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Klp61F Klp61F pav pav CG32232 CG32232 feo feo Klp10A Klp10A nod nod Grip91 Grip91 Grip128 Grip128 Grip84 Grip84 polo polo mop mop DCTN1-p150 DCTN1-p150 Grip163 Grip163 pbl pbl CG32371 CG32371 CG7716 CG7716 CG2955 CG2955 Mms19 Mms19 ifc ifc Cks30A Cks30A Grip75 Grip75 CG18109 CG18109 grp grp Grip71 Grip71 RacGAP84C RacGAP84C pont pont mgr mgr Pp1-87B Pp1-87B Det Det bond bond wdb wdb dgt6 dgt6 fest fest sub sub tum tum cid cid Vhl Vhl Incenp Incenp chb chb Lis-1 Lis-1 sau sau CG18190 CG18190 Eb1 Eb1 CG3437 CG3437 mtsh mtsh larp larp CG42399 CG42399 Mzt1 Mzt1 Skeletor Skeletor dia dia mud mud BuGZ BuGZ CG15306 CG15306 Tnks Tnks SRPK SRPK wac wac Wee1 Wee1 Mtor Mtor gammaTub37C gammaTub37C Synd Synd Pp2A-29B Pp2A-29B Aladin Aladin Nup154 Nup154 wisp wisp mts mts Mst27D Mst27D ncd ncd sofe sofe mst mst Klp67A Klp67A
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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Klp61FKinesin-like protein Klp61F; Important role in mitotic dividing cells. Microtubule motor required for spindle body separation. Slow plus-end directed microtubule motor capable of cross-linking and sliding apart antiparallel microtubules, thereby pushing apart the associated spindle poles during spindle assembly and function. Forms cross-links between microtubules within interpolar microtubule bundles. Contributes to the length of the metaphase spindle, maintains the prometaphase spindle by antagonizing Ncd, drives anaphase B, and also contributes to normal chromosome congression, kinet [...] (1066 aa)
pavKinesin-like protein; Pavarotti (pav) encodes a microtubule motor protein from the Kinesin superfamily. It plays important roles during the mitotic cycle including spindle formation, cortical cytoskeleton reorganization and cytokinesis. It also negatively regulates Wnt activity. (887 aa)
CG32232Gamma-tubulin complex component; Gamma-tubulin binding; microtubule minus-end binding. It is involved in the biological process described with: mitotic cell cycle; spindle assembly; microtubule nucleation by interphase microtubule organizing center; meiotic cell cycle; cytoplasmic microtubule organization. (975 aa)
feoFascetto (feo) encodes a protein that binds the central spindle microtubules and is required for proper midbody formation and cytokinesis. It also has roles in centrosome duplication and neurogenesis. (671 aa)
Klp10AKinesin-like protein Klp10A; Required during anaphase to drive sister chromatid separation to promote flux by actively depolymerizing kinetochore microtubules at their pole-associated minus ends, thereby moving chromatids through a 'poleward flux'. Involved in asymmetric cell division of sensory organ precursor (SOP) cells by playing a role in the asymmetric localization of Sara- expressing endosomes to the pIIa daughter cell but not to the pIIb cell. Klp98A targets Sara-expressing endosomes to the central spindle which is symmetrically arranged in early cell division. During late cyto [...] (805 aa)
nodKinesin-like protein Nod; No distributive disjunction (nod) encodes a kinesin-like protein that is important for nonexchange chromosome biology. The nod product is necessary for chromosome segregation during meiosis and for proper chromosome alignment along the meiotic spindle. (666 aa)
Grip91Gamma-tubulin complex component 3; Gamma-tubulin ring protein 91 (Grip91) encodes a gamma-tubulin binding protein involved in male meiotic division and the organization of the meiotic spindle; Belongs to the TUBGCP family. (917 aa)
Grip128Grip128 (Grip128) encodes a component of the Gamma-tubulin ring complex, which is a potent microtubule nucleator in eukaryotic cells essential for successful chromosome segregation and cell division. (1092 aa)
Grip84Gamma-tubulin complex component 2 homolog; Gamma-tubulin binding; microtubule minus-end binding. (926 aa)
poloSerine/threonine-protein kinase polo; May play a role in regulating both nuclear and cytoplasmic aspects of the mitotic cycle. Regulates localization of the augmin complex during mitosis by ensuring its location on mitotic spindles. Also regulates augmin complex localization during male meiosis by promoting its placement at kinetochores while preventing its association with spindle microtubules ; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily. (576 aa)
mopMyopic (mop) encodes an endocytic protein that is required for normal Egfr signaling and for the progression of the product of Egfr through the endocytic pathway. It also controls the endosomal localization and signaling activity of the product of yki. (1833 aa)
DCTN1-p150Dynactin 1, p150 subunit (DCTN1-p150) encodes the p150 subunit of the dynactin complex. Dynactin is thought to act as a dynein receptor that modulates binding of dynein to cellular cargoes and enhances the processivity of dynein movement. The roles of the product of DCTN1-p150 include oocyte polarity, mitotic cell division, embryonic development, neuronal transport and neurogenesis. (1265 aa)
Grip163Grip163 (Grip163) encodes a gamma-tubulin binding protein involved in the mitotic cell cycle. (1351 aa)
pblPebble, isoform B; Pebble (pbl) encodes a Rho guanine nucleotide exchange factor that contributes to multiple processes involving actin cytoskeleton reorganization, including cytokinesis, axogenesis and wound healing as well as cell shape regulation and cell migration during gastrulation. (1311 aa)
CG32371MIP05284p; Microtubule binding; microtubule plus-end binding. It is involved in the biological process described with: protein localization to microtubule; protein localization to microtubule plus-end; regulation of microtubule polymerization or depolymerization; spindle assembly. (294 aa)
CG7716Gamma-tubulin complex component; Microtubule minus-end binding; gamma-tubulin binding. It is involved in the biological process described with: microtubule nucleation by interphase microtubule organizing center; meiotic cell cycle; cytoplasmic microtubule organization; mitotic cell cycle; spindle assembly. (728 aa)
CG2955GH14206p; Microtubule plus-end binding; microtubule binding. It is involved in the biological process described with: spindle assembly; regulation of microtubule polymerization or depolymerization; protein localization to microtubule plus-end; protein localization to microtubule. (565 aa)
Mms19GH06271p; It is involved in the biological process described with: iron-sulfur cluster assembly; protein maturation by iron-sulfur cluster transfer. (959 aa)
ifcSphingolipid delta-4 desaturase activity. It is involved in the biological process described with: spermatogenesis; spindle assembly involved in male meiosis; ceramide biosynthetic process; Belongs to the fatty acid desaturase type 1 family. DEGS subfamily. (321 aa)
Cks30ACyclin-dependent kinase subunit 30A (Cks30A) encodes a protein that promotes progression through female meiosis and the mitotic divisions of the early embryo. It interacts with the product of Cdk1 and is required in prometaphase for spindle assembly, and at the metaphase to anaphase transition for the destruction of the cyclin encoded by CycA. (74 aa)
Grip75Gamma-tubulin complex component 4 homolog; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family. (650 aa)
CG18109GCP_N_terminal domain-containing protein; Gamma-tubulin binding; microtubule minus-end binding. It is involved in the biological process described with: spindle assembly; mitotic cell cycle; microtubule nucleation by interphase microtubule organizing center; cytoplasmic microtubule organization; meiotic cell cycle. (1931 aa)
grpSerine/threonine-protein kinase grp; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. May phosphorylate the CDC25 phosphatase stg, which promotes its degradation. This results in increased inhibitory tyrosine phosphorylation of Cdk1-cyclin complexes and consequent inhibition of cell cycle progression. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase [...] (512 aa)
Grip71Grip71; Gamma-tubulin binding. It is involved in the biological process described with: centrosome cycle; protein localization to centrosome; regulation of cell cycle; spindle assembly involved in female meiosis I; mitotic cell cycle. (646 aa)
RacGAP84CGTPase-activating protein RacGAP84C; Involved in the morphogenesis of the adult appendages. GTPase-activating protein for p21-Rac. Promotes the exchange of Rac- bound GDP by GTP. (384 aa)
pontRuvB-like helicase 1; Acts as a transcriptional coactivator in Wg signaling caused by altered arm signaling. Pont and rept interfere antagonistically with nuclear arm signaling function, and are required to enhance or reduce arm activity, respectively. Also an essential cofactor for the normal function of Myc; required for cellular proliferation and growth. (456 aa)
mgrPrefoldin subunit 3; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity). Required for tubulin stability and spindle and centrosome formation in cooperation with Vhl. (194 aa)
Pp1-87BSerine/threonine-protein phosphatase alpha-2 isoform; Is essential for the regulation of mitotic chromosomal segregation as well as regulation of chromatin condensation during interphase; Belongs to the PPP phosphatase family. PP-1 subfamily. (302 aa)
DetGEO07887p1; Deterin (Det) encodes a component of the chromosomal passenger complex involved in regulation of apoptosis and cytokinesis. (153 aa)
bondJames bond (bond) encodes a member of the Elov1 family of enzymes that function as very long chain fatty acid elongases. It contributes to sperm generation and the production of the male sex pheromone CH503 in the ejaculatory bulb. (322 aa)
wdbWiderborst (wdb) encodes a B' regulatory subunit of the serine/threonine phosphatase complex PP2A. It regulates Hedgehog, protein kinase B and insulin receptor signaling pathways. (524 aa)
dgt6Augmin complex subunit dgt6; As part of the augmin complex, plays a role in centrosome- independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules. dgt6 is required for kinetochore fiber formation, mediating nucleation and/or initial stabilization of chromosome-induced microtubules ; Belongs to the HAUS6 family. (654 aa)
festWurstfest, isoform A; It is involved in the biological process described with: spindle assembly involved in male meiosis I; multicellular organism reproduction. (513 aa)
subKinesin-like protein subito; Subito (sub) encodes a kinesin-6 homolog. Kinesin-6 proteins are known to bundle antiparallel microtubules. The product of sub is required for cytokinesis in mitosis and spindle organization and chromosome segregation in female meiosis; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (628 aa)
tumTumbleweed (tum) encodes a GTPase activating protein for Rho family GTPases involved in Wnt signalling regulation. (625 aa)
cidHistone H3-like centromeric protein cid; Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. (225 aa)
VhlProtein Vhl; Involved in development of tracheal vasculature. Probably involved in halting cell migration at the end of vascular tube outgrowth. Possesses E3 ubiquitin ligase activity when in complex with Elongin BC complex, Cul2 and Rox1a/Rbx1, and can target sima/Hif1a for ubiquitination. May play a critical role in promoting microtubule stabilization when tubulins are correctly folded by the prefoldin complex. If tubulin is incorrectly folded, may promote its degradation. (178 aa)
IncenpInner centromere protein (Incenp) encodes a component of the chromosomal passenger complex, acting as a subunit that targets and activates the product of aurB. It controls different processes during cell division, including regulation of chromosome structure, kinetochore-microtubule error correction, chromosome segregation and cytokinesis. (755 aa)
chbCLIP-associating protein; Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Required for several aspects of mitotic spindle formation including the formation of the overlapping central spindle microtubules and kinetochore attachment. Required for the incorporation of tubulin subunits at the plus ends of kinetochore microtubules during poleward microtubule flux. Acts antagonistically to Klp10A and Klp67A to maintain metaphase spindle length. Also required for guidance of CNS axons downstream of Abl. May function to identify a subset of microt [...] (1491 aa)
Lis-1Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as nuclear migration during cell division, mitotic spindle formation and the removal of mitotic checkpoint proteins from kinetochores at the metaphase to anaphase transition. Required for several aspects of neurogenesis including neuroblast proliferation, neuronal cell differentiation, dendritic growth, b [...] (411 aa)
sauGolgi phosphoprotein 3 homolog sauron; Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (By similarity). May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion (By similarity). Also involved in the control of the local [...] (294 aa)
CG18190FI16628p1; Microtubule plus-end binding; microtubule binding. It is involved in the biological process described with: protein localization to microtubule plus-end; protein localization to microtubule; spindle assembly; regulation of microtubule polymerization or depolymerization. (248 aa)
Eb1Eb1, isoform F; Eb1 (Eb1) encodes a microtubule end-binding protein that contributes to organization of the microtubule cytoskeleton. It is involved in chromosome segregation, wound healing and flight behavior. (297 aa)
CG3437Uncharacterized protein; It is involved in the biological process described with: centrosome duplication; spindle assembly. (349 aa)
mtshMitoshell (mtsh) encodes a protein with a bromodomain-related region. It is required during spermatogenesis for proper temporal coordination of meiotic divisions with the morphogenetic events that usually follow meiosis. (649 aa)
larpLa-related protein 1; RNA-binding protein required during male meiosis and development of the syncytial embryo. Binds poly-(A) tails of mRNAs and regulates their expression by regulating their stability or translation. (1673 aa)
CG42399Uncharacterized protein, isoform B; Microtubule binding. It is involved in the biological process described with: microtubule cytoskeleton organization. (1655 aa)
Mzt1Mitotic spindle organizing protein 1; Gamma-tubulin binding. It is involved in the biological process described with: gamma-tubulin complex localization; microtubule nucleation by interphase microtubule organizing center; mitotic spindle assembly. (82 aa)
SkeletorProtein Skeletor, isoforms D/E; Skeletor (Skeletor) encodes a protein that localizes to chromosomes at interphase and interacts directly with the product of Chro to mark regions of open chromatin. It forms part of a matrix embedding the microtubule spindle apparatus, which is important for normal cell cycle progression and functions as a spatial regulator of cell cycle factors. (1503 aa)
diaProtein diaphanous; Required for cytokinesis in both mitosis and meiosis. Has a role in actin cytoskeleton organization and is essential for many, if not all, actin-mediated events involving membrane invagination. May serve as a mediator between signaling molecules and actin organizers at specific phases of the cell cycle. Possible component of the contractile ring or may control its function. (1098 aa)
mudMushroom body defect (mud) encodes regulates spindle orientation via interactions with the dynein complex. (2567 aa)
BuGZBub3 interacting GLEBS and Zinc finger domain protein (BuGZ) encodes a protein involved in dendrite morphogenesis. (622 aa)
CG15306Uncharacterized protein, isoform A; Microtubule plus-end binding; microtubule binding. It is involved in the biological process described with: spindle assembly; regulation of microtubule polymerization or depolymerization; protein localization to microtubule plus-end; protein localization to microtubule. (357 aa)
TnksTankyrase (Tnks) encodes an ADP-ribose polymerase that regulates Wnt signalling by contributing to the degradation of Axn. (1520 aa)
SRPKSR Protein Kinase (SRPK) encodes a protein involved in spindle microtubule assembly and karyosome formation in oocytes. (939 aa)
wacAugmin complex subunit wac; As part of the augmin complex, plays a role in centrosome- independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules. wac is dispensable for somatic mitosis and for assembly of spindle microtubules in oocytes during female meiosis but is required during female meiosis for chromosome alignment and segregation. It is required for microtubule assembly near spindle poles in oocytes. It is also required for acentrosomal microtubule nucleation and [...] (163 aa)
Wee1Wee1-like protein kinase; Wee1 kinase (Wee1) encodes a tyrosine kinase required for triggering entry into mitosis. The activity of the Wee1 product contributes to spindle assembly and alignment and separation of the chromosomes; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily. (609 aa)
MtorNucleoprotein TPR; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC. Plays a role in chromosomal organization and gene expression regulation; stimulates transcription by promoting the formation of an open chromatin environment. Binds chromatin to nucleoporin-associated regions (NARs) that define transcriptionally active regions of the genome. Associates with extended chromosomal regions that alternate between domains of high density binding with those of lo [...] (2346 aa)
gammaTub37CTubulin gamma-2 chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly. Required for oocyte activation and consequently for organization of the female meiotic spindle. Essential for centrosome organization and assembly of biastral mitotic spindles in embryos. Plays a role in stabilizing the augmin complex on the meiotic spindle. (457 aa)
SyndSyndapin, isoform C; Lipid binding; phospholipid binding; cytoskeletal protein binding; protein binding. (495 aa)
Pp2A-29BSerine/threonine-protein phosphatase PP2A 65 kDa regulatory subunit; Protein phosphatase 2A at 29B (Pp2A-29B) encodes the structural A subunit of the trimeric PP2A phosphatase enzyme. It links the catalytic C subunit encoded by mts and a variable regulatory B family subunit, which directs the enzyme to distinct substrates. The roles of Pp2A-29B product include centriole duplication, chromosome segregation, autophagy, axonal transport, growth regulation, and active zone stabilization. (650 aa)
AladinAladin; Involved in mitotic spindle assembly. (466 aa)
Nup154Nuclear pore complex protein Nup154; Component of the nuclear pore complex. Has a role in the organization of the inner nuclear membrane proteins at the nuclear envelope. In germ cells, plays a role in the nuclear localization of components of the dpp signaling pathways, such as Medea and phosphorylated Mad. Binds to chromatin, and together with Nup62 and Nup93-1, contributes to karyosome morphology and chromatin organization including attachment to the nuclear envelope in oocytes and nurse cells. Has a role in female fertility including egg chamber development; in nurse cells, has a r [...] (1365 aa)
wispPoly(A) RNA polymerase gld-2 homolog B; Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific maternal RNAs (bcd, Tl, and tor), forming a poly(A) tail, during late oogenesis and early embryogenesis. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs. Required for localization of mRNAs to both poles of the egg, to recruit or maintain known centrosomal proteins with two types of microtubule organizing centers (MTOCs): the central MTOC that forms between the meiosis II tandem spindles and [...] (1373 aa)
mtsSerine/threonine-protein phosphatase PP2A; Microtubule star (mts) encodes the catalytic subunit of protein phosphatase 2A. It is involved in various developmental processes and signaling pathways, such as Hh signaling and Wingless signaling; Belongs to the PPP phosphatase family. PP-2A subfamily. (309 aa)
Mst27DIP12509p; Microtubule plus-end binding; microtubule binding. It is involved in the biological process described with: protein localization to microtubule plus-end; protein localization to microtubule; spindle assembly; regulation of microtubule polymerization or depolymerization. (424 aa)
ncdProtein claret segregational; Non-claret disjunctional (ncd) encodes a minus-end-directed kinesin microtubule motor protein and the sole member of the kinesin-14 motor family. It is required for spindle assembly in oocytes and chromosome attachment to spindles in early embryos; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. NCD subfamily. (700 aa)
sofeSister of feo, isoform A; Microtubule binding. It is involved in the biological process described with: mitotic cytokinesis; G protein-coupled receptor signaling pathway; mitotic spindle midzone assembly; microtubule cytoskeleton organization. (607 aa)
mstMisato (mst) encodes a conserved protein that acts as a co-factor of the TCP-1 tubulin chaperone complex. It is required for mitotic spindle assembly and viability and for tubulin polymerization and stability. (574 aa)
Klp67AKinesin-like protein at 67A (Klp67A) encodes a microtubule motor protein involved in chromosome congression and mitotic spindle morphogenesis; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (814 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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