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Gr61a Gr61a Gr5a Gr5a Gr59d Gr59d Gr59c Gr59c Galphas Galphas Gr10a Gr10a Tmc Tmc Galphao Galphao Gr22b Gr22b Gr64e Gr64e Gr64c Gr64c Gr98d Gr98d Gr22d Gr22d Mvl Mvl Ac78C Ac78C Gr64d Gr64d Gr43a Gr43a Gr97a Gr97a Gr98c Gr98c Gr98b Gr98b Gr94a Gr94a Gr36c Gr36c Gr36b Gr36b Gr36a Gr36a Gr22f Gr22f Gr22c Gr22c Gr22a Gr22a Gr22e Gr22e Gr10b Gr10b Gr64f Gr64f Gr64b Gr64b Gr64a Gr64a
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
Gr61aGustatory receptor for sugar taste 61a; One of the few identified sugar gustatory receptors identified so far with glucose being its primary ligand and which mediates acceptance behavior. (436 aa)
Gr5aGustatory receptor 5a for trehalose; Gustatory receptor required for response to the sugar trehalose in taste neurons. Gr5a neurons selectively respond to sugars, in contrast to Gr66a cells which respond to bitter compounds. Flies are attracted to sugars and avoid bitter substances, suggesting that Gr5a neuron activity is sufficient to mediate acceptance behavior. Sugar signal transduction occurs through coupling with G-proteins such as Galpha49B and G-salpha60A. (444 aa)
Gr59dPutative gustatory receptor 59d; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (390 aa)
Gr59cPutative gustatory receptor 59c; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (397 aa)
GalphasG protein alpha s subunit (Galphas) encodes an alpha subunit of the class of heterotrimeric G proteins, found on the cytosolic face of the plasma membrane. An inactive GDP-bound form forms a heterotrimer with beta and gamma subunits. On activation by a 7-TM receptor, the product of Galphas exchanges GDP for GTP, dissociates from the trimer, and activates adenylyl cyclase, thus initiating cAMP signaling. Galphas roles include neurophysiology, and behaviors including learning; Belongs to the G-alpha family. G(s) subfamily. (385 aa)
Gr10aGustatory receptor 10a; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (408 aa)
TmcTransmembrane channel-like (Tmc) encodes a protein involved in proprioception and locomotory behavior in larvae. (2036 aa)
GalphaoG protein alpha o subunit (Galphao) encodes the most abundant G protein in the nervous tissue and is involved in signaling by a variety of GPCRs. It contributes to heart development, axonogenesis, neuro-muscular junction formation, asymmetric cell division, planar cell polarity, blood-brain barrier establishment, Wnt signaling, and gustatory and olfactory sensory perception; Belongs to the G-alpha family. G(i/o/t/z) subfamily. (354 aa)
Gr22bPutative gustatory receptor 22b; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates (By similarity). Seems to be involved in the sensing of bitter taste since it is expressed in neurons that mediate sensitivity to bitter compounds. (386 aa)
Gr64eGustatory receptor for sugar taste 64e; One of the few identified sugar gustatory receptors identified so far and which promotes the starvation-induced increase of feeding motivation. confers responsiveness to glycerol and is required for feeding preference for beer and other sources that have fermenting yeast. (460 aa)
Gr64cGustatory receptor for sugar taste 64c; One of the few identified sugar gustatory receptors identified so far and which promotes the starvation-induced increase of feeding motivation. (419 aa)
Gr98dPutative gustatory receptor 98d; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates; Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr2a subfamily. (412 aa)
Gr22dGustatory receptor 22d (Gr22d) encodes a transmembrane domain protein unrelated to GPCRs that is predicted to mediate response to non-volatile compounds. (387 aa)
MvlMalvolio (Mvl) encodes a member of the SLC11 family of metal ion transporters that transports divalent metal cations, including Mn[2+] and Fe[2+]. Its function has been linked to feeding-related decisions, possibly via modulation of dopaminergic signaling. (639 aa)
Ac78CAdenylyl cyclase 78C; [Isoform B]: Catalyzes the formation of the signaling molecule cAMP in response to G-protein coupled receptor signaling. Probably downstream of gustatory receptors, involved in taste perception of sucrose, trehalose and caffeine. Has no role in bitter perception. In the circadian brain neuron evening cells (E- cells), involved in circadian pacemaker synchronization by playing a role in signaling downstream of the G protein-coupled receptor Pdfr, probably in conjunction with other, as yet unidentified, adenylate cyclases. (1727 aa)
Gr64dGustatory receptor for sugar taste 64d; One of the few identified sugar gustatory receptors identified so far and which promotes the starvation-induced increase of feeding motivation; Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr5a subfamily. (417 aa)
Gr43aGustatory receptor for sugar taste 43a; Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. Gr43a is the main sugar receptor in larvae. Functions as a narrowly tuned fructose receptor in taste neurons but also as a fructose receptor in the brain. Necessary and sufficient to sense hemolymph fructose and promote feeding in hungry flies but suppress feeding in satiated flies. (453 aa)
Gr97aPutative gustatory receptor 97a; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (425 aa)
Gr98cPutative gustatory receptor 98c; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates; Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr2a subfamily. (408 aa)
Gr98bPutative gustatory receptor 98b; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates; Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr2a subfamily. (403 aa)
Gr94aPutative gustatory receptor 94a; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (404 aa)
Gr36cPutative gustatory receptor 36c; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (390 aa)
Gr36bPutative gustatory receptor 36b; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (391 aa)
Gr36aPutative gustatory receptor 36a; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates; Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr22e subfamily. (391 aa)
Gr22fPutative gustatory receptor 22f; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (378 aa)
Gr22cPutative gustatory receptor 22c; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (383 aa)
Gr22aPutative gustatory receptor 22a; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. (394 aa)
Gr22eGustatory receptor for bitter taste 22e; Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. Seems to be involved in the sensing of bitter taste since it is expressed in neurons that mediate sensitivity to bitter compounds which are also avoidance-type taste neurons. (389 aa)
Gr10bPutative gustatory receptor 10b; Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates; Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr10a subfamily. (373 aa)
Gr64fGustatory receptor for sugar taste 64f; One of the few identified sugar gustatory receptors identified so far and which promotes the starvation-induced increase of feeding motivation. Required in combination with Gr64a to detect sucrose, maltose, and glucose. (469 aa)
Gr64bGustatory receptor for sugar taste 64b; One of the few identified sugar gustatory receptors identified so far and which promotes the starvation-induced increase of feeding motivation. (406 aa)
Gr64aGustatory receptor for sugar taste 64a; One of the few identified sugar gustatory receptors identified so far and which promotes the starvation-induced increase of feeding motivation. Required in combination with Gr64f to detect sucrose, maltose, and glucose. Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr5a subfamily. (456 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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