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Pgd Pgd CG7140 CG7140 G6P G6P Rpe Rpe Pgi Pgi Hex-C Hex-C Hex-t2 Hex-t2 Hex-t1 Hex-t1 Zw Zw CG17333 CG17333 Taldo Taldo Hex-A Hex-A Rpi Rpi
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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Your Input:
Pgd6-phosphogluconate dehydrogenase, decarboxylating; Phosphogluconate dehydrogenase (Pgd) encodes a cytosolic enzyme that catalyzes the oxidation of 6-phosphogluconate to ribulose 5-phosphate, with the concomitant reduction of NADP[+] to NADPH. The products of Pgd and Zw are the two NADP[+] reducing enzymes in the pentose phosphate pathway. (481 aa)
CG7140Glucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (533 aa)
G6PGlucose-6-phosphatase activity. It is involved in the biological process described with: gluconeogenesis; glucose 6-phosphate metabolic process. (350 aa)
RpeMetal ion binding; ribulose-phosphate 3-epimerase activity. It is involved in the biological process described with: cellular carbohydrate metabolic process; pentose catabolic process; pentose-phosphate shunt, non-oxidative branch. (221 aa)
PgiPhosphoglucose isomerase (Pgi) encodes an enzyme involved in glucose homeostasis. (558 aa)
Hex-CPhosphotransferase; Hexokinase C (Hex-C) encodes a hexokinase involved in glucose homeostasis. (454 aa)
Hex-t2Hexokinase type 2; Catalyzes the phosphorylation of various hexoses to hexose 6- phosphate. (486 aa)
Hex-t1Hexokinase type 1; Catalyzes the phosphorylation of various hexoses to hexose 6- phosphate. (465 aa)
ZwGlucose-6-phosphate 1-dehydrogenase; Cytosolic glucose-6-phosphate dehydrogenase that catalyzes the first and rate-limiting step of the oxidative branch within the pentose phosphate pathway/shunt, an alternative route to glycolysis for the dissimilation of carbohydrates and a major source of reducing power and metabolic intermediates for fatty acid and nucleic acid biosynthetic processes. (524 aa)
CG17333Probable 6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (243 aa)
TaldoProbable transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (331 aa)
Hex-APhosphotransferase; Hexokinase A (Hex-A) encodes a hexokinase involved in glucose homeostasis. (541 aa)
RpiRibose-5-phosphate isomerase activity. It is involved in the biological process described with: age-dependent response to reactive oxygen species; D-ribose metabolic process; pentose-phosphate shunt, non-oxidative branch. (241 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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