(6 nodes) Mitotic spindle midzone assembly network (Drosophila melanogaster)

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Your Input:
	sofe	Sister of feo, isoform A; Microtubule binding. It is involved in the biological process described with: mitotic cytokinesis; G protein-coupled receptor signaling pathway; mitotic spindle midzone assembly; microtubule cytoskeleton organization. (607 aa)
	RacGAP84C	GTPase-activating protein RacGAP84C; Involved in the morphogenesis of the adult appendages. GTPase-activating protein for p21-Rac. Promotes the exchange of Rac- bound GDP by GTP. (384 aa)
	tum	Tumbleweed (tum) encodes a GTPase activating protein for Rho family GTPases involved in Wnt signalling regulation. (625 aa)
	feo	Fascetto (feo) encodes a protein that binds the central spindle microtubules and is required for proper midbody formation and cytokinesis. It also has roles in centrosome duplication and neurogenesis. (671 aa)
	pav	Kinesin-like protein; Pavarotti (pav) encodes a microtubule motor protein from the Kinesin superfamily. It plays important roles during the mitotic cycle including spindle formation, cortical cytoskeleton reorganization and cytokinesis. It also negatively regulates Wnt activity. (887 aa)
	DCTN1-p150	Dynactin 1, p150 subunit (DCTN1-p150) encodes the p150 subunit of the dynactin complex. Dynactin is thought to act as a dynein receptor that modulates binding of dynein to cellular cargoes and enhances the processivity of dynein movement. The roles of the product of DCTN1-p150 include oocyte polarity, mitotic cell division, embryonic development, neuronal transport and neurogenesis. (1265 aa)

Your Current Organism:

Drosophila melanogaster

NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
RacGAP84C	feo	FBpp0081099	FBpp0073266	GTPase-activating protein RacGAP84C; Involved in the morphogenesis of the adult appendages. GTPase-activating protein for p21-Rac. Promotes the exchange of Rac- bound GDP by GTP.	Fascetto (feo) encodes a protein that binds the central spindle microtubules and is required for proper midbody formation and cytokinesis. It also has roles in centrosome duplication and neurogenesis.	0.783
RacGAP84C	pav	FBpp0081099	FBpp0073083	GTPase-activating protein RacGAP84C; Involved in the morphogenesis of the adult appendages. GTPase-activating protein for p21-Rac. Promotes the exchange of Rac- bound GDP by GTP.	Kinesin-like protein; Pavarotti (pav) encodes a microtubule motor protein from the Kinesin superfamily. It plays important roles during the mitotic cycle including spindle formation, cortical cytoskeleton reorganization and cytokinesis. It also negatively regulates Wnt activity.	0.993
RacGAP84C	sofe	FBpp0081099	FBpp0312030	GTPase-activating protein RacGAP84C; Involved in the morphogenesis of the adult appendages. GTPase-activating protein for p21-Rac. Promotes the exchange of Rac- bound GDP by GTP.	Sister of feo, isoform A; Microtubule binding. It is involved in the biological process described with: mitotic cytokinesis; G protein-coupled receptor signaling pathway; mitotic spindle midzone assembly; microtubule cytoskeleton organization.	0.783
RacGAP84C	tum	FBpp0081099	FBpp0086767	GTPase-activating protein RacGAP84C; Involved in the morphogenesis of the adult appendages. GTPase-activating protein for p21-Rac. Promotes the exchange of Rac- bound GDP by GTP.	Tumbleweed (tum) encodes a GTPase activating protein for Rho family GTPases involved in Wnt signalling regulation.	0.592
feo	RacGAP84C	FBpp0073266	FBpp0081099	Fascetto (feo) encodes a protein that binds the central spindle microtubules and is required for proper midbody formation and cytokinesis. It also has roles in centrosome duplication and neurogenesis.	GTPase-activating protein RacGAP84C; Involved in the morphogenesis of the adult appendages. GTPase-activating protein for p21-Rac. Promotes the exchange of Rac- bound GDP by GTP.	0.783
feo	pav	FBpp0073266	FBpp0073083	Fascetto (feo) encodes a protein that binds the central spindle microtubules and is required for proper midbody formation and cytokinesis. It also has roles in centrosome duplication and neurogenesis.	Kinesin-like protein; Pavarotti (pav) encodes a microtubule motor protein from the Kinesin superfamily. It plays important roles during the mitotic cycle including spindle formation, cortical cytoskeleton reorganization and cytokinesis. It also negatively regulates Wnt activity.	0.992
feo	tum	FBpp0073266	FBpp0086767	Fascetto (feo) encodes a protein that binds the central spindle microtubules and is required for proper midbody formation and cytokinesis. It also has roles in centrosome duplication and neurogenesis.	Tumbleweed (tum) encodes a GTPase activating protein for Rho family GTPases involved in Wnt signalling regulation.	0.949
pav	RacGAP84C	FBpp0073083	FBpp0081099	Kinesin-like protein; Pavarotti (pav) encodes a microtubule motor protein from the Kinesin superfamily. It plays important roles during the mitotic cycle including spindle formation, cortical cytoskeleton reorganization and cytokinesis. It also negatively regulates Wnt activity.	GTPase-activating protein RacGAP84C; Involved in the morphogenesis of the adult appendages. GTPase-activating protein for p21-Rac. Promotes the exchange of Rac- bound GDP by GTP.	0.993
pav	feo	FBpp0073083	FBpp0073266	Kinesin-like protein; Pavarotti (pav) encodes a microtubule motor protein from the Kinesin superfamily. It plays important roles during the mitotic cycle including spindle formation, cortical cytoskeleton reorganization and cytokinesis. It also negatively regulates Wnt activity.	Fascetto (feo) encodes a protein that binds the central spindle microtubules and is required for proper midbody formation and cytokinesis. It also has roles in centrosome duplication and neurogenesis.	0.992
pav	sofe	FBpp0073083	FBpp0312030	Kinesin-like protein; Pavarotti (pav) encodes a microtubule motor protein from the Kinesin superfamily. It plays important roles during the mitotic cycle including spindle formation, cortical cytoskeleton reorganization and cytokinesis. It also negatively regulates Wnt activity.	Sister of feo, isoform A; Microtubule binding. It is involved in the biological process described with: mitotic cytokinesis; G protein-coupled receptor signaling pathway; mitotic spindle midzone assembly; microtubule cytoskeleton organization.	0.959
pav	tum	FBpp0073083	FBpp0086767	Kinesin-like protein; Pavarotti (pav) encodes a microtubule motor protein from the Kinesin superfamily. It plays important roles during the mitotic cycle including spindle formation, cortical cytoskeleton reorganization and cytokinesis. It also negatively regulates Wnt activity.	Tumbleweed (tum) encodes a GTPase activating protein for Rho family GTPases involved in Wnt signalling regulation.	0.999
sofe	RacGAP84C	FBpp0312030	FBpp0081099	Sister of feo, isoform A; Microtubule binding. It is involved in the biological process described with: mitotic cytokinesis; G protein-coupled receptor signaling pathway; mitotic spindle midzone assembly; microtubule cytoskeleton organization.	GTPase-activating protein RacGAP84C; Involved in the morphogenesis of the adult appendages. GTPase-activating protein for p21-Rac. Promotes the exchange of Rac- bound GDP by GTP.	0.783
sofe	pav	FBpp0312030	FBpp0073083	Sister of feo, isoform A; Microtubule binding. It is involved in the biological process described with: mitotic cytokinesis; G protein-coupled receptor signaling pathway; mitotic spindle midzone assembly; microtubule cytoskeleton organization.	Kinesin-like protein; Pavarotti (pav) encodes a microtubule motor protein from the Kinesin superfamily. It plays important roles during the mitotic cycle including spindle formation, cortical cytoskeleton reorganization and cytokinesis. It also negatively regulates Wnt activity.	0.959
sofe	tum	FBpp0312030	FBpp0086767	Sister of feo, isoform A; Microtubule binding. It is involved in the biological process described with: mitotic cytokinesis; G protein-coupled receptor signaling pathway; mitotic spindle midzone assembly; microtubule cytoskeleton organization.	Tumbleweed (tum) encodes a GTPase activating protein for Rho family GTPases involved in Wnt signalling regulation.	0.805
tum	RacGAP84C	FBpp0086767	FBpp0081099	Tumbleweed (tum) encodes a GTPase activating protein for Rho family GTPases involved in Wnt signalling regulation.	GTPase-activating protein RacGAP84C; Involved in the morphogenesis of the adult appendages. GTPase-activating protein for p21-Rac. Promotes the exchange of Rac- bound GDP by GTP.	0.592
tum	feo	FBpp0086767	FBpp0073266	Tumbleweed (tum) encodes a GTPase activating protein for Rho family GTPases involved in Wnt signalling regulation.	Fascetto (feo) encodes a protein that binds the central spindle microtubules and is required for proper midbody formation and cytokinesis. It also has roles in centrosome duplication and neurogenesis.	0.949
tum	pav	FBpp0086767	FBpp0073083	Tumbleweed (tum) encodes a GTPase activating protein for Rho family GTPases involved in Wnt signalling regulation.	Kinesin-like protein; Pavarotti (pav) encodes a microtubule motor protein from the Kinesin superfamily. It plays important roles during the mitotic cycle including spindle formation, cortical cytoskeleton reorganization and cytokinesis. It also negatively regulates Wnt activity.	0.999
tum	sofe	FBpp0086767	FBpp0312030	Tumbleweed (tum) encodes a GTPase activating protein for Rho family GTPases involved in Wnt signalling regulation.	Sister of feo, isoform A; Microtubule binding. It is involved in the biological process described with: mitotic cytokinesis; G protein-coupled receptor signaling pathway; mitotic spindle midzone assembly; microtubule cytoskeleton organization.	0.805