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Fer1HCH Fer1HCH Irp-1B Irp-1B IscU IscU CG6523 CG6523 Cisd2 Cisd2 AGBE AGBE CG33672 CG33672 VhaAC39-1 VhaAC39-1 fh fh ABCB7 ABCB7 Fer3HCH Fer3HCH Mco4 Mco4 Zip99C Zip99C stw stw Mco1 Mco1 Mvl Mvl Fer2LCH Fer2LCH Ho Ho Fbl6 Fbl6 mfrn mfrn Mco3 Mco3 Irp-1A Irp-1A
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Fer1HCHFerritin 1 heavy chain homologue (Fer1HCH) encodes one of two subunits of the major iron storage complex, the ferritin molecule. In insects, ferritin is assembled from 12 Fer1HCH and 12 Fer2LCH subunits and can be found in the secretory pathway of cells and in hemolymph. The product of Fer1HCH has ferroxidase activity required for iron loading into ferritin and is essential for embryogenesis. (245 aa)
Irp-1BIron regulatory protein 1B (Irp-1B) encodes a cytosolic aconitase highly homologous to the product of Irp-1A; Belongs to the aconitase/IPM isomerase family. (899 aa)
IscUIron-sulfur cluster assembly enzyme; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. (154 aa)
CG6523LD40224p; Protein disulfide oxidoreductase activity; electron transfer activity. It is involved in the biological process described with: cellular iron ion homeostasis; cell redox homeostasis. (216 aa)
Cisd2CDGSH iron-sulfur domain-containing protein 2 homolog; 2 iron, 2 sulfur cluster binding; Belongs to the CISD protein family. CISD2 subfamily. (133 aa)
AGBE1,4-Alpha-Glucan Branching Enzyme (AGBE) encodes a protein that is inferred to be a hydrolase involved in glycogen synthesis and hypoxia, based on the function of its orthologs. It contributes to the determination of lifespan. (685 aa)
CG33672GEO02273p1; Iron-sulfur cluster binding. It is involved in the biological process described with: cellular iron ion homeostasis; [2Fe-2S] cluster assembly. (86 aa)
VhaAC39-1V-type proton ATPase subunit d 1; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity); Belongs to the V-ATPase V0D/AC39 subunit family. (350 aa)
fhFrataxin homolog, mitochondrial; Promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+). May be able to store large amounts of the metal in the form of a ferrihydrite mineral by oligomerization. Required for ecdysteroidogenesis in the prothoracic gland which is necessary for larval to pupal transition. Belongs to the frataxin family. (190 aa)
ABCB7ATP binding cassette subfamily B member 7 (ABCB7) encodes a transporter that likely dimerizes to form a functional transporter. It may act in the mitochondria to transport substrates necessary for the maturation of ICS proteins, which are involved in iron homeostasis. (743 aa)
Fer3HCHFerritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Belongs to the ferritin family. (186 aa)
Mco4Multicopper oxidase 4; Ferroxidase activity; copper ion binding. It is involved in the biological process described with: iron ion homeostasis; iron ion transport; oxidation-reduction process; Belongs to the multicopper oxidase family. (645 aa)
Zip99CZinc/iron regulated transporter-related protein 99C (Zip99C) encodes an iron transporter located on the Golgi and endoplasmic reticulum that moves iron from the cytoplasm into the secretory compartments; Belongs to the ZIP transporter (TC 2.A.5) family. KE4/Catsup subfamily. (355 aa)
stwStraw, isoform E; Oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor; ferroxidase activity; copper ion binding. It is involved in the biological process described with: oxidation-reduction process; chitin-based cuticle development; iron ion homeostasis; iron ion transport. (784 aa)
Mco1Multicopper oxidase 1 (Mco1) encodes a plasma membrane-bound multicopper oxidase that is positioned to oxidize substrates in the hemolymph, such as ascorbate, and its biological role is unknown. (959 aa)
MvlMalvolio (Mvl) encodes a member of the SLC11 family of metal ion transporters that transports divalent metal cations, including Mn[2+] and Fe[2+]. Its function has been linked to feeding-related decisions, possibly via modulation of dopaminergic signaling. (639 aa)
Fer2LCHFerritin 2 light chain homologue (Fer2LCH) encodes one of two subunits of the major iron storage complex, the ferritin molecule. In insects, ferritin is assembled from 12 Fer1HCH and 12 Fer2LCH subunits and can be found in the secretory pathway of cells and in hemolymph. The product of Fer2LCH provides iron nucleation sites in the internal cavity of the complex required for iron mineralization and is essential for embryogenesis. (236 aa)
HoHeme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (296 aa)
Fbl6F-box and leucine-rich repeat protein 6, isoform A; SAM domain binding. It is involved in the biological process described with: positive regulation of ubiquitin-dependent protein catabolic process; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; regulation of protein stability; ubiquitin-dependent protein catabolic process. (720 aa)
mfrnMitoferrin; Mitochondrial iron transporter that mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly; Belongs to the mitochondrial carrier (TC 2.A.29) family. (379 aa)
Mco3Multicopper oxidase 3 (Mco3) encodes a multi-copper oxidase enzyme that is located in the cellular secretory pathway. It is developmentally regulated and has been proposed to affect iron and copper homeostasis. (677 aa)
Irp-1AIron regulatory protein 1A (Irp-1A) encodes a cytosolic aconitase that under iron deficiency (or if cytosolic superoxide is present) loses its iron-sulfur cluster, changes confirmation and binds iron regulatory elements (so far identified on the products of SdhB and Fer1HCH mRNAs); Belongs to the aconitase/IPM isomerase family. (902 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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