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Hcf Hcf ash2 ash2 CG14282 CG14282 Cfp1 Cfp1 Dpy-30L1 Dpy-30L1 Wdr82 Wdr82 Rbbp5 Rbbp5 CG3515 CG3515 Dpy-30L2 Dpy-30L2 CG17440 CG17440 Set1 Set1 CG3347 CG3347 CG33060 CG33060 wds wds
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
HcfHCF C-terminal chain; May be involved in control of the cell cycle. (1500 aa)
ash2Set1/Ash2 histone methyltransferase complex subunit ASH2; Transcriptional regulator. Regulates a number of genes involved in wing development including activation of net and bs and repression of rho and kni and controls vein-intervein patterning during wing development. Required for correct expression of a number of homeotic genes including Scr in the first leg imaginal disk and Ubx in the third leg imaginal disk and haltere disks. Required for stabilization of the histone-lysine N-methyltransferase trr and for trimethylation of 'Lys-4' of histone H3. Plays a role in maintenance of tra [...] (556 aa)
CG14282IP09474p; It is involved in the biological process described with: histone H3-K4 methylation. (293 aa)
Cfp1CXXC-type zinc finger protein 1; Component of the SET1 complex that specifically di- and trimethylates 'Lys-4' of histone H3. Essential for Set1 association with chromatin and trimethylation of histone H3 at 'Lys-4' at transcription puffs. Additionally, is critical for general chromosomal association of Set1. (663 aa)
Dpy-30L1Dpy-30-like 1 (Dpy-30L1) encodes a protein that is part of the COMPASS complex, a histone H3K4 methyltransferase complex thought to be responsible for the bulk of the histone H3K4 di- and trimethylation. The product of Dpy-30L1 binds to, and thereby inhibits, the metal-responsive transcription factor encoded by MTF-1. (134 aa)
Wdr82WD repeat domain 82 (Wdr82) encodes a component of the Compass complex, which performs K4 methylation of the histone encoded by His3. (317 aa)
Rbbp5Retinoblastoma-binding protein 5 homolog; Component of the SET1 complex that specifically di- and trimethylates 'Lys-4' of histone H3 and of the MLL3/4 complex which also methylates histone H3 'Lys-4'. (489 aa)
CG3515FI19335p1; Chromatin binding; histone methyltransferase activity (H3-K4 specific). It is involved in the biological process described with: histone H3-K4 trimethylation. (395 aa)
Dpy-30L2Dpy-30-like 2 (Dpy-30L2) is expressed in elongated spermatids but not in early or mature sperm. Targeted disruption of the gene results in sperm motility impairment and male sterility. (98 aa)
CG17440AT26187p; It is involved in the biological process described with: positive regulation of transcription, DNA-templated. (366 aa)
Set1Histone-lysine N-methyltransferase SETD1; Catalytic component of the SET1 complex that specifically di- and trimethylates 'Lys-4' of histone H3 and is the main di- and trimethyltransferase throughout development. Set1-dependent trimethylation regulates chromatin changes at active promoters that ensure optimal RNA polymerase II release into productive elongation, thereby contributing to optimal transcription. (1641 aa)
CG3347FI16849p1; It is involved in the biological process described with: positive regulation of transcription, DNA-templated. (538 aa)
CG33060Uncharacterized protein; It is involved in the biological process described with: histone H3-K4 methylation. (121 aa)
wdsProtein will die slowly; Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at 'Lys-4'. (361 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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