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| | Seipin | Seipin; Is a regulator of lipid catabolism essential for adipocyte differentiation. May also be involved in the central regulation of energy homeostasis (By similarity). Necessary for correct lipid storage and lipid droplets maintenance; plays a tissue-autonomous role in controlling lipid storage in adipocytes and in preventing ectopic lipid droplet formation in non-adipose tissues. May participate in phosphatidic acid metabolism and subsequently down-regulate lipogenesis. (370 aa) |
| | Pgam5 | Serine/threonine-protein phosphatase Pgam5, mitochondrial; Displays phosphatase activity for serine/threonine residues, and dephosphorylates and activates Pk92B kinase. Has apparently no phosphoglycerate mutase activity. (289 aa) |
| | DAAM | Dishevelled Associated Activator of Morphogenesis (DAAM) encodes a formin type of actin assembly factor regulated by Rho GTPases. It plays a role in tracheal tube length regulation, tracheal cuticle pattern formation, growth cone filopodia formation, sarcomerogenesis and axonal growth regulation in embryonic and mushroom body neurons. (1463 aa) |
| | Ank2 | Ankyrin 2, isoform U; Ankyrin 2 (Ank2) encodes a cytoskeletal binding protein required for proper function of the product of beta-Spec via direct interaction. It contributes to the regulation of short-term memory, sound perception, microtubule cytoskeleton and neuromuscular junction development and synapsis. (13559 aa) |
| | EcR | Ecdysone receptor (EcR) encodes a protein that interacts with the product of usp to form the nuclear ecdysone receptor heterodimer, which modulates, in conjunction with co-activators and co-repressors, the activities of hundreds of genes in a tissue- and stage-specific way. EcR is widely expressed in embryonic and larval tissues and in some adult tissues where its activities (modulated by the hormone ecdysone) trigger both molting and metamorphosis. (878 aa) |
| | bsk | Stress-activated protein kinase JNK; Responds to activation by environmental stress by phosphorylating a number of transcription factors, primarily components of AP-1 such as Jra and also the transcriptional repressor aop, and thus regulates transcriptional activity. Component of the immune response activated by bacterial infection, and is involved in wound healing and in dorsal closure, a morphogenetic movement during embryogenesis. Functions in the systematic response to wounding acting downstream of the Hayan-phenoloxidase PPO1 cascade. Exhibits cytoprotective activity in neuronal c [...] (372 aa) |
| | CG42638 | Cation channel activity. (652 aa) |
| | pcm | 5'-3' exoribonuclease 1; Pacman (pcm) encodes an exoribonuclease that degrades decapped mRNA. It is involved in epithelial closure, male fertility, apoptosis and growth control. (1613 aa) |
| | dlg1 | Disks large 1 tumor suppressor protein; During embryonic development, some isoforms are essential for proper neuronal differentiation and organization. Required for cell polarity; maintenance of apicobasal polarity. Plays a critical role at septate junctions in cellular growth control during larval development. The presence of a guanylate kinase domain suggests involvement in cellular adhesion as well as signal transduction to control cellular proliferation. (1030 aa) |
| | kat-60L1 | Katanin p60 ATPase-containing subunit A1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. (673 aa) |
| | Atg1 | Autophagy-related 1, isoform B; Autophagy-related 1 (Atg1) encodes a protein kinase that functions downstream of the product of Tor in the regulation of autophagy. (855 aa) |
| | Nedd4 | E3 ubiquitin-protein ligase Nedd-4; Essential E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Down- regulates Notch/N signaling pathway by promoting Notch ubiquitination, endocytosis and degradation. (1007 aa) |
| | mnb | Minibrain (mnb) encodes a Ser/Thr protein kinase of the DYRK subfamily. It interacts with several signaling pathways and it is involved in behavior, cell cycle, cytoskeleton dynamics, neural proliferation, neurogenesis, neuronal differentiation, synaptic plasticity, and tissue growth. (1047 aa) |
| | kis | Kismet, isoform C; Kismet (kis) encodes a chromodomain containing ATP-dependent transcription factor that controls gene expression through epigenetic mechanisms. The roles of the product of kis include developmental patterning of the embryo, cell proliferation, eye development, synaptic transmission, axonal pruning, and memory. (5517 aa) |
| | bun | Protein bunched, class 2/F/G isoform; Probable transcription factor required for peripheral nervous system morphogenesis, eye development and oogenesis. May be required for the transmission of the dpp signal and for a morphogenetic movement of the medulla in the brain that reorients the second optic lobe relative to the first. Plays a role in determining proper dorsal cell fates leading to the formation of the dorsal appendages. (1331 aa) |
| | Fis1 | Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Functions downstream of Pink1 and upstream of Drp1 to regulate mitochondrial fission. (154 aa) |
| | Hr51 | Hormone receptor 51 (Hr51) encodes a chromatin binding protein that regulates gene expression and contributes to axon guidance, neuron remodeling, mushroom body development and circadian rhythm regulation. (582 aa) |
| | nudE | Nuclear distribution protein nudE homolog; nudE (nudE) encodes a conserved protein that localizes to kinetochores and spindle microtubules. It contributes to the spindle checkpoint, spindle orientation, centrosome behavior and dendrite morphogenesis. (377 aa) |
| | dar1 | Dendritic arbor reduction protein 1; Transcriptional regulator which promotes dendrite growth by suppressing, either directly or indirectly, the expression of the microtubule-severing protein spas. Determines multipolar neuron morphology in postmitotic neurons by positively regulating the expression of genes involved in nuclear positioning including several dynein genes and the nuclear migration protein nudC ; Belongs to the krueppel C2H2-type zinc-finger protein family. (751 aa) |
| | pyr | Pyramus (pyr) encodes a Fibroblast growth factor (FGF) and ligand for the FGF receptor encoded by htl. It regulates the development of somatic and visceral muscle in the mesoderm, cardioblasts and glial cells. Its roles include acting as a chemoattractant in directional cell migration, and regulating adhesion, differentiation, and cell survival. (766 aa) |
| | ec | Echinus splice form 3; Echinus (ec) encodes a protein phosphatase 1 (PP1) binding protein involved in interommatidial cell sorting and cell death. (1765 aa) |
| | PIP4K | Phosphatidylinositol 5-phosphate 4-kinase (PIP4K) encodes an enzyme that mediates the conversion of phosphatidylinositol 4 phosphate to phosphatidylinositol 4,5 bisphosphate. It has been implicated in the regulation of mTOR signalling and control of cell size. (404 aa) |
| | hh | Protein hedgehog C-product; Intercellular signal essential for a variety of patterning events during development. Establishes the anterior-posterior axis of the embryonic segments and patterns the larval imaginal disks. Binds to the patched (ptc) receptor, which functions in association with smoothened (smo), to activate the transcription of target genes wingless (wg), decapentaplegic (dpp) and ptc. In the absence of hh, ptc represses the constitutive signaling activity of smo through fused (fu). Essential component of a signaling pathway which regulates the Duox-dependent gut immune r [...] (471 aa) |
| | Pink1 | PTEN-induced putative kinase 1 (Pink1) is the ortholog of human PINK1, a gene mutated in autosomal recessive Parkinson's disease. Pink1 encodes a mitochondrially targeted Ser-Thr kinase. It has been linked to a number of cellular functions including altering mitochondrial dynamics, the autophagic degradation of dysfunctional mitochondria, and the proper function of Complex I of the electron transport chain. (721 aa) |
| | ey | Paired box protein Pax-6; Eyeless (ey) encodes a transcription factor that is involved in eye development as part of the retinal determination gene network, and contributes to brain formation. (898 aa) |
| | Vmat | Vesicular monoamine transporter (Vmat) encodes a protein responsible for packaging the neurotransmitters dopamine, serotonin and octopamine into secretory vesicles. (646 aa) |
| | Mlf | Myeloid leukemia factor; Transcription factor binding; chaperone binding. It is involved in the biological process described with: regulation of cell proliferation involved in compound eye morphogenesis; protein stabilization; regulation of transcription, DNA-templated; positive regulation of crystal cell differentiation. (376 aa) |
| | otu | Protein ovarian tumor locus; Essential for female fertility; germ cell division and differentiation. (853 aa) |
| | Tm2 | Tropomyosin-2; Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction. May also regulate motor systems required to maintain nuclear integrity and apico-basal polarity during embryogenesis. (284 aa) |
| | chic | Profilin; Chickadee (chic) encodes an actin monomer binding protein that provides the major cellular pool of readily polymerizing ATP-actin monomers. It is involved in oogenesis, spermatogenesis, cell division, bristle formation, cellular morphogenesis, axon growth, filopodia formation, dorsal closure, wound healing and stem cell maintenance. (126 aa) |
| | Lis-1 | Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as nuclear migration during cell division, mitotic spindle formation and the removal of mitotic checkpoint proteins from kinetochores at the metaphase to anaphase transition. Required for several aspects of neurogenesis including neuroblast proliferation, neuronal cell differentiation, dendritic growth, b [...] (411 aa) |
| | pnt | ETS-like protein pointed; ETS transcription factor with a prominent role during development of the eye and the nervous system. Required for glial- neuronal cell interactions at the ventral midline which are necessary for the proper elaboration of commissures in the embryonic CNS. [Isoform P1]: Required for normal EGFR-induced photoreceptor development. Following transcriptional activation by isoform P2, acts as a constitutive activator of transcription, leading to induction of target genes essential for photoreceptor development. In larval brains, involved in the maintenance of type II [...] (718 aa) |
| | TBPH | TAR DNA-binding protein-43 homolog (TBPH) encodes an RNA-binding protein that belongs to the hnRNP family. It contributes to synaptic growth of motor neurons and glial wrapping. (531 aa) |
| | PlexA | Plexin A (PlexA) encodes a transmembrane receptor for Semaphorin ligands encoded by Sema1a and Sema1b. The intracellular region of this receptor has GTPase activating protein (GAP) activity on Ras/Rap small GTPases. The signaling by the product of PlexA alters actin, microtubules and cell adhesion in developmental processes such as axon guidance. (1945 aa) |
| | Actbeta | Inhibin beta chain; Controls several aspects of neuronal morphogenesis; essential for optic lobe development, EcR-B1 expression in larval brains, mushroom body remodeling, dorsal neuron morphogenesis and motoneuron axon guidance. Ligands Actbeta and daw act redundantly through the Activin receptor Babo and its transcriptional mediator Smad2 (Smox), to regulate neuroblast numbers and proliferation rates in the developing larval brain; Belongs to the TGF-beta family. (946 aa) |
| | ci | Transcriptional activator cubitus interruptus; Has a dual function as a transcriptional activator and a repressor of the hedgehog (Hh) pathway. The full-length ci form (ciFL), acts as an activator (ciA) while ciR, its C-terminally truncated form, acts as a repressor. Involved in segment polarity. Required for the normal development of the posterior half of each embryonic segment. Engrailed protein directly represses ci expression in posterior compartment cells. Essential component of a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; requ [...] (1397 aa) |
| | pk | Protein prickle; Acts in a planar cell polarity (PCP) complex; polarization along the apical/basal axis of epithelial cells. Correct expression of the alternative isoforms is required for PCP signaling in imaginal disks. PCP signaling in the wing disk requires the receptor fz and the cytoplasmic proteins dsh and pk. These act in a feedback loop leading to activation of the jnk cascade and subsequent polarized arrangement of hairs and bristles. Dgo and pk compete with one another for dsh binding, thereby modulating fz dsh activity and ensuring tight control over fz PCP signaling. Vang, [...] (1299 aa) |
| | Cul1 | Cullin homolog 1; Core component of multiple SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin- conjugating enzyme. During early metamorphosis, part of the SCF-slmb complex that negatively regulates the InR/PI3K/TOR pathway to activate the pruning of unnecessary larv [...] (774 aa) |
| | dpn | Protein deadpan; Transcriptional repressor of genes that require a bHLH protein for their transcription. In the larval brain, required to maintain the self- renewal and identity of type II neuroblasts by regulating the expression of the transcriptional repressor erm together with other self-renewal transcriptional repressors such as klu and E(spl)mgamma- HLH. As part of its role in neuroblasts development, has been shown to be a direct target of the Notch signaling pathway, however might work also independently of N/Notch. In the developing larval and pupal brain, required for mushroom [...] (435 aa) |
| | pnut | Peanut (pnut) encodes a protein that belongs to the septin family of polymerizing GTPases. Together with the products of Sep1 and Sep2, it forms the septin complex. It participates in cytokinesis and other processes that involve organization of the cell cortex. (539 aa) |
| | babo | Receptor protein serine/threonine kinase; Baboon (babo) encodes the type I receptor for the activin-like ligands encoded by daw, Actbeta and myo. There are three isoforms of the product of babo that differ only in their extracellular domain likely resulting in different ligand binding specificity. It can form a complex with the type II receptors put or wit in the presence of an activin like ligand. This results in the transcriptional regulation of activin responsive genes; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (622 aa) |
| | Dp | Transcription factor Dp; Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. In follicle cells, the complex plays a central role in the site-specific DNA replication at the chorion loci. During development, the complex represses transcription of developmentally controlled E2F target genes. Can stimulate E2F-dependent transcription. (445 aa) |
| | shot | Short stop (shot) encodes a member of the spectraplakin family of large cytoskeletal linker molecules. It binds both actin and microtubules, as well as scaffold proteins, certain signalling factors and calcium. It plays developmental and maintenance roles in the nervous system, the epidermis, at muscle attachments, the foregut, the wing, tracheae and oocytes. (8805 aa) |
| | Opa1 | Optic atrophy 1 (Opa1) encodes a dynamin-related GTPase that mediates fusion of the inner membrane of mitochondria. It usually works with the product of Marf to coordinately fuse both mitochondrial membranes. The product of Opa1 activity is regulated by proteolytic processing; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (972 aa) |
| | Sin1 | Stress-activated map kinase-interacting protein 1; Component of a multiprotein complex that phosphorylates Akt1, a protein that regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. (569 aa) |
| | CG10257 | RH51312p; It is involved in the biological process described with: negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; positive regulation of neurogenesis; I-kappaB kinase/NF-kappaB signaling. (228 aa) |
| | IntS8 | Integrator complex subunit 8; Component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box- dependent processing. Involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5. (1007 aa) |
| | Gbp1 | Growth-blocking peptide 1 (Gbp1) encodes a cytokine that regulates the humoral immune response. (118 aa) |
| | Dark | Death-associated APAF1-related killer, isoform B; Death-associated APAF1-related killer (Dark) encodes an essential component of the apoptosome. The products of Dark and Dronc form a pivotal holoenzyme required for apoptotic cell death with the products of Dark acting as an adaptor of the multimeric complex. (1440 aa) |
| | Snx16 | Sorting nexin 16 (Snx16) encodes a protein that regulates synaptic growth at the neuromuscular junction. (407 aa) |
| | stau | Maternal effect protein staufen; RNA-binding protein which forms ribonucleoprotein complexes (RNPs) that play critical roles in the localization, translational repression and turnover of RNAs during embryogenesis, neurotransmission and neurogenesis. In the oocyte, essential for the localization of both the osk/oskar mRNA to the posterior pole and bcd/bicoid RNA to the anterior pole, and is therefore required for the correct anterior- posterior patterning of the developing embryo. Association with osk or bcd at their respective poles, appears to promote the formation and stabilization o [...] (1026 aa) |
| | Drice | Caspase subunit p12; Death related ICE-like caspase (Drice) encodes a major effector apoptotic caspase. It is essential for both developmental and damaged induced cell death, as well as several non-apoptotic vital cellular processes. It is activated by the product of Dark and the initiator caspase encoded by Dronc and is inhibited by the inhibitor of apoptosis encoded by Diap1; Belongs to the peptidase C14A family. (339 aa) |
| | FBgn0002733 | Enhancer of split mbeta protein; Transcriptional repressor of genes that require a bHLH protein for their transcription (By similarity). May serve as a transcriptional regulator of the Achaete-scute complex (AS-C) genes. Contributes to the neural-epidermal lineage decision during early neurogenesis. Part of the Notch signaling pathway. (195 aa) |
| | E(spl)m3-HLH | Enhancer of split m3 protein; Transcriptional repressor of genes that require a bHLH protein for their transcription. May serve as a transcriptional regulator of the Achaete-scute complex (AS-C) genes. Belongs to notch signaling pathway and depends on Su(H) for transcriptional activation. (224 aa) |
| | FBgn0002735 | Enhancer of split mgamma protein; Transcriptional repressor of genes that require a bHLH protein for their transcription. May serve as a transcriptional regulator of the Achaete-scute complex (AS-C) genes. Contributes to the neural-epidermal lineage decision during early neurogenesis. Part of the Notch signaling pathway, plays a role in neuroblasts proliferation in embryos and larvae. In the larval brain, together with other self-renewal transcriptional repressors such as klu and dpn, required for type II neuroblast self-renewal and for maintaining erm in an inactive state in intermedi [...] (205 aa) |
| | Nf1 | Neurofibromin 1 (Nf1) encodes a protein that functions as a GTPase activating protein for the products of Ras85D and Ras64B in the larval and adult nervous system. Loss of Nf1 results in excess Ras-Raf-ERK signaling and to a non-cell-autonomous cAMP/PKA signaling defect. The product of Nf1 contributes to postembryonic growth, learning/memory, and circadian rhythm. (2802 aa) |
| | bam | Bag of marbles (bam) encodes a protein involved in gametogenesis that is associated with the fusome, a germ cell-specific organelle. It contributes to the fate determination of germline stem cells, in which bam is negatively regulated by the BMP signaling pathway. (442 aa) |
| | RIOK2 | RIO kinase 2; Protein kinase activity; protein serine/threonine kinase activity; ATP binding. It is involved in the biological process described with: positive regulation of glial cell proliferation; maturation of SSU-rRNA; protein phosphorylation. (538 aa) |
| | atl | Atlastin; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate microtubule polymerization and Golgi biogenesis. Required for dopaminergic neurons survival and the growth of muscles and synapses at neuromuscular junctions. (541 aa) |
| | spas | Spastin; ATP-dependent microtubule severing protein. Stimulates microtubule minus-end depolymerization and poleward microtubule flux in the mitotic spindle. Regulates microtubule stability in the neuromuscular junction synapse. Involved in lipid metabolism by regulating the size and distribution of lipid droplets. Involved in axon regeneration by regulating microtubule severing. Belongs to the AAA ATPase family. Spastin subfamily. (758 aa) |
| | nau | Nautilus (nau) encodes a protein that belongs to the bHLH family of transcription factors. It is the unique Drosophila ortholog of the mammalian family of bHLH Myogenic Regulatory Factors. It is involved in somatic muscle myogenesis. (332 aa) |
| | Rassf | Ras association family member (Rassf) encodes a RASSF (ras-association domain family) protein that binds to the kinase encoded by hpo and promotes its dephosphorylation by the STRIPAK PP2A complex. (806 aa) |
| | fzo | Transmembrane GTPase fzo; Essential transmembrane GTPase, which mediates mitochondrial fusion during spermatogenesis. In early spermatocytes, fusion of mitochondria give rise to two organelles named Nebenkern and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. Essential for fertility. (718 aa) |
| | p53 | P53 protein long form variant 1; P53 (p53) encodes a transcriptional factor required for adaptive responses to genotoxic stress, including cell death, compensatory proliferation and DNA repair. (495 aa) |
| | Sar1 | Secretion-associated Ras-related 1 (Sar1) encodes a small GTPase that is recruited to the endoplasmic reticulum and initiates the recruitment of the COPII subunit complex Sec23/Sec24. (193 aa) |
| | InR | Insulin-like receptor subunit beta 1; Has a ligand-stimulated tyrosine-protein kinase activity. Required for cell survival. Regulates body size and organ size by altering cell number and cell size in a cell-autonomous manner. Involved in the development of the embryonic nervous system, and is necessary for axon guidance and targeting in the visual system. Also plays a role in life-span determination. (2144 aa) |
| | Archease | Protein archease-like; Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RtcB (CG9987). (156 aa) |
| | Rab1 | FI01544p; Rab1 (Rab1) encodes a small GTPase which regulates endoplasmic reticulum to Golgi and intra Golgi trafficking through different effectors. It has been involved in Notch signaling, cell migration, autophagy and cytokinesis. (205 aa) |
| | repo | Reversed polarity (repo) encodes a homeodomain transcription factor specifically expressed in glial cells. It is is a direct target of the pan-glial fate determinant encoded by gcm and is required for acquisition of glial fate and subsequent terminal glial differentiation. (612 aa) |
| | htl | Fibroblast growth factor receptor homolog 1; Heartless (htl) encodes a transmembrane tyrosine kinase receptor for secreted FGF ligands that utilizes the intracellular Ras-MAP kinase pathway. It contributes to embryonic mesoderm migration and the specification of several mature mesodermal cell derivatives; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily. (729 aa) |
| | abd-A | Homeobox protein abdominal-A; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for segmental identity of the second through eighth abdominal segments. Once a pattern of abd-A expression is turned on in a given parasegment, it remains on the more posterior parasegment, so that the complex pattern of expression is built up in the successive parasegments. Appears to repress expression of Ubx whenever they appear in the same cell, but abd-A is repressed [...] (590 aa) |
| | Ubx | Homeotic protein ultrabithorax; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds the consensus region 5'-TTAAT[GT][GA]-3'. This homeotic protein controls development of the cells in the posterior thoracic and first abdominal segments. It activates the synthesis of the decapentaplegic (DPP) growth factor; Belongs to the Antp homeobox family. (389 aa) |
| | Akt1 | RAC serine/threonine-protein kinase; Serine/threonine kinase involved in various developmental processes. During early embryogenesis, acts as a survival protein. During mid-embryogenesis, phosphorylates and activates trh, a transcription factor required for tracheal cell fate determination. Also regulates tracheal cell migration. Later in development, acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and antagonizing FOXO transcription factor. Controls follicle cell size during oogenesis. M [...] (611 aa) |
| | omd | Integrator complex subunit 5; Component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box- dependent processing. Involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5. May mediate recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (By similarity). (994 aa) |
| | Ilp6 | Insulin-like peptide 6 (Ilp6) encodes a protein that promotes growth during starvation. (107 aa) |
| | Desat1 | Desaturase 1 (Desat1) encodes a transmembrane fatty acid desaturase that utilizes myristate and stearate (C16:0 and C18:0) to synthesize myristoleic and oleic acids (C16:1 and C18:1). It is involved in the synthesis of unsaturated fatty acids. (383 aa) |
| | Arfip | Arfaptin (Arfip) a protein that functions to tether the dynactin complex to the Golgi membrane in motor neurons. This function is required for normal synaptic growth during larval development. (355 aa) |
| | Ras85D | Ras-like protein 1; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays a role in eye development by regulating cell growth, survival of postmitotic ommatidial cells and differentiation of photoreceptor cells. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis. (189 aa) |
| | stck | LIM domain-containing protein; Steamer duck (stck) encodes PINCH, an adapter protein that directly binds and forms a complex with the products of Ilk and ics. PINCH is required for integrin-dependent cell adhesion and signaling. (348 aa) |
| | Atg13 | Autophagy-related protein 13 homolog; Autophagy factor required for autophagosome formation. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of Atg13 and Atg1. The Atg1- Atg13 complex functions at multiple levels to mediate and adjust nutrient-dependent autophagic signaling. Involved in the autophagic degradation of dBruce which controls DNA fragmentation in nurse cells. (523 aa) |
| | Dfd | Homeotic protein deformed; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Homeotic protein controlling Drosophila head development. Transcriptional activator of the apoptotic activator protein rpr in cells at the maxillary/mandibular boundary; Belongs to the Antp homeobox family. Deformed subfamily. (586 aa) |
| | Ama | Protein amalgam. (341 aa) |
| | Mcm10 | Protein MCM10 homolog; Proposed to be involved in DNA replication and to participate in the activation of the pre-replication complex (pre-RC). May be involved in chromosome condensation. (776 aa) |
| | sNPF | Short neuropeptide F precursor (sNPF) encodes a protein that binds to the product of sNPF-R and activates ERK-Dilps signaling or the PKA-CREB pathway. Its roles include the regulation of cell and organism growth, carbohydrate metabolism, lifespan, feeding behavior, locomotion, circadian rhythm, and sleep. (281 aa) |
| | Nf-YB | Nuclear factor Y-box B (Nf-YB) encodes a subunit of the nuclear transcription factor Y, which binds to the CCAAT box regulatory sequence. It regulates gene transcription and is involved in eye and thorax development. (156 aa) |
| | spi | Protein spitz; Ligand for the EGF receptor (Gurken). Involved in a number of unrelated developmental choices, for example, dorsal-ventral axis formation, glial migration, sensory organ determination, and muscle development. It is required for photoreceptor determination. (234 aa) |
| | dl | Embryonic polarity protein dorsal; Embryonic developmental protein. The lateral or ventral identity of a cell depends upon the concentration of this protein in its nucleus during the blastoderm stage. A morphogenetic protein that specifically binds to the kappa B-related consensus sequence 5'- GRGAAAANCC-3', located in the enhancer region of zygotic genes such as Zen, Twist, Snail and Decapentaplegic. Mediates an immune response in larvae. Part of a signaling pathway involving NF- kappa-B and Toll-related receptors, that functions in the apoptosis of unfit cells during cell competition [...] (999 aa) |
| | Sec71 | Secretory 71; Small GTPase binding; ARF guanyl-nucleotide exchange factor activity; guanyl-nucleotide exchange factor activity. It is involved in the biological process described with: positive regulation of neuron remodeling; positive regulation of endocytosis; Golgi to plasma membrane protein transport; regulation of ARF protein signal transduction. (1653 aa) |
| | p38b | P38b MAP kinase (p38b) encodes the serine/threonine kinase that constitutes MAP kinase signaling cascades. It is phosphorylated by MAPK kinases and phosphorylates various substrates that play roles in stress responses, immune responses and differentiation; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. (365 aa) |
| | dmGlut | Dietary and metabolic glutamate transporter (dmGlut) encodes a sodium-independent transmembrane glutamate transporter. It plays an essential role during early embryogenesis. It causes megamitochondria formation when it is overexpressed. (496 aa) |
| | wg | Protein wingless; Binds as a ligand to a family of frizzled seven-transmembrane receptors and acts through a cascade of genes on the nucleus. Segment polarity protein. May be a growth factor. Acts on neighboring cells to regulate at least one gene, the homeobox segmentation gene engrailed. Wg signal represses arm phosphorylation. Wg signaling operates by inactivating the sgg repression of engrailed autoactivation. Wg and Wnt2 have a role in the developing trachea and together are responsible for all dorsal trunk formation. Wg also acts in the developing epidermis. Acts as a morphogen, [...] (468 aa) |
| | bchs | Blue cheese (bchs) is a neuronally expressed gene that encodes a member of the BEACH (Beige and Chediak-Higashi)-domain superfamily, whose members are involved in vesicle trafficking. It antagonizes the activity of the product of Rab11. It serves as a scaffold for autophagy proteins, and contributes to ref(2)P-mediated aggrephagy. It contributes to nervous system development, lysosome transport and sphingolipid metabolism. (3489 aa) |
| | tkv | Receptor protein serine/threonine kinase; Thickveins (tkv) encodes a transforming growth factor beta type I receptor. Together with the product of put, it functions as a receptor of the product of dpp and therefore contributes to the BMP signaling pathway; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (575 aa) |
| | Rheb | GTP-binding protein Rheb homolog; Binds GTP and exhibits intrinsic GTPase activity (By similarity). Activates the protein kinase activity of TORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K through activation of TORC1 signaling. May also have a role in activating TORC2 signaling. (182 aa) |
| | Sec8 | Exocyst complex component 4; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Involved in regulation of synaptic microtubule formation, and also regulation of synaptic growth and glutamate receptor trafficking. Does not appear to be required for basal neurotransmission. (985 aa) |
| | Arf79F | ADP-ribosylation factor 1; GTP-binding protein involved in protein trafficking; has a role in Golgi organization and may modulate vesicle budding and uncoating within the Golgi apparatus (Probable). Has a role in eye development. Required for cleavage furrow ingression in embryonic cells. (182 aa) |
| | Mkrn1 | Makorin 1, isoform A; Ubiquitin protein ligase activity; metal ion binding; ubiquitin-protein transferase activity; zinc ion binding. It is involved in the biological process described with: protein polyubiquitination; positive regulation of insulin receptor signaling pathway; positive regulation of oogenesis. (386 aa) |
| | park | Parkin (park) encodes an E3 ubiquitin ligase with a key role in protein ubiquitination. It is involved in mitochondrion organization, oxidative stress and locomotion; Belongs to the RBR family. Parkin subfamily. (482 aa) |
| | Gs1 | Glutamine synthetase 1 (Gs1) encodes the mitochondrial enzyme that uses glutamate and ammonia as substrates to synthesize glutamine, which is a precursor of purine and pyrimidine synthesis. An adequate level of maternally supplied Gs1 product activity is necessary in the early embryonic development. High level of glutamine in mitochondria causes megamitochondrial formation in cells. (399 aa) |
| | shv | DnaJ homolog shv; Maintains stem cell niche architecture in the testes. Activates an extracellular integrin beta-PS pathway which regulates DE- cadherin (shg) levels in somatic hub cells, and is essential for maintaining the number of germline stem cells and the structure and localization of hub cells. (354 aa) |
| | cac | Voltage-dependent calcium channel type A subunit alpha-1; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, neurotransmitter release, gene expression, cell motility, cell division and cell death (By similarity). Probably encodes a dihydropyridine- insensitive current. Vital for survival to adulthood. (2110 aa) |
| | ctp | Dynein light chain 1, cytoplasmic; Cut up (ctp) encodes the 8 kDa (LC8/DLC1) subunit of the cytoplasmic Dynein, as well as the Myosin V. It homodimerizes and binds to a variety of proteins. It is involved in both dynein-dependent and independent functions such as cell viability, axonal guidance, spermatid growth and individualization, and regulation of spermatogonial divisions; Belongs to the dynein light chain family. (267 aa) |
| | nmo | Mitogen-activated protein kinase; Nemo (nmo) encodes an atypical proline-directed serine/threonine kinase with roles in numerous developmental processes, including ommatidial rotation/planar cell polarity, retinal specification and neuronal function, and circadian clock speed. It regulates the activity of several signal transduction pathways, including BMP, Wnt, and Notch, and is implicated in fly models of neurodegenerative diseases; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (439 aa) |
| | oc | Homeotic protein ocelliless; Transcriptional regulator involved in pattern formation and cell determination in the embryonic CNS and larval imaginal disks. Also later in development to coordinate the expression of regulatory and structural genes required for photoreceptor cell fate in the ocelli. Has a dual role in the terminal differentiation of subtypes of photoreceptors by regulating rhodopsin (rh) expression: essential for establishing the expression of rh genes in the pale subset of ommatidia as well as repressing Rh6 in outer photoreceptors. Belongs to the paired homeobox family. (664 aa) |
| | upd2 | Unpaired 2 (upd2) encodes a secreted molecule that acts at a distance as a ligand for the JAK/STAT signal transduction pathway. upd2 mutants are viable due to redundancy with other Upd-family genes. (406 aa) |
| | yki | Transcriptional coactivator yorkie; Transcriptional coactivator which is the critical downstream regulatory target in the Hippo/SWH (Sav/Wts/Hpo) signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. The Hippo/ [...] (418 aa) |
| | Abd-B | Homeobox protein abdominal-B; Abdominal B (Abd-B) is one of the three hox genes of the bithorax complex. The product of Abd-B specifies the identity of the posterior abdominal segments, the external genitalia and the gonads. It is also involved in regulating the post-mating-response. (493 aa) |
| | Tctp | Translationally controlled tumor protein (Tctp) encodes a protein that belongs to the TCTP family. It interacts with the GTPase encoded by Rheb to regulate organ growth. It is required for DNA damage response and genome stability. (172 aa) |
| | Mul1 | Mitochondrial E3 ubiquitin protein ligase 1; Exhibits weak E3 ubiquitin-protein ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Plays a role in the control of mitochondrial morphology by promoting mitochondrial fission. Negatively regulates the mitochondrial fusion protein marf by promoting its ubiquitination, acting in a pathway that is parallel to the park/pink1 regulatory pathway. (338 aa) |
| | Naus | Uncharacterized protein CG10915; It is involved in the biological process described with: regulation of Arp2/3 complex-mediated actin nucleation; positive regulation of neuron projection arborization; positive regulation of lamellipodium morphogenesis; actin filament bundle retrograde transport; protein localization to actin cytoskeleton. (609 aa) |
| | rl | Mitogen-activated protein kinase ERK-A; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway to regulate poliferation, differentiation and effect cell fate decisions in various tissues. Required downstream of phl/Raf in the sev/sevenless, tor/torso, and EGF receptor homolog Egfr signal transduction pathways. Required for embryonic epithelial tissue repair. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis. (376 aa) |
| | Zyx | Zyx102.44 isoform; Zyxin (Zyx) encodes an actin cytoskeleton regulator found at cell-matrix junctions and cell-cell adherens junctions. Its roles include mechanotransduction and regulation of the Hippo signaling pathway. (585 aa) |
| | E2f1 | Transcription factor E2f1; Transcriptional activator that binds to E2f sites. Required for wild-type growth in mitotic and polytene tissues, Contributes to the expression of replication genes at the G1-S transition and Cyclin E. Activates cell proliferation in wing imaginal disk, which requires expression of vg; Belongs to the E2F/DP family. (821 aa) |
| | RhoGAP92B | Rho GTPase-activating protein 92B; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. (740 aa) |
| | Raf | Raf homolog serine/threonine-protein kinase Raf; Serine/threonine kinase required in the early embryo for the formation of terminal structure. Also required during the proliferation of imaginal cells. May act downstream of Ras85D in the tor signal transduction pathway. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily. (739 aa) |
| | Marf | Transmembrane GTPase Marf; Mitochondrial assembly regulatory factor (Marf) encodes a dynamin-family GTPase that mediates outer mitochondrial membrane tethering and fusion. Marf loss causes mitochondrial fragmentation and endoplasmic reticular stress that evoke skeletal muscle, retinal and heart tube dysfunction; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. Mitofusin subfamily. (814 aa) |
| | Sox14 | Sox box protein 14 (Sox14) encodes a transcription factor involved in neurogenesis and metamorphosis. (669 aa) |
| | Wnt5 | Protein Wnt-5; Binds as a ligand to a family of frizzled seven-transmembrane receptors and acts through a cascade of genes on the nucleus. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. May have a role in limb and CNS development; may be a downstream target of Dll that acts in the specification of these primordia; Belongs to the Wnt family. (1004 aa) |
| | Sdc | Syndecan (Sdc) encodes a transmembrane heparan sulfate proteoglycan. It binds to the products of sli and robo1 to regulate axon guidance at the CNS midline, and it cooperates with the product of Lar to promote synapse growth at the larval neuromuscular junction. (495 aa) |
| | trol | Terribly reduced optic lobes (trol) encodes the extracellular matrix component Perlecan, a secreted heparan sulfate proteoglycan. It regulates cell-signaling by multiple growth factors including those in the hedgehog, wingless/WNT, FGF, TGFbeta, EGF, and VEGF families, thus playing a role in many developmental patterning decisions. (4479 aa) |
| | PICK1 | Membrane curvature sensor activity; phospholipid binding; protein kinase C binding; protein domain specific binding. (577 aa) |
| | Smox | Mothers against decapentaplegic homolog; Smad on X (Smox) encodes the primary transcription factor that mediates Activin signalling. Upon phosphorylation by the receptor encoded by babo, it forms a complex with the co-Smad protein encoded by Med. This complex translocates to the nucleus where it regulates expression of target genes. (486 aa) |
| | mys | Integrin beta-PS; Integrin alpha-PS1/beta-PS is a receptor for laminin. Integrin alpha-PS2/beta-PS is a receptor for Tig, wb and Ten-m. Contributes to endodermal integrity and adhesion between the midgut epithelium and the surrounding visceral muscle. Essential for migration of the primordial midgut cells and for maintaining, but not establishing, cell polarity in the midgut epithelium. The two beta subunits mediate midgut migration by distinct mechanisms: beta-PS requires rhea/talin and Itgbn does not. Required for rhea/talin correct cellular localization in the midgut. Required for m [...] (846 aa) |
| | Arp53D | Actin-like protein 53D; It is involved in the biological process described with: mitotic cytokinesis; Belongs to the actin family. ARP1 subfamily. (411 aa) |
| | Top3beta | DNA topoisomerase 3-beta; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)- enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils. [...] (875 aa) |
| | wap | Wings apart (wap) encodes a protein required for growth, viability, muscle development, and proper wing venation. It physically interacts with the product of ds, and functions in the Hippo pathway to regulate growth. (343 aa) |
| | Med | Mothers against decapentaplegic homolog; Medea (Med) encodes a protein that belongs to the highly conserved Smad family. It can bind its siblings encoded by Mad or Smox to facilitate signal transduction for the product of dpp or Activin ligands in the TGF-beta family. Med-complexes function as transcriptional regulators. Many developmental roles include dorsal-ventral patterning, patterning and proliferation of the wing disc and gene expression in the mushroom body of the larval brain. (771 aa) |
| | Tor | Serine/threonine-protein kinase Tor; Promotes cell and tissue growth, maintains tissue homeostatis and controls responses to environmental stress and aging. Regulates growth during animal development by coupling growth factor signaling to nutrient availability. Central regulators of autophagy. May be involved in atg1 phosphorylation. May also be involved, directly or indirectly, in the control of neuronal function. Phosphorylates S6K/p70S6K, in vitro. May regulate the activity of S6K. Overexpression inhibits growth and reduces cell size. Affects the timing of neuronal cell differentiat [...] (2471 aa) |
| | gcm | Glial cells missing (gcm) encodes an essential zinc finger transcription factor that determines the fate of the lateral glial cells. It is involved in the differentiation of plasmatocytes, tendon cells and specific neurons. (504 aa) |
| | Strica | Ser/Thr-rich caspase (Strica) encodes a member of initiator caspases. It contributes, redundantly or cooperatively with the product of Dronc, to the apoptosis of selective larval neurons during metamorphosis and nurse cells during oogenesis, and competitive apoptosis of heterozygous mutant cells; Belongs to the peptidase C14A family. (527 aa) |
| | Drp1 | Dynamin related protein 1 (Drp1) encodes a dynamin-like GTPase that mediates mitochondrial fission through a process that involves translocation to the mitochondrial outer membrane and oligomerization. It is required for normal neuronal development and maintenance of postmitotic neuronal function and viability; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (735 aa) |
| | daw | Dawdle, isoform A; Dawdle (daw) encodes an Activin- like ligand of the TGF beta superfamily that is required for proper tricarboxylic acid cycle function in the fat body and also regulates insulin release from IPC neurons. (586 aa) |
| | Orct2 | Organic cation transporter 2 (Orct2) encodes an organic cation transporter of the major facilitator superfamily, and a transcriptional target of the insulin receptor pathway. (567 aa) |
| | Synd | Syndapin, isoform C; Lipid binding; phospholipid binding; cytoskeletal protein binding; protein binding. (495 aa) |
| | Pi3K92E | Phosphoinositide 3-kinase, Dp110; Pi3K92E (Pi3K92E) encodes the catalytic subunit of a class I phosphatidylinositol 3-kinase that functions downstream of the product of InR and other receptors during several processes, including cell and tissue growth; Belongs to the PI3/PI4-kinase family. (1088 aa) |
| | Pak | P21-activated kinase (Pak) encodes a serine/threonine effector kinase for the small GTPases Rac and the product of Cdc42 involved in cytoskeletal regulation. The product of Pak contributes to growth cone guidance, synaptic development, and epithelial morphogenesis in both the ovary and embryo. (840 aa) |
| | tsl | Torso-like (tsl) encodes a protein present in many organs. In particular it is produced and secreted by two cell clusters in the egg chamber, initially anchored at the vitelline membrane and then translocated to the oocyte plasma membrane where it is required for the activation of the receptor encoded by tor. (353 aa) |
| | btsz | Bitesize, isoform I; Bitesize (btsz) encodes a membrane-trafficking protein that contributes to actin cytoskeleton organization. It is involved in the establishment of planar cell polarity, apical junction assembly and the morphogenesis of salivary glands and the tracheal system. (3734 aa) |
| | RhoGAP68F | Rho GTPase activating protein at 68F (RhoGAP68F) encodes a GTPase activating protein acting upon small Rho-family GTPases involved in epithelial morphogenesis. It localizes to Rab4 recycling endosomes, forms a complex with the product of Rab4 and modulates the transport of Rab4 recycling endosomes back to the cell surface. (476 aa) |
| | Fhos | Formin homology 2 domain containing (Fhos) encodes a protein that regulates actin-dependent remodeling of muscle cytoskeleton via induction of actin stress fibers, directs macrophage migration during cellular immune response, and is involved in autophagic programmed cell death. (2528 aa) |
| | Cals | Calsyntenin-1; May modulate calcium-mediated postsynaptic signals. (979 aa) |
| | hzg | Phosphatase Herzog; Prion-like membrane-associated phosphatase. Phosphatase activity depends on amyloid-like assembly at the membrane. Might have a role in establishment of segment polarity in embryos. (352 aa) |
| | chico | Insulin receptor substrate 1; Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity). May mediate the control of various cellular processes by insulin-like peptides. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains. Involved in control of cell proliferation, cell size, and body and organ growth throughout development. Also has a role in a signaling pathway controlling the physiological response required to endure periods of low nutrient conditions. Insulin/insulin-like growth fac [...] (968 aa) |
| | Hr4 | Hormone receptor 4; Coordinates growth and maturation by mediating endocrine responses to the attainment of critical weight during larval development. Plays a central role in the genetic cascades triggered by the steroid hormone ecdysone at the onset of metamorphosis, acting as both a repressor of the early ecdysone-induced regulatory genes and an inducer of the ftz-f1 midprepupal competence factor. Belongs to the nuclear hormone receptor family. NR1 subfamily. (2123 aa) |
| | Pdk1 | 3-phosphoinositide-dependent protein kinase 1; Serine/threonine kinase required for embryonic development. Inhibits apoptosis. Acts in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and activating Akt1 and S6k. May be involved in axonal pathfinding and synaptogenesis, and in spermatogenesis. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily. (836 aa) |
| | G9a | G9a, isoform B; G9a (G9a) encodes a histone-lysine methyltransferase involved in epigenetic regulation. It contributes to multiple processes including gene expression, dendrite morphogenesis, larval locomotory behavior as well as short and long-term memory. (1657 aa) |
| | Hsp83 | Heat shock protein 83; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Together with Hop and piwi, mediates canalization, also known as develop [...] (717 aa) |
| | Dhc64C | Dynein heavy chain 64C (Dhc64C) encodes the heavy chain subunit of the cytoplasmic dynein motor complex. The product of Dhc64C forms a dimer, which binds and hydrolyzes ATP providing the power for movement of dynein. It has an essential function in oocyte polarity, mitotic cell division, embryonic development, and neuronal transport and neurogenesis. (4661 aa) |
| | sNPF-R | Short neuropeptide F receptor (sNPF-R) encodes the G-protein-coupled receptor for the neuropeptide ligand encoded by sNPF, which utilizes the intracelluar ERK pathway or PKA-CREB pathway. It contributes to the regulation of growth, food intake, food-search behavior, appetitive memory, and sleep. (600 aa) |
| | tral | Trailer hitch (tral) encodes a protein required for oocyte dorsoventral patterning via actin and microtubule cytoskeleton organization. (657 aa) |
| | step | Steppke, isoform C; Steppke (step) encodes a member of the cytohesin family of guanine nucleotide exchange factors, which regulate small GTPases of the ADP-ribosylation factor (ARF) family. It contributes to multiple signaling pathways, such as Egfr, MAPK, PI3K and insulin signaling. It is involved in wing and eye development, germ cell segregation and cell growth. (727 aa) |
| | Mad | Mothers against dpp (Mad) encodes the primary transcription factor that mediates cellular response to the BMP like ligands encoded by dpp, scw and gbb. Upon phosphorylation by either the products of sax or tkv (type I BMP receptors), it forms a complex with the product of Med and translocates to the nucleus where, together with cofactors, it regulates expression of BMP response target genes; Belongs to the dwarfin/SMAD family. (525 aa) |
| | Wbp2 | WW domain binding protein 2 (Wbp2) encodes a protein that binds to the Hippo pathway component encoded by yki. It has been linked to promotion of tissue growth via the product of yki. (384 aa) |
| | Rac1 | Ras-related protein Rac1; During various developmental processes, regulates changes in cell morphology in response to extracellular signals. During oogenesis, mediates signaling from the tyrosine kinase (RTK) chemoattractant receptors (Egfr and Pvr) to the guidance pathway that control the directional persistent collective migration of the border cell (BC) cluster through the nurse cells to the oocyte. Once activating by Pvr and Egfr, promotes the formation of forward-directed actin protrusions which stabilize the DE- cadherin (shg)-mediated adhesions. In turn, DE-mediated adhesion bet [...] (192 aa) |
| | Pdcd4 | Programmed cell death 4, isoform A; It is involved in the biological process described with: germarium-derived female germ-line cyst formation; negative regulation of transcription, DNA-templated; positive regulation of stem cell differentiation. (509 aa) |
| | bru1 | Bruno 1 (bru1) encodes an RNA binding protein acting in multiple forms of post-transcriptional gene regulation including repression and activation of translation and alternative splicing of pre-mRNAs. The product of bru1 is required for gametogenesis, developmental patterning, and muscle organization. (810 aa) |
| | cpb | Capping protein beta (cpb) encodes an actin-binding protein that, together with cpa, binds to the fast growing ends of actin filaments, restricting the addition or loss of actin monomers. It restricts JNK signaling, modulates Hippo signaling, maintains epithelial integrity and neuronal homeostasis, controls proliferation/apoptosis in wing imaginal discs, and promotes oogenesis. (276 aa) |
| | Myc | Myc protein; Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence CAC[GA]TG. Seems to activate the transcription of growth-related genes; required for cellular proliferation and growth. Functions in the TORC2-mediated regulation of cell growth, acting downstream of the TORC2 complex. Inhibits the demethylase activity of Lid. Activates transcription of mbm. Has a role in ribosome biogenesis and endoreplication in fat body cells by activating the transcription of LTV1. Able to induce the SCF E3 ubiqui [...] (717 aa) |
| | simj | Simjang, isoform E; Simjang (simj) encodes a component of the NURD complex, which couples chromatin remodelling and histone deacetylation to mediate transcriptional repression. The product of simj is involded in cardiogenesis and habituation. (937 aa) |
| | Vang | Vang-like protein; Van Gogh (Vang) encodes a four-pass transmembrane protein that localizes to cell junctions. It is part of the Frizzled-dependent planar polarity pathway that establishes planar polarity in epithelia. It is also implicated in nervous system patterning. (608 aa) |
| | stan | Protocadherin-like wing polarity protein stan; Involved in the fz signaling pathway that controls wing tissue polarity. Also mediates homophilic cell adhesion. May play a role in initiating prehair morphogenesis. May play a critical role in tissue polarity and in formation of normal dendrite fields. During planar cell polarity, stabilizes asymmetric PCP domains together with ATP6AP2. (3648 aa) |
| | erm | Fez family zinc finger protein erm; Zinc-finger transcriptional repressor. In larval brain, involved in the maintenance of cell fate of intermediate neural progenitors (INPs) that derive from type II neuroblasts. Restricts INP developmental potential and dedifferentiation by interacting with HDAC3 and the chromatin remodeling Brahma-associated protein (BAP) complex. Restricts INP proliferation by regulating neuroblast specific factors such as prospero, pnt and grh, and by antagonizing the function of self-renewal factors, such as klu, dpn and E(spl)mgamma-HLH. In the optic lobe, essent [...] (698 aa) |
| | RasGAP1 | GTPase-activating protein; Inhibitory regulator of the Ras-cyclic AMP pathway. May function as a negative regulator of Ras85D/Ras1 in the sev signaling pathway. Acts cell autonomously in cone cell precursors as a negative regulator of R7 photoreceptor cell determination. (1181 aa) |
| | sif | Protein still life, isoform SIF type 1; Regulates synaptic differentiation through the organization of actin cytoskeleton possibly by activating Rho-like GTPases. Is likely a factor in the cascade of Rac1 or Cdc42 in the neurons. May play a role in maintaining proper septate junction functions. Required for eye development and most likely affects corneal lens-formation. (2734 aa) |
| | Octbeta2R | Octopamine receptor beta-2R; Autoreceptor for octopamine (OA), which is a neurotransmitter, neurohormone, and neuromodulator in invertebrates. Essential for ovulation and fertilization. During ovulation it mediates the OA-induced relaxation of the oviduct visceral muscles, by increasing cAMP levels and activating effectors such as calmodulin- dependent kinase II (CaMKII) and cAMP-dependent protein kinase A (PKA) pathways. Positively regulates synaptic growth; an action that is antagonized by Octbeta1R. (630 aa) |
| | fz | Frizzled; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to inv [...] (612 aa) |
| | klu | Klumpfuss, isoform B; Cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; sequence-specific DNA binding; RNA polymerase II regulatory region sequence-specific DNA binding. (818 aa) |
| | spn-F | Protein spindle-F; Plays a role in oocyte axis determination and microtubule organization during oogenesis. Also required for polarized organization of the bristle. Required, with jvl, for activation of the kinase IKKepsilon in the germ line. Also required for localization of IKKepsilon to the distal tip of elongating bristles by acting as an adapter linking IKKepsilon and cytoplasmic dynein. Involved in dendrite pruning in larval sensory neurons during metamorphosis. (376 aa) |
| | wit | Receptor protein serine/threonine kinase; Wishful thinking (wit) encodes a BMP Type II Receptor that, upon binding of the ligand encoded by gbb, makes a complex with either tkv or sax encoding BMP type I receptors. This complex initiates phosphorylation and nuclear translocation of the transcription factor encoded by Mad. wit product controls synaptic homeostasis and neurotransmission at the neuromusclular junction during larval development. It also regulates the peptidergic phenotype of several neurosecretory cells; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase [...] (913 aa) |
| | slmb | Supernumerary limbs (slmb) encodes an essential, conserved F-box protein and a component of the SCF (Skp/Cullin/F-box) E3 ubiquitin-ligase, providing substrate specificity to the SCF. It negatively regulates multiple signaling pathways and cellular processes by promoting the proteasome-mediated degradation or cleavage of its targets, including the products of arm and ci (Wg and Hh signaling), SAK, per and Cap-H2. (597 aa) |
| | Pak3 | Non-specific serine/threonine protein kinase; Pak3 (Pak3) encodes a Ser/Thr kinase implicated in myoblast fusion, synapse development, wound healing and border cell migration. It functions downstream of the small Rac GTPases to regulate actin cytoskeletal organization. (583 aa) |
| | Sec24CD | Secretory 24CD (Sec24CD) encodes a subunit of the coat protein complex of COPII vesicles, which transport cargo from the endoplasmic reticulum to the Golgi apparatus. It is essential for export of membrane and secreted proteins from the endoplasmic reticulum. It is involved in epithelial morphogenesis and differentiation. (1231 aa) |
| | spict | Spichthyin, isoform B; Spichthyin (spict) encodes a BMP signaling pathway regulator involved in synaptic growth regulation at neuromuscular junctions. (393 aa) |
| | Smn | Survival motor neuron protein; The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm, is required for pre-mRNA splicing in the nucleus and acts as a chaperone that discriminates target and non- target RNAs of Sm proteins. Required for normal expression of spliceosomal snRNAs and for U12 intron splicing. Required in cholinergic neurons, but not in motor neurons, to ensure correct splicing and proper levels of stas mRNA and normal neurotransmitter release by motor neurons. However, Smn is required in motor neurons, but not in cholinergic neurons, for nor [...] (226 aa) |
| | aPKC | Atypical protein kinase C; Serine/threonine protein kinase which is required for apico- basal cell polarity in the germ line as well as in epithelial and neural precursor cells, for epithelial planar cell polarity and for cell proliferation. During oocyte development, required for the posterior translocation of oocyte specification factors and for the posterior establishment of the microtubule organizing center within the presumptive oocyte. Phosphorylates l(2)gl which restricts l(2)gl activity to the oocyte posterior and regulates posterior enrichment of par-1, leading to establishmen [...] (958 aa) |
| | Arp2 | Actin-related protein 2; Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity). (399 aa) |
| | Rop | Protein ROP; May be a component of one of the vesicle trafficking pathways. May interact functionally with Ras2 protein. (597 aa) |
| | Sec23 | Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (781 aa) |
| | sax | Receptor protein serine/threonine kinase; Saxophone (sax) encodes a type I BMP receptor. Together with the BMP receptors encoded by tkv and put, it transduces signaling of the BMP ligands encoded by dpp, gbb and scw, in a wide variety of developmental processes including embryonic and imaginal disc patterning; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (582 aa) |
| | Roc1a | RING-box protein 1A; Core component of multiple SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Required for the specific SCF-dependent proteolysis of CI, but not that of ARM, suggesting that it also participates in the selection of substrates inside the SCF complex. During early metamorphosis, part of [...] (136 aa) |
| | PlexB | Plexin-B; Involved in peripheral and central nervous system axon guidance. Acts as a receptor for Sema-2a and seems to transduce signal by suppressing Rac activity and enhancing Rho activity. Belongs to the plexin family. (2051 aa) |
| | Fmr1 | Synaptic functional regulator FMR1; Polyribosome-associated RNA-binding protein that plays a role in neuronal development and synaptic plasticity through the regulation of protein synthesis of mRNAs. Plays a role as a negative translational regulator of specific mRNAs. Represses translation of the microtubule-associated protein futsch mRNA to regulate microtubule-dependent synaptic growth and function. May also be involved in microRNA (miRNA)-mediated translational suppression as part of the RNA-induced silencing complex (RISC). Required for stability of the central pair of microtubule [...] (729 aa) |
| | Mob4 | MOB kinase activator 4 (Mob4) encodes a protein that contributes to microtubule organization, axonal transport, mitotic spindle assembly and regulation of Hippo signaling; Belongs to the MOB1/phocein family. (227 aa) |
| | ari-1 | E3 ubiquitin-protein ligase ariadne-1; Atypical E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 Ubc10. Controls the subcellular localization and morphology of muscle nuclei (myonuclei) by regulating the protein levels and distribution of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex. Functions by mediating the monoubiquitination of the LINC complex subunit koi leading to its subsequent proteasomal degradation. Appears to function, at least partially redundantly, with the RBR E3 ligase family mem [...] (503 aa) |
| | Dap160 | Dynamin associated protein 160 (Dap160) encodes an adaptor protein that contributes to endocytosis. It regulates the Notch pathway and mediates the asymmetric accumulation of a number or proteins, including the product of aPKC during neuroblast division. (1190 aa) |
| | Cka | Connector of kinase to AP-1, isoform E; Protein binding. (749 aa) |
| | nudC | Nuclear migration protein NudC; nudC (nudC) encodes a component of a specialized dynein complex involved in nucleus localization and positive regulation of dendrite morphogenesis. (332 aa) |
| | Imp | IGF-II mRNA-binding protein (Imp) encodes a protein that regulates the stability, translation and/or transport of its associated mRNAs, a large number of them encoding F-actin regulators. It is an essential protein required for neural and germline stem cell maturation, neuronal remodeling, as well as the expression modulation of asymmetrically localized maternal mRNAs. (638 aa) |
| | foxo | Forkhead box protein O; Transcription factor involved in the regulation of the insulin signaling pathway. Consistently activates both the downstream target Thord4EBP and the feedback control target InR. Involved in negative regulation of the cell cycle, modulating cell growth and proliferation. In response to cellular stresses, such as nutrient deprivation or increased levels of reactive oxygen species, foxo is activated and inhibits growth through the action of target genes such as Thor. Foxo activated in the adult fat body can regulate lifespan in adults; an insulin peptide itself m [...] (622 aa) |
| | pros | Homeobox protein prospero; Homeodomain protein that controls neuronal identity. As a transcriptional factor, regulates the expression of ftz, eve and en in a subset of neuroblast progeny and modulates the transcriptional activity of other homeodomain proteins such as Dfd. Required for proper neuronal differentiation, axonal outgrowth and pathfinding of most or all neurons and their precursors in central and peripheral nervous systems. Regulates asymmetric stem cell self- renewal together with brat. (1835 aa) |
| | d | Dachs, isoform E; Dachs (d) encodes a myosin family protein that participates in Dachsous-Fat signaling, which polarizes its localization. It influences planar cell polarity, partly through interaction with the product of pk, and growth, through interaction with the product of wts; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1426 aa) |
| | ebi | F-box-like/WD repeat-containing protein ebi; F-box-like component of E3 ubiquitin ligase complexes; involved in R7 photoreceptor cell differentiation, cone cell development and neuronal cell cycle control. E3 ubiquitin ligase complexes mediate ubiquitination and subsequent proteasomal degradation of target proteins. Required for specification of R7 photoreceptor cell fate in the eye by participating in the ubiquitination and subsequent proteasomal degradation of Tramtrack (ttk), a general inhibitor of photoreceptor differentiation. Required to block the S phase entry in the peripheral [...] (700 aa) |
| | dpp | Protein decapentaplegic; Required during oogenesis for eggshell patterning and dorsal/ventral patterning of the embryo. Acts as a morphogen during embryogenesis to pattern the dorsal/ventral axis, specifying dorsal ectoderm and amnioserosa cell fate within the dorsal half of the embryo; this activity is antagonized by binding to sog and tsg. Induces the formation of visceral mesoderm and the heart in early embryos. Required later in embryogenesis for dorsal closure and patterning of the hindgut. Also functions postembryonically as a long-range morphogen during imaginal disk development [...] (588 aa) |
| | morgue | Modifier of rpr and grim, ubiquitously expressed (morgue) encodes an F box/ubiquitin conjugase domain protein. It regulates cell death by controlling the levels of the apoptosis inhibitor encoded by Diap1. (491 aa) |
| | Prpk | P53-related protein kinase (Prpk) encodes an atypical Ser/Thr kinase part of the KEOPS/EKC complex. It phosphorylates the product of p53 and is regulated by the products of Akt1 and Rab35. It is involved in tRNAs modification, telomere and chromatin dynamics. (224 aa) |
| | DnaJ-1 | DnaJ-like-1 (DnaJ-1) encodes a heat-shock protein co-factor that regulates and interacts with larger heat shock proteins providing client specificity. It regulates the folding of proteins whose misfolding leads to age-dependent neurodegeneration. (334 aa) |
| | vito | LD10447p; Viriato (vito) is a Myc-target gene encoding a nucleolar protein that is required for proper cell and tissue growth. In the developing eye, it is required for correct signal transduction in the cells receiving the product of dpp. (264 aa) |
| | Arp3 | Actin-related protein 3; Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks (By similarity). Seems to contact the pointed end of the daughter actin filament (By similarity). Required during embryogenesis for the developmental migration of tail hemocytes anteriorly, along the ventral midline. (418 aa) |
| | Dronc | Caspase Nc subunit 1; Involved in the activation cascade of caspases responsible for apoptosis execution. Effector of steroid-mediated apoptosis during insect metamorphosis. Overexpression promotes programmed cell death. Interaction with Diap1 is required to suppress Dronc-mediated cell death; via Diap1-mediated ubiquitination of Dronc. Rate-limiting caspase in rpr and hid death pathway. (450 aa) |
| | Ilp2 | Probable insulin-like peptide 2 A chain; Plays a role in regulating body size by increasing cell size and cell number of individual organs. Probably mediates its growth effects by acting as a ligand for the insulin receptor and transducing a signal via the Chico/PI3K/Akt(PKB) pathway. (137 aa) |
| | RIOK1 | Serine/threonine-protein kinase RIO1; ATP binding; protein kinase activity; protein serine/threonine kinase activity. It is involved in the biological process described with: protein phosphorylation; positive regulation of glial cell proliferation; maturation of SSU-rRNA; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. (585 aa) |
| | CycA | G2/mitotic-specific cyclin-A; Cyclin A (CycA) encodes a protein that binds to the product of Cdk1, thereby promoting Cdk1's protein kinase activity. The CycA-Cdk1 complex controls important aspects of progression through the cell cycle, including entry into mitosis. During the G2 phase, this complex is important for prevention of premature DNA re-replication. During mitosis and G1, the product of CycA is rapidly degraded (involving APC/C and the proteasome), resulting in inactivation of Cdk1 protein kinase activity. (491 aa) |
| | ssp | LD31163p; Sunspot (ssp) encodes a protein that contributes to Wingless signaling and endoreplication. (368 aa) |
| | Abp1 | Actin binding protein 1 (Abp1) encodes an F-actin-binding protein. It plays important roles in cytoskeletal functions of both Scar/WAVE- and wasp-mediated Arp2/3 complex activation during synapse formation, bristle formation and eye development; Belongs to the ABP1 family. (531 aa) |
| | btl | Fibroblast growth factor receptor homolog 2; May be required for patterning of muscle precursor cells: generation of mesodermal and endodermal layers, invaginations of various types of cells, and CNS formation. Essential for the ability of the migrating tracheal and midline cells to recognize external guiding cues. (1052 aa) |
| | DCTN1-p150 | Dynactin 1, p150 subunit (DCTN1-p150) encodes the p150 subunit of the dynactin complex. Dynactin is thought to act as a dynein receptor that modulates binding of dynein to cellular cargoes and enhances the processivity of dynein movement. The roles of the product of DCTN1-p150 include oocyte polarity, mitotic cell division, embryonic development, neuronal transport and neurogenesis. (1265 aa) |
| | mop | Myopic (mop) encodes an endocytic protein that is required for normal Egfr signaling and for the progression of the product of Egfr through the endocytic pathway. It also controls the endosomal localization and signaling activity of the product of yki. (1833 aa) |
| | hid | Cell death protein hid; Activator of apoptosis, with grim and rpr, that acts on the effector Dredd. Seems to act genetically upstream of baculoviral anti-apoptotic p35. Blocks Diap2 from binding and inactivating the effector caspase Drice. (410 aa) |
| | wnd | Wallenda (wnd) encodes a kinase in the mixed lineage family of MAP Kinase Kinase Kinases. Its roles include axonal injury signaling (it becomes activated in neurons after axotomy), and in regulation of the structure of presynaptic boutons. (977 aa) |
| | Trpml | Transient receptor potential cation channel, mucolipin (Trpml) encodes a ion channel involved in autophagy, lateral inhibition and TOR signalling regulation. (652 aa) |
| | zld | Zelda, isoform A; Zelda (zld) encodes a zinc finger transcription factor that functions in early blastoderm development. It works as a zygotic genome activator because it has a global role in regulating early expressed genes, such as genes essential for cellularization, sex determination and pattern formation. It is also required at later times in development. (1596 aa) |
| | pico | Pico, isoform A; Pico (pico) encodes an intracellular adapter protein belonging to the MRL family of proteins, which transduce signals from growth factor receptors to changes in the actin cytoskeleton. Its roles include the regulation of growth and cell migration. (1162 aa) |
| | rictor | Rapamycin-insensitive companion of Tor (rictor) encodes an essential component of TOR complex 2 where it controls phosphorylation of protein kinases, such as those encoded by Akt1 and trc. The product of rictor contributes to the regulation of tissue growth, dendritic tiling, long term memory, tolerance to heat stress, and mitochondrial quality control. (1936 aa) |
| | IntS2 | Integrator complex subunit 2; Component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box- dependent processing. Involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5. May mediate recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (By similarity). (1105 aa) |
| | CG13001 | RE69682p; It is involved in the biological process described with: nervous system development. (335 aa) |
| | mbt | Serine/threonine-protein kinase PAK mbt; Involved in neurogenesis of the adult central nervous system, and together with Cdc42, regulates photoreceptor cell morphogenesis. Phosphorylates exogenous substrates when activated by Cdc42. (639 aa) |
| | caz | Cabeza (caz) encodes a chromatin binding protein involved in locomotion, synaptic growth at the neuromuscular junction and eye development. (399 aa) |
| | jub | LIM domain-containing protein jub; Regulates organ size by inhibiting apoptosis and promoting cell proliferation by influencing the expression of G1/S-specific cyclin-E (CycE) and apoptosis 1 inhibitor (th). Negatively regulates the Hippo signaling pathway; Belongs to the zyxin/ajuba family. (728 aa) |
| | lic | Licorne (lic) encodes a serine/threonine kinase that phosphorylates p38 MAP kinases. (334 aa) |
| | dsh | Segment polarity protein dishevelled; Required to establish coherent arrays of polarized cells and segments in embryos. Plays a role in wingless (wg) signaling, possibly through the reception of the wg signal by target cells and subsequent redistribution of arm protein in response to that signal in embryos. This signal seems to be required to establish planar cell polarity and identity. (623 aa) |
| | ImpL2 | Neural/ectodermal development factor IMP-L2; Essential developmental role during embryogenesis, in particular the normal development of the nervous system. May be involved in some aspect of cell adhesion. (267 aa) |
| | Cdc37 | Hsp90 co-chaperone Cdc37; Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. Required for cytokinesis and chromosome segregation in mitosis and male meiosis. Belongs to the CDC37 family. (389 aa) |
| | trio | Trio, isoform A; Trio (trio) encodes a Rho guanine nucleotide exchange factor (GEF) that activates the Rho-family GTPases to regulate actin structure and cell adhesion. The GEF encoded by trio acts in several signaling pathways, including Abl tyrosine kinase and BMP signaling pathways. The product of trio is involved in neural wiring (axon and dendrite patterning and synaptogenesis) and muscle development. (2263 aa) |
| | nerfin-1 | Nervous fingers 1 (nerfin-1) encodes a zinc finger transcription factor that regulates early axon guidance at the embryonic stage and is required for the maintenance of larval neuron differentiation. In the larval medulla cortex, nerfin-1 is expressed in medulla neurons at the early stage and protects them from dedifferentiation via the repression of Notch signaling pathway. (469 aa) |
| | Hipk | Homeodomain interacting protein kinase (Hipk) encodes a protein that belongs to the DYRK family kinases. It can modulate signaling pathways including Wingless, Notch, Hippo, Hedgehog, JNK, and cell death. It plays roles in development, proliferation and patterning of many tissues, including the eye, wing, and the embryo. (1340 aa) |
| | Pgam5-2 | Phosphoglycerate mutase 5-2; Phosphoprotein phosphatase activity. It is involved in the biological process described with: protein dephosphorylation; positive regulation of mitochondrial fission. (280 aa) |
| | Orcokinin | Orcokinin, isoform A. (133 aa) |
| | IntS1 | Integrator complex subunit 1; Component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box- dependent processing. Involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5. Required for the normal expression of the Integrator complex component IntS12. May mediate recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (By similarity). (2053 aa) |
| | gbb | Protein 60A; Glass bottom boat (gbb) encodes a BMP ligand in the TGF-beta/BMP family of dimeric signaling molecules. It binds to a receptor complex to transduce signal through phosphorylation of the product of Mad. It contributes to maintain stem cell populations, control cell fate specification, proliferation, synapse growth and neuropeptide release. (455 aa) |
| | Pi3K59F | Phosphatidylinositol 3-kinase catalytic subunit type 3; Phosphotidylinositol 3 kinase 59F (Pi3K59F) encodes a lipid kinase that is required for formation of Phosphatidylinositol 3-phosphate. It functions in a core protein complex that includes the products of Atg6 and Vps15. It is involved in the control of vesicle trafficking, including autophagy, endocytosis and phagocytosis. (949 aa) |
| | GM130 | Golgi matrix protein 130 kD (GM130) encodes a protein involved in Golgi compartmental organization and regulation of dendrite morphogenesis. (795 aa) |
| | Egfr | Epidermal growth factor receptor; Binds to four ligands: Spitz, Gurken, Vein and Argos, which is an antagonist. Transduces the signal through the ras-raf-MAPK pathway. Involved in a myriad of developmental decisions. Critical for the proliferation of imaginal tissues, and for the determination of both the antero-posterior and dorso-ventral polarities of the oocyte. In the embryo, plays a role in the establishment of ventral cell fates, maintenance of amnioserosa and ventral neuroectodermal cells, germ band retraction, cell fate specification in the central nervous system and production [...] (1426 aa) |
| | lz | Protein lozenge; Involved in prepatterning photoreceptor precursors in the developing eye; in the larval eye disk it defines a subset of cells as an equipotential group that is competent to respond to the sevenless developmental signal and another subset that confer proper photoreceptor identity by positively regulating the homeo box gene Bar. Involved in the aop/pnt dynamic in a Ras-dependent manner to regulate pros expression. Promotes apoptosis in the pupal eye by directly activating aos and klu. Also modulates hid- and rpr-mediated cell death. Regulates amos function in olfactory s [...] (826 aa) |
| | l(1)G0193 | Lethal (1) G0193, isoform A. (664 aa) |
| | cv | Crossveinless, isoform A; Crossveinless (cv) encodes a member of the tumor suppressor gene family of BMP binding proteins. Its primary function is to help specify the posterior crossvein during pupal wing development by enhancing Dpp/Gbb signaling. (257 aa) |
| | lva | Protein lava lamp; Lva and spectrin may form a Golgi-based scaffold that mediates interaction of Golgi bodies with microtubules and facilitates Golgi-derived membrane secretion required for the formation of furrows during cellularization. Under starvation conditions recruited by ema to developing autophagsosomes where it may function in autophagosome growth. (2779 aa) |
| | N | Processed neurogenic locus Notch protein; Essential signaling protein which has a major role in many developmental processes. Functions as a receptor for membrane-bound ligands Delta and Serrate to regulate cell-fate determination. Upon ligand activation, and releasing from the cell membrane, the Notch intracellular domain (NICD) forms a transcriptional activator complex with Su(H) (Suppressor of hairless) and activates genes of the E(spl) complex. Regulates oogenesis, the differentiation of the ectoderm and the development of the central and peripheral nervous system, eye, wing disk, [...] (2703 aa) |
