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v | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. Required during larval growth to control the level of potentially harmful free tryptophan in the hemolymph. In the adult the same reaction is the first step in the ommochrome biosynthetic pathway. (379 aa) | ||||
g | AP-3 complex subunit delta; Garnet (g) encodes a protein that forms the Adaptor protein 3 (AP-3) complex together with the other subunits encoded by or, rb and cm. These complexes select cargo for inclusion into vesicles for transport within the cell. AP-3 delivers protein cargo to a number of specialized organelles including pigment granules, late endosomes, lysosomes and synaptic vesicles. AP-3 genes were first found through defects in pigment granules that alter eye color. (1034 aa) | ||||
st | Protein scarlet; Part of a membrane-spanning permease system necessary for the transport of pigment precursors into pigment cells responsible for eye color. Scarlet and white complex transports a metabolic intermediate (such as 3-hydroxy kynurenine) from the cytoplasm into the pigment granules. (666 aa) | ||||
se | Pyrimidodiazepine synthase; Mediates the conversion of 2-amino-4-oxo-6-pyruvoyl-5,6,7,8- tetrahydropteridine (6-PTP; also named 6-pyruvoyltetrahydropterin) to 2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido(4,5-b)[1,4]diazepin-4- one (pyrimidodiazepine or PDA), a key intermediate in red eye pigment drosopterin biosynthesis. (243 aa) | ||||
Culd | CUB and LDLa domain (Culd) encodes a photoreceptor-cell enriched transmembrane protein. It localizes to endocytic vesicles and is required for endocytic trafficking of the products of ninaE and trpl. (965 aa) | ||||
Hn | Henna (Hn) encodes a tryptophan phenylalanine hydroxylase. It is a dual function enzyme: it hydroxylates both phenylalanine to generate tyrosine, as well as tryptophan to generate the precursor for peripheral (non-neuronal) serotonin. It is also involved in pteridine synthesis. (452 aa) | ||||
y | Yellow (y) is the founding gene of the Yellow family. Lack of y function results in an abnormal male courtship behavior and a characteristic yellow color of the adult cuticle and larval mouthparts; Belongs to the major royal jelly protein family. (541 aa) | ||||
ninaA | Peptidyl-prolyl cis-trans isomerase, rhodopsin-specific isozyme; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts on the folding of rhodopsin RH1 and RH2 (but not RH3) and is required for visual transduction. Belongs to the cyclophilin-type PPIase family. (237 aa) | ||||
DhpD | Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia. Also has 7,8-dihydropterin deaminase activity, which plays a role in synthesis of the red eye pigment aurodrosopterin. (448 aa) | ||||
eya | Developmental protein eyes absent; Tyrosine phosphatase thought to play a role in transcription regulation during organogenesis through its intrinsic protein phosphatase activity. The phosphatase activity was shown in vitro. Appears to function together with So and Dac in eye development. Required for the survival of eye progenitor cells at a critical stage in morphogenesis. Belongs to the HAD-like hydrolase superfamily. EYA family. (766 aa) | ||||
PAPLA1 | Phosphatidic Acid Phospholipase A1 (PAPLA1) encodes a protein required for the endoplasmic reticulum to Golgi trafficking of a family of G-protein coupled receptors. (2016 aa) | ||||
EMC3 | ER Membrane protein Complex 3 (EMC3) encodes a subunit of the ER membrane protein complex (EMC). In fly retinas, EMC has been shown to be essential for the biosynthesis of multi-pass membrane proteins, but not for single-pass membrane proteins and secretory proteins. (247 aa) | ||||
ninaD | Neither inactivation nor afterpotential D (ninaD) encodes a scavenger receptor involved in carotenoid transport, light detection and rhodopsin biosynthesis; Belongs to the CD36 family. (513 aa) | ||||
Ddc | Aromatic-L-amino-acid decarboxylase; Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Variation in the synthesis of bioamines may be a factor contributing to natural variation in life span. Belongs to the group II decarboxylase family. (510 aa) | ||||
ninaG | Neither inactivation nor afterpotential protein G; Oxidoreductase involved in biosynthesis of 3-hydroxyretinal, a chromophore for rhodopsin Rh1. Not responsible for the initial hydroxylation of the retinal ring but rather acts in a subsequent step in chromophore production. May catalyze the conversion of (3R)-3- hydroxyretinol to the 3S enantiomer. (597 aa) | ||||
ry | Xanthine dehydrogenase; Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid (By similarity). (1335 aa) | ||||
yellow-f2 | L-dopachrome tautomerase yellow-f2; Tautomerization of L-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI). Also catalyzes the tautomerization of the methyl ester of L-dopachrome and dopamine chrome. May play a role in melanization reactions during late pupal and adult stages. Belongs to the major royal jelly protein family. (452 aa) | ||||
yellow-f | L-dopachrome tautomerase yellow-f; Tautomerization of L-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI). Also catalyzes the tautomerization of the methyl ester of L-dopachrome and dopamine chrome. May play a role in melanization reactions during late pupal and adult stages. May play a role in melanization reactions during larval and early pupal stages. Belongs to the major royal jelly protein family. (429 aa) | ||||
ninaB | Carotenoid isomerooxygenase; Catalyzes the oxidative cleavage at the 15,15'-double bond of carotenoids and the simultaneous all-trans to 11-cis isomerization of one cleavage product. Carotenoids like 11-cis retinal can promote visual pigment biogenesis in the dark. Essential for the biosynthesis of the 3-hydroxyretinal chromophore of rhodopsin from zeaxanthin and for proper photoreceptor development. Also essential for larval light perception. (620 aa) | ||||
Xport-A | Exit protein of rhodopsin and TRP A (Xport-A) encodes a TRP channel chaperone. It mediates the transport to the plasma membrane of the products of ninaE and trp. (116 aa) | ||||
e | LP19442p; Ebony (e) encodes a protein that links beta-alanine to biogenic amines like dopamine or histamine. It controls the amount of free biogenic amine, e.g. of dopamine in cuticle formation and of histamine in visual signal transduction of the eye. It is also involved in behavioral rhythmicity. (879 aa) | ||||
Burs | Bursicon (Burs) encodes a cystine knot protein that dimerizes with the product of Pburs to form the bursicon neurohormone. Bursicon neurohormone is released after adult emergence and acts on the receptor encoded by rk for tanning and hardening of the cuticle and expansion of the wings. (173 aa) | ||||
pn | EG:152A3.5 protein (Fbgn0003116;pn protein); Prune (pn) encodes a phosphoesterase that localizes to the mitochondrial matrix. It hydrolyzes cAMP and negatively regulates mitochondrial cAMP signaling. It is involved in mtDNA maintenance and eye pigment biosynthesis. (405 aa) | ||||
dor | Vacuolar protein sorting-associated protein 18 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes probably as part of the class C core vacuole/endosome tethering (CORVET) complex. In larval neuromuscular junctions, essential for endosomal sorting which traffics old or dysfunctional synaptic vesicle proteins through a degradative endolysosomal route. Required for the biogenesis of eye pigment granules. Required to maintain normal levels of rush, which functions in endosome formation [...] (1002 aa) | ||||
cd | Cardinal (cd) encodes a phenoxazinone synthetase involved in the kynurenine pathway. It contributes to ommochrome biosynthesis, neuron death and siRNA-mediated gene silencing. (830 aa) | ||||
Cnx99A | Calnexin 99A (Cnx99A) encodes an endoplasmic reticulum chaperone that colocalizes and genetically interacts with the sodium channel subunit encoded by para. (605 aa) | ||||
ca | Claret, isoform A; Claret (ca) encodes a protein that is required for wild-type eye color. ca mutant flies show a wine-red eye color. (1961 aa) | ||||
HPS4 | Hermansky-Pudlak Syndrome 4 (HPS4) encodes a tethering factor that regulates gene silencing by small RNAs via endosomal trafficking. (858 aa) | ||||
fdl | Probable beta-hexosaminidase fdl; Involved in brain restructurization via hormonal control during metamorphosis. Implicated in N-glycan processing. Belongs to the glycosyl hydrolase 20 family. (673 aa) | ||||
Rab32 | Rab32, isoform B; Rab32 (Rab32) encodes a small GTPase that contributes to vesicle trafficking regulation. It is involved in eye development, autophagy and lipid storage. (686 aa) | ||||
hh | Protein hedgehog C-product; Intercellular signal essential for a variety of patterning events during development. Establishes the anterior-posterior axis of the embryonic segments and patterns the larval imaginal disks. Binds to the patched (ptc) receptor, which functions in association with smoothened (smo), to activate the transcription of target genes wingless (wg), decapentaplegic (dpp) and ptc. In the absence of hh, ptc represses the constitutive signaling activity of smo through fused (fu). Essential component of a signaling pathway which regulates the Duox-dependent gut immune r [...] (471 aa) | ||||
Duox | Dual oxidase; Plays a role in innate immunity limiting microbial proliferation in the gut. Acts downstream of a hh-signaling pathway to induce the production of reactive oxygen species (ROS) in response to intestinal bacterial infection. May generate antimicrobial oxidative burst through its peroxidase-like domain. (1537 aa) | ||||
ovo | Transcriptional activator shavenbaby; Transcriptional regulator with essential functions in the germline and soma. Plays an essential role in regulating the formation of apical cell extensions such as denticles and aristae, and initiating cytoskeletal remodeling during epidermal differentiation. [Transcriptional activator shavenbaby]: Transcriptional activator which initiates trichome development and also promotes tarsal joint development. Has an essential somatic role regulating the tal-dependent formation of trichomes, and initiating cytoskeletal remodeling during epidermal different [...] (1351 aa) | ||||
kar | Karmoisin, isoform B; Karmoisin (kar) encodes a protein involved in ommochrome biosynthesis. (612 aa) | ||||
b | Black (b) encodes an aspartate 1-decarboxylase. Mutations of b result in viable flies with a cuticular melanization phenotype. (575 aa) | ||||
rdhB | Retinol dehydrogenase B (rdhB) encodes a retinol dehydrogenase involved in rhodopsin biosynthesis. (248 aa) | ||||
Socs36E | Suppressor of cytokine signaling at 36E (Socs36E) encodes a negative regulator of the JAK/STAT and EGFR pathways. It is a transcriptional target of the product of Stat92E that mediates lysosomal degradation following pathway stimulation and inhibits basal pathway activity. (737 aa) | ||||
cl | Clot, isoform A; Clot (cl) encodes a protein with thioredoxin reductase and glutathione peroxidase enzymatic activity. cl is required for drosopterin biosynthesis and its product contributes to redox homeostasis and signaling and defence against oxidative stress. (126 aa) | ||||
dsx | Protein doublesex; Controls somatic sexual differentiation. Binds directly and specifically to the FBE (fat body enhancer) of the yolk protein 1 and 2 genes (Yp1 and Yp2). This enhancer is sufficient to direct the female- specific transcription characteristic of the Yp genes in adult fat bodies. Involved in regulation of male-specific expression of takeout in brain-associated fat body. (572 aa) | ||||
car | Vacuolar protein sorting-associated protein 33A; Required for the biogenesis of eye pigment granules. Plays a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes probably as part of the class C core vacuole/endosome tethering (CORVET) complex. (639 aa) | ||||
z | Regulatory protein zeste; Zeste (z) encodes a sequence-specific DNA-binding protein. It is often found in the proximal promoter region of many genes where it helps to recruit the BRM nucleosome remodeling complex. It is best known for the pairing-dependent repressive effects produced by some of its mutants on target genes, especially the w gene. (605 aa) | ||||
bi | Optomotor-blind protein; Bifid (bi) encodes a T-box transcription factor that controls cell proliferation, viability and cell migration. It contributes to the development of several tissues such as brain, eyes and wings. In wing development it is activated by the product of dpp and to a lesser extent by Wg signaling. (1023 aa) | ||||
cm | Mu3 subunit of clathrin-associated protein complex AP-3; Cargo adaptor activity; Belongs to the adaptor complexes medium subunit family. (415 aa) | ||||
alpha-Man-IIa | Alpha-mannosidase 2; Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N- glycans; the final hydrolytic step in the N-glycan maturation pathway (By similarity). (1109 aa) | ||||
ATP7 | ATP7, isoform B; ATP7 (ATP7) encodes a copper transmembrane transporter involved in cuticle pigmentation, copper homeostasis and larval development. (1254 aa) | ||||
alpha-Man-IIb | alpha-Mannosidase class II b (alpha-Man-IIb) encodes a mannosidase involved in cellular encapsulation response and glycoprotein metabolism. (1249 aa) | ||||
w | White (w) encodes a member of the ABCG2 class of transporters, transporting molecules such as cyclic GMP, biogenic amines and pigments including drosopterins and ommochromes. Mutation of w results in viable flies with white eyes. A shortened version of the gene (mini-w) has been widely used in transformation constructs as a selectable marker. (687 aa) | ||||
sdk | Protein sidekick; Participates in homotypic or heterotypic interactions in the eye during pattern formation to prevent extra cells from joining the precluster and differentiating as photoreceptor cells. (2265 aa) | ||||
lt | Vacuolar protein sorting-associated protein 41 homolog; Light (lt) encodes a cellular-protein trafficking protein that forms part of the homotypic fusion and vacuolar protein sorting (HOPS) and class C core vacuole/endosome tethering (CORVET) complexes. It is required for fusion of autophagosomes with lysosomes, endocytic down-regulation of Notch signaling, and eye pigment biogenesis; Belongs to the VPS41 family. (841 aa) | ||||
cn | Kynurenine 3-monooxygenase; Cinnabar (cn) encodes the enzyme that synthesizes 3-hydroxykynurenine (3-HK) as part of the kynurenine pathway of tryptophan degradation. 3-HK is an intermediate product in the formation of ommochromes, the brown pigments in the fly eye, and thus cn loss of function mutant flies exhibit altered eye color. Several kynurenine pathway metabolites are neuroactive and have been linked to the pathogenesis of neurodegenerative disorders. (465 aa) | ||||
mal | Molybdenum cofactor sulfurase; Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. (781 aa) | ||||
ple | Pale (ple) encodes a tyrosine hydroxylase, the first and rate-limiting step in the synthesis of dopamine (and eventually, melanin). Dopamine has critical roles in system development. (579 aa) | ||||
pinta | Retinol-binding protein pinta; Retinoid-binding protein which shows highest affinity for all-trans retinol. Can also bind all-trans forms of retinoic acid and retinal, but has lower affinity for cis form retinoids. Required in retinal pigment cells for rhodopsin biosynthesis. (273 aa) | ||||
santa-maria | Scavenger receptor acting in neural tissue and majority of rhodopsin is absent (santa-maria) encodes a class B scavenger receptor that contributes to the conversion of carotenoids to vitamin A. It is involved in phototransduction and thermotaxis; Belongs to the CD36 family. (563 aa) | ||||
p | Hermansky-Pudlak syndrome 5 protein homolog; Has a role in the biogenesis of eye pigment granules. Eye pigment granules are specialized forms of late endosomes or lysosomes. Biogenesis of pigment granules in the eye requires molecular components required for protein delivery to lysosomes. (826 aa) | ||||
Abd-B | Homeobox protein abdominal-B; Abdominal B (Abd-B) is one of the three hox genes of the bithorax complex. The product of Abd-B specifies the identity of the posterior abdominal segments, the external genitalia and the gonads. It is also involved in regulating the post-mating-response. (493 aa) | ||||
bw | Brown (bw) encodes a member of the traffic ATPase (or ABC) family of membrane transporters. It is believed to heterodimerize with the product of w. bw and w are necessary to import guanine, a precursor for the red pteridine pigments, into pigment cells of the eyes, Malpighian tubules and testis sheath. (675 aa) | ||||
roh | Reduction of Rh1, isoform A; It is involved in the biological process described with: rhodopsin biosynthetic process. (82 aa) | ||||
Pu | GTP cyclohydrolase 1; Isoform B is required for eye pigment production, Isoform C may be required for normal embryonic development and segment pattern formation. (324 aa) | ||||
t | Tan, isoform A; Tan (t) encodes a hydrolase involved in both the conversion of N-beta-alanyldopamine to dopamine in the cuticle and central nervous system, and the conversion of beta-alanylhistamine (carcinine) to histamine in the retina. It functions in vision, cuticular melanization, and neurotransmitter recycling. (387 aa) | ||||
rb | Ruby (rb) encodes the beta3-adaptin subunit of the Adaptor protein-3 (AP-3) complex involved in biogenesis of lysosome-related organelles. It is required for regulation of lipid storage, eye pigment biogenesis and the processing of the receptor encoded by N. (1160 aa) | ||||
or | Adaptor protein complex AP-3 small chain sigma3; Orange (or) encodes an AP-3 adaptor complex component involved in ommochrome biosynthesis. (191 aa) | ||||
bab1 | Protein bric-a-brac 1; Bric a brac 1 (bab1) encodes a transcriptional regulator that functions partially redundantly with the product of bab2. It is part of the conserved proximal-distal gene regulatory network module. It contributes to pattern formation, ovary morphogenesis, abdominal pigmentation and olfactory receptor neuron fate diversity. (977 aa) | ||||
Hexo1 | Beta-hexosaminidase; Hexosaminidase 1 (Hexo1) encodes a beta-N-acetylglucosaminidase involved in protein deglycosylation and rhodopsin biosynthesis. (622 aa) |