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| | CG6999 | CG6999; RNA binding. It is involved in the biological process described with: regulation of alternative mRNA splicing, via spliceosome; endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); small-subunit processome assembly. (233 aa) |
| | CG4021 | KH domain-containing protein; RNA binding; mRNA binding. It is involved in the biological process described with: regulation of alternative mRNA splicing, via spliceosome. (319 aa) |
| | qkr58E-1 | Quaking related 58E-1, isoform A; mRNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome; regulation of alternative mRNA splicing, via spliceosome. (396 aa) |
| | CG3927 | KH domain-containing protein; RNA binding; mRNA binding. It is involved in the biological process described with: regulation of alternative mRNA splicing, via spliceosome. (270 aa) |
| | vir | Protein virilizer; Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of mRNAs, a modification that plays a role in the efficiency of mRNA splicing and is required for sex determination. Required for sex determination and dosage compensation via Sxl alternative splicing: m6A methylation acts as a key regulator of Sxl pre-mRNA and promotes female-specific alternative splicing of Sxl, which determines female physiognomy. M6A methylation is also required for neuronal functions. Required for proper inclusion of regulated exons in Ubx trans [...] (1854 aa) |
| | hfp | Poly(U)-binding-splicing factor half pint; Splicing factor that regulates oogenesis and controls both mitosis and mRNA localization in the germline by regulating mRNA splicing of a subset of genes within the ovary. Probably acts by regulating the alternative splice site selection of the otu transcript. Also regulates the alternative splicing of eIF4E1 and grk, while it is not involved in the splicing of par-1, sqd and psq. Belongs to the RRM half pint family. (637 aa) |
| | CG7879 | FI22004p1; mRNA binding; RNA binding. It is involved in the biological process described with: regulation of RNA splicing; regulation of alternative mRNA splicing, via spliceosome. (985 aa) |
| | Ythdc1 | YTH domain-containing protein 1; Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs. Acts by acting as a reader of m6A methylation. Required for sex determination and dosage compensation via Sxl alternative splicing: m6A methylation acts as a key regulator of Sxl pre-mRNA and promotes female-specific alternative splicing of Sxl, which determines female physiognomy. M6A methylation is also required for neuronal functions. (721 aa) |
| | CG15747 | FI21110p1; It is involved in the biological process described with: mRNA splicing, via spliceosome. (387 aa) |
| | l(1)G0007 | Lethal (1) G0007 (l(1)G0007) encodes a protein involved in alternative mRNA splicing regulation. (1222 aa) |
| | CG6227 | LD41277p; ATP binding; RNA helicase activity; RNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome; regulation of alternative mRNA splicing, via spliceosome. (1224 aa) |
| | CG8565 | ATP binding; protein serine/threonine kinase activity; MAP kinase activity. It is involved in the biological process described with: spliceosomal complex assembly; intracellular signal transduction; regulation of mRNA processing; regulation of gene expression; protein phosphorylation. (790 aa) |
| | Flacc | Fl(2)d-associated complex component; Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of mRNAs, a modification that plays a role in the efficiency of mRNA splicing and is required for sex determination. In the WMM complex, acts as a key regulator of m6A methylation by bridging fl(2)d to the RNA-binding component nito. Required for sex determination and dosage compensation via Sxl alternative splicing: m6A methylation acts as a key regulator of Sxl pre-mRNA and promotes female-specific alternative splicing of Sxl, which determines fem [...] (1150 aa) |
| | asf1 | Histone chaperone asf1; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly. Plays a role in the formation of silent heterochromatin. (218 aa) |
| | Pep | Zinc finger protein on ecdysone puffs; May play a role in the process of early and late gene activation, or possibly in RNA processing, for a defined set of developmentally regulated loci. (716 aa) |
| | l(3)72Ab | Putative U5 small nuclear ribonucleoprotein 200 kDa helicase; Putative RNA helicase involved in the second step of RNA splicing; Belongs to the helicase family. SKI2 subfamily. (2142 aa) |
| | Srrm1 | FI04407p; SRm160 (SRm160) encodes a conserved RNA-binding protein that participates in the exon junction complex and is involved in pre-mRNA splicing and 3' end formation. It participates in somatic sex determination, cell death, retinal development and the control of circadian rhythm. Direct targets include rl. (954 aa) |
| | CG10418 | U6 snRNA-associated Sm-like protein LSm2; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (95 aa) |
| | ZC3H3 | Zinc finger CCCH domain-containing protein 3; Required for the export of polyadenylated mRNAs from the nucleu; binds to polyadenylated mRNA, and is involved in the regulation of mRNA polyadenylation. (597 aa) |
| | Cpsf6 | Cleavage and polyadenylation specificity factor subunit CG7185; May play a role in pre-mRNA 3'-processing; Belongs to the RRM CPSF6/7 family. (652 aa) |
| | CG4896 | Uncharacterized protein, isoform D; mRNA binding; RNA binding. It is involved in the biological process described with: regulation of alternative mRNA splicing, via spliceosome; mRNA splicing, via spliceosome. (949 aa) |
| | CG11454 | RRM domain-containing protein; mRNA binding; single-stranded RNA binding. It is involved in the biological process described with: regulation of alternative mRNA splicing, via spliceosome. (238 aa) |
| | Rm62 | ATP-dependent RNA helicase p62; As an RNA helicase, unwinds RNA and alters RNA structures through ATP binding and hydrolysis. Involved in multiple cellular processes, including pre-mRNA splicing, alternative splicing, rRNA processing and miRNA processing, as well as transcription regulation (By similarity). Plays a role in innate immunity. Specifically restricts bunyavirus infection, including Rift Valley fever virus (RVFV) or La Crosse virus (LACV), but not vesicular stomatitis virus (VSV), in an interferon- and DROSHA-independent manner. (719 aa) |
| | CG2926 | Uncharacterized protein, isoform A; Zinc ion binding. It is involved in the biological process described with: regulation of alternative mRNA splicing, via spliceosome. (2296 aa) |
| | CG14641 | LD46870p; pre-mRNA binding; mRNA binding; metal ion binding; U6 snRNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome; regulation of alternative mRNA splicing, via spliceosome. (418 aa) |
| | Hel25E | ATP-dependent RNA helicase WM6; Required for mRNA export out of the nucleus. Probable RNA helicase that may regulate entry into mitosis by down-regulating the expression of other genes whose activity may be rate-limiting for entry into mitosis during embryogenesis. Binds to salivary gland chromosomes and modifies position effect variegation. Promotes an open chromatin structure that favors transcription during development by regulating the spread of heterochromatin. (424 aa) |
| | x16 | X16 splicing factor (x16) encodes a protein involved in RNA splicing and RNA metabolism regulation. (258 aa) |
| | Mettl14 | N6-adenosine-methyltransferase non-catalytic subunit; Non-catalytic component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of mRNAs, a modification that plays a role in the efficiency of mRNA splicing and is required for sex determination. In the heterodimer formed with Ime4/Mettl3, Mettl14 constitutes the RNA- binding scaffold that recognizes the substrate rather than the catalytic core (By similarity). Required for sex determination and dosage compensation via Sxl alternative splicing: m6A methylation acts as a key regulator of Sxl pre-mRNA and pro [...] (397 aa) |
| | Srp54 | LD29830p; Srp54 (Srp54) encodes a protein that regulates mRNA alternative splicing, the processing of the mRNA 3'-end and the selection of the transcriptional start site. (513 aa) |
| | Son | Son DNA binding protein, isoform A; Double-stranded RNA binding; RNA binding. (874 aa) |
| | Rbp1 | RNA-binding protein 1; Contributes to the activation of female-specific DSX splicing in vivo by recognizing the RBP1 target sequences within the purine-rich polypyrimidine tract of the female-specific 3' splice site. Belongs to the splicing factor SR family. (144 aa) |
| | sqd | RNA-binding protein squid; This protein is a component of ribonucleosomes. Could be needed to organize a concentration gradient of a dorsalizing morphogen (Dm) originating in the germinal vesicle. At least one of the isoforms is essential in somatic tissues. (344 aa) |
| | obe | Obelus (obe) encodes a Ski2-family helicase that regulates alternative mRNA splicing of crb. It is required for cell polarity and adherens junction organization. (2183 aa) |
| | Sf3a1 | Splicing factor 3a subunit 1; RNA binding. It is involved in the biological process described with: regulation of alternative mRNA splicing, via spliceosome; mRNA splicing, via spliceosome; mitotic cell cycle; spermatogenesis. (784 aa) |
| | SF1 | Splicing factor 1, isoform A; Zinc ion binding; pre-mRNA branch point binding; RNA binding; mRNA binding. It is involved in the biological process described with: regulation of alternative mRNA splicing, via spliceosome; mRNA splicing, via spliceosome. (787 aa) |
| | snRNP-U1-C | U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region (By similarity). Regulat [...] (145 aa) |
| | tst | Twister, isoform A; Twister (tst) encodes a protein that regulates mRNA alternative splicing. (1197 aa) |
| | Mettl3 | N6-adenosine-methyltransferase MT-A70-like protein; Catalytic component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of mRNAs, a modification that plays a role in the efficiency of mRNA splicing and is required for sex determination. In the heterodimer formed with Mettl14, constitutes the catalytic core (By similarity). Required for sex determination and dosage compensation via Sxl alternative splicing: m6A methylation acts as a key regulator of Sxl pre-mRNA and promotes female-specific alternative splicing of Sxl, which determines female physiognomy [...] (608 aa) |
| | CG5728 | LD41803p; RNA binding. It is involved in the biological process described with: mRNA processing; regulation of alternative mRNA splicing, via spliceosome. (1430 aa) |
| | Nab2 | Nuclear polyadenosine RNA-binding 2 (Nab2) encodes a zinc-finger polyadenosine RNA binding protein that is expressed widely in many cell types but required specifically within the developing nervous system for proper behavior and axonogenesis. The product of Nab2 in supports in neurons short term memory and development of the brain mushroom bodies. (1004 aa) |
| | Saf-B | Scaffold attachment factor B, isoform B; mRNA binding; sequence-specific DNA binding. It is involved in the biological process described with: regulation of mRNA processing; regulation of transcription by RNA polymerase II; regulation of alternative mRNA splicing, via spliceosome. (928 aa) |
| | Hrb98DE | Heterogeneous nuclear ribonucleoprotein at 98DE (Hrb98DE) encodes a nuclear RNA-binding protein. It controls hnRNA stability, splicing, IRES-dependent translation, and translational repression. It represents one of the main targets of the poly(ADP-ribosyl)ation pathway. It also regulates tissue polarity patterning and germ-line stem cell fate. (365 aa) |
| | CG1646 | Pre-mRNA-processing factor 39; Involved in pre-mRNA splicing. (1066 aa) |
| | mle | Dosage compensation regulator; Required in males for dosage compensation of X chromosome linked genes. Mle, msl-1 and msl-3 are colocalized on X chromosome. Each of the msl proteins requires all the other msls for wild-type X- chromosome binding. Probably unwinds double-stranded DNA and RNA in a 3' to 5' direction; Belongs to the DEAD box helicase family. DEAH subfamily. (1293 aa) |
| | Prp19 | Pre-RNA processing factor 19 (Prp19) encodes a protein involved in chromatin organization and alternative mRNA splicing regulation. (505 aa) |
| | Psi | P-element somatic inhibitor (Psi) encodes a protein that has dual roles in RNA processing and transcriptional regulation. It is required for activating Myc transcription. (797 aa) |
| | pea | ATP-dependent RNA helicase DHX8; Involved in pre-mRNA splicing as component of the spliceosome. Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome (By similarity). Before and after egg-chamber formation, required for nurse-cell chromatin dispersal (NCCD) probably by playing a role in spliceosome localization to chromatin/interchromatin spaces. (1242 aa) |
| | fand | Pre-mRNA-splicing factor syf1 homolog; Subunit of the NTC(Nineteen)/Prp19 complex, which is part of the spliceosome. The complex participates in spliceosome assembly, its remodeling and is required for efficient spliceosome activation. Essential for efficient pre-mRNA splicing. In embryos, efficient pre-mRNA splicing of zygotic transcripts is essential during dynamic cellular processes that require rapid division and/or dramatic changes in gene expression such as blastoderm cellularization, tracheal branching morphogenesis, Malpighian morphogenesis and epidermal development. Part of it [...] (883 aa) |
| | fl(2)d | Pre-mRNA-splicing regulator female-lethal(2)D; Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of mRNAs, a modification that plays a role in the efficiency of mRNA splicing and is required for sex determination. Required for sex determination and dosage compensation via Sxl alternative splicing: m6A methylation acts as a key regulator of Sxl pre-mRNA and promotes female-specific alternative splicing of Sxl, which determines female physiognomy. M6A methylation is also required for neuronal functions. Required for proper inclusion of [...] (536 aa) |
| | Lsm11 | FI05704p; Lsm11 (Lsm11) encodes one of the seven proteins that form a heptameric Sm ring in the U7 snRNP, which is a key factor involved in 3' end processing of histone pre-mRNAs. It interacts with the product of FLASH. The two interacting proteins form a biochemical platform that recruits a number of polyadenylation subunits to the U7 snRNP, including the products of Sym, Cpsf100, Cpsf73 and CstF64. (256 aa) |
| | Dbp45A | Probable ATP-dependent RNA helicase Dbp45A; Probable ATP-binding RNA helicase; Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily. (521 aa) |
| | nito | RNA-binding protein spenito; RNA-binding protein that acts as an associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of mRNAs. M6a modification plays a role in the efficiency of mRNA splicing and is required for sex determination. In the WMM complex, may act by binding target RNAs and recruiting the WMM complex. Required for sex determination and dosage compensation via Sxl alternative splicing: m6A methylation acts as a key regulator of Sxl pre-mRNA and promotes female-specific alternative splicing of Sxl, which determines female physi [...] (793 aa) |
| | Caper | Caper, isoform A; Caper (Caper) encodes an RNA-binding protein involved in regulation of alternative mRNA splicing. (594 aa) |
| | salm | Homeotic protein spalt-major; Spalt major (salm) encodes a zinc finger transcriptional repressor. It mediates most dpp functions during development of the central part of the wing through regulation of the products of kni and ara. The product of salm is required for cell specification during the development of the nervous system, muscle, eye or trachea. (1365 aa) |
| | tra2 | Transformer-2 sex-determining protein; Required for female sex determination in somatic cells and for spermatogenesis in male germ cells. Positive regulator of female- specific splicing and/or polyadenylation of doublesex (dsx) pre-mRNA. Splicing requires an enhancer complex, dsxRE (dsx repeat element: which contains six copies of a 13-nucleotide repeat and a purine-rich enhancer (PRE)). DsxRE is formed through cooperative interactions between tra, tra2 and the sr proteins, and these interactions require both the repeat sequences and PRE. PRE is required for specific binding of tra2 to [...] (264 aa) |
| | HnRNP-K | Heterogeneous nuclear ribonucleoprotein K (HnRNP-K) encodes a member of the hnRNP family of DNA/RNA binding proteins. It localizes, along with other hnRNPs, in nucleoplasmic omega speckles. It is involved in gene regulation, post-transcriptional RNA processing and RNA transport. (502 aa) |
| | LSm-4 | Like Sm protein 4, isoform B; It is involved in the biological process described with: regulation of alternative mRNA splicing, via spliceosome. (205 aa) |
| | Spf45 | RNA binding motif protein 17; Spf45 (Spf45) encodes a bi-functional protein with roles in both splicing and DNA repair. (403 aa) |
| | Doa | Serine/threonine-protein kinase Doa; Negative regulator of the copia retrotransposon element of the white (w) gene. In the eye, it is required for normal pigmentation, photoreceptor cell development and for organization of interommatidial bristles. Also essential for embryonic segmentation and differentiation of the nervous system. Functions in the control of alternative splicing by phosphorylating the arginine/serine-rich splicing factors, SR proteins; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily. (2045 aa) |
| | CG17454 | LD28068p; RNA binding. It is involved in the biological process described with: mRNA processing; regulation of alternative mRNA splicing, via spliceosome; mRNA splicing, via spliceosome. (243 aa) |
| | Larp7 | La related protein 7 (Larp7) encodes an obligate component of the 7SK snRNP. The 7SK snRNP plays an essential role in RNA polymerase II elongation control by regulating the activity of the positive transcription elongation factor encoded by Cdk9. (595 aa) |
| | Rbp1-like | Rbp1-like, isoform B; Rbp1-like (Rbp1-like) encodes a mRNA binding protein involved in RNA splicing and RNA metabolism. (247 aa) |
| | CG10445 | Uncharacterized protein, isoform C; ATP binding. It is involved in the biological process described with: regulation of alternative mRNA splicing, via spliceosome. (945 aa) |
| | SF2 | Splicing factor 2 (SF2) encodes a protein involved in alternative mRNA splicing, RNA export from the nucleus and the regulation of the RNA metabolism. (255 aa) |
| | pps | Protein partner of snf (pps) encodes a protein that is part of the machinery required for sex-specific splicing of the Sxl and tra pre-mRNAs. (2018 aa) |
| | bru2 | Bruno 2, isoform E; RNA binding; mRNA binding. It is involved in the biological process described with: negative regulation of translation; mRNA splice site selection; regulation of alternative mRNA splicing, via spliceosome. (893 aa) |
| | mub | Mushroom-body expressed, isoform K; Mushroom-body expressed (mub) encodes a protein involved in thermosensory behavior and regulation of alternative mRNA splicing. (573 aa) |
| | Rbfox1 | RNA-binding Fox protein 1 (Rbfox1) encodes RNA-binding proteins that bind to (U)GCAUG elements. Nuclear isoforms of the product of Rbfox1 regulate tissue specific alternative splicing, while cytoplasmic isoforms regulate mRNA translation. It functions in a number of processes, including germline cyst development. (962 aa) |
| | SC35 | SR family splicing factor SC35 (SC35) encodes a mRNA binding protein that regulates mRNA alternative splicing, the processing of the mRNA 3'-end and the selection of the transcriptional start site. (195 aa) |
| | Srpk79D | Serine-arginine protein kinase at 79D (Srpk79D) is required to prevent the formation of axonal protein aggregates containing the active zone-protein encoded by brp. (1018 aa) |
| | fne | Found in neurons (fne) encodes an RNA binding protein that works as a post-transcriptional regulator. It is present in the cytoplasm of all neurons. Lack of fne produces fusion of the mushroom body beta-lobes and altered male courtship behaviour. (356 aa) |
| | Hrb27C | Heterogeneous nuclear ribonucleoprotein 27C; This protein is a component of ribonucleosomes. Could be needed to organize a concentration gradient of a dorsalizing morphogen (Dm) originating in the germinal vesicle. (421 aa) |
| | eIF4A | Eukaryotic initiation factor 4A; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. Involved in germ cell formation. (403 aa) |
| | elav | Protein elav; Required for the proper development and maintenance of neurons presumably by affecting RNA metabolism. Belongs to the RRM elav family. (483 aa) |
| | U2af50 | U2 small nuclear riboprotein auxiliary factor 50 (U2af50) encodes the large subunit of the heterodimeric complex U2AF. U2AF binds to the intron pyrimidine tract between the branchpoint and the 3' splice site and targets U2 snRNP to the branch site early in spliceosome assembly. (427 aa) |
| | Fmr1 | Synaptic functional regulator FMR1; Polyribosome-associated RNA-binding protein that plays a role in neuronal development and synaptic plasticity through the regulation of protein synthesis of mRNAs. Plays a role as a negative translational regulator of specific mRNAs. Represses translation of the microtubule-associated protein futsch mRNA to regulate microtubule-dependent synaptic growth and function. May also be involved in microRNA (miRNA)-mediated translational suppression as part of the RNA-induced silencing complex (RISC). Required for stability of the central pair of microtubule [...] (729 aa) |
| | B52 | Serine-arginine protein 55; Essential for development. May have a critical role in splicing or in controlling alternative splice site use of at least some pre-mRNA in vivo. Not required for all splicing. May play a general role in the condensation or decondensation of chromatin. (355 aa) |
| | CG11360 | LD09246p1; Ubiquitin protein ligase activity; RNA binding; zinc ion binding. It is involved in the biological process described with: regulation of alternative mRNA splicing, via spliceosome. (628 aa) |
| | bru3 | Bruno 3 (bru3) encodes an RNA binding protein that binds to the EDEN element and mediates maternal mRNA translational repression. (422 aa) |
| | SRPK | SR Protein Kinase (SRPK) encodes a protein involved in spindle microtubule assembly and karyosome formation in oocytes. (939 aa) |
| | Hakai | E3 ubiquitin-protein ligase Hakai; E3 ubiquitin-protein ligase required during early development. E3 ubiquitin-protein ligases mediate ubiquitination of target proteins. Required for epithelial integrity and midgut morphogenesis. Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Its function in the WMM complex is unknown. Belongs to the Hakai family. (473 aa) |
| | Sxl | Protein sex-lethal; Sex determination switch protein which controls sexual development by sex-specific splicing. Regulates dosage compensation in females by suppressing hyperactivation of X-linked genes. Expression of the embryo-specific isoform is under the control of primary sex- determining signal, which depends on the ratio of X chromosomes relative to autosomes (X:A ratio). Expression occurs in 2X:2A cells, but not in X:2A cells. The X:A ratio seems to be signaled by the relative concentration of the X-linked transcription factors SIS-A and SIS-B. As a result, the embryo-specific [...] (722 aa) |
| | swm | Zinc finger protein swm; Negatively regulates Hedgehog (hh) protein signal in wing development. Regulates neural-specific glycosylation by binding to FucTA mRNA and facilitating its nuclear export in neural cells. (1063 aa) |
| | snRNP-U1-70K | Small ribonucleoprotein particle U1 subunit 70K (snRNP-U1-70K) encodes a protein component of the U1 snRNP. The U1 snRNP combines with other snRNPs on the pre-mRNA to assemble a spliceosome. (448 aa) |
| | qkr54B | Quaking related 54B, isoform E; mRNA binding; RNA binding. It is involved in the biological process described with: regulation of alternative mRNA splicing, via spliceosome. (617 aa) |
| | bru1 | Bruno 1 (bru1) encodes an RNA binding protein acting in multiple forms of post-transcriptional gene regulation including repression and activation of translation and alternative splicing of pre-mRNAs. The product of bru1 is required for gametogenesis, developmental patterning, and muscle organization. (810 aa) |
| | Rox8 | Rox8, isoform D; Rox8 (Rox8) encodes a protein involved in the regulation of alternative mRNA splicing. (470 aa) |
| | U2af38 | U2 small nuclear riboprotein auxiliary factor 38 (U2af38) encodes the small subunit of the pre-mRNA splicing factor complex U2AF. This heterodimeric complex binds to the intron pyrimidine tract and targets the product of snf to the branch site early in spliceosome assembly. The U2af38 product binds to the AG dinucleotide at the 3' splice site. (264 aa) |
| | Rsf1 | RNA-binding protein Rsf1; May control important aspects of development. (200 aa) |
| | ps | Pasilla, isoform R; Pasilla (ps) encodes a nuclear RNA binding protein implicated in splicing. It is expressed at high levels in the embryonic salivary gland and other tissues. Loss of function results in a significant reduction in secretory volume and secretory vesicles in the salivary gland and irregular gland morphology. (780 aa) |
| | Hrb87F | Heterogeneous nuclear ribonucleoprotein at 87F (Hrb87F) encodes a hnRNP-A family RNA-binding protein, involved in gene expression and RNA processing. It is an essential component of the nucleoplasmic omega speckles and necessary for telomere maintenance. Hrb87F null mutants show defects in development, female fertility and stress tolerance. (385 aa) |
| | Tnpo-SR | Transportin-Serine/Arginine rich (Tnpo-SR) encodes a importin-beta family protein involved in the regulation of mRNA splicing. It contributes to the import into the nucleus of serine/arginine-rich (SR) proteins, which are involved in mRNA splicing. (932 aa) |
| | how | Protein held out wings; Required for integrin-mediated cell-adhesion in wing blade. Vital role in steroid regulation of muscle development and to control heart rate. Required during embryogenesis, in late stages of somatic muscle development, for myotube migration and during metamorphosis for muscle reorganization. (418 aa) |
| | mbl | Muscleblind (mbl) encodes an RNA binding protein that regulates RNA metabolism at the levels of alternative splicing, transcript localization and miRNA and circRNA biogenesis. It contributes to terminal muscle, eye and neural differentiation. (956 aa) |
| | qkr58E-2 | Quaking related 58E-2, isoform A; mRNA binding. It is involved in the biological process described with: regulation of alternative mRNA splicing, via spliceosome. (416 aa) |
| | qkr58E-3 | Quaking related 58E-3 (qkr58E-3) encodes an RNA binding protein that contributes to mRNA splicing and apoptosis. (317 aa) |
| | CG4119 | BcDNA.LD23634; mRNA binding. It is involved in the biological process described with: regulation of alternative mRNA splicing, via spliceosome; mRNA splicing, via spliceosome. (998 aa) |
| | dom | Helicase domino; Mediates the ATP-dependent exchange of unmodified histone H2AV for its phosphorylated and acetylated form H2AVK5acS138ph, leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in Notch signaling. Represses E2F target genes. Required for somatic stem cell self-renewal but not for germline stem cell self-renewal. Involved in oogenesis. Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. (3233 aa) |
| | CG10384 | IP21806p; mRNA binding. It is involved in the biological process described with: regulation of alternative mRNA splicing, via spliceosome. (492 aa) |
| | trv | Trivet, isoform I; Nucleic acid binding. It is involved in the biological process described with: regulation of alternative mRNA splicing, via spliceosome. (651 aa) |
| | CG34354 | Uncharacterized protein, isoform F; Nucleic acid binding; mRNA binding. (550 aa) |
| | nsr | Novel spermatogenesis regulator, isoform A; RNA binding; mRNA binding. It is involved in the biological process described with: regulation of alternative mRNA splicing, via spliceosome; posttranscriptional regulation of gene expression; sperm axoneme assembly; sperm individualization. (340 aa) |
| | CG6841 | LD04472p; RNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome; spliceosomal tri-snRNP complex assembly; regulation of alternative mRNA splicing, via spliceosome. (931 aa) |
| | crn | Crooked neck (crn) encodes a component of the splicing complex involved in axon ensheathment, glial cell migration and Malpighian tubule morphogenesis; Belongs to the crooked-neck family. (702 aa) |
| | snf | U1 small nuclear ribonucleoprotein A; Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP (By similarity). Plays a role in regulating sex-lethal splicing; Belongs to the RRM U1 A/B'' family. (216 aa) |
