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egh egh BG642312 BG642312 Pink1 Pink1 Ih Ih Clk Clk Ets96B Ets96B Pka-C1 Pka-C1 Tbh Tbh Dup99B Dup99B rho-5 rho-5 Pura Pura Sh Sh Gadd45 Gadd45 sand sand trsn trsn Rho1 Rho1 Pdf Pdf InR InR Ktl Ktl cry cry Atx2 Atx2 ppk ppk hll hll bgm bgm Sirt1 Sirt1 AstC AstC me31B me31B Dh31 Dh31 5-HT2A 5-HT2A Itpr Itpr SLC22A SLC22A park park S S dod dod Lkr Lkr Ilp2 Ilp2 SP SP Lk Lk Mip Mip cyc cyc Nca Nca rut rut Fbxl4 Fbxl4 cue cue Trh Trh spag spag Galphas Galphas iav iav dyw dyw per per qvr qvr 5-HT1A 5-HT1A CrebB CrebB tim tim Tmc Tmc Gr43a Gr43a wake wake Fas2 Fas2 Bx Bx SPR SPR inc inc Pi3K92E Pi3K92E BTBD9 BTBD9 Shab Shab Rdl Rdl TfAP-2 TfAP-2 Acer Acer Est-6 Est-6 rho rho Hsp83 Hsp83 sNPF-R sNPF-R Alk Alk Rac1 Rac1 Drip Drip Hk Hk Pi3K21B Pi3K21B Oamb Oamb Dop1R1 Dop1R1 Dop1R2 Dop1R2 homer homer nan nan RYa RYa Pdfr Pdfr Mbs Mbs Fmr1 Fmr1 AGO1 AGO1 SIFa SIFa foxo foxo mld mld Trim9 Trim9 Pka-R1 Pka-R1 EcR EcR Cul3 Cul3 Gabat Gabat mnb mnb ITP ITP Ide Ide
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eghBeta-1,4-mannosyltransferase egh; Glycosyltransferase with a proposed role in glycosphingolipid biosynthesis. Neurogenic protein implicated in epithelial development. Critical component of a differential oocyte-follicle cell adhesive system; Belongs to the glycosyltransferase 2 family. (457 aa)
BG642312BG642312, isoform A; BG642312 (BG642312) encodes a peptide produced in the male accessory glands and transferred to females during mating. (77 aa)
Pink1PTEN-induced putative kinase 1 (Pink1) is the ortholog of human PINK1, a gene mutated in autosomal recessive Parkinson's disease. Pink1 encodes a mitochondrially targeted Ser-Thr kinase. It has been linked to a number of cellular functions including altering mitochondrial dynamics, the autophagic degradation of dysfunctional mitochondria, and the proper function of Complex I of the electron transport chain. (721 aa)
IhI[[h]] channel (Ih) encodes a low-threshold, voltage-gated ion channel. It may influence excitatory postsynaptic potential kinetics and integration. (1327 aa)
ClkCircadian locomoter output cycles protein kaput; Circadian regulator that acts as a transcription factor and generates a rhythmic output with a period of about 24 hours. Oscillates in antiphase to the cycling observed for period (PER) and timeless (TIM). According to reaches peak abundance within several hours of the dark-light transition at ZT0 (zeitgeber 0), whereas describes bimodal oscillating expression with maximum at ZT5 and ZT23. Clock-cycle heterodimers activate cycling transcription of PER and TIM by binding to the E-box (5'-CACGTG-3') present in their promoters. Once induced [...] (1027 aa)
Ets96BETV5-related protein Ets96B; Required in dopaminergic neurons to regulate expression of genes involved in dopamine signaling. Decreases expression of the dopamine transporter DAT and increases expression of the dopamine transporter Vmat and the tyrosine 3-monooxygenase ple which is involved in dopamine biosynthesis. Also involved in negatively regulating the expression of a group of endoplasmic reticulum proteins, the molecular chaperone Calr and the protein disulfide isomerases CaBP1 and ERp60. (640 aa)
Pka-C1cAMP-dependent protein kinase catalytic subunit 1; Serine/threonine-protein kinase involved in memory formation. Promotes long-term memory by phosphorylating meng and by regulating CrebB protein stability and activity. As part of ethanol response in the glia, mediates ethanol-induced structural remodeling of actin cytoskeleton and perineurial membrane topology when anchored to the membrane. (353 aa)
TbhTyramine beta-hydroxylase; Converts tyramine into octopamine, a neurotransmitter involved in ovulation and locomotion. Functions in an amine-mediated Bacc-dependent signaling pathway that negatively regulates acute ethanol sensitivity. Belongs to the copper type II ascorbate-dependent monooxygenase family. (670 aa)
Dup99BDuctus ejaculatorius peptide 99B; Induces post-mating responses; increased oviposition and reduced receptivity. (54 aa)
rho-5Inactive rhomboid protein 1; Rhomboid protease-like protein which has no protease activity but regulates the secretion of several ligands of the epidermal growth factor receptor. Indirectly activates the epidermal growth factor receptor signaling pathway and may thereby regulate sleep, cell survival, proliferation and migration. (1429 aa)
PuraPuratrophin-1-like, isoform A; Puratrophin-1-like (Pura) encodes a RhoGEF involved in leg morphogenesis, neuron morphogenesis, and locomotor rhythm regulation. (1904 aa)
ShPotassium voltage-gated channel protein Shaker; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Forms rapidly inactivating tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient and may contribute to A- type currents. Plays a role in the regulation of sleep need or efficiency ; Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) s [...] (655 aa)
Gadd45Growth arrest and DNA damage-inducible 45; It is involved in the biological process described with: regulation of oviposition; activation of MAPKKK activity; JNK cascade; regulation of cell cycle. (163 aa)
sandRE21922p; Potassium ion leak channel activity; potassium channel activity. It is involved in the biological process described with: negative regulation of membrane potential; negative regulation of circadian sleep/wake cycle, sleep; stabilization of membrane potential; potassium ion transmembrane transport; cellular response to dopamine; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (395 aa)
trsnGM27569p; Translin (trsn) encodes a protein that, together with the product of Trax, forms the Trsn/Trax complex, a ribonuclease that facilitates RNA-induced silencing complex (RISC) activation and has been implicated in many different processes, including starvation-induced sleep suppression. (235 aa)
Rho1Ras-like GTP-binding protein Rho1; Has a role in regulating actin cytoskeletal organization: required during early development for proper execution of morphogenetic movements of individual cells and groups of cells important for the formation of the embryonic body plan. Plays a role in regulating dorsal closure during embryogenesis. During axis elongation, required for Rho-kinase Rok planar polarity and adherens junction localization as well as for generating a planar polarized distribution of the actin-binding protein Shrm. During embryogenesis, acts upstream of wash to regulate the d [...] (192 aa)
PdfPDF precursor-related peptide; Pigment-dispersing factor (Pdf) encodes a secreted biologically active neuropeptide that acts via a specific G-protein-coupled receptor to trigger intracellular signaling. It has a prominent role in the physiology of circadian rhythms, as well as contributing to other processes such as control of flight and digestion. (102 aa)
InRInsulin-like receptor subunit beta 1; Has a ligand-stimulated tyrosine-protein kinase activity. Required for cell survival. Regulates body size and organ size by altering cell number and cell size in a cell-autonomous manner. Involved in the development of the embryonic nervous system, and is necessary for axon guidance and targeting in the visual system. Also plays a role in life-span determination. (2144 aa)
KtlKctd12-like, isoform A; Kctd12-like (Ktl) encodes a protein involved in male aggression and mating behavior. (228 aa)
cryCryptochrome-1; Blue light-dependent regulator that is the input of the circadian feedback loop. Has no photolyase activity for cyclobutane pyrimidine dimers or 6-4 photoproducts. Regulation of expression by light suggests a role in photoreception for locomotor activity rhythms. Functions, together with per, as a transcriptional repressor required for the oscillation of peripheral circadian clocks and for the correct specification of clock cells. Genes directly activated by the transcription factors Clock (Clk) and cycle (cyc) are repressed by cry. Necessary for light-dependent magneto [...] (542 aa)
Atx2Ataxin-2 homolog; RNA binding protein that regulates various processes including circadian behaviors, actin filament formation, eye development and oocyte formation. Forms a complex with tyf and pAbp which functions in adult circadian pacemaker neurons to sustain circadian rhythms likely by switching between activator and repressor modes of post-transcriptional regulation via interaction with Lsm12a or me31B. Forms an activator complex (Atx2-tyf activator complex) via association with Lsm12a and activates the TYF-dependent translation of per to maintain 24 hour periodicity in circadian [...] (1084 aa)
ppkAmiloride-sensitive Na+ channel; Pickpocket (ppk) encodes an acid-sensing sodium channel from the degenerin/epithelial sodium channel (DEG/ENaC) family. It contributes to mechanical nociception, larval behavior and dendrite morphogenesis. (606 aa)
hllLong-chain-fatty-acid--CoA ligase heimdall; Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Probably by regulating lipid storage and catabolism, plays a role in neuronal function ; Belongs to the ATP-dependent AMP-binding enzyme family. Bubblegum subfamily. (681 aa)
bgmVery long-chain-fatty-acid--CoA ligase bubblegum; Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Probably by regulating lipid storage and catabolism, plays a role in neuronal function. (666 aa)
Sirt1NAD-dependent histone deacetylase sirtuin-1; NAD-dependent histone deacetylase involved in heterochromatic silencing. Mildly suppresses the heterochromatin-mediated silencing phenomenon known as position-effect variegation (PEV). Required for epigenetic silencing of the polycomb group proteins. Has histone H4 deacetylase activity in vitro. Required maternally for establishing proper segmentation of the embryo. Involved in sex determination. May be involved in the regulation of life span. (823 aa)
AstCAllatostatin C (AstC) encodes a myotropic factor involved in heart rate decrease. (122 aa)
me31BATP-dependent RNA helicase me31b; ATP-dependent RNA helicase which is a core component of a variety of ribonucleoprotein complexes (RNPs) that play critical roles in translational repression and mRNA decapping during embryogenesis, oogenesis, neurogenesis and neurotransmission. Recruits core components and translational repressors to some RNP complexes, and mediates RNP aggregation into processing granules such as P-bodies. As part of a RNP complex containing tral, eIF4E1, cup, and pAbp, involved in RNP-mediated translational repression of maternal mRNAs during oogenesis and embryogene [...] (459 aa)
Dh31Diuretic hormone class 2; Regulation of fluid secretion. Stimulates Malpighian tubules fluid secretion by activating the apical membrane V-ATPase via cyclic AMP of principal cells in the main secretory segment. (117 aa)
5-HT2A5-hydroxytryptamine (serotonin) receptor 2A (5-HT2A) encodes a 5-hydroxytryptamine (serotonin) GPCR that belongs to the Class A GPCR family. They bind and transmit the signal from the neurotransmitter 5-HT (serotonin). The family can be subdivided into several subclasses based on pharmacology, signal transduction and structure. There are 5 genes encoding serotonin receptors in the Drosophila melanogaster genome: 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, and 5-HT7. (930 aa)
ItprInositol 1,4,5,-trisphosphate receptor (Itpr) encodes an intracellular ligand gated calcium channel. It functions downstream of G-protein coupled receptors that activate Gq/PLCbeta signaling and generate inositol tris-phosphate. Itpr depletion affects ecdysone release, response to nutritional stress, lipid metabolism and flight; Belongs to the InsP3 receptor family. (2837 aa)
SLC22ASLC22A family member (SLC22A) encodes a plasma membrane transporter and a member of the conserved family of SLC22A transporters. The product of SLC22A is preferentially localized in the dendrites of mushroom body neurons, where it functions to terminate synaptic transmission from cholinergic projection neurons through uptake of the released neurotransmitter acetylcholine. Impairing the function of SLC22A enhances the acquisition and retention of olfactory memory by allowing the neurotransmitter signal from projection neurons to be more persistent. (568 aa)
parkParkin (park) encodes an E3 ubiquitin ligase with a key role in protein ubiquitination. It is involved in mitochondrion organization, oxidative stress and locomotion; Belongs to the RBR family. Parkin subfamily. (482 aa)
SStar (S) encodes a type II transmembrane protein that facilitates trafficking of transmembrane Egfr ligands from the endoplasmic reticulum to the late secretory compartment. It is involved in growth regulation, cell survival and developmental patterning. (597 aa)
dodPeptidyl-prolyl cis-trans isomerase activity; transcription factor binding. It is involved in the biological process described with: positive regulation of protein ubiquitination; regulation of locomotor rhythm. (166 aa)
LkrLeucokinin receptor (Lkr) encodes a 7-transmembrane domain G-protein-coupled receptor (GPCR) with the product of Lk as a ligand. It signals through intracellular calcium, and is implicated in ion regulation by the Malpighian tubules and in feeding control. (542 aa)
Ilp2Probable insulin-like peptide 2 A chain; Plays a role in regulating body size by increasing cell size and cell number of individual organs. Probably mediates its growth effects by acting as a ligand for the insulin receptor and transducing a signal via the Chico/PI3K/Akt(PKB) pathway. (137 aa)
SPAccessory gland-specific peptide 70A; Male seminal protein which triggers short- and long-term post-mating behavioral responses (PMR) in female Drosophila. Binds initially to sperm where it is later cleaved to release an active peptide within the female reproductive tract. Signals via the sex peptide receptor (SPR) in female flies; may also act via other receptors. Moderates the activity of distinct neuronal circuitries in the female genital tract to promote specific PMRs including: enhanced ovulation, increased egg laying rate, increased feeding/foraging rate, induced antimicrobial pe [...] (55 aa)
LkLeucokinin (Lk) encodes a neuropeptide that regulates water balance and food intake. Three groups of leucokinergic neurons are identified in the brain and abdominal ganglion of larvae and adults. Serotonin and insulin peptides have receptors in the abdominal leucokinergic neurons. (160 aa)
MipAllatostatins MIP; Ligand for the sex peptide receptor (SPR). Stabilizes sleep and maintains sleep homeostasis to inhibit the activity of wake-promoting circuits, such as those that involve the pigment dispersing factor (pdf) neurons. Regulated by the circadian clock network and pathways associated with a sleep homeostat. May also have a regulatory role in gut motility. (211 aa)
cycProtein cycle; Putative transcription factor involved in the generation of biological rhythms. Activates cycling transcription of Period (PER) and Timeless (TIM) by binding to the E-box (5'-CACGTG-3') present in their promoters. (413 aa)
NcaNeurocalcin homolog; Calcium-binding protein that is essential for promoting night-time sleep and inhibiting nocturnal hyperactivity. During the night-time it promotes sleep by limiting synaptic output from arousal- and wake-promoting neurons within the C01- and A05- domains that include the mushroom body, and the antennal mechanosensory and motor center. Regulated by the circadian clock network and light- sensing circuits that include the CRY photoreceptor; it is likely that both of these internal and external cues are required to define the temporal window (the night-time) during whi [...] (190 aa)
rutCa(2+)/calmodulin-responsive adenylate cyclase; Rutabaga (rut) encodes a membrane-bound Ca[2+]/calmodulin-activated adenylyl cyclase that is responsible for synthesis of cAMP. It plays a key role in regulating behavioral, neuroanatomical, and electrophysiological plasticity. (2248 aa)
Fbxl4F box and leucine-rich-repeat gene 4; It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; protein polyubiquitination; negative regulation of synaptic transmission, GABAergic; negative regulation of circadian sleep/wake cycle, sleep; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. (669 aa)
cueProtein cueball; Has a role in spermatogenesis and oogenesis. Might have a role in triglyceride homeostasis. Probably by regulating lipid storage and catabolism, plays a role in neuronal function. (644 aa)
TrhTryptophan hydroxylase (Trh) encodes an enzyme that functions as the first and rate-limiting step in the synthesis of serotonin. (555 aa)
spagFI17138p1; Spaghetti (spag) encodes a TPR domain-containing co-chaperone that associates with Hsp70 and Hsp90 to regulate their activity in macromolecular complexes like RNA polymerase, ribonucleoproteins and Phosphatidyl-Inositol 3-kinase-related kinases. It has been shown to regulate the product of dco levels, with consequences for circadian rhythms and apoptosis. (534 aa)
GalphasG protein alpha s subunit (Galphas) encodes an alpha subunit of the class of heterotrimeric G proteins, found on the cytosolic face of the plasma membrane. An inactive GDP-bound form forms a heterotrimer with beta and gamma subunits. On activation by a 7-TM receptor, the product of Galphas exchanges GDP for GTP, dissociates from the trimer, and activates adenylyl cyclase, thus initiating cAMP signaling. Galphas roles include neurophysiology, and behaviors including learning; Belongs to the G-alpha family. G(s) subfamily. (385 aa)
iavInactive (iav) encodes a protein involved in the response to different stimuli such as startle, heat or sound; Belongs to the transient receptor (TC 1.A.4) family. (1123 aa)
dywCircadian clock-controlled protein; Component of the circadian clock or downstream effector of clock function. (260 aa)
perPeriod circadian protein; Essential for biological clock functions. Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promot [...] (1218 aa)
qvrProtein quiver; Required for homeostatic regulation of sleep under normal conditions and after sleep deprivation. Important regulator of the Sh K(+) channel, acting as a signaling molecule that connects sleep drive to lowered membrane excitability, possibly by enhancing K(+) channel activity and thus reducing neuronal excitability. (158 aa)
5-HT1A5-hydroxytryptamine (serotonin) receptor 1A (5-HT1A) encodes a 5-hydroxytryptamine (serotonin) GPCR that belongs to the Class A GPCR family. They bind and transmit the signal from the neurotransmitter 5-HT (serotonin). The family can be subdivided into several subclasses based on pharmacology, signal transduction and structure. There are 5 genes encoding serotonin receptors in the Drosophila melanogaster genome: 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, and 5-HT7. The product of 5-HT1A has been implicated in several aspects of adult behavior, including baseline sleep, aggression, courtship, as w [...] (846 aa)
CrebBCyclic AMP response element-binding protein B; Isoform E is a PKA-dependent transcriptional activator. Isoform J is a direct antagonist of activation by isoform E in cell culture. Binds the cAMP response element (CRE) (consensus: 5'- GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Has a role in long-term memory ; Belongs to the bZIP family. ATF subfamily. (331 aa)
timProtein timeless; Required for the production of circadian rhythms. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition. Belongs to the timeless family. (1421 aa)
TmcTransmembrane channel-like (Tmc) encodes a protein involved in proprioception and locomotory behavior in larvae. (2036 aa)
Gr43aGustatory receptor for sugar taste 43a; Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. Gr43a is the main sugar receptor in larvae. Functions as a narrowly tuned fructose receptor in taste neurons but also as a fructose receptor in the brain. Necessary and sufficient to sense hemolymph fructose and promote feeding in hungry flies but suppress feeding in satiated flies. (453 aa)
wakeWide awake, isoform G; Wide awake (wake) encodes a clock output molecule that regulates the timing of sleep onset. It upregulates the GABA receptor encoded by Rdl in the arousal-promoting large ventrolateral neurons, thus suppressing activity of the these cells at dusk and facilitating sleep onset at that time. (1648 aa)
Fas2Fasciclin-2; Neuronal recognition molecule for the MP1 axon pathway, pathway recognition for axons during the development of nerve fascicles. (885 aa)
BxBeadex, isoform D; Beadex (Bx) encodes a LIM-only protein that regulates activity of LIM-homeodomain proteins such as the product of ap by binding to form hetero-tetramers. It regulates the activity of the product of ap in the wing disc, and presumably other tissues. (424 aa)
SPRSex peptide receptor; Receptor for two functionally unrelated ligands; SP (A70A) for controlling reproductive behaviors and MIP for controlling sleep behavior. MIP-SPR pathway functions as a sleep homeostat which perceives the need for sleep and stabilizes it by providing a slow-acting inhibitory input to the fly arousal system that involve the pigment dispersing factor (pdf) neurons. SP-SPR is one of the multiple SP pathways that induce female post- mating behavioral responses (PMR) such as the suppression of mating receptivity and initiation of egg laying. The PMR switch is achieved [...] (435 aa)
incInsomniac, isoform B; Insomniac (inc) encodes a BTB domain-containing protein that is essential in neurons for normal sleep-wake cycles. (211 aa)
Pi3K92EPhosphoinositide 3-kinase, Dp110; Pi3K92E (Pi3K92E) encodes the catalytic subunit of a class I phosphatidylinositol 3-kinase that functions downstream of the product of InR and other receptors during several processes, including cell and tissue growth; Belongs to the PI3/PI4-kinase family. (1088 aa)
BTBD9BTB/POZ domain-containing protein 9; Essential for the homeostatic regulation of sleep and motor activity, by depressing hyperactivity and wakefulness. May function, at least in part, by ensuring dopamine biosynthesis. (722 aa)
ShabPotassium voltage-gated channel protein Shab; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. (1607 aa)
RdlGamma-aminobutyric acid receptor subunit beta; Resistant to dieldrin (Rdl) encodes a widely-expressed ligand-gated chloride channel which mediates the fast inhibitory effects of GABA. It has been shown to have roles in the circuits underlying visual processing, odor coding, learning and memory, sleep and courtship behavior. (608 aa)
TfAP-2Transcription factor AP-2 (TfAP-2) encodes a transcription factor with essential roles in leg, proboscis, and central nervous system development. It mediates Notch signaling in the developing tarsus. (471 aa)
AcerAngiotensin-converting enzyme-related (Acer) encodes an enzyme with peptidyl-dipeptidase activity that regulates heart rate and circadian sleep/wake cycle; Belongs to the peptidase M2 family. (630 aa)
Est-6Esterase-6; Transferred from the ejaculatory bulbs of males to the female genitals upon copulation, plays an important role in the reproductive biology. (544 aa)
rhoProtein rhomboid; Acts early in embryonic development to establish position along the dorsoventral axis and then again later to specify the fate of neuronal precursor cells. Involved in EGF receptor signaling; cleaves Spitz to release the active growth factor. Belongs to the peptidase S54 family. (355 aa)
Hsp83Heat shock protein 83; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Together with Hop and piwi, mediates canalization, also known as develop [...] (717 aa)
sNPF-RShort neuropeptide F receptor (sNPF-R) encodes the G-protein-coupled receptor for the neuropeptide ligand encoded by sNPF, which utilizes the intracelluar ERK pathway or PKA-CREB pathway. It contributes to the regulation of growth, food intake, food-search behavior, appetitive memory, and sleep. (600 aa)
AlkAnaplastic lymphoma kinase (Alk) encodes a protein that employs Ras/ERK and PI3K signalling pathways to function in multiple contexts including embryonic visceral muscle development, growth and organ size regulation, retinal axon targeting, modulation of neuromuscular transmission as well as sleep regulation and olfactory learning. Its ligand is the secreted protein encoded by jeb. (1701 aa)
Rac1Ras-related protein Rac1; During various developmental processes, regulates changes in cell morphology in response to extracellular signals. During oogenesis, mediates signaling from the tyrosine kinase (RTK) chemoattractant receptors (Egfr and Pvr) to the guidance pathway that control the directional persistent collective migration of the border cell (BC) cluster through the nurse cells to the oocyte. Once activating by Pvr and Egfr, promotes the formation of forward-directed actin protrusions which stabilize the DE- cadherin (shg)-mediated adhesions. In turn, DE-mediated adhesion bet [...] (192 aa)
DripAquaporin; Drip (Drip) encodes a protein that belongs to the MIP/aquaporin family involved in the transport of water across the cell membrane. In addition to its cellular roles, it has been implicated in regulating aspects of reproduction and aging. (278 aa)
HkHyperkinetic, isoform M; Hyperkinetic (Hk) encodes a beta-subunit of Sh K[+] channels and modulates its channel function. It is important in regulating action potentials in neurons and muscles, and transmitter release. (887 aa)
Pi3K21BPi3K21B, isoform B; Pi3K21B (Pi3K21B) encodes an adaptor protein (p60) that binds the product of Pi3K92E to form the functional cllass IA phosphoinositide 3-kinase. This heterodimeric kinase is involved in phosphatidylinositol phosphorylation and regulates cell size and proliferation. (496 aa)
OambOctopamine receptor Oamb; Receptor for octopamine (OA) which is a neurotransmitter, neurohormone and neuromodulator in invertebrates. Stimulates intracellular accumulation of cAMP and Ca(2+) following ligand binding. Required for ovulation. Following activation on mature follicle cells by OA, induces activity of the metalloprotease Mmp2 which leads to breakdown of the posterior follicle wall, resulting in ovulation. Ligand binding probably also leads to activation of CamKII which is also required for ovulation. Modulates sleep/wake behavior by acting in neurons of the pars intercerebra [...] (751 aa)
Dop1R1Dopamine receptor 1; Receptor for dopamine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Might be involved in the processing of visual information and/or visual learning. Important for Pavlovian conditioning: required in the mushroom body as a receptor conveying unconditional stimuli information, has a role in memory formation for aversive and appetitive learning. Sleep-deprivation-induced impairments in learning can be partially explained through alterations in dopamine signaling, Dop1R1 expression levels are reduced; sleep may have a role i [...] (560 aa)
Dop1R2Dopamine receptor 2; Receptor for dopamine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Also capable of generating a calcium signal. In terms of antagonist responses, would be classed with the D1-like dopamine receptor group. This receptor is an attractive candidate for initiating biochemical cascades underlying olfactory learning. (807 aa)
homerHomer, isoform E; Homer (homer) encodes a protein that acts as an adaptor protein binding to group I metabotropic glutamate receptors and other intracellular signaling proteins. It contributes to regulation of sleep, locomotor activity and ethanol tolerance. (531 aa)
nanNanchung, isoform B; Nanchung (nan) encodes a member of the transient Receptor Potential (TRP) channel family. It is involved in the response to different stimuli such as startle, humidity or sound. (834 aa)
RYaRYamide neuropeptides; Neuropeptides RYamide-1 and RYamide-2 are ligands for the G- protein coupled receptor RYa-R. May suppress feeding behavior. (109 aa)
PdfrPDF receptor; Pigment-dispersing factor receptor (Pdfr) encodes a G-Protein Coupled Receptor in the Family B class of GPCRs (Secretin Receptor-like) that can be activated by the product of Pdf. It has been implicated in regulation of circadian physiology, development of the flight motor system, and regulation of mating. (738 aa)
MbsMyosin binding subunit (Mbs) encodes a regulatory subunit of myosin phosphatase. It interacts with the catalytic subunit of the myosin phosphatase encoded by flw. It is involved in cell movement in various biological processes and in the arrest of constriction of contractile rings and ring canals during oogenesis. (1273 aa)
Fmr1Synaptic functional regulator FMR1; Polyribosome-associated RNA-binding protein that plays a role in neuronal development and synaptic plasticity through the regulation of protein synthesis of mRNAs. Plays a role as a negative translational regulator of specific mRNAs. Represses translation of the microtubule-associated protein futsch mRNA to regulate microtubule-dependent synaptic growth and function. May also be involved in microRNA (miRNA)-mediated translational suppression as part of the RNA-induced silencing complex (RISC). Required for stability of the central pair of microtubule [...] (729 aa)
AGO1Argonaute-1, isoform A; Argonaute-1 (AGO1) encodes an Argonaute/Piwi family protein, which interacts with microRNAs to form miRNA-induced silencing complexes (miRISCs). miRISCs are guided to target and repress mRNAs either by transcript destabilisation, translational inhibition, or both. (984 aa)
SIFaNeuropeptide SIFamide; Ligand for the neuropeptide SIFamide receptor. Modulates sexual behavior by negatively regulating female receptivity to male courtship and by playing a role in male sex discrimination. Also involved in promoting sleep. Belongs to the FARP (FMRFamide related peptide) family. (72 aa)
foxoForkhead box protein O; Transcription factor involved in the regulation of the insulin signaling pathway. Consistently activates both the downstream target Thord4EBP and the feedback control target InR. Involved in negative regulation of the cell cycle, modulating cell growth and proliferation. In response to cellular stresses, such as nutrient deprivation or increased levels of reactive oxygen species, foxo is activated and inhibits growth through the action of target genes such as Thor. Foxo activated in the adult fat body can regulate lifespan in adults; an insulin peptide itself m [...] (622 aa)
mldMolting defective (mld) encodes a nuclear zinc finger protein required for ecdysone biosynthesis. (1965 aa)
Trim9E3 ubiquitin-protein ligase TRIM9; E3 ubiquitin-protein ligase activity (By similarity). During embryonic and larval development, regulates the pattern of axonal projections of class IV nociceptive sensory neurons (C4da) downstream of netrin receptor fra. Regulates fine-scale topography of C4da axon terminals upon neuronal activity. During eye development, consolidates the attachment of R8 photoreceptor growth cones to the target medulla layer, probably downstream of fra. Belongs to the TRIM/RBCC family. (740 aa)
Pka-R1Protein kinase, cAMP-dependent, regulatory subunit type 1 (Pka-R1) encodes a cAMP-dependent protein kinase regulator that contributes to actin filament and microtubule organization. It is involved in neuromuscular synaptic transmission, molting and response to ethanol. (464 aa)
EcREcdysone receptor (EcR) encodes a protein that interacts with the product of usp to form the nuclear ecdysone receptor heterodimer, which modulates, in conjunction with co-activators and co-repressors, the activities of hundreds of genes in a tissue- and stage-specific way. EcR is widely expressed in embryonic and larval tissues and in some adult tissues where its activities (modulated by the hormone ecdysone) trigger both molting and metamorphosis. (878 aa)
Cul3Cullin 3, isoform F; Ubiquitin protein ligase binding; molecular adaptor activity; ubiquitin-protein transferase activity; protein binding; Belongs to the cullin family. (934 aa)
GabatGamma-aminobutyric acid transaminase (Gabat) encodes an enzyme involved in the breakdown of the sleep-promoting neurotransmitter gamma-aminobutyric (GABA). It functions in mitochondria, in a shunt of the TCA cycle, and is implicated in the regulation of sleep as well as in metabolism; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (486 aa)
mnbMinibrain (mnb) encodes a Ser/Thr protein kinase of the DYRK subfamily. It interacts with several signaling pathways and it is involved in behavior, cell cycle, cytoskeleton dynamics, neural proliferation, neurogenesis, neuronal differentiation, synaptic plasticity, and tissue growth. (1047 aa)
ITPIon transport peptide (ITP) encodes three identified alternative splice-forms of neuropeptides, one short and two longer forms. The short isoform is produced in several neurosecretory neurons and interneurons in the CNS controling the evening peak of locomotor activity of the fly; Belongs to the arthropod CHH/MIH/GIH/VIH hormone family. (119 aa)
IdeInsulin-degrading enzyme; Insulin degrading metalloproteinase (Ide) encodes a metalloprotease that controls growth in a cell-autonomous manner by regulating the level of the insulin-like peptide encoded by Ilp2. (990 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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