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| | RpS8 | Ribosomal protein S8 (RpS8) encodes a structural constituent of ribosomes that is involved in larval lymph gland hemopoiesis; Belongs to the eukaryotic ribosomal protein eS8 family. (208 aa) |
| | deltaCOP | Coatomer subunit delta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (532 aa) |
| | gt | Protein giant; Represses the expression of both the krueppel and knirps segmentation gap genes. Binds, in vitro, to the krueppel regulatory elements CD1 and CD2. It is required in the early embryo for the development of portions of the head and abdomen; Belongs to the bZIP family. (448 aa) |
| | N | Processed neurogenic locus Notch protein; Essential signaling protein which has a major role in many developmental processes. Functions as a receptor for membrane-bound ligands Delta and Serrate to regulate cell-fate determination. Upon ligand activation, and releasing from the cell membrane, the Notch intracellular domain (NICD) forms a transcriptional activator complex with Su(H) (Suppressor of hairless) and activates genes of the E(spl) complex. Regulates oogenesis, the differentiation of the ectoderm and the development of the central and peripheral nervous system, eye, wing disk, [...] (2703 aa) |
| | lz | Protein lozenge; Involved in prepatterning photoreceptor precursors in the developing eye; in the larval eye disk it defines a subset of cells as an equipotential group that is competent to respond to the sevenless developmental signal and another subset that confer proper photoreceptor identity by positively regulating the homeo box gene Bar. Involved in the aop/pnt dynamic in a Ras-dependent manner to regulate pros expression. Promotes apoptosis in the pupal eye by directly activating aos and klu. Also modulates hid- and rpr-mediated cell death. Regulates amos function in olfactory s [...] (826 aa) |
| | shg | DE-cadherin; Cadherins are calcium-dependent cell adhesion proteins. In connecting cells they preferentially interact with themselves in a homophilic manner; cadherins may thus contribute to the sorting of heterogeneous cell types. During oogenesis, integral component of the guidance mechanisms that regulate the directional persistent collective migration of the border cell (BC) cluster through the nurse cells to the oocyte. Functions downstream of the two chemoattractant receptors, Pvr and Egfr, to promote BC adhesion between the leader cells of the migrating cluster and the surroundi [...] (1507 aa) |
| | Egfr | Epidermal growth factor receptor; Binds to four ligands: Spitz, Gurken, Vein and Argos, which is an antagonist. Transduces the signal through the ras-raf-MAPK pathway. Involved in a myriad of developmental decisions. Critical for the proliferation of imaginal tissues, and for the determination of both the antero-posterior and dorso-ventral polarities of the oocyte. In the embryo, plays a role in the establishment of ventral cell fates, maintenance of amnioserosa and ventral neuroectodermal cells, germ band retraction, cell fate specification in the central nervous system and production [...] (1426 aa) |
| | retn | Protein dead ringer; Transcription factor which is a downstream target of gcm and repo. Directly or indirectly activates the transcription of locos and pros, which are essential for the development of some glial cells. Plays an essential role in defining the cell shape and migration characteristics of longitudinal glia that enable them to establish a normal axon scaffold. (911 aa) |
| | sigmar | Tumor necrosis factor alpha-induced protein 8-like protein; Salivary glands marred (sigmar) encodes a TNFAIP8-like (TIPE) protein family member. Its expression levels are responsive to the TNF ligand encoded by egr. The product of sigmar contribute to JNK signaling modulation, cytoskeletal remodeling and autophagy. (210 aa) |
| | ocm | Over compensating males, isoform A; DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II regulatory region sequence-specific DNA binding; RNA polymerase II activating transcription factor binding. It is involved in the biological process described with: positive regulation of transcription by RNA polymerase II; dosage compensation; larval lymph gland hemopoiesis; cell fate specification; negative regulation of transcription by RNA polymerase II. (2175 aa) |
| | gsb | Protein gooseberry; Expressed in segmentally repeating pattern to define the polarity of embryonic segments. (427 aa) |
| | Gale | UDP-glucose 4-epimerase; Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP- Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconvers [...] (350 aa) |
| | ecd | Ecdysoneless (ecd) encodes a protein that physically interacts with several components of the U5 snRPN pre-mRNA splicing complex. Its loss result in intron retention within spok, accounting for ecdysone deficiency of some ecd mutants; Belongs to the ECD family. (684 aa) |
| | sty | Protein sprouty; Inhibitor of tracheal branching that restricts branch budding by antagonizing the BNL-FGF pathway (BNL: branchless, an fgf inducer of branching). Acts as an antagonist of EGFR-mediated signaling in the eye (where it is important for cell determination) midline glia, chordotonal organs, wing and ovarian follicle cells. (589 aa) |
| | dsh | Segment polarity protein dishevelled; Required to establish coherent arrays of polarized cells and segments in embryos. Plays a role in wingless (wg) signaling, possibly through the reception of the wg signal by target cells and subsequent redistribution of arm protein in response to that signal in embryos. This signal seems to be required to establish planar cell polarity and identity. (623 aa) |
| | hop | Tyrosine-protein kinase hopscotch; Tyrosine kinase of the non-receptor type, phosphorylates the marelle protein. Required maternally for the establishment of the normal array of embryonic segments: involved in the control of pair- rule gene transcription in a stripe-specific manner. Together with Hsp83 and piwi, mediates canalization, also known as developmental robustness, likely via epigenetic silencing of existing genetic variants and suppression of transposon-induced new genetic variation. (1177 aa) |
| | BthD | Selenoprotein BthD; May be involved in a redox-related process. Required for survival and specifically for salivary gland morphogenesis. (249 aa) |
| | Pvf1 | PDGF- and VEGF-related factor 1 (Pvf1) encodes a PDGF- and VEGF-related factor that binds to and activates the receptor tyrosine kinase encoded by Pvr. It is involved in cell migration regulation and it has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1, Rho family small GTPases and the JNK cascade, in a context-dependent manner; Belongs to the PDGF/VEGF growth factor family. (325 aa) |
| | gig | Gigas, isoform A; Gigas (gig) encodes a tumour suppressor protein that, together with with the product of Tsc1, controls cellular growth via antagonizing insulin and TOR signalling pathways. (1847 aa) |
| | kto | Mediator of RNA polymerase II transcription subunit 12; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for leg and ey [...] (2531 aa) |
| | rept | RuvB-like helicase 2; Acts as a transcriptional coactivator in Wg signaling caused by altered arm signaling. Pont and rept interfere antagonistically with nuclear arm signaling function, and are required to enhance or reduce arm activity, respectively. Also an essential cofactor for the normal function of Myc; required for cellular proliferation and growth. (481 aa) |
| | rpr | Cell death protein rpr; Reaper (rpr) encodes Reaper, Hid, Grim (RHG) protein. It contributes to the caspase dependent apoptosis by inhibiting the anti-apoptotic protein encoded by Diap1. (65 aa) |
| | hid | Cell death protein hid; Activator of apoptosis, with grim and rpr, that acts on the effector Dredd. Seems to act genetically upstream of baculoviral anti-apoptotic p35. Blocks Diap2 from binding and inactivating the effector caspase Drice. (410 aa) |
| | Adgf-A | Adenosine deaminase-related growth factor A (Adgf-A) encodes an extracellular deaminase that regulates the level of extracellular adenosine by converting adenosine to inosine. This activity is important for regulation of systemic metabolism, especially during stress and infection. (553 aa) |
| | Arl1 | ADP-ribosylation factor-like protein 1; GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. (180 aa) |
| | GlyRS | Glycyl-tRNA synthetase, isoform B; Glycyl-tRNA synthetase (GlyRS) encodes a protein involved in dendrite morphogenesis and larval lymph gland hemopoiesis. (765 aa) |
| | Dronc | Caspase Nc subunit 1; Involved in the activation cascade of caspases responsible for apoptosis execution. Effector of steroid-mediated apoptosis during insect metamorphosis. Overexpression promotes programmed cell death. Interaction with Diap1 is required to suppress Dronc-mediated cell death; via Diap1-mediated ubiquitination of Dronc. Rate-limiting caspase in rpr and hid death pathway. (450 aa) |
| | MED24 | Mediator of RNA polymerase II transcription subunit 24; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for activated t [...] (993 aa) |
| | BI-1 | Bax inhibitor 1; Suppressor of apoptosis (By similarity). Modulates unfolded protein response signaling. Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation. (245 aa) |
| | bip1 | Bip1, isoform A; POZ domain binding. It is involved in the biological process described with: larval lymph gland hemopoiesis. (419 aa) |
| | bin | Forkhead box protein biniou; Component of a regulatory network controlling visceral mesoderm development and midgut morphogenesis. Transcriptional regulator involved in the activation of a large number of genes in the visceral mesoderm including betaTub60D, dpp and Hand. Binds to and regulates a number of enhancers driving expression in the visceral mesoderm in a temporally and spatially restricted manner. Also to binds to enhancers cooperatively with activators, such as bap or HLH54F, to coregulate expression of shared target genes in the visceral mesoderm. Binds to the Ndg enhancer a [...] (676 aa) |
| | Tnpo | Transportin, isoform A; Transportin (Tnpo) encodes a protein involved in Hh signalling regulation by mediating the import of the transcription factor encoded by ci into the nucleus. (893 aa) |
| | l(3)psg2 | Lethal (3) persistent salivary gland 2; It is involved in the biological process described with: ecdysone-mediated induction of salivary gland cell autophagic cell death; imaginal disc-derived leg morphogenesis; regulation of programmed cell death. (1929 aa) |
| | dpp | Protein decapentaplegic; Required during oogenesis for eggshell patterning and dorsal/ventral patterning of the embryo. Acts as a morphogen during embryogenesis to pattern the dorsal/ventral axis, specifying dorsal ectoderm and amnioserosa cell fate within the dorsal half of the embryo; this activity is antagonized by binding to sog and tsg. Induces the formation of visceral mesoderm and the heart in early embryos. Required later in embryogenesis for dorsal closure and patterning of the hindgut. Also functions postembryonically as a long-range morphogen during imaginal disk development [...] (588 aa) |
| | Itpr | Inositol 1,4,5,-trisphosphate receptor (Itpr) encodes an intracellular ligand gated calcium channel. It functions downstream of G-protein coupled receptors that activate Gq/PLCbeta signaling and generate inositol tris-phosphate. Itpr depletion affects ecdysone release, response to nutritional stress, lipid metabolism and flight; Belongs to the InsP3 receptor family. (2837 aa) |
| | hkb | Huckebein (hkb) is expressed in patches within the embryonic neuroectoderm and a subset of neuroblasts and their progeny, where it is required for proper neuronal specification and axon targeting. It is a terminal gap gene mediating the maternal terminal information at the posterior end of the blastoderm embryo. (297 aa) |
| | eya | Developmental protein eyes absent; Tyrosine phosphatase thought to play a role in transcription regulation during organogenesis through its intrinsic protein phosphatase activity. The phosphatase activity was shown in vitro. Appears to function together with So and Dac in eye development. Required for the survival of eye progenitor cells at a critical stage in morphogenesis. Belongs to the HAD-like hydrolase superfamily. EYA family. (766 aa) |
| | Pvf2 | PDGF- and VEGF-related factor 2 (Pvf2) encodes a ligand for the receptor tyrosine kinase enocded by Pvr. It has roles in embryonic plasmatocyte survival and migration, and in the proliferation of adult midgut intestinal stem cells. (405 aa) |
| | wg | Protein wingless; Binds as a ligand to a family of frizzled seven-transmembrane receptors and acts through a cascade of genes on the nucleus. Segment polarity protein. May be a growth factor. Acts on neighboring cells to regulate at least one gene, the homeobox segmentation gene engrailed. Wg signal represses arm phosphorylation. Wg signaling operates by inactivating the sgg repression of engrailed autoactivation. Wg and Wnt2 have a role in the developing trachea and together are responsible for all dorsal trunk formation. Wg also acts in the developing epidermis. Acts as a morphogen, [...] (468 aa) |
| | CG4036 | Uncharacterized protein, isoform A; Demethylase activity; 2-oxoglutarate-dependent dioxygenase activity; oxidoreductase activity. It is involved in the biological process described with: larval lymph gland hemopoiesis; oxidative demethylation. (304 aa) |
| | Utx | Utx histone demethylase (Utx) encodes a Jumonji C containing protein that catalyzes the removal of methyl groups from Histone H3 lysine 27. Together with the products of trr and Lpt, it is thought to regulate chromatin structure at transcriptional enhancers. (1136 aa) |
| | kuz | Kuzbanian, isoform A; Kuzbanian (kuz) encodes an ADAM metalloendopeptidase that regulates activation of the receptors encoded by N and robo1 by cleavage. (1238 aa) |
| | Syx5 | Syntaxin-5; Syntaxin 5 (Syx5) encodes a type II transmembrane protein in the Q-SNARE family that forms hetero tetramers required for membrane function in the early secretory pathway (ER and Golgi). It has been involved in cytokinesis during spermatogenesis. (467 aa) |
| | heix | UbiA prenyltransferase domain-containing protein 1 homolog; Prenyltransferase that mediates the formation of menaquinone- 4 (MK-4), a vitamin K2 isoform, thereby acting as a mitochondrial electron carrier. Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. MK-4 acts as a membrane electron carrier downstream of a electron transport chain complex, improving mitochondrial oxygen consumption. (359 aa) |
| | tup | Tailup, isoform A; Tailup (tup) encodes a transcription factor that regulates neuronal sub-type identity, including motor, serotonergic and dopaminergic neuron identity. It regulates germ band retraction, dorsal closure, muscle and heart development. (534 aa) |
| | Antp | Homeotic protein antennapedia; Antennapedia (Antp) is the distal-most member of the Antennapedia complex; one of two Hox gene complexes. Antp encodes a sequence-specific homeodomain transcription factor, which is part of a developmental regulatory system that specifies segmental identity in the pro- and mesothorax. In adults Antp loss of function is associated with a transformation of leg into antenna while ectopic expression in the head is associated with antenna to leg and eye to wing transformations. (378 aa) |
| | Zif | Zinc-finger protein (Zif) encodes a C2H2-type zinc-finger transcription factor that is required for cell polarity and neuroblast self-renewal by regulating the expression and asymmetric localization of the product of aPKC. The phosphorylated product of Zif by aPKC is excluded from the nucleus, thus being the inactive form. (388 aa) |
| | hb | Protein hunchback; Gap class segmentation protein that controls development of head structures; Belongs to the hunchback C2H2-type zinc-finger protein family. (758 aa) |
| | betaTub85D | Tubulin beta-2 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Belongs to the tubulin family. (446 aa) |
| | CG8149 | LD31448p; It is involved in the biological process described with: wing disc dorsal/ventral pattern formation; larval lymph gland hemopoiesis. (308 aa) |
| | dmt | Dalmatian (dmt) encodes a nuclear protein that localizes to centromeric heterochromatin and other polytene chromosome bands. It is required to block expression of rpr and hid during the radiation resistant stage of embryonic development, when cells become irreversibly committed to cell fate. (857 aa) |
| | Ras85D | Ras-like protein 1; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays a role in eye development by regulating cell growth, survival of postmitotic ommatidial cells and differentiation of photoreceptor cells. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis. (189 aa) |
| | hth | Homeobox protein homothorax; All isoforms are required for patterning of the embryonic cuticle. Acts with exd to delimit the eye field and prevent inappropriate eye development. Isoforms that carry the homeodomain are required for proper localization of chordotonal organs within the peripheral nervous system and antennal identity; required to activate antennal-specific genes, such as sal and to repress the leg-like expression of dac. Necessary for the nuclear localization of the essential HOX cofactor, extradenticle (exd). Both necessary and sufficient for inner photoreceptors to adopt [...] (487 aa) |
| | AdamTS-A | ADAM metallopeptidase with thrombospondin type 1 motif A (AdamTS-A) encodes a secreted matrix metalloprotease involved in cell migration. Loss of AdamTS-A in the salivary glands results in apical surface irregularities and cell elongation defects. (1688 aa) |
| | srp | Box A-binding factor; May function as a transcriptional activator protein and may play a key role in the organogenesis of the fat body. Binds a sequence element (5'-[TA]GATAA-3') found in the larval promoters of all known alcohol dehydrogenase (ADH) genes. Acts as a homeotic gene downstream of the terminal gap gene HKB to promote morphogenesis and differentiation of anterior and posterior midgut. (1264 aa) |
| | pnr | GATA-binding factor A; Transcriptional regulator involved in several developmental processes during embryonic and imaginal disks development. Involved in determining dorsal cell fate. Acts as an essential transcriptional regulator of proneural achaete-scute complex (AS-C) and is required for its spatial regulation during development of the adult peripheral nervous system, and hence for the positioning of neural precursors. It is the only factor to directly activate AS-C genes. (540 aa) |
| | htl | Fibroblast growth factor receptor homolog 1; Heartless (htl) encodes a transmembrane tyrosine kinase receptor for secreted FGF ligands that utilizes the intracellular Ras-MAP kinase pathway. It contributes to embryonic mesoderm migration and the specification of several mature mesodermal cell derivatives; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily. (729 aa) |
| | Mdh2 | Malate dehydrogenase 2 (Mdh2) encodes one of the enzymes in the tricarboxylic acid cycle in mitochondria; Belongs to the LDH/MDH superfamily. (336 aa) |
| | tin | Muscle-specific homeobox protein tinman; Required for the development of heart and visceral muscle; for the formation of somatic muscles. Has a crucial function in the early mesodermal subdivisions. (416 aa) |
| | InR | Insulin-like receptor subunit beta 1; Has a ligand-stimulated tyrosine-protein kinase activity. Required for cell survival. Regulates body size and organ size by altering cell number and cell size in a cell-autonomous manner. Involved in the development of the embryonic nervous system, and is necessary for axon guidance and targeting in the visual system. Also plays a role in life-span determination. (2144 aa) |
| | Idh3b | Isocitrate dehydrogenase 3b (Idh3b) encodes a mitochondrial enzyme of the tricarboxylic acid cycle involved in salivary gland cell autophagy. (370 aa) |
| | Nup98-96 | Nuclear pore complex protein Nup98-Nup96; Part of the nuclear pore complex (NPC). Required for MAD import as part of the Nup107-160 complex and required for nuclear export of Moe probably via its association with Rae1. Plays a role in nuclear mRNA export. Promotes cell antiviral response by upregulating FoxK-dependent antiviral gene transcription. In germline stem cells, involved in their maintenance and division together with the TGF-Beta and EGFR signaling pathways. In larval lymph glands, has a role in the maintenance of hematopoiesis by regulating Pvr expression. [Nuclear pore comp [...] (1960 aa) |
| | Tsc1 | LD23779p; Tsc1 (Tsc1) encodes a tumour suppressor protein that forms a complex with the product of gig. They control cellular growth via antagonizing insulin and TOR signalling pathways. (1100 aa) |
| | BRWD3 | BRWD3 (BRWD3) encodes a member of the Bromodomain and WD repeat_containing protein (BRWD) family. It regulates ecdysone and JAK-STAT signaling pathways and contributes to eye development, cell death and phagocytosis. (2232 aa) |
| | Mtl | Mig-2-like (Mtl) encodes a Rho GTPase involved in actin organization regulation. It contributes to multiple actin-mediated processes including dorsal closure, wound healing, cell migration, germ band shortening and salivary gland morphogenesis. (195 aa) |
| | Noa36 | Zinc finger protein 330 homolog; Zinc ion binding. It is involved in the biological process described with: larval lymph gland hemopoiesis. (315 aa) |
| | Drice | Caspase subunit p12; Death related ICE-like caspase (Drice) encodes a major effector apoptotic caspase. It is essential for both developmental and damaged induced cell death, as well as several non-apoptotic vital cellular processes. It is activated by the product of Dark and the initiator caspase encoded by Dronc and is inhibited by the inhibitor of apoptosis encoded by Diap1; Belongs to the peptidase C14A family. (339 aa) |
| | hdc | Headcase short protein; Required for imaginal cell differentiation, may be involved in hormonal responsiveness during metamorphosis. Involved in an inhibitory signaling mechanism to determine the number of cells that will form unicellular sprouts in the trachea. Regulated by transcription factor esg. The longer hdc protein is completely functional and the shorter protein carries some function. (1080 aa) |
| | PH4alphaSG2 | Prolyl 4-hydroxylase alpha-related protein PH4[alpha]SG2; Prolyl-4-hydroxylase-alpha SG2 (PH4alphaSG2) encodes an enzyme that hydroxylates prolines in collagens and other secreted matrix proteins. It is required for proper salivary gland development. (527 aa) |
| | PH4alphaSG1 | Prolyl-4-hydroxylase-alpha SG1 (PH4alphaSG1) encodes an enzyme that hydroxylates prolines in collagens and other secreted matrix proteins. It is required for proper salivary gland development. (540 aa) |
| | tll | Protein tailless; Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity. This receptor binds to the consensus sequence [AG][AG]AAGTCAA. Plays a key role in the establishment of non-metameric domains at the anterior and posterior poles of the embryo. It may also play a role in the nervous system. The maternal terminal pathway activates the tll gene in the termini; TLL activity then represses segmentation and activ [...] (452 aa) |
| | prod | Non-histone chromosomal protein Prod; It is involved in the biological process described with: mitotic chromosome condensation; regulation of circadian rhythm; lymph gland development. (346 aa) |
| | lolal | Longitudinals lacking protein-like; Required, together with Trl, for maintaining the repressed state of target genes including homeotic genes Scr and Ubx. May also be involved in the activation of homeotic genes. Binds to a DNA Polycomb response element (PRE) at the bithorax complex. Also binds to polytene chromosomes at several hundred sites, many of which are shared with Trl and ph-p. Required during embryonic development. (127 aa) |
| | Dark | Death-associated APAF1-related killer, isoform B; Death-associated APAF1-related killer (Dark) encodes an essential component of the apoptosome. The products of Dark and Dronc form a pivotal holoenzyme required for apoptotic cell death with the products of Dark acting as an adaptor of the multimeric complex. (1440 aa) |
| | Rho1 | Ras-like GTP-binding protein Rho1; Has a role in regulating actin cytoskeletal organization: required during early development for proper execution of morphogenetic movements of individual cells and groups of cells important for the formation of the embryonic body plan. Plays a role in regulating dorsal closure during embryogenesis. During axis elongation, required for Rho-kinase Rok planar polarity and adherens junction localization as well as for generating a planar polarized distribution of the actin-binding protein Shrm. During embryogenesis, acts upstream of wash to regulate the d [...] (192 aa) |
| | scb | Integrin alpha-PS3 heavy chain; Integrin alpha-PS3/beta-PS is a receptor for laminin. Also binds to wb. Important during embryogenesis for the development of the trachea, dorsal vessel and salivary gland, as well as for dorsal closure. Required for short-term memory processes. Minor involvement in the establishment of the oocyte anterior-posterior length. Plays a role in timely border cell migration during oogenesis, probably mediated by JNK signaling. Integrin alpha-PS3/Itgbn is required for effective phagocytosis of apoptotic cells during embryonic development and for the phagocytic [...] (1115 aa) |
| | fsd | Fates-shifted (fsd) encodes an F-box protein with a role in the gradient formation of the product of bcd and fatemap specification through targeting bcd protein for ubiquitination and degradation. (312 aa) |
| | fra | Frazzled, isoform A; Frazzled (fra) encodes a DCC-like Netrin receptor that mediates axon guidance. It also contributes to dendrite guidance, development and morphogenesis. (1526 aa) |
| | garz | Gartenzwerg, isoform B; Gartenzwerg (garz) encodes a guanine nucleotide exchange factor localized to the cis-Golgi apparatus. The roles of the product of garz include membrane and protein trafficking between the Golgi apparatus and the endoplasmic reticulum. It is required for epithelial morphogenesis in the embryo. (1983 aa) |
| | SmD3 | Small ribonucleoprotein particle protein SmD3 (SmD3) encodes an RNA binding protein that forms a heterodimeric sub-complex with the product of SmB. They function as part of the heteroheptameric ring complex Sm core, which is involved in the formation of spliceosomal small nuclear RNPs (U1, U2, U4 and U5), which together catalyze pre-mRNA splicing. The product of SmD3 also has a function in germline specification, as it is required for localization of the product of osk to the posterior pole of the oocyte. (151 aa) |
| | ths | Thisbe, isoform A; Thisbe (ths) encodes is a Fibroblast growth factor (FGF) and ligand for the FGF receptor encoded by htl. It regulates the development of somatic and visceral muscle in the mesoderm, cardioblasts and glial cells. Its roles include acting as a chemoattractant in directional cell migration, and regulating adhesion, differentiation, and cell survival. (748 aa) |
| | drosha | Ribonuclease; Drosha (drosha) encodes a protein that contributes to miRNA processing. It is involved in salivary gland histolysis and oocyte development. (1327 aa) |
| | Wnt4 | Protein Wnt-4; Binds as a ligand to a family of frizzled seven-transmembrane receptors and acts through a cascade of genes on the nucleus. Acts downstream of homeotic complex genes in the visceral mesoderm and is required for embryonic segmentation. Also required for cell movement and FAK regulation during ovarian morphogenesis. (539 aa) |
| | pnt | ETS-like protein pointed; ETS transcription factor with a prominent role during development of the eye and the nervous system. Required for glial- neuronal cell interactions at the ventral midline which are necessary for the proper elaboration of commissures in the embryonic CNS. [Isoform P1]: Required for normal EGFR-induced photoreceptor development. Following transcriptional activation by isoform P2, acts as a constitutive activator of transcription, leading to induction of target genes essential for photoreceptor development. In larval brains, involved in the maintenance of type II [...] (718 aa) |
| | so | Sine oculis (so) encodes a homeobox-containing transcription factor that functions with the product of eya as a transcriptional co-activator. It contributes to both cell and tissue fate specification, promotion of cell proliferation and suppression of apoptosis. (416 aa) |
| | chic | Profilin; Chickadee (chic) encodes an actin monomer binding protein that provides the major cellular pool of readily polymerizing ATP-actin monomers. It is involved in oogenesis, spermatogenesis, cell division, bristle formation, cellular morphogenesis, axon growth, filopodia formation, dorsal closure, wound healing and stem cell maintenance. (126 aa) |
| | CrebA | Cyclic-AMP response element binding protein A (CrebA) encodes a leucine-zipper transcription factor that upregulates genes encoding protein components of the canonical secretory pathway and tissue-specific genes in the salivary gland and epidermis. (516 aa) |
| | h | Hairy (h) encodes a bHLH transcriptional repressor that recruits the corepressor encoded by gro to target promoters. It is a pair-rule gene that contributes to embryonic segmentation and peripheral neurogenesis. (337 aa) |
| | mRpL53 | Mitochondrial ribosomal protein L53; Structural constituent of ribosome. It is involved in the biological process described with: larval lymph gland hemopoiesis; mitochondrial translation. (155 aa) |
| | Eip74EF | Ecdysone-induced protein 74EF (Eip74EF) encodes a transcription factor that responds to different concentrations of 20-hydroxyecdysone. It contributes to puparium formation and autophagy; Belongs to the ETS family. (883 aa) |
| | CG33155 | RH74701p; It is involved in the biological process described with: larval lymph gland hemopoiesis. (60 aa) |
| | pan | Protein pangolin, isoform J; Pangolin (pan) encodes an HMG-domain transcription factor that is a key component of the canonical Wingless signaling pathway. It toggles between acting as a transcriptional repressor (when bound to the product of gro) and activator (when bound to the product of arm) to promote cell fate specification. (1192 aa) |
| | Btk29A | Btk family kinase at 29A (Btk29A) encodes a non-receptor tyrosine kinase with diverse roles including cellularization, morphogenesis, patterning and germ cell proliferation; Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily. (786 aa) |
| | pyr | Pyramus (pyr) encodes a Fibroblast growth factor (FGF) and ligand for the FGF receptor encoded by htl. It regulates the development of somatic and visceral muscle in the mesoderm, cardioblasts and glial cells. Its roles include acting as a chemoattractant in directional cell migration, and regulating adhesion, differentiation, and cell survival. (766 aa) |
| | egl | Egalitarian, isoform B; Egalitarian (egl) encodes an RNA binding protein that links specific mRNAs to the minus end-directed microtubule motor, cytoplasmic dynein-1. (1004 aa) |
| | Pten | Phosphatase and tensin homolog (Pten) encodes a dual lipid and protein phosphatase that primarily counters the effects of the insulin-regulated lipid kinase, encoded by Pi3K92E. It inhibits cell growth, cell proliferation and cellular events controlling cytoskeletal and junctional rearrangements. (514 aa) |
| | Trf2 | TATA box binding protein-related factor 2 (Trf2) encodes a core promoter recognition factor that mediates gene transcription. It contributes to spiracle morphogenesis, pupal development and salivary gland cell death. (1715 aa) |
| | if | Integrin alpha-PS2 heavy chain; Inflated (if) encodes one of five fly integrin alpha subunits, and when in a heterodimer with an integrin beta subunit makes a receptor for extracellular matrix proteins containing an RGD motif, such as those encoded by Tig, wb laminin and Tsp. It is required in numerous tissues for cell migration and adhesion between cell layers. (1396 aa) |
| | Dif | Dorsal-related immunity factor Dif; Mediates an immune response in larvae. DIF binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of the immunity gene CECA1. Involved in the melanization immune response to bacterial challenge, possibly by acting in a Toll signaling pathway that downregulates Spn27A in response to infection. Part of a signaling pathway involving NF-kappa-B (rel) and Toll-related receptors, that functions in the apoptosis of unfit cells during cell competition. May be part of a NF-kappa-B and Tollo signaling cascade that regulates dev [...] (987 aa) |
| | NetB | Netrin-B; Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either fra or unc-5 receptors will lead to axon attraction or repulsion, respectively. While short-range repulsion requires both fra and unc-5 receptors, long-range repulsion only requires unc-5. (793 aa) |
| | Pvr | Receptor protein-tyrosine kinase; PDGF- and VEGF-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (encoded by Pvf1, Pvf2 or Pvf3). It is involved in cell migration regulation and it has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1, Rho family small GTPases and the JNK cascade, in a context-dependent manner. (1577 aa) |
| | CG42637 | Receptor-type guanylate cyclase Gyc76C; Guanylate cyclase involved in the production of the second messenger cGMP. Acts as a receptor for the NPLP1-4 peptide and modulates the innate immune IMD pathway in response to salt stress by inducing nuclear translocation of NF-kappa-B protein Rel which leads to increased expression of the antimicrobial peptide diptericin. Plays a role in Sema-1a-mediated axon repulsion which is required for the correct establishment of neuromuscular connectivity. Required in developing embryonic somatic muscle for correct patterning of ventral and lateral muscl [...] (1525 aa) |
| | Gyc76C | Guanylyl cyclase at 76C (Gyc76C) encodes a membrane-associated guanylate cyclase that catalyzes the conversion of GTP to the second messenger cGMP. It has roles in embryonic development (epithelia and muscle), axonal guidance, Malpighian tubule function, innate immunity and salt stress tolerance. (1525 aa) |
| | EcR | Ecdysone receptor (EcR) encodes a protein that interacts with the product of usp to form the nuclear ecdysone receptor heterodimer, which modulates, in conjunction with co-activators and co-repressors, the activities of hundreds of genes in a tissue- and stage-specific way. EcR is widely expressed in embryonic and larval tissues and in some adult tissues where its activities (modulated by the hormone ecdysone) trigger both molting and metamorphosis. (878 aa) |
| | crb | Protein crumbs; Plays a central role in cell polarity establishment. Participates in the assembly, positioning and maintenance of adherens junctions via its interaction with the SAC complex. Controls the coalescence of the spots of zonula adherens (ZA) into a adhesive ring around the cells. It may act as a signal. Involved in morphogenesis of the photoreceptor rhabdomere, for positioning and growth of rhabdomere and AJ during the crucial period of photoreceptor extension along the proximodistal axis of the retina. Component of the crb-galla-Xpd (CGX) complex which is essential for prop [...] (2253 aa) |
| | Cam | Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+) (By similarity). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). In photoreceptor cells, light-induced Ca(2+) influx activates calmodulin, which in turn is likely to promote Crag activity in trafficking of newly synthesized ninaE (Rh1) from the trans-Golgi network to rhabdomere membranes. Together with Akap200, regulates PKA activity and ethanol-induced sensitivity and tolerance. (149 aa) |
| | foxo | Forkhead box protein O; Transcription factor involved in the regulation of the insulin signaling pathway. Consistently activates both the downstream target Thord4EBP and the feedback control target InR. Involved in negative regulation of the cell cycle, modulating cell growth and proliferation. In response to cellular stresses, such as nutrient deprivation or increased levels of reactive oxygen species, foxo is activated and inhibits growth through the action of target genes such as Thor. Foxo activated in the adult fat body can regulate lifespan in adults; an insulin peptide itself m [...] (622 aa) |
| | dia | Protein diaphanous; Required for cytokinesis in both mitosis and meiosis. Has a role in actin cytoskeleton organization and is essential for many, if not all, actin-mediated events involving membrane invagination. May serve as a mediator between signaling molecules and actin organizers at specific phases of the cell cycle. Possible component of the contractile ring or may control its function. (1098 aa) |
| | l(2)gl | Lethal(2) giant larvae protein; Essential for the development of polarized epithelia, for cell polarity associated with asymmetric cell division of neuroblasts during development, and for oocyte polarity formation. Promotes the formation of actin-rich projections at the oocyte cortex and the posterior enrichment of par-1 which is required for oocyte polarization. Regulates the localization of axis-specifying morphogens such as stau and grk. [Isoform p127]: Has an accessory function in control of cell proliferation and differentiation during development. (1161 aa) |
| | slv | Sugar transporter SWEET1; Mediates both low-affinity uptake and efflux of sugar across the membrane. (226 aa) |
| | ush | Zinc finger protein ush; Transcription regulator that modulates expression mediated by transcription factors of the GATA family such as pnr and srp. Represses transcription of proneural achaete-scute complex (AS-C), which is usually activated by pnr. Involved in cardiogenesis, blood, and eye development. During hematopoiesis, it is required to restrict the number of crystal cells, probably via its interaction with the isoform SrpNC of srp. Negatively regulates expression of sr. Probably acts by interacting with the GATA-type zinc finger of proteins such as pnr and srp, possibly antagon [...] (1212 aa) |
| | robo2 | Roundabout 2 (robo2) encodes a member of the Robo receptor family that responds to the ligand encoded by sli as a repulsive cue in axons, dendrites, muscles, trachea and heart development. It can also inhibit robo1 signaling, likely explaining why the product of robo2 can appear to be an attractive receptor in certain contexts. (1519 aa) |
| | gl | Glass (gl) encodes a zinc finger transcription factor involved in cell fate specification. It is primarily transcribed in photoreceptors, where its expression is activated by the retinal determination member encoded by so. gl is required for correctly patterning the retina, rhabdomere formation, and for the expression of phototransduction proteins. (679 aa) |
| | rib | Ribbon, isoform C; Ribbon (rib) encodes a nuclear BTB-domain protein, expressed in most embryonic cells. It is required for development of the salivary gland and trachea, as well as for dorsal closure. It regulates both growth and differentiation of salivary gland cells. (680 aa) |
| | trn | Tartan, isoform B; Tartan (trn) encodes a transmembrane leucine-rich repeat protein. It is closely related to caps and genetically interacts with it. Together they regulate embryonic motor axon guidance and innervation of antennal lobe glomeruli by olfactory sensory axons. The product of trn is a substrate for the product of Ptp52F and genetically interacts with it to regulate guidance of SNa motor axons. (751 aa) |
| | gammaCOP | Coatomer subunit gamma; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Required for limiting lipid storage in lipid droplets. Involved in the expansion of luminal extracellular matrices and apical membrane during tubulogenesis. Required [...] (897 aa) |
| | fz | Frizzled; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to inv [...] (612 aa) |
| | trh | Protein trachealess; Transcription factor, master regulator of tracheal cell fates in the embryo, necessary for the development of the salivary gland duct, Malpighian tubules and the posterior spiracles. It may induce a general fate of branched tubular structures of epithelial origin. Functions with tgo to regulate expression of btl. (1022 aa) |
| | fz2 | Frizzled-2; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...] (806 aa) |
| | drl | Tyrosine-protein kinase Drl; Probable coreceptor of Wnt proteins. Involved in neuronal pathway recognition and ventral muscle attachment site selection. Non- vital for development. May be part of a signal transduction cascade involved in learning and possibly memory. (645 aa) |
| | fkh | Fork head (fkh) encodes a winged-helix nuclear transcription factor most studied for its role in salivary gland formation, where it is required for salivary gland viability, invagination, and maintaining expression of other early-expressed salivary gland transcription factors. It works with the product of sage to activate expression of salivary gland specific gene products, such as secreted proteins and their modifying enzymes. (692 aa) |
| | br | Broad-complex core protein isoform 6; Broad-complex proteins are required for puffing and transcription of salivary gland late genes during metamorphosis. (1011 aa) |
| | sli | Slit (sli) encodes a secreted glycoprotein that acts as a ligand for the Robo receptor family and co-receptors, including the products of Sdc and Dscam1. The product of sli functions as second messenger (via Abl) and receptor dependent, providing repellent (neural growth cone), attractive (trachea), and polarising (cardioblasts) cues for differentiating cells. (2157 aa) |
| | zfh1 | Zinc finger protein 1; Involved in the development of the embryonic central nervous system, embryonic mesoderm and adult musculature. Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family. (1206 aa) |
| | Rac1 | Ras-related protein Rac1; During various developmental processes, regulates changes in cell morphology in response to extracellular signals. During oogenesis, mediates signaling from the tyrosine kinase (RTK) chemoattractant receptors (Egfr and Pvr) to the guidance pathway that control the directional persistent collective migration of the border cell (BC) cluster through the nurse cells to the oocyte. Once activating by Pvr and Egfr, promotes the formation of forward-directed actin protrusions which stabilize the DE- cadherin (shg)-mediated adhesions. In turn, DE-mediated adhesion bet [...] (192 aa) |
| | kug | Fat-like cadherin-related tumor suppressor homolog; Required for the planar polarity of actin filament orientation at the basal side of ovarian follicle cells. Required for proper egg chamber shape and elongation of the egg chamber during oogenesis. Required for the correct planar polarization of Rab10 within the basal follicle cell epithelium and is therefore indirectly involved in the Rab10-dependent remodeling of the basal membrane during egg chamber elongation. (4699 aa) |
| | Rac2 | Ras-related protein Rac2; Involved in integrin alpha-PS3/beta-nu-mediated phagocytosis of Gram-positive S.aureus by hemocytes. (192 aa) |
| | asrij | OCIA domain-containing protein 1; Asrij (asrij) encodes a conserved ovarian carcinoma immunoreactive antigen domain-containing endosomal protein that maintains stemness. It positively regulates JAK/STAT signalling and negatively regulates the Notch pathway. It interacts with the GTP-bound form of the product of Arf79F to regulate hematopoiesis and immunity; Belongs to the OCIAD1 family. (258 aa) |
| | stwl | Stonewall, isoform A; Stonewall (stwl) encodes a protein that is associated with heterochromatin and modifies levels of trimethylated H3K27 and H3K9. stwl product is required for maintenance of female germline stem cells and for survival of genotoxic stress induced by DNA replication inhibition. (1037 aa) |
| | jeb | Jelly belly (jeb) encodes a secreted, low-density lipoprotein (LDL) repeat containing protein that functions as signalling ligand for the product of Alk. Binding of the ligand to its receptor activates intracellular Ras/ERK and PI3K signalling pathways. The roles of the product of jeb include embryonic visceral muscle development, growth and organ size regulation, retinal axon targeting, modulation of neuromuscular transmission as well as sleep regulation and olfactory learning. (560 aa) |
| | fog | G protein-coupled receptor ligand; Coordinates cell shape changes during formation of the ventral furrow and invagination of the posterior midgut primordium, by inducing apical constriction of cells in spatially and temporally defined manners. Could function as a secreted signal to initiate apical constriction by acting as a ligand for an unidentified G protein- coupled receptor, which in turn activates the G protein alpha subunit encoded by concertina, in neighboring cells. Such an intracellular pathway would ultimately induce contraction of the apical actin-myosin network. In the ven [...] (730 aa) |
| | rho | Protein rhomboid; Acts early in embryonic development to establish position along the dorsoventral axis and then again later to specify the fate of neuronal precursor cells. Involved in EGF receptor signaling; cleaves Spitz to release the active growth factor. Belongs to the peptidase S54 family. (355 aa) |
| | exd | Homeobox protein extradenticle; Transcription factor which acts with the selector homeodomain proteins altering the regulation of downstream target genes such as wingless (wg), teashirt (tsh) and decapentaplegic (dpp), thus affecting segmental identity. Delimits the eye field and prevent inappropriate eye development. Required for proper localization of chordotonal organs within the peripheral nervous system. (376 aa) |
| | shi | Dynamin; Microtubule-associated force-producing protein which is involved in the production of microtubule bundles and which is able to bind and hydrolyze GTP. Implicated in endocytic protein sorting; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (896 aa) |
| | Fhos | Formin homology 2 domain containing (Fhos) encodes a protein that regulates actin-dependent remodeling of muscle cytoskeleton via induction of actin stress fibers, directs macrophage migration during cellular immune response, and is involved in autophagic programmed cell death. (2528 aa) |
| | drpr | Protein draper; Receptor which is involved in the phagocytosis of a variety of cells including apoptotic cells, severed and pruned axons, degenerating dendrites, salivary gland cells, germline cells and bacteria. Binds to the ligand prtp which relocates from the endoplasmic reticulum to the cell surface during apoptosis. Ligand-binding may promote tyrosine phosphorylation mediated by Src42a, interaction with shark and subsequent activation of phagocytosis. Also binds to the membrane phospholipid phosphatidylserine which is exposed on the surface of apoptotic cells. Required for the pha [...] (1042 aa) |
| | btsz | Bitesize, isoform I; Bitesize (btsz) encodes a membrane-trafficking protein that contributes to actin cytoskeleton organization. It is involved in the establishment of planar cell polarity, apical junction assembly and the morphogenesis of salivary glands and the tracheal system. (3734 aa) |
| | bel | ATP-dependent RNA helicase bel; ATP-dependent RNA helicase that is essential and required for cellular function, larval growth, and for male and female fertility. Also required for RNA interference (RNAi), double-stranded RNA induces potent and specific gene silencing, by acting downstream of dsRNA internalization. RNAi is mediated by the RNA-induced silencing complex (RISC), a sequence-specific, multicomponent nuclease that destroys or silences messenger RNAs homologous to the silencing trigger. Belongs to the DEAD box helicase family. DDX3/DED1 subfamily. (801 aa) |
| | Pak | P21-activated kinase (Pak) encodes a serine/threonine effector kinase for the small GTPases Rac and the product of Cdc42 involved in cytoskeletal regulation. The product of Pak contributes to growth cone guidance, synaptic development, and epithelial morphogenesis in both the ovary and embryo. (840 aa) |
| | Stat92E | Signal-transducer and activator of transcription protein at 92E (Stat92E) encodes a transcription factor that shuttles between the cytosol and nucleus and functions in the JAK/STAT pathway. Its roles include proliferation, growth control, organismal metabolism, cell competition, stem cell self-renewal, immunity and developmental patterning. (818 aa) |
| | Pi3K92E | Phosphoinositide 3-kinase, Dp110; Pi3K92E (Pi3K92E) encodes the catalytic subunit of a class I phosphatidylinositol 3-kinase that functions downstream of the product of InR and other receptors during several processes, including cell and tissue growth; Belongs to the PI3/PI4-kinase family. (1088 aa) |
| | Atg17 | Autophagy-related 17 (Atg17) encodes a subunit of the evolutionarily conserved Atg1 kinase complex, which controls the initiation of autophagosome formation. The product of Atg17 also has a role in maintaining neuromuscular function and normal lifespan. (1357 aa) |
| | RpS21 | 40S ribosomal protein S21; May be an associated component of the ribosome rather than a core structural subunit. May act as a translation initiation factor. Has a role in regulation of cell proliferation in the hematopoietic organs and the imaginal disks of larva. (83 aa) |
| | Drp1 | Dynamin related protein 1 (Drp1) encodes a dynamin-like GTPase that mediates mitochondrial fission through a process that involves translocation to the mitochondrial outer membrane and oligomerization. It is required for normal neuronal development and maintenance of postmitotic neuronal function and viability; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (735 aa) |
| | Src42A | Tyrosine-protein kinase Src42A; Required directly or indirectly for the phosphorylation of drpr which is necessary for the interaction of drpr with shark and subsequent glial phagocytic activity. Together with drpr and shark, promotes the migration of macrophages to sites of wounding as part of a signaling cascade where Scr42a detects production of hydrogen peroxide at wound sites which triggers phosphorylation of drpr and subsequent recruitment and activation of shark. Essential for correct eye morphogenesis (ommatidial R7 neuron formation) which requires the Ras1/MAPK signal transduc [...] (1597 aa) |
| | Strica | Ser/Thr-rich caspase (Strica) encodes a member of initiator caspases. It contributes, redundantly or cooperatively with the product of Dronc, to the apoptosis of selective larval neurons during metamorphosis and nurse cells during oogenesis, and competitive apoptosis of heterozygous mutant cells; Belongs to the peptidase C14A family. (527 aa) |
| | DCAF12 | DDB1 and CUL4 associated factor 12, isoform A; It is involved in the biological process described with: regulation of programmed cell death; salivary gland cell autophagic cell death. (459 aa) |
| | Tor | Serine/threonine-protein kinase Tor; Promotes cell and tissue growth, maintains tissue homeostatis and controls responses to environmental stress and aging. Regulates growth during animal development by coupling growth factor signaling to nutrient availability. Central regulators of autophagy. May be involved in atg1 phosphorylation. May also be involved, directly or indirectly, in the control of neuronal function. Phosphorylates S6K/p70S6K, in vitro. May regulate the activity of S6K. Overexpression inhibits growth and reduces cell size. Affects the timing of neuronal cell differentiat [...] (2471 aa) |
| | dnt | Tyrosine-protein kinase Dnt; Doughnut on 2 (dnt) encodes a Ryk family Wnt receptor-tyrosine kinase-related protein. It can form homo- and heterodimers with the other two Ryks (encoded by Drl-2 and drl) via binding the ligand encoded by Wnt5. dnt and drl products act during embryonic muscle attachment site selection. (584 aa) |
| | Drl-2 | Derailed 2 (Drl-2) is a member of the RYK gene family encoding a receptor tyrosine kinase that transduces Wnt5 signaling. It regulates salivary gland positioning, muscle attachment site selection and olfactory system development. The products of Drl-2 and drl can play both cooperative and opposing roles, depending on the cells where they are differentially expressed. (648 aa) |
| | eyg | Eyegone, isoform A; Eyegone (eyg) encodes a Pax family transcription factor that acts as a transcriptional repressor. In eye development, the product of eyg promotes cell proliferation in the larval eye disc through activation of Jak/STAT pathway. It also plays both positive and negative roles in head vortex development. (670 aa) |
| | unc-5 | Netrin receptor unc-5; Receptor for netrin required for motor axon guidance. Mediates both short- and long-range axon motor repulsion in the developing nervous system upon ligand binding. Also involved in glial migration. While short-range repulsion requires both fra and unc-5, long-range repulsion only requires unc-5. (1072 aa) |
| | mys | Integrin beta-PS; Integrin alpha-PS1/beta-PS is a receptor for laminin. Integrin alpha-PS2/beta-PS is a receptor for Tig, wb and Ten-m. Contributes to endodermal integrity and adhesion between the midgut epithelium and the surrounding visceral muscle. Essential for migration of the primordial midgut cells and for maintaining, but not establishing, cell polarity in the midgut epithelium. The two beta subunits mediate midgut migration by distinct mechanisms: beta-PS requires rhea/talin and Itgbn does not. Required for rhea/talin correct cellular localization in the midgut. Required for m [...] (846 aa) |
| | mew | Integrin alpha-PS1 heavy chain; Multiple edematous wings (mew) encodes one of 5 fly integrin alpha subunits, and when in a heterodimer with an integrin beta subunit makes a receptor for the extracellular matrix protein laminin. It is required in numerous tissues for cell migration, adhesion between cell layers, and cell differentiation. (1243 aa) |
| | raw | Raw, isoform A; Raw (raw) encodes a membrane protein involved in dendrite patterning and the subcellular localization of JNK signalling components. (989 aa) |
| | HUWE1 | Uncharacterized protein, isoform H; Ubiquitin-protein transferase activity; ubiquitin protein ligase activity. It is involved in the biological process described with: protein ubiquitination; ubiquitin-dependent protein catabolic process; protein polyubiquitination; dsRNA transport. (5151 aa) |
| | sog | Dorsal-ventral patterning protein Sog; Short gastrulation (sog) encodes a secreted BMP antagonist that is expressed in the embryonic ventral neuroectoderm. sog product promotes neural development by preventing dorsally produced dpp from diffusing into the neuroectoderm and suppressing expression of neural genes. sog protein also diffuses dorsally where it helps establish a BMP activity gradient essential for partitioning that domain into cells giving rise to the dorsal epidermis versus amnioserosa. (1038 aa) |
| | robo1 | Roundabout 1 (robo1) encodes a member of the Robo receptor family that uses the secreted glycoprotein encoded by sli as ligand and the products of Sdc and Dscam1 as co-receptors. It contributes to axon guidance and dendrite morphogenesis as well as regulating trachea and heart tube development. (1395 aa) |
| | Wnt5 | Protein Wnt-5; Binds as a ligand to a family of frizzled seven-transmembrane receptors and acts through a cascade of genes on the nucleus. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. May have a role in limb and CNS development; may be a downstream target of Dll that acts in the specification of these primordia; Belongs to the Wnt family. (1004 aa) |
| | lola | Longitudinals lacking protein, isoforms F/I/K/T; Longitudinals lacking (lola) encodes a protein involved in Notch signaling, cell death, regulation of retrotransposons and expression of axon and dendrite patterning genes. It contributes to oogenesis, spermatogenesis, neural wiring, eye development and a variety of behaviors. (970 aa) |
| | Marf | Transmembrane GTPase Marf; Mitochondrial assembly regulatory factor (Marf) encodes a dynamin-family GTPase that mediates outer mitochondrial membrane tethering and fusion. Marf loss causes mitochondrial fragmentation and endoplasmic reticular stress that evoke skeletal muscle, retinal and heart tube dysfunction; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. Mitofusin subfamily. (814 aa) |
| | Src64B | Tyrosine-protein kinase Src64B; Src oncogene at 64B (Src64B) encodes a Src family nonreceptor tyrosine kinase. It has many biological roles, including ring canal morphogenesis in oogenesis and the male germline, microfilament ring constriction during cellularization, and modulation of growth and apoptosis. Some of its roles overlap with those of the product of Src42A. (553 aa) |
| | Raf | Raf homolog serine/threonine-protein kinase Raf; Serine/threonine kinase required in the early embryo for the formation of terminal structure. Also required during the proliferation of imaginal cells. May act downstream of Ras85D in the tor signal transduction pathway. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily. (739 aa) |
| | Ser | Protein serrate; Acts as a ligand for Notch (N) receptor. Essential for proper ectodermal development. Serrate represents an element in a network of interacting molecules operating at the cell surface during the differentiation of certain tissues. (1407 aa) |
| | LanB2 | Laminin B2 (LanB2) encodes a subunit of laminin, a heterotrimeric protein found in the extracellular matrix (ECM) and a major component of the basal lamina. Laminins interact with a variety of cell surface molecules such as integrin receptors and other secreted ECM components. It contributes to ECM organization, tissue adhesion, cell motility and developmental patterning. (1639 aa) |
| | CG1129 | Mannose-1-phosphate guanyltransferase beta; Mannose-1-phosphate guanylyltransferase activity. It is involved in the biological process described with: larval lymph gland hemopoiesis; biosynthetic process. (369 aa) |
| | E2f1 | Transcription factor E2f1; Transcriptional activator that binds to E2f sites. Required for wild-type growth in mitotic and polytene tissues, Contributes to the expression of replication genes at the G1-S transition and Cyclin E. Activates cell proliferation in wing imaginal disk, which requires expression of vg; Belongs to the E2F/DP family. (821 aa) |
| | rl | Mitogen-activated protein kinase ERK-A; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway to regulate poliferation, differentiation and effect cell fate decisions in various tissues. Required downstream of phl/Raf in the sev/sevenless, tor/torso, and EGF receptor homolog Egfr signal transduction pathways. Required for embryonic epithelial tissue repair. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis. (376 aa) |
| | Rrp40 | Ribosomal RNA processing 40 (Rrp40) encodes a protein involved in gene expression regulation. (232 aa) |
| | twi | Twist (twi) encodes a transcription factor required for mesoderm cell fate. The product of twi is essential for gastrulation, the development of mesodermal derivatives, including somatic and visceral muscle, fat body and maintenance of muscle stem cells. (490 aa) |
| | CTPsyn | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides (By similarity). Isoform 1 is required for cytoophidium assembly in female germline cells. (627 aa) |
| | IP3K2 | Kinase; Inositol 1,4,5-triphosphate kinase 2 (IP3K2) encodes a kinase that regulates calcium levels by influencing IP3 signaling; Belongs to the inositol phosphokinase (IPK) family. (691 aa) |
| | sage | Salivary gland-expressed bHLH (sage) is only expressed in embryonic salivary glands. The product of sage works with the product of fkh to activate expression of salivary gland specific gene products (secreted proteins and enzymes that modify the secreted proteins). (268 aa) |
| | caps | Capricious, isoform E; Capricious (caps) encodes a transmembrane receptor with leucine-rich repeats that mediates cell interaction in a homophilic or heterophilic manner. caps product contributes to cellular interaction critical for synapse formation and axon guidance, as well as mediating morphogenesis of multiple tissues, including wings, legs and the tracheal system. (811 aa) |
| | pre-lola-G | Longitudinals lacking protein, isoform G; Putative transcription factor required for axon growth and guidance in the central and peripheral nervous systems. Repels CNS axons away from the midline by promoting the expression of the midline repellent sli and its receptor robo. (436 aa) |
| | Scr | Homeotic protein Sex combs reduced; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Controls the segmental transformation of the first to the second thoracic segment (prothorax to mesothorax) and of the labial palps into maxillary palps. In embryo, required for fusion of labial lobes and development of the T1 denticle belt. In adult, expression in the head is necessary for proper development of the labium. In the first thoracic segment of the adult, required [...] (508 aa) |
| | ctp | Dynein light chain 1, cytoplasmic; Cut up (ctp) encodes the 8 kDa (LC8/DLC1) subunit of the cytoplasmic Dynein, as well as the Myosin V. It homodimerizes and binds to a variety of proteins. It is involved in both dynein-dependent and independent functions such as cell viability, axonal guidance, spermatid growth and individualization, and regulation of spermatogonial divisions; Belongs to the dynein light chain family. (267 aa) |
