Your Input: | |
| | CG4830 | RE54693p; CoA-ligase activity; fatty acid ligase activity. It is involved in the biological process described with: fatty acid biosynthetic process. (534 aa) |
| | Gnmt | Glycine N-methyltransferase (Gnmt) encodes an enzyme that catalyzes the methylation reaction of glycine to generate sarcosine (N-methylglycine). It is abundantly expressed in the fat body and controls the amount of methyl donor S-adenosylmethionine; Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family. (289 aa) |
| | Vha55 | V-type proton ATPase subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells; Belongs to the ATPase alpha/beta chains family. (490 aa) |
| | ry | Xanthine dehydrogenase; Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid (By similarity). (1335 aa) |
| | Adgf-C | Adenosine deaminase-related growth factor C; Adenosine deaminase activity. It is involved in the biological process described with: inosine biosynthetic process; adenosine catabolic process. (506 aa) |
| | Adgf-D | Adenosine deaminase-related growth factor D (Adgf-D) encodes an adenosine deaminase involved in cell proliferation. (502 aa) |
| | ATPsynO | ATP synthase subunit O, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the centr [...] (209 aa) |
| | Gyc89Db | Soluble guanylate cyclase 89Db; Heterodimers with Gyc88E are activated in response to changing oxygen concentrations, alerting flies to hypoxic environments. Under normal oxygen concentrations, oxygen binds to the heme group and results in low levels of guanylyl cyclase activity. When exposed to reduced oxygen concentrations, the oxygen dissociates from the heme group resulting in activation of the enzyme. (669 aa) |
| | CG17562 | Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. (499 aa) |
| | CG17560 | Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. (499 aa) |
| | AdSL | Adenylosuccinate Lyase (AdSL) encodes a protein that might be a lyase involved in purine nucleotide metabolic process based on orthology; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (481 aa) |
| | CG11391 | Uncharacterized protein; Fatty acid ligase activity; CoA-ligase activity. It is involved in the biological process described with: fatty acid biosynthetic process. (542 aa) |
| | CG11407 | GH20840p; Fatty acid ligase activity; CoA-ligase activity. It is involved in the biological process described with: fatty acid biosynthetic process. (538 aa) |
| | CG11453 | Uncharacterized protein; Fatty acid ligase activity; CoA-ligase activity. It is involved in the biological process described with: fatty acid biosynthetic process. (539 aa) |
| | CG11659 | RE32325p; Fatty acid ligase activity; CoA-ligase activity. It is involved in the biological process described with: fatty acid biosynthetic process. (546 aa) |
| | CG6300 | Uncharacterized protein; Fatty acid ligase activity; CoA-ligase activity. It is involved in the biological process described with: fatty acid biosynthetic process. (537 aa) |
| | CG4770 | Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. (490 aa) |
| | AdSS | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity). Plays a role in the regulation of adult life span. (447 aa) |
| | r-l | Orotidine 5'-phosphate decarboxylase; Rudimentary-like (r-l) encodes an enzyme involved in the novo pyrimidine biosynthesis; In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (493 aa) |
| | PyK | Pyruvate kinase (PyK) encodes an enzyme involved in muscle development, glycolysis and glucose homeostasis; Belongs to the pyruvate kinase family. (533 aa) |
| | CG7069 | Pyruvate kinase activity; potassium ion binding; magnesium ion binding. It is involved in the biological process described with: pyruvate metabolic process; glycolytic process. (744 aa) |
| | CG7059 | Phosphoglycerate mutase activity. It is involved in the biological process described with: glycolytic process; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (267 aa) |
| | Hmgcr | 3-hydroxy-3-methylglutaryl-coenzyme A reductase; Synthesis of mevalonate for the production of non-sterol isoprenoids, which are essential for growth differentiation. Provides spatial information during embryogenesis to guide migrating primordial germ cells (the pole cells) from the ectoderm to the mesoderm. Also required for association of the pole cells with the gonadal mesoderm. Belongs to the HMG-CoA reductase family. (920 aa) |
| | CG6178 | GM05240p; CoA-ligase activity; long-chain fatty acid-CoA ligase activity; fatty acid ligase activity; fatty-acyl-CoA synthase activity. It is involved in the biological process described with: long-chain fatty acid metabolic process; fatty-acyl-CoA biosynthetic process; fatty acid biosynthetic process; acyl-CoA metabolic process. (544 aa) |
| | CG11089 | RE29555p; IMP cyclohydrolase activity; phosphoribosylaminoimidazolecarboxamide formyltransferase activity. It is involved in the biological process described with: wound healing; 'de novo' IMP biosynthetic process. (590 aa) |
| | Nmnat | Nicotinamide mononucleotide adenylyltransferase (Nmnat) encodes an essential enzyme in the NAD salvage pathway, catalyzing the last step of NAD synthesis. It is also a neuronal maintenance factor that protects neurons from excitotoxicity, environmental stress and protein misfolding induced degeneration. (389 aa) |
| | CLS | Probable cardiolipin synthase (CMP-forming); Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG). CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions. (322 aa) |
| | Cmpk | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (253 aa) |
| | Ald1 | Fructose-bisphosphate aldolase; May take part in developmental stage-specific or tissue -specific sugar-phosphate metabolisms. Protein acts on two substrates fructose 1,6-bisphosphate and fructose 1-phosphate (like other class I aldolases). (363 aa) |
| | Ald2 | Fructose-bisphosphate aldolase activity. It is involved in the biological process described with: fructose 1,6-bisphosphate metabolic process; glycolytic process. (364 aa) |
| | Hex-t1 | Hexokinase type 1; Catalyzes the phosphorylation of various hexoses to hexose 6- phosphate. (465 aa) |
| | Hex-t2 | Hexokinase type 2; Catalyzes the phosphorylation of various hexoses to hexose 6- phosphate. (486 aa) |
| | CG6330 | GH09623p; Uridine phosphorylase activity. It is involved in the biological process described with: nucleoside metabolic process; gravitaxis; nucleotide catabolic process. (368 aa) |
| | Gfat2 | Glutamine:fructose-6-phosphate aminotransferase 2; Glutamine-fructose-6-phosphate transaminase (isomerizing) activity; carbohydrate derivative binding. It is involved in the biological process described with: UDP-N-acetylglucosamine metabolic process; fructose 6-phosphate metabolic process; protein N-linked glycosylation. (683 aa) |
| | wat | Fatty acyl-CoA reductase wat; Catalyzes the reduction of saturated fatty acyl-CoA to fatty alcohols. The preferred substrates are C24:0 and C26:0. Necessary for the final stages of tracheal maturation, to facilitate the transition from water-filled to gas-filled tubes. May help to maintain the integrity of the outer hydrophobic envelope of the trachea. (517 aa) |
| | Pdhb | Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (365 aa) |
| | Pglym78 | Phosphoglyceromutase 78 (Pglym78) encodes an enzyme involved in myoblast fusion and somatic muscle development; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (255 aa) |
| | Mesh1 | Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1; Metazoan SpoT homolog-1 (Mesh1) encodes a structural and functional ortholog of bacterial protein SpoT. It hydrolyzes ppGpp to GDP. Its mutants show retarded growth in amino acid-starved media, suggesting the conserved role in stringent responses. (179 aa) |
| | Gycalpha99B | Head-specific guanylate cyclase; Guanylyl cyclase alpha-subunit at 99B (Gycalpha99B) encodes a guanylate cyclase involved in cyclic GMP biosynthesis and phototaxis mediated by rhodopsin. (676 aa) |
| | ATPsyngamma | ATP synthase subunit gamma, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the [...] (297 aa) |
| | Tpi | Triose phosphate isomerase (Tpi) encodes a soluble metabolic protein dimer that functions in glycolysis catalyzing the isomerization between dihydroxyacetone phosphate and glyceraldehyde 3-phosphate, which is essential for efficient ATP production. (348 aa) |
| | CG2246 | GH23275p; Magnesium ion binding; ribose phosphate diphosphokinase activity. It is involved in the biological process described with: nucleotide biosynthetic process; 5-phosphoribose 1-diphosphate biosynthetic process; nucleoside metabolic process; purine nucleotide biosynthetic process. (406 aa) |
| | Gycbeta100B | Guanylyl cyclase beta-subunit at 100B (Gycbeta100B) encodes an enzyme that synthesizes cyclic GMP and is activated by nitric oxide; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (787 aa) |
| | ATPsynC | ATP synthase, subunit C, isoform A; Proton-transporting ATP synthase activity, rotational mechanism. It is involved in the biological process described with: ATP synthesis coupled proton transport; proton transmembrane transport. (138 aa) |
| | CG1635 | LD44914p; acyl-CoA hydrolase activity. It is involved in the biological process described with: acyl-CoA metabolic process. (448 aa) |
| | CG1774 | GH08048p; acyl-CoA hydrolase activity. It is involved in the biological process described with: acyl-CoA metabolic process. (472 aa) |
| | Ac3 | Adenylate cyclase 3 (Ac3) encodes an adenylate cyclase that is coupled to the receptor encoded by Pdfr via Gs signaling in the Morning circadian pacemakers. (1167 aa) |
| | Mccc2 | Probable methylcrotonoyl-CoA carboxylase beta chain, mitochondrial; Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3- methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism (By similarity). Vital for adult survival. (578 aa) |
| | l(2)k01209 | ATP binding; kinase activity; uridine kinase activity. It is involved in the biological process described with: nucleoside metabolic process; pyrimidine-containing compound salvage. (626 aa) |
| | NT5E-2 | Ecto-5'-nucleotidase 2 (NT5E-2) encodes a glycosyl phosphatidylinositol (GPI)-linked membrane-bound glycoprotein with 5'-nucleotidase activity that converts extracellular AMP to adenosine; Belongs to the 5'-nucleotidase family. (585 aa) |
| | CG30103 | Uncharacterized protein; It is involved in the biological process described with: AMP catabolic process; Belongs to the 5'-nucleotidase family. (584 aa) |
| | CG9010 | Glyceraldehyde-3-phosphate dehydrogenase; Peptidyl-cysteine S-nitrosylase activity; NADP binding; NAD binding; glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity. It is involved in the biological process described with: oxidation-reduction process; glycolytic process; glucose metabolic process. (343 aa) |
| | CG8306 | Putative fatty acyl-CoA reductase CG8306; Catalyzes the reduction of C16 or C18 fatty acyl-CoA to fatty alcohols. (516 aa) |
| | knon | Knotted onions; Proton transmembrane transporter activity. It is involved in the biological process described with: Nebenkern assembly; ATP synthesis coupled proton transport. (734 aa) |
| | Hmgs | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (465 aa) |
| | Hex-C | Phosphotransferase; Hexokinase C (Hex-C) encodes a hexokinase involved in glucose homeostasis. (454 aa) |
| | Pgm2b | Phosphoglucomutase 2b; Intramolecular transferase activity, phosphotransferases. It is involved in the biological process described with: carbohydrate metabolic process. (628 aa) |
| | Adgf-E | Adenosine deaminase-related growth factor E; It is involved in the biological process described with: inosine biosynthetic process. (539 aa) |
| | CG33156 | Uncharacterized protein, isoform E; NAD+ kinase activity. It is involved in the biological process described with: NAD metabolic process; NADP biosynthetic process. (490 aa) |
| | CG6145 | RH58004p; NAD+ kinase activity. It is involved in the biological process described with: NADP biosynthetic process. (548 aa) |
| | CG33671 | Mevalonate kinase activity; ATP binding. It is involved in the biological process described with: isopentenyl diphosphate biosynthetic process, mevalonate pathway; isoprenoid biosynthetic process; cholesterol biosynthetic process. (390 aa) |
| | Ak6 | Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. AMP is the best phosphate acceptor, and CMP is also a good substrate. All nucleoside triphosphates ATP, TTP, CTP, GTP, and UTP are accepted as phosphate donors. ATP is the best phosphate donor. May have a role in nuclear energy homeostasis; Belongs to the adenylate kinase family. AK6 subfamily. (175 aa) |
| | Dera | Deoxyribose-phosphate aldolase activity. It is involved in the biological process described with: carbohydrate catabolic process; deoxyribonucleotide catabolic process. (347 aa) |
| | CG8834 | Uncharacterized protein; Fatty acid ligase activity; CoA-ligase activity. It is involved in the biological process described with: fatty acid biosynthetic process. (535 aa) |
| | RnrS | Ribonucleoside-diphosphate reductase subunit M2; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (393 aa) |
| | CG30016 | Hydroxyisourate hydrolase activity. It is involved in the biological process described with: purine nucleobase metabolic process; Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily. (113 aa) |
| | Pfk | ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (950 aa) |
| | CG1441 | Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. (517 aa) |
| | Pgm2a | Phosphoglucomutase 2a; Magnesium ion binding; intramolecular transferase activity, phosphotransferases. It is involved in the biological process described with: carbohydrate metabolic process. (623 aa) |
| | Pgi | Phosphoglucose isomerase (Pgi) encodes an enzyme involved in glucose homeostasis. (558 aa) |
| | Gapdh1 | Glyceraldehyde 3 phosphate dehydrogenase 1 (Gapdh1) encodes a glyceraldehyde-3-phosphate dehydrogenase involved in glycolysis, myoblast fusion and the development of somatic muscle. (332 aa) |
| | Adk3 | GM02629p; Adenosine kinase activity. (366 aa) |
| | r | Glutamine-dependent carbamoyl-phosphate synthase; Rudimentary (r) encodes the CAD protein that catalyzes the initial steps of de novo pyrimidine biosynthesis. r depletion results in wing malformations and pyrimidine auxotrophy. (2224 aa) |
| | CG33958 | FI12009p; Peptide receptor activity; guanylate cyclase activity. It is involved in the biological process described with: receptor guanylyl cyclase signaling pathway; cGMP biosynthetic process; signal transduction; intracellular signal transduction. (710 aa) |
| | UGP | UTP--glucose-1-phosphate uridylyltransferase; UGP (UGP) encodes an enzyme involved in hyperoxia response. (520 aa) |
| | mt:ATPase8 | ATP synthase protein 8; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subuni [...] (53 aa) |
| | Gyc88E | Soluble guanylate cyclase 88E; Heterodimers with Gyc-89Da and Gyc-89Db are activated in response to changing oxygen concentrations, alerting flies to hypoxic environments. Under normal oxygen concentrations, oxygen binds to the heme group and results in low levels of guanylyl cyclase activity. When exposed to reduced oxygen concentrations, the oxygen dissociates from the heme group resulting in activation of the enzyme. (1097 aa) |
| | Gyc89Da | Soluble guanylate cyclase 89Da; Heterodimers with Gyc-89Da and Gyc-89Db are activated in response to changing oxygen concentrations, alerting flies to hypoxic environments. Under normal oxygen concentrations, oxygen binds to the heme group and results in low levels of guanylyl cyclase activity. When exposed to reduced oxygen concentrations, the oxygen dissociates from the heme group resulting in activation of the enzyme. (667 aa) |
| | CG34261 | Macro domain-containing protein; ADP-ribosylglutamate hydrolase activity; purine nucleoside binding. It is involved in the biological process described with: peptidyl-glutamate ADP-deribosylation; purine nucleoside metabolic process. (148 aa) |
| | sdt | Stardust, isoform G; Stardust (sdt) encodes membrane-associated guanylate kinase (MAGUK) protein involved in the maintenance of apico-basal cell polarity and the organization of zonula adherens; Belongs to the MAGUK family. (2020 aa) |
| | Gyc32E | ATP binding; guanylate cyclase activity; peptide receptor activity; signaling receptor activity. It is involved in the biological process described with: cGMP biosynthetic process; signal transduction; cGMP-mediated signaling; receptor guanylyl cyclase signaling pathway; protein phosphorylation. (1191 aa) |
| | CG1638 | Uncharacterized protein; acyl-CoA hydrolase activity. It is involved in the biological process described with: acyl-CoA metabolic process. (443 aa) |
| | ATPsynepsilonL | ATP synthase, epsilon subunit-like, isoform A; Proton-transporting ATP synthase activity, rotational mechanism; ATPase activity. It is involved in the biological process described with: ATP synthesis coupled proton transport; proton transmembrane transport. (64 aa) |
| | CRMP | Collapsin Response Mediator Protein (CRMP) encodes a protein that contributes to pyrimidine catabolism, beta-alanine biosynthesis, neurogenesis and behavior. (594 aa) |
| | CG3216 | Guanylate cyclase; Signaling receptor activity; guanylate cyclase activity; peptide receptor activity; ATP binding. It is involved in the biological process described with: cGMP biosynthetic process; signal transduction; receptor guanylyl cyclase signaling pathway; protein phosphorylation; cGMP-mediated signaling. (1161 aa) |
| | CG31115 | Purine nucleoside phosphorylase; Purine nucleoside phosphorylase involved in purine salvage. Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. (290 aa) |
| | Uck | Uridine-cytidine kinase; (Microbial infection) Required for optimal replication of E.chaffeensis in the immune tissues, hemocytes, and fat body. Belongs to the uridine kinase family. (305 aa) |
| | Dhod | Dihydroorotate dehydrogenase (Dhod) encodes a protein that is associated with the inner mitochondrial membrane. It catalyzes the fourth step of de novo pyrimidine biosynthesis, which is required for normal cuticle formation and oogenesis. (405 aa) |
| | ATPCL | ATP-citrate synthase; ATP citrate lyase (ATPCL) encodes a protein involved in glucose homeostasis; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family. (1112 aa) |
| | CG14893 | Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. (510 aa) |
| | CG18586 | IP13241p; CoA-ligase activity. (545 aa) |
| | dlg1 | Disks large 1 tumor suppressor protein; During embryonic development, some isoforms are essential for proper neuronal differentiation and organization. Required for cell polarity; maintenance of apicobasal polarity. Plays a critical role at septate junctions in cellular growth control during larval development. The presence of a guanylate kinase domain suggests involvement in cellular adhesion as well as signal transduction to control cellular proliferation. (1030 aa) |
| | CG32301 | Uncharacterized protein, isoform C; Adenylate cyclase activity. It is involved in the biological process described with: adenylate cyclase-activating G protein-coupled receptor signaling pathway; chaeta development; notum development; cyclic nucleotide biosynthetic process. (1111 aa) |
| | CG32305 | Uncharacterized protein; Adenylate cyclase activity. It is involved in the biological process described with: cyclic nucleotide biosynthetic process; adenylate cyclase-activating G protein-coupled receptor signaling pathway. (1164 aa) |
| | ScsbetaA | Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (503 aa) |
| | CG5065 | Putative fatty acyl-CoA reductase CG5065; Catalyzes the reduction of C16 or C18 fatty acyl-CoA to fatty alcohols. (625 aa) |
| | CG42637 | Receptor-type guanylate cyclase Gyc76C; Guanylate cyclase involved in the production of the second messenger cGMP. Acts as a receptor for the NPLP1-4 peptide and modulates the innate immune IMD pathway in response to salt stress by inducing nuclear translocation of NF-kappa-B protein Rel which leads to increased expression of the antimicrobial peptide diptericin. Plays a role in Sema-1a-mediated axon repulsion which is required for the correct establishment of neuromuscular connectivity. Required in developing embryonic somatic muscle for correct patterning of ventral and lateral muscl [...] (1525 aa) |
| | Gyc76C | Guanylyl cyclase at 76C (Gyc76C) encodes a membrane-associated guanylate cyclase that catalyzes the conversion of GTP to the second messenger cGMP. It has roles in embryonic development (epithelia and muscle), axonal guidance, Malpighian tubule function, innate immunity and salt stress tolerance. (1525 aa) |
| | CG10738 | Guanylate cyclase activity; peptide receptor activity; ATP binding; signaling receptor activity. (1250 aa) |
| | pdgy | Pudgy, isoform A; Pudgy (pdgy) encodes an acyl-CoA synthetase that activates fatty acids by conjugating them to CoA. It is a FOXO transcriptional target that preferentially activates fatty acids destined for beta-oxidation. (597 aa) |
| | CG3788 | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (378 aa) |
| | CG42814 | MIP29220p; UDP-sugar diphosphatase activity; metal ion binding. It is involved in the biological process described with: ribose phosphate metabolic process; nucleoside phosphate metabolic process. (237 aa) |
| | ATPsynE | ATP synthase, subunit E, isoform A; Proton transmembrane transporter activity. It is involved in the biological process described with: proton transmembrane transport; ATP synthesis coupled proton transport. (81 aa) |
| | Prat | Amidophosphoribosyltransferase; Phosphoribosylamidotransferase (Prat) encodes a type-2 glutamine amidotransferase that converts phosphoribosylpyrophosphate to phosphoribosylamine using glutamine. It is an essential enzyme in the pathway for de novo synthesis of the purine nucleotide inosine monophosphate (IMP). IMP is the precursor for purine nucleotides required for nucleic acids, energy transfer, cell signaling, and coenzymes; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (546 aa) |
| | Ac76E | Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1312 aa) |
| | Sarm | NAD(+) hydrolase sarm1; NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism. Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site. Wallerian degeneration is triggered by NAD(+) depletion: in response to injury, it is activated and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR), cyclic ADPR (cADPR) and nicotinamide; NAD(+) c [...] (1730 aa) |
| | ATPsynCF6 | ATP synthase-coupling factor 6, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of t [...] (106 aa) |
| | ATPsynG | ATP synthase subunit; Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proto [...] (99 aa) |
| | Parg | Poly(ADP-ribose) glycohydrolase (Parg) encodes a nuclear enzyme that degrades poly(ADP-ribose) to mono(ADP-ribose) from the acceptor proteins after their modification by the product of Parp. It performs several vital roles, including regulation of developmental patterning and germ-line stem cell fate. (723 aa) |
| | CG43373 | Uncharacterized protein, isoform C; Adenylate cyclase activity. It is involved in the biological process described with: adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; adenylate cyclase-activating G protein-coupled receptor signaling pathway; cAMP biosynthetic process. (1854 aa) |
| | CG12268 | Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. (531 aa) |
| | b | Black (b) encodes an aspartate 1-decarboxylase. Mutations of b result in viable flies with a cuticular melanization phenotype. (575 aa) |
| | ACXE | Adenylyl cyclase X E; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1123 aa) |
| | dnk | Deoxynucleoside kinase; Deoxyribonucleoside kinase that has a broad specificity phosphorylating thymidine, 2'-deoxyriboadenosine, 2'-deoxyribocytidine and 2'-deoxyriboguanosine. Specificity is higher for pyrimidine nucleosides. Several anti-viral and anti-cancer nucleoside analogs are also efficiently phosphorylated. (250 aa) |
| | fal | Falten, isoform B; Falten (fal) encodes a protein with potential GTPase activity. It is expressed in the mesoderm and is elevated in embryos lacking how function. (368 aa) |
| | CG5828 | Uncharacterized protein, isoform A; Pantothenate kinase activity. It is involved in the biological process described with: coenzyme A biosynthetic process. (361 aa) |
| | Mtap | S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. (360 aa) |
| | CG5757 | CG5757-PA; Thymidylate kinase activity; ATP binding; nucleoside diphosphate kinase activity; uridylate kinase activity. It is involved in the biological process described with: dUDP biosynthetic process; dTTP biosynthetic process; dTDP biosynthetic process. (211 aa) |
| | Ppcs | Phosphopantothenoylcysteine synthetase, isoform C; Phosphopantothenate--cysteine ligase activity. (373 aa) |
| | Pde6 | cGMP-specific 3',5'-cyclic phosphodiesterase; Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Has cAMP phosphodiesterase activity in vitro but not in vivo. Has a role regulating cGMP transport in Malpighian tubule principal cells. (1124 aa) |
| | Ac78C | Adenylyl cyclase 78C; [Isoform B]: Catalyzes the formation of the signaling molecule cAMP in response to G-protein coupled receptor signaling. Probably downstream of gustatory receptors, involved in taste perception of sucrose, trehalose and caffeine. Has no role in bitter perception. In the circadian brain neuron evening cells (E- cells), involved in circadian pacemaker synchronization by playing a role in signaling downstream of the G protein-coupled receptor Pdfr, probably in conjunction with other, as yet unidentified, adenylate cyclases. (1727 aa) |
| | Gnpnat | Monosaccharide binding; N-acetyltransferase activity; glucosamine 6-phosphate N-acetyltransferase activity. It is involved in the biological process described with: UDP-N-acetylglucosamine biosynthetic process; Belongs to the acetyltransferase family. GNA1 subfamily. (228 aa) |
| | Pde9 | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A; Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP. (1623 aa) |
| | Fign | Fidgetin-like protein 1; ATP binding; magnesium ion binding; ATPase activity; microtubule-severing ATPase activity; hydrolase activity. (523 aa) |
| | CG16758 | Uncharacterized protein, isoform H; Purine-nucleoside phosphorylase activity. It is involved in the biological process described with: nucleoside metabolic process. (396 aa) |
| | CG7362 | Uncharacterized protein; Potassium ion binding; magnesium ion binding; pyruvate kinase activity. It is involved in the biological process described with: glycolytic process. (793 aa) |
| | CG9541 | Uncharacterized protein, isoform D; Nucleoside diphosphate kinase activity; ATP binding. It is involved in the biological process described with: nucleoside diphosphate phosphorylation; purine nucleotide metabolic process; nucleoside triphosphate biosynthetic process. (646 aa) |
| | CG42249 | Uncharacterized protein, isoform C; Nucleotide binding; nucleoside-diphosphatase activity; nucleoside-triphosphatase activity; metal ion binding. It is involved in the biological process described with: AMP catabolic process; Belongs to the 5'-nucleotidase family. (558 aa) |
| | CG8360 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. (158 aa) |
| | CG8353 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (170 aa) |
| | NTPase | NTPase, isoform F; Uridine-diphosphatase activity; guanosine-diphosphatase activity; Belongs to the GDA1/CD39 NTPase family. (524 aa) |
| | Ac13E | Adenylyl cyclase 13E, isoform C; Adenylate cyclase activity. It is involved in the biological process described with: cyclic nucleotide biosynthetic process; adenylate cyclase-activating G protein-coupled receptor signaling pathway. (1703 aa) |
| | Acsl | Acyl-CoA synthetase long-chain, isoform J; Long-chain fatty acid-CoA ligase activity; palmitoyl-CoA ligase activity. (728 aa) |
| | Sgp | Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. (523 aa) |
| | ATPsynbeta | ATP synthase subunit beta, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the c [...] (511 aa) |
| | CG4020 | Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. (494 aa) |
| | Pde1c | Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1; Cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Required for male fertility and male mating behavior. (1173 aa) |
| | Pgk | Phosphoglycerate kinase (Pgk) encodes an enzyme involved in myoblast fusion; Belongs to the phosphoglycerate kinase family. (415 aa) |
| | Ak3 | GTP:AMP phosphotransferase, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (216 aa) |
| | CG11883 | Uncharacterized protein, isoform C; Hydrolase activity. It is involved in the biological process described with: nucleotide catabolic process. (792 aa) |
| | Gart | Trifunctional purine biosynthetic protein adenosine-3; GART trifunctional enzyme (Gart) encodes a multifunctional enzyme that exhibits phosphoribosylamine-glycine ligase, phosphoribosylformylglycinamidine cyclo-ligase and phosphoribosylglycinamide formyltransferase activities; In the N-terminal section; belongs to the GARS family. In the C-terminal section; belongs to the GART family. (1353 aa) |
| | CG12866 | Uncharacterized protein, isoform D; Monocarboxylic acid transmembrane transporter activity. It is involved in the biological process described with: transmembrane transport. (859 aa) |
| | CG8303 | Putative fatty acyl-CoA reductase CG8303; Catalyzes the reduction of C16 or C18 fatty acyl-CoA to fatty alcohols. (543 aa) |
| | veil | Veil, isoform A; Veil (veil) encodes a GPI-linked protein that functions as a 5'-nucleotidase; Belongs to the 5'-nucleotidase family. (599 aa) |
| | CG11164 | Uncharacterized protein, isoform A; RNA-DNA hybrid ribonuclease activity. It is involved in the biological process described with: ribonucleotide metabolic process; RNA catabolic process. (340 aa) |
| | CG32549 | Uncharacterized protein, isoform G; 5'-nucleotidase activity. (709 aa) |
| | AMPdeam | AMP deaminase activity. It is involved in the biological process described with: IMP biosynthetic process; IMP salvage; AMP metabolic process; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (798 aa) |
| | Ppcdc | Phosphopantothenoylcysteine decarboxylase activity. It is involved in the biological process described with: coenzyme A biosynthetic process. (191 aa) |
| | CG6106 | Uncharacterized protein, isoform A; Allantoinase activity; cobalt ion binding; zinc ion binding. It is involved in the biological process described with: purine nucleobase catabolic process; allantoin catabolic process. (486 aa) |
| | Pde11 | Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11; Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively. (1451 aa) |
| | bur | Burgundy, isoform B; Burgundy (bur) encodes a GMP synthetase required for axon guidance. It regulates the activity of the ubiquitin protease encoded by Usp7. (683 aa) |
| | ATPsyndelta | ATP synthase, delta subunit, isoform A; Proton-transporting ATP synthase activity, rotational mechanism. It is involved in the biological process described with: ATP synthesis coupled proton transport; proton transmembrane transport. (157 aa) |
| | Pde8 | High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (By similarity). Involved in the positive regulation of MAP kinase signaling and in inhibiting oxidative stress-induced cell death. (1050 aa) |
| | CG34342 | Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. (572 aa) |
| | CG1129 | Mannose-1-phosphate guanyltransferase beta; Mannose-1-phosphate guanylyltransferase activity. It is involved in the biological process described with: larval lymph gland hemopoiesis; biosynthetic process. (369 aa) |
| | CTPsyn | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides (By similarity). Isoform 1 is required for cytoophidium assembly in female germline cells. (627 aa) |
| | CG10932 | LD24105p; acetyl-CoA C-acetyltransferase activity; acetyl-CoA C-acyltransferase activity. It is involved in the biological process described with: fatty acid beta-oxidation; fatty acid biosynthetic process; pyruvate metabolic process; Belongs to the thiolase-like superfamily. Thiolase family. (410 aa) |
| | CG15543 | Uncharacterized protein, isoform A; Cytidylate kinase activity; nucleoside diphosphate kinase activity; ATP binding; adenylate kinase activity. It is involved in the biological process described with: nucleoside diphosphate phosphorylation; purine nucleotide metabolic process; nucleoside triphosphate biosynthetic process. (290 aa) |
| | awd | Nucleoside diphosphate kinase; Abnormal wing discs (awd) encodes a nucleotide diphosphate kinase that regulates with the product of shi the endocytosis of different surface proteins (e.g. those encoded by N, btl, Pvr, and shg). During development, it regulates morphogenesis of trachea, follicular epithelium, and imaginal discs and contributes to neurotransmission and border cell migration; Belongs to the NDK family. (168 aa) |
| | CG31183 | ATP binding; guanylate cyclase activity; peptide receptor activity; signaling receptor activity. It is involved in the biological process described with: protein phosphorylation; receptor guanylyl cyclase signaling pathway; cGMP-mediated signaling; signal transduction; cGMP biosynthetic process. (1417 aa) |
| | ATPsynD | ATP synthase subunit d, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the cent [...] (178 aa) |
| | Ahcy | Adenosylhomocysteinase (Ahcy) encodes S-adenosyl-L-homocysteine hydrolase, the rate-limiting enzyme in methionine metabolism. This tetrameric enzyme catalyzes the reversible hydrolysis of S-Adenosylhomocysteine (SAH) to adenosine and L-homocysteine. The function of Ahcy product is required to maintain proper concentrations of SAH, which serves as an inhibitor of S-adenosylmethionine-dependent methylation reactions. (432 aa) |
| | Mvd | Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. (388 aa) |
| | Aprt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (182 aa) |
| | Adk2 | Adenosine kinase activity. It is involved in the biological process described with: purine ribonucleoside salvage; AMP biosynthetic process. (345 aa) |
| | CG10096 | Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. (502 aa) |
| | CG10097 | Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. (501 aa) |
| | CG42813 | Uncharacterized protein, isoform A; Metal ion binding; UDP-sugar diphosphatase activity. It is involved in the biological process described with: ribose phosphate metabolic process; nucleoside phosphate metabolic process. (212 aa) |
| | mt:ATPase6 | ATP synthase subunit a; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subuni [...] (224 aa) |
| | CG34357 | Guanylate cyclase; Signaling receptor activity; guanylate cyclase activity; peptide receptor activity; ATP binding. It is involved in the biological process described with: cGMP-mediated signaling; receptor guanylyl cyclase signaling pathway; protein phosphorylation; cGMP biosynthetic process; signal transduction. (1689 aa) |
| | ras | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (590 aa) |
| | Dpck | dephospho-CoA kinase activity; ATP binding. It is involved in the biological process described with: coenzyme A biosynthetic process. (236 aa) |
| | CG10268 | Phosphomevalonate kinase activity. It is involved in the biological process described with: isopentenyl diphosphate biosynthetic process, mevalonate pathway; cholesterol biosynthetic process; isoprenoid biosynthetic process. (189 aa) |
| | CG16848 | FI21750p1; FMN adenylyltransferase activity. It is involved in the biological process described with: FAD biosynthetic process. (254 aa) |
| | Vha68-1 | V-type proton ATPase catalytic subunit A isoform 1; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (614 aa) |
| | Vha68-3 | Vacuolar H[+] ATPase 68kD subunit 3; ATP binding; proton-transporting ATPase activity, rotational mechanism. It is involved in the biological process described with: proton transmembrane transport; ATP metabolic process. (743 aa) |
| | Vha68-2 | Vacuolar H[+] ATPase 68 kDa subunit 2 (Vha68-2) encodes a component of the V1 subunit of the vacuolar ATPase, which acidifies endosomal compartments including the lysosome and influences the activity of several signaling pathways. (614 aa) |
| | ACXA | Adenylyl cyclase X A, isoform A; Adenylate cyclase activity. It is involved in the biological process described with: adenylate cyclase-activating G protein-coupled receptor signaling pathway; cyclic nucleotide biosynthetic process; spermatogenesis. (1112 aa) |
| | ACXB | Adenylyl cyclase X B; Adenylate cyclase activity. It is involved in the biological process described with: spermatogenesis; cyclic nucleotide biosynthetic process; adenylate cyclase-activating G protein-coupled receptor signaling pathway. (1114 aa) |
| | ACXC | Adenylyl cyclase X C, isoform A; Adenylate cyclase activity. It is involved in the biological process described with: cyclic nucleotide biosynthetic process; spermatogenesis; adenylate cyclase-activating G protein-coupled receptor signaling pathway. (1130 aa) |
| | CG5418 | IU_nuc_hydro domain-containing protein. (355 aa) |
| | dUTPase | Deoxyuridine triphosphatase, isoform A; dUTP diphosphatase activity; magnesium ion binding. It is involved in the biological process described with: dUMP biosynthetic process; dUTP metabolic process; dUTP catabolic process. (188 aa) |
| | RnrL | Ribonucleoside-diphosphate reductase large subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (812 aa) |
| | CG8349 | CMP/dCMP-type deaminase domain-containing protein; Cytidine deaminase activity; zinc ion binding. It is involved in the biological process described with: cytidine deamination. (264 aa) |
| | Uro | Uricase; Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin. (352 aa) |
| | CG17896 | Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial; Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA (By similarity). (520 aa) |
| | FarO | Fatty acyl-CoA reductase in oenocytes (FarO) encodes a long-chain-fatty-acyl-CoA reductase involved in the regulation of cell growth and lipid storage. (504 aa) |
| | Pdha | Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (443 aa) |
| | CG7024 | Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (479 aa) |
| | Shmt | Serine hydroxymethyl transferase (Shmt) encodes a conserved pyridoxal phosphate-containing enzyme that converts serine into glycine and N5,N10-methylentetrahydrofolate. This reaction represents a major source for activated C1 units and tetrahydrofolate-mediated C1 metabolism; Belongs to the SHMT family. (537 aa) |
| | CG12065 | Uncharacterized protein, isoform A; Catalytic activity. It is involved in the biological process described with: nucleoside metabolic process. (687 aa) |
| | su(r) | Suppressor of rudimentary (su(r)) encodes a dihydropyrimidine dehydrogenase, the first step of pyrimidine catabolism. su(r) depletion does not produce visible phenotypes, but synergistic effects are exhibited by combining mutants with genes affecting pyrimidine biosynthesis and beta-alanine metabolism. (1031 aa) |
| | Hex-A | Phosphotransferase; Hexokinase A (Hex-A) encodes a hexokinase involved in glucose homeostasis. (541 aa) |
| | CG9993 | Uncharacterized protein; CoA-ligase activity; fatty acid ligase activity. It is involved in the biological process described with: fatty acid biosynthetic process. (543 aa) |
| | CG17999 | GH16244p; Fatty acid ligase activity; CoA-ligase activity. It is involved in the biological process described with: fatty acid biosynthetic process. (545 aa) |
| | blw | ATP synthase subunit alpha, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the [...] (552 aa) |
| | Gmer | Probable GDP-L-fucose synthase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction; Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily. (321 aa) |
| | CG18128 | FI08065p; Purine-nucleoside phosphorylase activity. It is involved in the biological process described with: nucleoside metabolic process. (339 aa) |
| | Ak2 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways; Belongs to the adenylate kinase family. AK2 subfamily. (240 aa) |
| | cN-IIIB | 7-methylguanosine phosphate-specific 5'-nucleotidase; Specifically hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7-methylguanosine and inorganic phosphate. Also able to mediate hydrolysis of diphosphate (m(7)GDP) to 7-methylguanosine and 2 inorganic phosphate with lower activity. The specific activity for m(7)GMP may protect cells against undesired salvage of m(7)GMP and its incorporation into nucleic acids. Also has weak activity for CMP. UMP and purine nucleotides are poor substrates. Belongs to the pyrimidine 5'-nucleotidase family. (319 aa) |
| | ATPsynF | Putative ATP synthase subunit f, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of [...] (107 aa) |
| | CG4563 | RE01528p; Fatty acid ligase activity; CoA-ligase activity. It is involved in the biological process described with: fatty acid biosynthetic process. (537 aa) |
| | CG30427 | CG30427 encodes a fatty-acyl-CoA reductase involved in production of NADPH, sensory perception of pain, phagocytosis and determination of lifespan. (506 aa) |
| | DIP2 | DISCO Interacting Protein 2 (DIP2) encodes a member of DIP2 family. It interacts physically with the product of disco in vitro and participates in axonal bifurcation and guidance downstream of the JNK pathway. (1773 aa) |
| | ACXD | Adenylyl cyclase X D, isoform A; Adenylate cyclase activity. It is involved in the biological process described with: cyclic nucleotide biosynthetic process; adenylate cyclase-activating G protein-coupled receptor signaling pathway. (1162 aa) |
| | AhcyL1 | Adenosylhomocysteinase like 1 (AhcyL1) encodes a protein that, together with the product of AhcyL2, belongs to AHCY-like proteins. AhcyL1 and AhcyL2 products have lost their canonical enzymatic functions due to critical mutations in their AHCY-domains. However, via hetero-multimerization, the products of AhcyL1 and AhcyL2 can suppress the activity of the enzyme encoded by Ahcy, which catalyzes the hydrolysis of S-Adenosylhomocysteine. The presence of a N-terminal IRBIT domain confers AhcyL1 and AhcyL2 proteins new functions in Ca[2+] signaling, intracellular pH regulation and productio [...] (521 aa) |
| | CG12016 | SD05789p2; Kinase activity; ribosylnicotinamide kinase activity. It is involved in the biological process described with: nicotinamide riboside metabolic process; nicotinamide nucleotide biosynthetic process. (323 aa) |
| | Ack | Activated Cdc42 kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1073 aa) |
| | ATPsynCF6L | ATP synthase, coupling factor 6-like; ATPase activity; proton transmembrane transporter activity. It is involved in the biological process described with: ATP metabolic process; ATP synthesis coupled proton transport. (147 aa) |
| | v | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. Required during larval growth to control the level of potentially harmful free tryptophan in the hemolymph. In the adult the same reaction is the first step in the ommochrome biosynthetic pathway. (379 aa) |
| | FucT6 | Alpha-(1,6)-fucosyltransferase; Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. The addition is prevented if the GlcNAc residue is already fucosylated. (619 aa) |
| | CG4407 | LD26737p; FMN adenylyltransferase activity. It is involved in the biological process described with: FAD biosynthetic process. (322 aa) |
| | Paics | Phosphoribosylaminoimidazole-succinocarboxamide synthase; PAICS bifunctional enzyme (Paics) encodes an essential enzyme in the pathway for de novo synthesis of the purine nucleotide inosine monophosphate (IMP). IMP is the precursor for purine nucleotides required for nucleic acids, energy transfer, cell signaling, and coenzymes; In the N-terminal section; belongs to the SAICAR synthetase family. (429 aa) |
| | CG11158 | RH22417p. (344 aa) |
| | Nadsyn | Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source (By similarity). Because of its role in energy metabolism, involved in the modulation of aged- related cardiac function, mobility, and lifespan. (787 aa) |
| | CG12177 | RE18811p. (362 aa) |
| | nmdyn-D6 | Nucleoside diphosphate kinase activity. It is involved in the biological process described with: GTP biosynthetic process; nucleoside triphosphate biosynthetic process; CTP biosynthetic process; UTP biosynthetic process; nucleoside diphosphate phosphorylation. (151 aa) |
| | rut | Ca(2+)/calmodulin-responsive adenylate cyclase; Rutabaga (rut) encodes a membrane-bound Ca[2+]/calmodulin-activated adenylyl cyclase that is responsible for synthesis of cAMP. It plays a key role in regulating behavioral, neuroanatomical, and electrophysiological plasticity. (2248 aa) |
| | Gapdh2 | Glyceraldehyde 3 phosphate dehydrogenase 2 (Gapdh2) encodes a glyceraldehyde-3-phosphate dehydrogenase involved in glucose homeostasis; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (332 aa) |
| | sun | Protein stunted; Activates the G-protein coupled receptor mth in vitro, leading to increased intracellular calcium ion levels. (61 aa) |
| | scu | 3-hydroxyacyl-CoA dehydrogenase type-2; May function in mitochondrial tRNA maturation. Catalyzes the beta-oxidation at position 17 of androgens and estrogens, and has 3- alpha-hydroxysteroid dehydrogenase activity with androsterone. Catalyzes the third step in the beta-oxidation of fatty acids. Carries out oxidative conversions of 7-beta-hydroxylated bile acids. Also exhibits 20-beta-OH and 21-OH dehydrogenase activities with C21 steroids. Required for cell survival during embryonic development. May play a role in germline formation; Belongs to the short-chain dehydrogenases/reductases [...] (255 aa) |
| | Pfrx | 6-phosphofructo 2-kinase/fructose 2,6-bisphosphatase long form; ATP binding; 6-phosphofructo-2-kinase activity; fructose-2,6-bisphosphate 2-phosphatase activity. It is involved in the biological process described with: glycolytic process; fructose metabolic process; fructose 2,6-bisphosphate metabolic process; carbohydrate phosphorylation. (716 aa) |
| | CG6951 | Probable deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase. (203 aa) |
| | Papss | PAPS synthetase (Papss) encodes an enzyme that catalyzes the synthesis of 3'-phosphoadenosine 5'-phosphosulfate (PAPS), the sulfate donor compound in all sulfotransferase reactions. Maternally provided Papss product is required for the formation of the embryonic dorsal-ventral axis mediated by the sulfotransferase encoded by pip. (657 aa) |
| | Uggt | UDP-glucose-glycoprotein glucosyltransferase (Uggt) encodes an enzyme that recognizes glycoproteins with folding defects and adds glucose to N-glycans near the misfolded part of the protein. Uggt product is a component of the calnexin cycle and promotes protein folding in the endoplasmic reticulum along with the protein encoded by Cnx99A and Calr; Belongs to the glycosyltransferase 8 family. (1548 aa) |
| | Adgf-A | Adenosine deaminase-related growth factor A (Adgf-A) encodes an extracellular deaminase that regulates the level of extracellular adenosine by converting adenosine to inosine. This activity is important for regulation of systemic metabolism, especially during stress and infection. (553 aa) |
| | Adgf-A2 | Adenosine deaminase-related growth factor A2 (Adgf-A2) encodes a growth factor involved in spermatid development. (561 aa) |
| | Adgf-B | Adenosine deaminase-related growth factor B; Adenosine deaminase activity. It is involved in the biological process described with: inosine biosynthetic process; adenosine catabolic process. (520 aa) |
| | CG12229 | AT14039p; Pyruvate kinase activity; magnesium ion binding; potassium ion binding. It is involved in the biological process described with: glycolytic process; pyruvate biosynthetic process. (571 aa) |
| | ATPsynbetaL | ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (622 aa) |
| | CG13474 | GEO02333p1. (148 aa) |
| | CG17300 | GEO09554p1; Proton transmembrane transporter activity. It is involved in the biological process described with: ATP synthesis coupled proton transport. (152 aa) |
| | Pmm2 | Probable phosphomannomutase; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions. (254 aa) |
| | nst | Nesthocker (nst) encodes a phospho-acetylglucosamine mutase, an essential enzyme in the biosynthetic pathway of N-Acetylglucosamine (GlcNAc). In the embryo, it is required for normal GlcNAc levels and affects Fibroblast-Growth-Factor signaling. (549 aa) |
| | Ak1 | ATP binding; adenylate kinase activity; uridylate kinase activity; Belongs to the adenylate kinase family. (229 aa) |
| | Aps | Aps, isoform A; Aps (Aps) encodes a diphosphoinositol-polyphosphate diphosphatase that hydrolyses a range of (di)nucleoside polyphosphates. It is involved in glucose and lipid homeostasis. (177 aa) |
| | CG11811 | GH06691p; Guanylate kinase activity. It is involved in the biological process described with: purine nucleotide metabolic process. (233 aa) |
| | ATPsynB | ATP synthase subunit b, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the cent [...] (243 aa) |
| | Prps | Uncharacterized protein, isoform B; Magnesium ion binding; ATP binding; ribose phosphate diphosphokinase activity. It is involved in the biological process described with: ribonucleoside monophosphate biosynthetic process; purine nucleotide biosynthetic process; nucleoside metabolic process; nucleotide biosynthetic process; 5-phosphoribose 1-diphosphate biosynthetic process. (388 aa) |
| | Prat2 | Amidophosphoribosyltransferase; Phosphoribosylamidotransferase 2 (Prat2) encodes a type-2 glutamine amidotransferase that is essential in the pathway for de novo synthesis of inosine monophosphate (IMP). IMP is the precursor for purine nucleotides that are required for nucleic acids, energy transfer, cell signaling, and coenzymes; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (547 aa) |
| | CG5568 | LD47944p; CoA-ligase activity; fatty acid ligase activity. It is involved in the biological process described with: fatty acid biosynthetic process. (545 aa) |
| | Ppat-Dpck | Bifunctional Phosphopantetheine adenylyltransferase - Dephospho-CoA kinase (Ppat-Dpck) encodes a bifunctional enzyme that carries out the last two steps of the canonical Coenzyme A (CoA) biosynthesis pathway. The Ppat part converts 4'-phosphopantetheine into dephospho-CoA and subsequently the Dpck part phosphorylates dephospho-CoA to form CoA. (518 aa) |
| | ScsbetaG | Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (416 aa) |
| | Fitm | Fat storage-inducing transmembrane protein; Plays an important role in lipid droplet accumulation. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for correct morphology of nociceptive multi-dendritic sensory neurons. Required for normal mechanical amplification in hearing. (480 aa) |
| | Naprt | Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis; Belongs to the NAPRTase family. (667 aa) |
| | CG17224 | FI09636p; Uridine phosphorylase activity. It is involved in the biological process described with: nucleotide catabolic process; nucleoside metabolic process. (300 aa) |
| | ATPsynGL | ATP synthase subunit; Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proto [...] (107 aa) |
| | muc | Midline uncoordinated, isoform B; Pyruvate dehydrogenase (NAD+) activity; dihydrolipoyllysine-residue acetyltransferase activity. It is involved in the biological process described with: grooming behavior; acetyl-CoA biosynthetic process from pyruvate. (512 aa) |
| | CG13771 | Uncharacterized protein, isoform A; acyl-CoA hydrolase activity. It is involved in the biological process described with: acyl-CoA metabolic process. (451 aa) |
| | mmy | Mummy, isoform A; Mummy (mmy) encodes an UDP-N-acetylglucosamine diphosphorylase. It functions in apical extracellular matrix formation by producing GlcNAc residues needed for chitin synthesis and protein glycosylation. It regulates cuticle production, tracheal morphogenesis, and axon guidance. (520 aa) |
| | CG9547 | GH06693p; glutaryl-CoA dehydrogenase activity; flavin adenine dinucleotide binding; fatty-acyl-CoA binding. It is involved in the biological process described with: fatty acid beta-oxidation using acyl-CoA dehydrogenase; lysine catabolic process; hydroxylysine catabolic process; fatty-acyl-CoA biosynthetic process; tryptophan metabolic process. (419 aa) |
| | Pfas | Phosphoribosylformylglycinamidine synthase (Pfas) encodes a phosphoribosylformylglycinamidine synthase, which is an essential enzyme in the pathway for de novo synthesis of the purine nucleotide inosine monophosphate (IMP). IMP is the precursor for purine nucleotides required for nucleic acids, energy transfer, cell signaling, and coenzymes; In the N-terminal section; belongs to the FGAMS family. (1354 aa) |
| | Gmd | GDP-mannose 4,6 dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. (395 aa) |
| | CG8891 | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (191 aa) |
| | DhpD | Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia. Also has 7,8-dihydropterin deaminase activity, which plays a role in synthesis of the red eye pigment aurodrosopterin. (448 aa) |
| | CG11249 | Uncharacterized protein; Potassium ion binding; magnesium ion binding; pyruvate kinase activity. It is involved in the biological process described with: glycolytic process. (642 aa) |
| | AcCoAS | Acetyl-coenzyme A synthetase; Activates acetate so that it can be used for lipid synthesis or for energy generation; Belongs to the ATP-dependent AMP-binding enzyme family. (670 aa) |
| | CG33054 | GEO13066p1; Purine nucleoside binding; ADP-ribosylglutamate hydrolase activity. It is involved in the biological process described with: peptidyl-glutamate ADP-deribosylation; purine nucleoside metabolic process. (161 aa) |
| | CG33056 | GH17661p; ADP-ribosylglutamate hydrolase activity; purine nucleoside binding. It is involved in the biological process described with: peptidyl-glutamate ADP-deribosylation; purine nucleoside metabolic process. (343 aa) |
| | fbl | Fumble, isoform E; Fumble (fbl) encodes an enzyme that phosphorylates pantothenate (vitamin B5), which is one of the early steps of the Coenzyme A de novo biosynthesis pathway. (512 aa) |
| | Eno | Enolase (Eno) encodes a phosphopyruvate hydratase involved in glucose homeostasis; Belongs to the enolase family. (500 aa) |
| | CG9961 | Phosphoglycerate kinase activity; ADP binding; ATP binding. It is involved in the biological process described with: positive regulation of oxidative phosphorylation; gluconeogenesis; glycolytic process. (448 aa) |
| | CG2964 | Pyruvate kinase activity; magnesium ion binding; potassium ion binding. It is involved in the biological process described with: pyruvate metabolic process; glycolytic process. (554 aa) |
| | HINT1 | RH02823p; Hydrolase activity. It is involved in the biological process described with: purine ribonucleotide catabolic process. (150 aa) |
| | Ts | Thymidylate synthase activity. It is involved in the biological process described with: dTMP biosynthetic process. (321 aa) |
| | Pglym87 | Phosphoglycerate mutase activity. It is involved in the biological process described with: glycolytic process; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (292 aa) |
| | Adk1 | AT16233p; Adenosine kinase activity. It is involved in the biological process described with: purine ribonucleoside salvage; AMP biosynthetic process. (396 aa) |
| | Mpi | Zinc ion binding; mannose-6-phosphate isomerase activity. It is involved in the biological process described with: GDP-mannose biosynthetic process; carbohydrate metabolic process. (396 aa) |
| | nmdyn-D7 | FI21821p1; ATP binding; nucleoside diphosphate kinase activity. It is involved in the biological process described with: nucleoside diphosphate phosphorylation; UTP biosynthetic process; CTP biosynthetic process; GTP biosynthetic process; nucleoside triphosphate biosynthetic process; Belongs to the NDK family. (387 aa) |
| | Ada | Adenosine deaminase-like protein; Catalyzes the hydrolysis of the free cytosolic methylated adenosine nucleotide N(6)-methyl-AMP (N6-mAMP) to produce inositol monophosphate (IMP) and methylamine. Is required for the catabolism of cytosolic N6-mAMP, which is derived from the degradation of mRNA containing N6-methylated adenine (m6A); Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (337 aa) |
| | pyd3 | Pyd3 (pyd3) encodes a beta-alanine synthase involved in pyrimidine catabolism, beta-alanine biosynthesis and cuticle pigmentation. (386 aa) |
| | CG2846 | Putative riboflavin kinase; Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN). (153 aa) |
