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| | b6 | FBgn0024897;b6 protein (Eg:9d2.1 protein). (558 aa) |
| | Tip60 | Histone acetyltransferase Tip60; Tat interactive protein 60kDa (Tip60) encodes a lysine acetyltransferase that acetylates histone proteins to regulate chromatin packaging and epigenetic gene control. It also acetylates non-histone proteins, and plays a role in apoptosis, DNA repair and various neural processes. (541 aa) |
| | Dcp-1 | Caspase-1 subunit p13; Death caspase-1 (Dcp-1) encodes an effector caspase that cleaves specific proteins during apoptosis. It typically acts downstream of the initiator caspase encoded by Dronc. It is also involved in non-apoptotic processes such as autophagy. (323 aa) |
| | gbb | Protein 60A; Glass bottom boat (gbb) encodes a BMP ligand in the TGF-beta/BMP family of dimeric signaling molecules. It binds to a receptor complex to transduce signal through phosphorylation of the product of Mad. It contributes to maintain stem cell populations, control cell fate specification, proliferation, synapse growth and neuropeptide release. (455 aa) |
| | mr | Morula (mr) encodes the APC2 subunit of the anaphase promoting complex (APC). mr strong alleles produce lethality, metaphase arrest and neuroblast polyploidy. mr weak alleles result in female sterility, affecting the endocycle in the nurse cells, as well as metaphase arrest in early embryonic mitoses; Belongs to the cullin family. (802 aa) |
| | CG10339 | COesterase domain-containing protein; Neurexin family protein binding; signaling receptor activity. (603 aa) |
| | gsb | Protein gooseberry; Expressed in segmentally repeating pattern to define the polarity of embryonic segments. (427 aa) |
| | spz5 | Protein spaetzle 5; Neurotrophin which may function as a ligand for the Toll- related receptors Toll-6 and Toll-7. Binds to Toll-7 and Toll-6, and probably acts as their ligands in the promotion of motor axon targeting and neuronal survival in the central nervous system (CNS). Involved in synaptic targeting of ISNb/d motorneurons and also some SNa motorneurons. May be involved in the normal development of specific neurons at the neuromuscular junction. (387 aa) |
| | Tomosyn | Tomosyn, isoform C; Tomosyn (Tomosyn) encodes a protein involved in long-term memory and neuromuscular synaptic transmission. (1470 aa) |
| | comt | Vesicle-fusing ATPase 1; Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin; Belongs to the AAA ATPase family. (745 aa) |
| | Syt12 | Synaptotagmin 12, isoform A. (787 aa) |
| | Nadsyn | Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source (By similarity). Because of its role in energy metabolism, involved in the modulation of aged- related cardiac function, mobility, and lifespan. (787 aa) |
| | Fbxl4 | F box and leucine-rich-repeat gene 4; It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; protein polyubiquitination; negative regulation of synaptic transmission, GABAergic; negative regulation of circadian sleep/wake cycle, sleep; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. (669 aa) |
| | stas | Transmembrane protein 41 homolog; Required in cholinergic neurons, but not in motor neurons, for normal neurotransmitter release by motor neurons. Involved in muscle growth; Belongs to the TMEM41 family. (320 aa) |
| | wgn | Tumor necrosis factor receptor superfamily member wengen; Receptor for egr. Involved in induction of apoptosis by triggering JNK signaling. Mediates the tumor suppressor activity of egr which eliminates oncogenic cells from epithelia, thereby maintaining epithelial integrity. Following UV-induced epidermal damage, binds to egr released from apoptotic epidermal cells and plays a role in development of thermal allodynia, a responsiveness to subthreshold thermal stimuli which are not normally perceived as noxious. Together with Moe, involved in control of axon targeting of R8 and R2-R5 ph [...] (343 aa) |
| | Cat | Catalase (Cat) encodes an enzyme that catalyzes the decomposition of hydrogen peroxide. It reduces the amount of oxidative damage to biomolecules and protects cells from the toxic effects of reactive oxygen species. (506 aa) |
| | Dysb | Dysbindin protein homolog; Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in pigment granule biogenesis and membrane trafficking in synapses. In response to high synaptic activity at neuromuscular junctions, stabilizes Pldn protein levels and, together with Pldn, plays a role in promoting efficient synaptic vesicle recycling and re-formation through early endosomes ; Belongs to the dysbindin family. (288 aa) |
| | crim | GEO04224p1; Crimpled (crim) encodes a protein involved in tracheal system development and the localization of septate junction components. (158 aa) |
| | rt | Protein O-mannosyltransferase 1; Rotated abdomen (rt) encodes a protein that transfers a mannose to the Ser/Thr residues of the product of Dg, via forming an heterodimer with the product of tw. Its roles include myogenesis, muscle architecture and cell adhesion. (886 aa) |
| | Sod1 | Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (153 aa) |
| | SH3PX1 | Sorting nexin; Phosphatidylinositol-4,5-bisphosphate binding; kinase binding; protein binding; Belongs to the sorting nexin family. (565 aa) |
| | Syt1 | Synaptotagmin 1; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. (474 aa) |
| | Snapin | SNAPIN protein homolog; Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in pigment granule biogenesis. May participate in the coupling of lysosomes to microtubule plus-end-directed kinesin motor (By similarity). (134 aa) |
| | CG31935 | Rab3 GTPase-activating protein catalytic subunit; Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily. Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP (By similarity). (916 aa) |
| | CG32447 | LP07906p; Glutamate receptor activity; G protein-coupled receptor activity; group II metabotropic glutamate receptor activity. It is involved in the biological process described with: G protein-coupled glutamate receptor signaling pathway; G protein-coupled receptor signaling pathway; regulation of synaptic transmission, glutamatergic. (658 aa) |
| | SLC22A | SLC22A family member (SLC22A) encodes a plasma membrane transporter and a member of the conserved family of SLC22A transporters. The product of SLC22A is preferentially localized in the dendrites of mushroom body neurons, where it functions to terminate synaptic transmission from cholinergic projection neurons through uptake of the released neurotransmitter acetylcholine. Impairing the function of SLC22A enhances the acquisition and retention of olfactory memory by allowing the neurotransmitter signal from projection neurons to be more persistent. (568 aa) |
| | GluRIIA | Glutamate receptor IIA (GluRIIA) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. (907 aa) |
| | CG14275 | GEO08095p1. (148 aa) |
| | Eaat1 | Excitatory amino acid transporter 1 (Eaat1) encodes a transmembrane protein with a glutamate:sodium symporter activity. It is regulated by Notch signalling and contributes to larval locomotion and lifespan. (479 aa) |
| | Rab3-GAP | Rab3 GTPase-activating protein regulatory subunit; Probable regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily. Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase- activating complex specifically converts active Rab3-GTP to the inactive form Rab3-GDP (By similarity). (1341 aa) |
| | crok | GEO12654p1; GPI anchor binding. It is involved in the biological process described with: septate junction assembly; sleep; positive regulation of voltage-gated potassium channel activity; regulation of tube size, open tracheal system; regulation of synaptic transmission, cholinergic. (151 aa) |
| | CG6583 | GEO13220p1. (154 aa) |
| | twit | Target of wit (twit) encodes a GPI-anchored membrane ligand of the Ly6 family that participates in retrograde signalling as a downstream target of the BMP pathway receptor encoded by wit. It acts in neurons, regulating spontaneous neurotransmitter release during the maturation of larval neuromuscular junctions. (166 aa) |
| | CG9336 | FI02856p. (148 aa) |
| | CG31675 | RE19849p. (148 aa) |
| | Nlg1 | Neuroligin 1 (Nlg1) encodes a transsynaptic adhesion protein of the neuroligin family that is expressed in muscles and accumulates at the postsynaptic side of neuromuscular junctions. Lack of Nlg1 causes smaller and underdeveloped neuromuscular junctions due to insufficient postsynaptic maturation and differentiation of synaptic boutons; Belongs to the type-B carboxylesterase/lipase family. (1354 aa) |
| | Syt4 | Synaptotagmin 4 (Syt4) encodes a vesicular calcium binding protein implicated in retrograde signaling at synapses. It is proposed to regulate calcium-dependent cargo trafficking within the postsynaptic compartment. (474 aa) |
| | Neurochondrin | Neurochondrin homolog; Strongly up-regulated in Mhc mutants suggesting a role in muscle function; Belongs to the neurochondrin family. (723 aa) |
| | ohgt | Protein cereblon homolog; Ohgata (ohgt) encodes a protein that controls growth by negatively regulating insulin signaling. It also has a role in maintaining presynaptic function in third-instar neuromuscular junction synapses; Belongs to the CRBN family. (585 aa) |
| | Sap47 | Synapse-associated protein 47kD (Sap47) encodes a conserved protein associated with synaptic vesicles. It is required for intact synaptic and behavioural plasticity. (551 aa) |
| | Akt1 | RAC serine/threonine-protein kinase; Serine/threonine kinase involved in various developmental processes. During early embryogenesis, acts as a survival protein. During mid-embryogenesis, phosphorylates and activates trh, a transcription factor required for tracheal cell fate determination. Also regulates tracheal cell migration. Later in development, acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and antagonizing FOXO transcription factor. Controls follicle cell size during oogenesis. M [...] (611 aa) |
| | GluRIID | Glutamate receptor IID (GluRIID) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. (902 aa) |
| | KaiR1D | Kainate-type ionotropic glutamate receptor subunit 1D; It is involved in the biological process described with: calcium ion import across plasma membrane; regulation of synaptic activity; synaptic transmission, glutamatergic; positive regulation of neuromuscular synaptic transmission; modulation of chemical synaptic transmission. (853 aa) |
| | spas | Spastin; ATP-dependent microtubule severing protein. Stimulates microtubule minus-end depolymerization and poleward microtubule flux in the mitotic spindle. Regulates microtubule stability in the neuromuscular junction synapse. Involved in lipid metabolism by regulating the size and distribution of lipid droplets. Involved in axon regeneration by regulating microtubule severing. Belongs to the AAA ATPase family. Spastin subfamily. (758 aa) |
| | Nmnat | Nicotinamide mononucleotide adenylyltransferase (Nmnat) encodes an essential enzyme in the NAD salvage pathway, catalyzing the last step of NAD synthesis. It is also a neuronal maintenance factor that protects neurons from excitotoxicity, environmental stress and protein misfolding induced degeneration. (389 aa) |
| | boss | Protein bride of sevenless; Acts as a ligand for sevenless tyrosine-kinase receptor during eye development. (896 aa) |
| | Cbp53E | Calbindin-32; Calbindin 53E (Cbp53E) encodes a 6 EF-hand domain-containing protein that regulates neuronal development. (310 aa) |
| | Arc1 | Activity-regulated cytoskeleton associated protein 1; Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer from motorneurons to muscles. Arc1 protein is released from motorneurons in extracellular vesicles that mediate the transfer of Arc1 mRNA into muscle cells, where Arc1 mRNA can undergo activity-dependent translation. Intercellular transfer od Arc1 mRNA is required for synaptic plasticity at the neuromuscular junction. May play a role in energy balance: required for regulation of body fat b [...] (254 aa) |
| | nemy | No extended memory (nemy) likely encodes a human cytochrome b561 homolog and is involved in middle-term olfactory associative memory and courtship conditioning memory. (290 aa) |
| | Rab3 | Ras-related protein Rab-3; Rab3 (Rab3) encodes a member of a large family of Ras-like small GTPases. Localized primarily at the synapse, Rab3 product is involved in mechanisms that control synaptic development and function, including the regulation of active zone protein composition at the neuromuscular junction. (220 aa) |
| | FMRFa | Corticotropin-releasing factor-like; FMRFamide (FMRFa) encodes a propeptide precursor that is processed to generate bioactive neuropeptides, many of which activate the G protein coupled receptor encoded by FMRFaR. Physiologically, FMRFa-encoded peptides contribute to neuromuscular physiology modulation and sleep regulation. (347 aa) |
| | egr | Protein eiger, membrane form; Cytokine which acts as a ligand for wgn. Also acts as a ligand for grnd. Induces apoptosis by triggering JNK signaling. Required for JNK-dependent non-autonomous apoptosis through release from apoptotic cells and activation of apoptosis in neighboring cells. Required for JNK-independent damage-induced apoptosis in the embryonic central nervous system through regulation of the pro-apoptotic gene hid. Involved in the innate immune response to extracellular pathogens. Plays a role in the melanization immune response through its involvement in the rupture of c [...] (415 aa) |
| | CG1909 | GH22690p; Protein-membrane adaptor activity; zinc ion binding; acetylcholine receptor binding. It is involved in the biological process described with: synaptic transmission, cholinergic. (606 aa) |
| | PGRP-LC | Peptidoglycan-recognition protein LC; Major activator of the imd/Relish pathway and is likely to encode a pattern recognition molecule for the humoral immune response. Required for Relish processing and nuclear translocation following proteolytic cleavage. Involved in the response to lipopolysaccharide (LPS) and peptidoglycan of Gram-negative bacteria. The different isoforms probably display different recognition capabilities to various microbial patterns. [Isoform x]: Mediates the response to LPS, peptidoglycan and Gram-negative bacteria; Belongs to the N-acetylmuramoyl-L-alanine amid [...] (520 aa) |
| | GluRIIB | Glutamate receptor IIB (GluRIIB) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. (913 aa) |
| | Sh | Potassium voltage-gated channel protein Shaker; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Forms rapidly inactivating tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient and may contribute to A- type currents. Plays a role in the regulation of sleep need or efficiency ; Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) s [...] (655 aa) |
| | Plc21C | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1318 aa) |
| | Pka-C1 | cAMP-dependent protein kinase catalytic subunit 1; Serine/threonine-protein kinase involved in memory formation. Promotes long-term memory by phosphorylating meng and by regulating CrebB protein stability and activity. As part of ethanol response in the glia, mediates ethanol-induced structural remodeling of actin cytoskeleton and perineurial membrane topology when anchored to the membrane. (353 aa) |
| | Frq1 | Frequenin-1; Ca(2+)-dependent modulation of synaptic efficacy. (187 aa) |
| | Ih | I[[h]] channel (Ih) encodes a low-threshold, voltage-gated ion channel. It may influence excitatory postsynaptic potential kinetics and integration. (1327 aa) |
| | ppk11 | Pickpocket 11 (ppk11) encodes a predicted member of the Degenerin/Epithelial Sodium Channel family. In the larval stage, it is expressed in the terminal organ for salt taste and tracheal cells for liquid clearance. It functions in salt taste in adult flies; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (516 aa) |
| | ppk16 | Pickpocket 16; Sodium channel activity. It is involved in the biological process described with: regulation of synaptic activity; sodium ion transport; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (531 aa) |
| | GluRIIE | Glutamate receptor IIE (GluRIIE) encodes an ion channel subunit involved in calcium ion transport. (897 aa) |
| | clumsy | Clumsy, isoform B; Glutamate receptor activity; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential; ligand-gated ion channel activity; signaling receptor activity; kainate selective glutamate receptor activity. It is involved in the biological process described with: ion transport; modulation of chemical synaptic transmission; synaptic transmission, glutamatergic; regulation of synaptic activity. (1002 aa) |
| | Ekar | Eye-enriched kainate receptor, isoform B; Eye-enriched kainate receptor (Ekar) encodes an ionotropic receptor that responds to the neurotransmitter glutamate. (899 aa) |
| | Dys | Dystrophin, isoforms A/C/F/G/H; Required for the maintenance of appropriate synaptic retrograde communication and the stabilization of muscle cell architecture or physiology. Both det and Dg are required for maintenance of early dpp signaling in the presumptive crossvein. Isoform A is not required to maintain muscle integrity, but plays a role in neuromuscular homeostasis by regulating neurotransmitter release. May play a role in anchoring the cytoskeleton to the plasma membrane. (3598 aa) |
| | Snap25 | Synaptosomal-associated protein 25kDa (Snap25) encodes a synaptic target SNARE protein and a component of SNARE protein complexes known to function in neurotransmitter release. It functions in synaptic transmission in larvae and is essential in adults; Belongs to the SNAP-25 family. (212 aa) |
| | cv-c | Crossveinless c (cv-c) encodes a RhoGTPase activating protein required for the morphogenesis of many tissues through the regulation of actin organization and localization of basement membrane receptors. It regulates synaptic homeostasis at the neuromuscular junction and is required for sleep homeostasis. (2351 aa) |
| | CG34402 | Uncharacterized protein, isoform C. (695 aa) |
| | NFAT | NFAT nuclear factor, isoform B; DNA-binding transcription factor activity; chromatin binding; transcription factor binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding. It is involved in the biological process described with: positive regulation of transcription by RNA polymerase II; negative regulation of synaptic vesicle exocytosis; response to salt stress. (1457 aa) |
| | Dyb | Dystrobrevin, isoform F; Zinc ion binding; structural constituent of muscle. It is involved in the biological process described with: synaptic signaling. (816 aa) |
| | qvr | Protein quiver; Required for homeostatic regulation of sleep under normal conditions and after sleep deprivation. Important regulator of the Sh K(+) channel, acting as a signaling molecule that connects sleep drive to lowered membrane excitability, possibly by enhancing K(+) channel activity and thus reducing neuronal excitability. (158 aa) |
| | atilla | Atilla, isoform B. (143 aa) |
| | Csk | C-terminal Src kinase (Csk) encodes a cytoplasmic tyrosine kinase that acts as a tumor suppressor through Src pathway inibition as well as a mediator of the activity of the product of Egfr. (1052 aa) |
| | CaMKII | Calcium/calmodulin-dependent protein kinase II (CaMKII) encodes an abundant Ca[2+]-calmodulin-regulated serine/threonine protein kinase. In neurons it has a wide range of substrates in multiple subcellular compartments, regulating synaptic plasticity, excitability and cytoskeletal interactions. (531 aa) |
| | vlc | Vulcan, isoform A; Vulcan (vlc) is induced above a basal level by 20-hydroxyecdysone in late third instar larvae. Its mutants die primarily as pharate adults with defects in ecdysone-induced leg morphogenesis. (605 aa) |
| | Atg1 | Autophagy-related 1, isoform B; Autophagy-related 1 (Atg1) encodes a protein kinase that functions downstream of the product of Tor in the regulation of autophagy. (855 aa) |
| | Pten | Phosphatase and tensin homolog (Pten) encodes a dual lipid and protein phosphatase that primarily counters the effects of the insulin-regulated lipid kinase, encoded by Pi3K92E. It inhibits cell growth, cell proliferation and cellular events controlling cytoskeletal and junctional rearrangements. (514 aa) |
| | Nlg4 | Neuroligin 4 (Nlg4) encodes a synaptic adhesion molecule involved in synapse formation and synaptic transmission. (1281 aa) |
| | Exn | Ephexin, isoform D; Ephexin (Exn) encodes a Eph-specific RhoGEF involved olfactory map formation. (2029 aa) |
| | Ank2 | Ankyrin 2, isoform U; Ankyrin 2 (Ank2) encodes a cytoskeletal binding protein required for proper function of the product of beta-Spec via direct interaction. It contributes to the regulation of short-term memory, sound perception, microtubule cytoskeleton and neuromuscular junction development and synapsis. (13559 aa) |
| | Rap1 | Ras-related protein Rap1; Rap1 GTPase (Rap1) encodes a small GTPase in the Ras superfamily. When GTP bound, it binds to a number of different effectors, one of which is the product of scno. Together they regulate many morphogenetic movements including mesoderm invagination and dorsal closure, help establish apical-basal polarity during cellularization, regulate macrophage migration, help define neuroblast asymmetric division, and play a role in planar cell polarity in the imaginal discs. (184 aa) |
| | Rim | Rab3 interacting molecule (Rim) encodes a scaffolding protein at the synaptic active zone, with important roles in promoting neurotransmitter release. (2798 aa) |
| | brp | Bruchpilot, isoform J; Bruchpilot (brp) encodes a cytoskeletal protein critical for structural integrity of electron-dense projection (T-bar) at pre-active zones. It contributes to Ca[2+] channel clustering, size regulation of the synaptic vesicle readily releaseable pool and anesthesia-resistant memory formation. (2238 aa) |
| | Dg | Dystroglycan, isoform D; Dystroglycan (Dg) encodes a major non-integrin extracellular matrix (ECM) receptor that connects the ECM to the actin cytoskeleton. It regulates animal survival and temperature preference, muscle integrity, myotendinous and neuromuscular junction formation and function, nervous system development, axon pathfinding, rhabdomere differentiation, neuronal stem cell division and epithelial polarity. (1262 aa) |
| | Toll-6 | Toll-like receptor 6; Toll-related receptor which binds to the neurotrophin spz5. Functions in olfactory circuit assembly by promoting synaptic partner matching between olfactory receptor neurons (ORN) axons and projection neurons (PN) dendrites partners in the antennal lobe. Involved in the targeting of specific classes of PN dendrites (Va1d, Va1v, DC3 and DA1). Functions with Toll-7 to regulate motor axon targeting and neuronal survival in the central nervous system (CNS). Possibly functions with 18w and Toll-8 during convergent extension, to help direct proper planar cell polarity, [...] (1514 aa) |
| | Nlg2 | Neuroligin 2 (Nlg2) encodes a transmembrane protein that interacts with the product of Nrx-1, and recruits scaffolding proteins for organization of postsynaptic neurotransmitter receptors. The product of Nlg2 functions in synaptic growth and regulation, and is involved in the modulation of social and courtship behavior. (1248 aa) |
| | CG14401 | Uncharacterized protein, isoform B. (198 aa) |
| | Fmr1 | Synaptic functional regulator FMR1; Polyribosome-associated RNA-binding protein that plays a role in neuronal development and synaptic plasticity through the regulation of protein synthesis of mRNAs. Plays a role as a negative translational regulator of specific mRNAs. Represses translation of the microtubule-associated protein futsch mRNA to regulate microtubule-dependent synaptic growth and function. May also be involved in microRNA (miRNA)-mediated translational suppression as part of the RNA-induced silencing complex (RISC). Required for stability of the central pair of microtubule [...] (729 aa) |
| | Cdc42 | Cdc42 (Cdc42) encodes a GTPase signaling protein that acts as a molecular switch and functions as key regulator of the actin cytoskeleton. It plays a central role in diverse biological processes including actin cytoskeleton organization, mophogenesis, hemocyte migration, cell polarity, and wound repair. (191 aa) |
| | Smn | Survival motor neuron protein; The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm, is required for pre-mRNA splicing in the nucleus and acts as a chaperone that discriminates target and non- target RNAs of Sm proteins. Required for normal expression of spliceosomal snRNAs and for U12 intron splicing. Required in cholinergic neurons, but not in motor neurons, to ensure correct splicing and proper levels of stas mRNA and normal neurotransmitter release by motor neurons. However, Smn is required in motor neurons, but not in cholinergic neurons, for nor [...] (226 aa) |
| | Mctp | Multiple C2 and transmembrane domain-containing protein; Calcium sensor which is essential for the stabilization of normal baseline neurotransmitter release and for the induction and long-term maintenance of presynaptic homeostatic plasticity. (982 aa) |
| | kek6 | Kekkon 6, isoform B; Neurotrophin binding; neurotrophin receptor activity. It is involved in the biological process described with: regulation of synaptic plasticity. (843 aa) |
| | BicD | Protein bicaudal D; This protein is essential for differentiation. It may play a role in localizing of Nanos (a maternal determinant) activity in oocytes. During oogenesis, plays a specific role, together with Rab6 but independently of Sec5, in the polarization of the oocyte microtubule cytoskeleton, in oskar mRNA localization and in the anterodorsal secretion of grk. Plays a role in the biogenesis of annulate lamellae containing nuclear pore complex components. (802 aa) |
| | sky | GTPase-activating protein skywalker; GTPase-activating protein (GAP) for Rab35 which regulates synaptic vesicle (SV) protein recycling and turnover at the neuromuscular junction boutons and possibly ventral nerve cord via endosomal trafficking. Inhibits Rab35-mediated endosomal sorting which traffics old or dysfunctional SV proteins through a degradative endolysosomal route that involves the ESCRT pathway and the HOPS complex members dor, vps39 and rab7. This function is essential for preventing excessive degradation and turnover of vesicles from the readily releasable pool which leads [...] (607 aa) |
| | slo | Calcium-activated potassium channel slowpoke; Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Kinetics are determined by alternative splicing, phosphorylation status and its combination interaction with Slob and 14-3-3-zeta. While the interaction with Slob1 alone increases its activity, its interaction with both Slob [...] (1217 aa) |
| | TkR99D | Tachykinin-like peptides receptor 99D; Receptor for tachykinin-like peptides. Belongs to the G-protein coupled receptor 1 family. (564 aa) |
| | CASK | Peripheral plasma membrane protein CASK; CASK (CASK) encodes a member of the MAGUK family of scaffolding proteins. In epithelial tissues, the product of CASK functions as an adhesion molecule involved in cell proliferation, cytoskeletal remodeling and cell migration. In neurons, the product of CASK serves as a scaffold for a number of signaling and transmembrane molecules and is involved in synaptic development and plasticity. (929 aa) |
| | dysc | Dyschronic, isoform G; Dyschronic (dysc) encodes a protein that regulates the localization of the calcium-activated potassium channel encoded by slo. The product of dysc impacts circadian locomotor patterns, synaptic morphology, active zone structure, and both spontaneous and evoked neurotransmitter release. (1254 aa) |
| | Slob | Slowpoke-binding protein; Regulator of calcium-activated channel Slo. Increases or decreases the voltage sensitivity of Slo, depending on the absence or presence of 14-3-3-zeta in the complex, respectively. (1347 aa) |
| | VGlut | Vesicular glutamate transporter, isoform A. (632 aa) |
| | Alk | Anaplastic lymphoma kinase (Alk) encodes a protein that employs Ras/ERK and PI3K signalling pathways to function in multiple contexts including embryonic visceral muscle development, growth and organ size regulation, retinal axon targeting, modulation of neuromuscular transmission as well as sleep regulation and olfactory learning. Its ligand is the secreted protein encoded by jeb. (1701 aa) |
| | mGluR | Metabotropic glutamate receptor; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. (976 aa) |
| | alpha-Spec | Spectrin alpha chain; Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. Essential for larval survival and development. Stabilizes cell to cell interactions that are critical for the maintenance of cell shape and subcellular organization within embryonic tissues. Lva and spectrin may form a Golgi-based scaffold that mediates interaction of Golgi bodies with microtubules and facilitates Golgi- derived membrane secretion [...] (2457 aa) |
| | CG9338 | GEO04151p1. (147 aa) |
| | jeb | Jelly belly (jeb) encodes a secreted, low-density lipoprotein (LDL) repeat containing protein that functions as signalling ligand for the product of Alk. Binding of the ligand to its receptor activates intracellular Ras/ERK and PI3K signalling pathways. The roles of the product of jeb include embryonic visceral muscle development, growth and organ size regulation, retinal axon targeting, modulation of neuromuscular transmission as well as sleep regulation and olfactory learning. (560 aa) |
| | Galphaq | G protein alpha q subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Could be the transducin analog, an amplifier and one of the transducers of a visual impulse that performs the coupling between opsin and cGMP-phosphodiesterase. Could mediate a subset of olfactory and gustatory responses. (396 aa) |
| | Frq2 | Frequenin 2 (Frq2) encodes s protein that binds calcium and interacts with the guanyl exchange factor encoded by ric8a to regulate the number of synapses and the probability of neurotransmitter release per synapse. (187 aa) |
| | chico | Insulin receptor substrate 1; Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity). May mediate the control of various cellular processes by insulin-like peptides. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains. Involved in control of cell proliferation, cell size, and body and organ growth throughout development. Also has a role in a signaling pathway controlling the physiological response required to endure periods of low nutrient conditions. Insulin/insulin-like growth fac [...] (968 aa) |
| | NT1 | Neurotrophin 1; Neurotrophin which may function as a ligand for the Toll- related receptors Toll-7 and Tollo. Binds to Toll-7 and probably acts as its ligand in promoting motor axon targeting and neuronal survival in the central nervous system (CNS). Involved in synaptic targeting of ISNb/d motorneurons and also some SNa motorneurons. In larvae, involved in the negative regulation of the tracheal immune response to bacterial infection perhaps by acting as a ligand for the Toll-related receptor Tollo. May be involved in the normal development of specific neurons at the neuromuscular junction. (1042 aa) |
| | Fife | Fife, isoform D; Fife (Fife) encodes a synaptic scaffolding protein that promotes neurotransmitter release and normal motor behavior. (1314 aa) |
| | pum | Maternal protein pumilio; Sequence-specific RNA-binding protein that acts as a post- transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'- UGUANAUA-3', that is related to the Nanos Response Element (NRE). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of deadenylase complexes leading to translational inhibition and mRNA degradation (By similarity). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs. Me [...] (1533 aa) |
| | Cals | Calsyntenin-1; May modulate calcium-mediated postsynaptic signals. (979 aa) |
| | CG11155 | FI01405p; Kainate selective glutamate receptor activity; signaling receptor activity; ligand-gated ion channel activity. It is involved in the biological process described with: ion transport; regulation of synaptic activity. (910 aa) |
| | shi | Dynamin; Microtubule-associated force-producing protein which is involved in the production of microtubule bundles and which is able to bind and hydrolyze GTP. Implicated in endocytic protein sorting; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (896 aa) |
| | Rdl | Gamma-aminobutyric acid receptor subunit beta; Resistant to dieldrin (Rdl) encodes a widely-expressed ligand-gated chloride channel which mediates the fast inhibitory effects of GABA. It has been shown to have roles in the circuits underlying visual processing, odor coding, learning and memory, sleep and courtship behavior. (608 aa) |
| | Shab | Potassium voltage-gated channel protein Shab; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. (1607 aa) |
| | Nlg3 | Neuroligin 3, isoform B; Neuroligin 3 (Nlg3) encodes a synaptic adhesion molecule involved in synapse formation and synaptic transmission. (1159 aa) |
| | beta-Spec | Beta Spectrin (beta-Spec) encodes an essential protein that interacts with the product of alpha-Spec to form a heterotetramer. The product of beta-Spec is typically associated with the plasma membrane. It functions in a lipoprotein pathway that delivers dietary fat to the larval fat body for storage. It is also believed to function in asymmetric division of germ line stem cells via cytoplasmic structures called spectrosomes and fusomes. (2308 aa) |
| | BTBD9 | BTB/POZ domain-containing protein 9; Essential for the homeostatic regulation of sleep and motor activity, by depressing hyperactivity and wakefulness. May function, at least in part, by ensuring dopamine biosynthesis. (722 aa) |
| | Nrx-1 | Neurexin 1, isoform F; Neurexin 1 (Nrx-1) encodes a transmembrane synaptic adhesive molecule that regulates the synaptic architecture and function in the brain and neuromuscular junction. It contributes to synaptic growth, transmission, synaptic formation and also regulation of learning and memory, locomotion and visual function. (1847 aa) |
| | Pi3K92E | Phosphoinositide 3-kinase, Dp110; Pi3K92E (Pi3K92E) encodes the catalytic subunit of a class I phosphatidylinositol 3-kinase that functions downstream of the product of InR and other receptors during several processes, including cell and tissue growth; Belongs to the PI3/PI4-kinase family. (1088 aa) |
| | Syp | Syncrip, isoform J; Syncrip (Syp) encodes an RNA-binding protein that regulates the localization and translation of mRNAs involved in multiple processes. It is required for synapse morphology and synaptic transmission at the neuromuscular junction as well as being involved in oocyte axis specification and control of neuronal cell fates in the mushroom body. (761 aa) |
| | Grik | Grik, isoform C; Transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential; glutamate receptor activity; signaling receptor activity; kainate selective glutamate receptor activity; ligand-gated ion channel activity. It is involved in the biological process described with: ion transport; modulation of chemical synaptic transmission; synaptic transmission, glutamatergic; regulation of synaptic activity. (907 aa) |
| | Src42A | Tyrosine-protein kinase Src42A; Required directly or indirectly for the phosphorylation of drpr which is necessary for the interaction of drpr with shark and subsequent glial phagocytic activity. Together with drpr and shark, promotes the migration of macrophages to sites of wounding as part of a signaling cascade where Scr42a detects production of hydrogen peroxide at wound sites which triggers phosphorylation of drpr and subsequent recruitment and activation of shark. Essential for correct eye morphogenesis (ommatidial R7 neuron formation) which requires the Ras1/MAPK signal transduc [...] (1597 aa) |
| | cdm | Cadmus, isoform A; Cadmus (cdm) encodes a member of the importin beta family of nucleocytoplasmic cargo shuttling proteins. It functions at the neuromuscular junction to maintain normal subsynaptic reticulum structure and presynaptic probability of release. (971 aa) |
| | cpx | Complexin (cpx) encodes a presynaptic cytosolic protein that regulates SNARE complex assembly and fuction. It has both positive and negative roles in synaptic transmission, serving as the synaptic vesicle fusion clamp and as an activator of evoked release; Belongs to the complexin/synaphin family. (157 aa) |
| | GluRIIC | Glutamate receptor IIC (GluRIIC) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. It is required for the synaptic localization of the products of GluRIIA and GluRIIB and for synaptic transmission. (940 aa) |
| | GABA-B-R2 | Metabotropic GABA-B receptor subtype 2, isoform C; G protein-coupled GABA receptor activity; protein heterodimerization activity; transmembrane signaling receptor activity. (1224 aa) |
| | CG31676 | GEO08323p1. (159 aa) |
| | Neto | Neuropilin and tolloid-like (Neto) encodes a transmembrane protein with no catalytic activities. It associates with several inotropic glutamate receptors (iGluRs) and modulates their sub-cellular distribution and function. At the neuromuscular junction, it enables iGluR clustering at the onset of synaptogenesis, and triggers postsynaptic differentiation. (822 aa) |
| | CG6329 | GEO05126p1; GPI anchor binding. It is involved in the biological process described with: positive regulation of voltage-gated potassium channel activity; sleep; regulation of synaptic transmission, cholinergic. (155 aa) |
| | FMRFaR | FMRFamide Receptor (FMRFaR) encodes a G protein coupled receptor activated by all FMRFamide peptides. It contributes to neurotransmitter release, muscle contraction, and larval escape responses to light; Belongs to the G-protein coupled receptor 1 family. (549 aa) |
| | Fas2 | Fasciclin-2; Neuronal recognition molecule for the MP1 axon pathway, pathway recognition for axons during the development of nerve fascicles. (885 aa) |
| | Src64B | Tyrosine-protein kinase Src64B; Src oncogene at 64B (Src64B) encodes a Src family nonreceptor tyrosine kinase. It has many biological roles, including ring canal morphogenesis in oogenesis and the male germline, microfilament ring constriction during cellularization, and modulation of growth and apoptosis. Some of its roles overlap with those of the product of Src42A. (553 aa) |
| | na | Narrow abdomen, isoform F; Narrow abdomen (na) encodes an ion channel involved in circadian locomotor rhythms and touch perception. (2233 aa) |
| | Csp | DnaJ homolog subfamily C member 5 homolog; Cysteine string protein (Csp) encodes a synaptic vesicle-associated co-chaperone of Hsc70 that is vital for presynaptic proteostasis and maintenance of synaptic function. The substartes of the product of Csp include SNARE proteins and the product of shi, which mediate synaptic vesicle exo- and endocytosis respectively. (249 aa) |
| | rl | Mitogen-activated protein kinase ERK-A; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway to regulate poliferation, differentiation and effect cell fate decisions in various tissues. Required downstream of phl/Raf in the sev/sevenless, tor/torso, and EGF receptor homolog Egfr signal transduction pathways. Required for embryonic epithelial tissue repair. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis. (376 aa) |
| | Sod2 | Superoxide dismutase 2 (Mn) (Sod2) encodes an enzyme that detoxifies superoxide radicals in mitochondria. The loss of Sod2 generates endogenous oxidative stress that results in reduced activity of critical mitochondrial enzymes, hypersensitivity to oxidative stress and neonatal lethality. A muscle restricted p38Kinase-Mef2-Sod2 signaling module influences life span and stress. (217 aa) |
| | hiw | E3 ubiquitin-protein ligase highwire; Atypical E3 ubiquitin-protein ligase which specifically mediates ubiquitination of threonine and serine residues on target proteins, instead of ubiquitinating lysine residues (By similarity). Shows esterification activity towards both threonine and serine, with a preference for threonine, and acts via two essential catalytic cysteine residues that relay ubiquitin to its substrate via thioester intermediates (By similarity). Required in the presynaptic motoneuron to down-regulate the levels of wnd and restrain synaptic terminal growth at the neuromu [...] (5233 aa) |
| | rtv | Retroactive, isoform A; Retroactive (rtv) encodes a membrane-inserted protein required for chitin organization in the cuticle and the tracheal system. (151 aa) |
| | CG7781 | GEO08076p1. (147 aa) |
| | dj-1beta | Protein dj-1beta; Plays an important role in cell protection against oxidative stress and cell death by acting as a oxidative stress sensor. Does not play a role in methylglyoxal detoxification. Plays a role in mitochondrial function together with Pink1. In motor neurons regulates structural synaptic plasticity of locomotor behavior as part of the PTEN- phosphatidylinositol 3-kinase pathway in response to oxygen species (ROS) levels. (187 aa) |
| | cac | Voltage-dependent calcium channel type A subunit alpha-1; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, neurotransmitter release, gene expression, cell motility, cell division and cell death (By similarity). Probably encodes a dihydropyridine- insensitive current. Vital for survival to adulthood. (2110 aa) |
