF-receptor-associated factor 4 (Traf4) encodes an adapter protein thought to bind the TNF receptor and activate downstream signaling. However, it also has TNF independent roles, especially with respect to morphogenesis. The product of Traf4 interacts with and localizes polarity and adherens junction proteins such as the products of baz and arm respectively. It is required for normal embryonic development, cell death, and cell growth.

Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.

TNF-receptor-associated factor 6 (Traf6) encodes a protein that belongs to a family of adaptor proteins involved in transducing downstream signaling by interacting with cell surface receptors. It mediates the pro-inflammatory effects of Toll and related receptor signaling, and the cell death induced by JNK activation via the product of egr.

Cylindromatosis, isoform D; Lys63-specific deubiquitinase activity; thiol-dependent ubiquitin-specific protease activity; ubiquitinyl hydrolase activity, acting on linear ubiquitin.

Plenty of SH3s (POSH) encodes a scaffold protein that regulates TNF-JNK signaling pathway.

Cylindromatosis, isoform D; Lys63-specific deubiquitinase activity; thiol-dependent ubiquitin-specific protease activity; ubiquitinyl hydrolase activity, acting on linear ubiquitin.

Mitogen-activated protein kinase kinase kinase 7; Component of a protein kinase signal transduction cascade. Mediator of TGF-beta signal transduction. Responsible for activation of the JNK MAPK pathway (basket, bsk and hemipterous, hep) in response to LPS. Component of the NF-kappa-B pathway; relish-mediated JNK inhibition involves proteasomal degradation of Tak1; certain targets of Relish that are induced during immune responses may facilitate destruction of Tak1 and switch off the JNK cascade. Participates in diverse roles such as control of cell shape and regulation of apoptosis.

Cylindromatosis, isoform D; Lys63-specific deubiquitinase activity; thiol-dependent ubiquitin-specific protease activity; ubiquitinyl hydrolase activity, acting on linear ubiquitin.

TNF-receptor-associated factor-like, isoform A; Protein binding. It is involved in the biological process described with: positive regulation of lipophagy.

Cylindromatosis, isoform D; Lys63-specific deubiquitinase activity; thiol-dependent ubiquitin-specific protease activity; ubiquitinyl hydrolase activity, acting on linear ubiquitin.

TNF-receptor-associated factor 4 (Traf4) encodes an adapter protein thought to bind the TNF receptor and activate downstream signaling. However, it also has TNF independent roles, especially with respect to morphogenesis. The product of Traf4 interacts with and localizes polarity and adherens junction proteins such as the products of baz and arm respectively. It is required for normal embryonic development, cell death, and cell growth.

Cylindromatosis, isoform D; Lys63-specific deubiquitinase activity; thiol-dependent ubiquitin-specific protease activity; ubiquitinyl hydrolase activity, acting on linear ubiquitin.

TNF-receptor-associated factor 6 (Traf6) encodes a protein that belongs to a family of adaptor proteins involved in transducing downstream signaling by interacting with cell surface receptors. It mediates the pro-inflammatory effects of Toll and related receptor signaling, and the cell death induced by JNK activation via the product of egr.

Cylindromatosis, isoform D; Lys63-specific deubiquitinase activity; thiol-dependent ubiquitin-specific protease activity; ubiquitinyl hydrolase activity, acting on linear ubiquitin.

Ubiquitin-conjugating enzyme variant 1A (Uev1A) encodes a conserved protein that contributes to ubiquitin conjugating enzyme activity, but not catalytically, since it lacks the conserved cysteine residue essential for ubiquitin conjugation. It regulates genomic integrity, IMD pathway-mediated innate immunity, JNK-pathway mediated cell death and tumor invasion.

Cylindromatosis, isoform D; Lys63-specific deubiquitinase activity; thiol-dependent ubiquitin-specific protease activity; ubiquitinyl hydrolase activity, acting on linear ubiquitin.

Mitogen-activated protein kinase kinase kinase; Activates the JUN N-terminal pathway during dorsal closure.

Cdc42 (Cdc42) encodes a GTPase signaling protein that acts as a molecular switch and functions as key regulator of the actin cytoskeleton. It plays a central role in diverse biological processes including actin cytoskeleton organization, mophogenesis, hemocyte migration, cell polarity, and wound repair.

Ced-12 (Ced-12) encodes a protein that functions with Dock family members (encoded by mbc or spg) to regulate GTPase activity. It contributes to myoblast fusion, apoptotic cell engulfment, cell migration, and embryonic cellularization.