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Dsor1 Dsor1 hep hep Pvf1 Pvf1 Shc Shc PVRAP PVRAP Thor Thor Pvf2 Pvf2 Ced-12 Ced-12 Sos Sos Ras85D Ras85D Akt1 Akt1 drk drk Crk Crk Pvf3 Pvf3 Vav Vav Pvr Pvr bsk bsk slpr slpr mbc mbc Cdc42 Cdc42 Socs16D Socs16D aop aop Rac1 Rac1 S6k S6k Pi3K92E Pi3K92E Tor Tor Lnk Lnk Raf Raf ksr ksr rl rl
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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Dsor1Dual specificity mitogen-activated protein kinase kinase dSOR1; Required downstream of Raf in the sevenless (sev), torso (tor), and Drosophila EGF receptor homolog (DER) signal transduction pathways. Involved in both positive regulation (at the posterior terminus) and negative regulation (at the anterior domain) of tll, as in other terminal class gene products, maybe via the ERK-A kinase. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. (396 aa)
hepDual specificity mitogen-activated protein kinase kinase hemipterous; Required for the epithelial cell sheet movement called dorsal closure (DC), which allows establishment of the dorsal epidermis. Controls the expression in the dorsal epithelium edges of another dorsal closure gene, puckered (puc). Phosphorylates and activates the MAP kinase bsk; bsk signal transduction pathway mediates an immune response and morphogenesis; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. (1178 aa)
Pvf1PDGF- and VEGF-related factor 1 (Pvf1) encodes a PDGF- and VEGF-related factor that binds to and activates the receptor tyrosine kinase encoded by Pvr. It is involved in cell migration regulation and it has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1, Rho family small GTPases and the JNK cascade, in a context-dependent manner; Belongs to the PDGF/VEGF growth factor family. (325 aa)
ShcSHC-adaptor protein (Shc) encodes a protein involved in receptor tyrosine kinase signalling. It regulates anti-parasitoid immune response and tracheal development. (409 aa)
PVRAPPVR adaptor protein (PVRAP) encodes a protein implicated in VEGF/PDGF signaling. It binds to the product of Pvr and is required for downstream activation of Target of Rapamycin Complex 1. (474 aa)
Thor4E-binding protein THOR; Thor (Thor) encodes a eukaryotic translation initiation factor 4E binding protein that is controlled by the product of tor. It contributes to translation regulation, response to environmental stress and cell growth regulation. (117 aa)
Pvf2PDGF- and VEGF-related factor 2 (Pvf2) encodes a ligand for the receptor tyrosine kinase enocded by Pvr. It has roles in embryonic plasmatocyte survival and migration, and in the proliferation of adult midgut intestinal stem cells. (405 aa)
Ced-12Ced-12 (Ced-12) encodes a protein that functions with Dock family members (encoded by mbc or spg) to regulate GTPase activity. It contributes to myoblast fusion, apoptotic cell engulfment, cell migration, and embryonic cellularization. (724 aa)
SosProtein son of sevenless; Promotes the exchange of Ras-bound GDP by GTP. Functions in signaling pathways initiated by the sevenless and epidermal growth factor receptor tyrosine kinases; implies a role for the ras pathway in neuronal development. (1596 aa)
Ras85DRas-like protein 1; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays a role in eye development by regulating cell growth, survival of postmitotic ommatidial cells and differentiation of photoreceptor cells. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis. (189 aa)
Akt1RAC serine/threonine-protein kinase; Serine/threonine kinase involved in various developmental processes. During early embryogenesis, acts as a survival protein. During mid-embryogenesis, phosphorylates and activates trh, a transcription factor required for tracheal cell fate determination. Also regulates tracheal cell migration. Later in development, acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and antagonizing FOXO transcription factor. Controls follicle cell size during oogenesis. M [...] (611 aa)
drkProtein enhancer of sevenless 2B; Downstream of receptor kinase (drk) encodes an adaptor protein that recognizes phosphorylated tyrosine residues of membrane receptors and triggers the Ras/Raf/MAPK pathway. drk product contributes to the regulation of cytoskeletal organization and participates in developmental and cognitive processes (associative learning, anesthesia resistant memory). (211 aa)
CrkAdapter molecule Crk; Adapter protein which interacts with C-terminal portion of mbc, homolog of human DOCK180. May play a role in cellular processes throughout development; Belongs to the CRK family. (271 aa)
Pvf3PDGF- and VEGF-related factor 3 (Pvf3) encodes a ligand for the receptor tyrosine kinase encoded by Pvr. It has roles in embryonic plasmatocyte survival and migration, and in the proliferation of adult midgut intestinal stem cells; Belongs to the PDGF/VEGF growth factor family. (651 aa)
VavVav guanine nucleotide exchange factor (Vav) encodes a protein that belongs to the Dbl GEF superfamily. It functions as a GDP/GTP exchange factor for the product of Rac1 and an adaptor protein. Both activities are activated by direct tyrosine phosphorylation. (1001 aa)
PvrReceptor protein-tyrosine kinase; PDGF- and VEGF-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (encoded by Pvf1, Pvf2 or Pvf3). It is involved in cell migration regulation and it has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1, Rho family small GTPases and the JNK cascade, in a context-dependent manner. (1577 aa)
bskStress-activated protein kinase JNK; Responds to activation by environmental stress by phosphorylating a number of transcription factors, primarily components of AP-1 such as Jra and also the transcriptional repressor aop, and thus regulates transcriptional activity. Component of the immune response activated by bacterial infection, and is involved in wound healing and in dorsal closure, a morphogenetic movement during embryogenesis. Functions in the systematic response to wounding acting downstream of the Hayan-phenoloxidase PPO1 cascade. Exhibits cytoprotective activity in neuronal c [...] (372 aa)
slprMitogen-activated protein kinase kinase kinase; Activates the JUN N-terminal pathway during dorsal closure. (1155 aa)
mbcMyoblast city (mbc) encodes an unconventional bipartite GEF that, in combination with the product of Ced-12, activates the monomeric GTPase encoded by Rac1. It contributes to myoblast fusion, border cell migration and dorsal closure; Belongs to the DOCK family. (2008 aa)
Cdc42Cdc42 (Cdc42) encodes a GTPase signaling protein that acts as a molecular switch and functions as key regulator of the actin cytoskeleton. It plays a central role in diverse biological processes including actin cytoskeleton organization, mophogenesis, hemocyte migration, cell polarity, and wound repair. (191 aa)
Socs16DSuppressor of Cytokine Signaling at 16D (Socs16D) encodes a member of the SOCS family. It binds to the product of Pvr when catalytically active and is required for downstream activation of Target of Rapamycin Complex 1, but not the product of rl. (1021 aa)
aopEts DNA-binding protein pokkuri; Anterior open (aop) encodes a transcriptional repressor of the ETS family. It acts downstream of receptor tyrosine kinase signaling to regulate cell fate transitions critical to the development of many tissues including the nervous system, heart, trachea and eye. (732 aa)
Rac1Ras-related protein Rac1; During various developmental processes, regulates changes in cell morphology in response to extracellular signals. During oogenesis, mediates signaling from the tyrosine kinase (RTK) chemoattractant receptors (Egfr and Pvr) to the guidance pathway that control the directional persistent collective migration of the border cell (BC) cluster through the nurse cells to the oocyte. Once activating by Pvr and Egfr, promotes the formation of forward-directed actin protrusions which stabilize the DE- cadherin (shg)-mediated adhesions. In turn, DE-mediated adhesion bet [...] (192 aa)
S6kRibosomal protein S6 kinase (S6k) encodes an important component of the target of rapamycin pathway. It is involved in the control of synapse development, autophagy and cell size. (490 aa)
Pi3K92EPhosphoinositide 3-kinase, Dp110; Pi3K92E (Pi3K92E) encodes the catalytic subunit of a class I phosphatidylinositol 3-kinase that functions downstream of the product of InR and other receptors during several processes, including cell and tissue growth; Belongs to the PI3/PI4-kinase family. (1088 aa)
TorSerine/threonine-protein kinase Tor; Promotes cell and tissue growth, maintains tissue homeostatis and controls responses to environmental stress and aging. Regulates growth during animal development by coupling growth factor signaling to nutrient availability. Central regulators of autophagy. May be involved in atg1 phosphorylation. May also be involved, directly or indirectly, in the control of neuronal function. Phosphorylates S6K/p70S6K, in vitro. May regulate the activity of S6K. Overexpression inhibits growth and reduces cell size. Affects the timing of neuronal cell differentiat [...] (2471 aa)
LnkLnk, isoform D; Lnk (Lnk) encodes a member of the SH2B family of adaptor proteins. It functions within the insulin signalling pathway as an intracellular adaptor for the insulin receptor. It stabilises the interaction between the activated insulin receptor and the insulin receptor substrate, which are encoded by InR and chico respectively. (728 aa)
RafRaf homolog serine/threonine-protein kinase Raf; Serine/threonine kinase required in the early embryo for the formation of terminal structure. Also required during the proliferation of imaginal cells. May act downstream of Ras85D in the tor signal transduction pathway. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily. (739 aa)
ksrKinase suppressor of ras (ksr) encodes a MAP-kinase scaffold protein. It mediates the activation of the serine/threonine kinase encoded by Dsor1. (966 aa)
rlMitogen-activated protein kinase ERK-A; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway to regulate poliferation, differentiation and effect cell fate decisions in various tissues. Required downstream of phl/Raf in the sev/sevenless, tor/torso, and EGF receptor homolog Egfr signal transduction pathways. Required for embryonic epithelial tissue repair. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis. (376 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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