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| | CG32819 | LD08455p; Structural constituent of cytoskeleton. It is involved in the biological process described with: flagellated sperm motility; microtubule nucleation. (601 aa) |
| | CG32820 | Structural constituent of cytoskeleton. It is involved in the biological process described with: flagellated sperm motility; microtubule nucleation. (601 aa) |
| | CG17450 | Uncharacterized protein, isoform B; It is involved in the biological process described with: sperm competition. (601 aa) |
| | CG1571 | FI19907p1; Dynein heavy chain binding; dynein light chain binding. It is involved in the biological process described with: microtubule-based movement; outer dynein arm assembly; cilium movement. (651 aa) |
| | CG10958 | Dynein regulatory complex protein 1 homolog; It is involved in the biological process described with: regulation of cilium movement; axonemal dynein complex assembly; cilium-dependent cell motility; Belongs to the DRC1 family. (743 aa) |
| | CG13502 | Uncharacterized protein, isoform A. (410 aa) |
| | CG30259 | NYD-SP28 domain-containing protein; It is involved in the biological process described with: axonemal dynein complex assembly; cilium-dependent cell motility; regulation of cilium movement. (540 aa) |
| | Klp59D | Kinesin-like protein at 59D (Klp59D) encodes a kinesin involved in the regulation spindle microtubule dynamics and sperm ciliogenesis; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (729 aa) |
| | Rsph4a | GH13165p; It is involved in the biological process described with: cilium movement; axoneme assembly. (708 aa) |
| | Oseg4 | Outer segment 4, isoform A; It is involved in the biological process described with: intraciliary retrograde transport; cilium assembly; positive regulation of canonical Wnt signaling pathway; non-motile cilium assembly. (1205 aa) |
| | Klp10A | Kinesin-like protein Klp10A; Required during anaphase to drive sister chromatid separation to promote flux by actively depolymerizing kinetochore microtubules at their pole-associated minus ends, thereby moving chromatids through a 'poleward flux'. Involved in asymmetric cell division of sensory organ precursor (SOP) cells by playing a role in the asymmetric localization of Sara- expressing endosomes to the pIIa daughter cell but not to the pIIb cell. Klp98A targets Sara-expressing endosomes to the central spindle which is symmetrically arranged in early cell division. During late cyto [...] (805 aa) |
| | CG11356 | Uncharacterized protein; GTP binding. It is involved in the biological process described with: cilium assembly. (248 aa) |
| | Mks1 | Meckel syndrome type 1 protein homolog; Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia. Required for ciliary structure and function. (699 aa) |
| | CG14186 | GH12423p; It is involved in the biological process described with: cilium assembly. (704 aa) |
| | Gorab | RAB6-interacting golgin; Required for centriole duplication probably through the interaction with Sas-6. During embryogenesis, maternally provided Gorab is required for centrosome duplication and nuclear division cycles of the syncytial embryos. In femoral chordotonal organs, required for sensory cilia structural integrity and functionality necessary for motor coordination. In male germline, has a role in cytokinesis which seems dependent on its localization to the Golgi. (338 aa) |
| | CG13032 | FI23334p1; It is involved in the biological process described with: non-motile cilium assembly; cytoplasmic microtubule organization. (660 aa) |
| | CG5048 | AT12351p; Chaperone binding. It is involved in the biological process described with: flagellated sperm motility. (210 aa) |
| | CG17687 | Uncharacterized protein. (1544 aa) |
| | CG14105 | Tetratricopeptide repeat protein 36 homolog; It is involved in the biological process described with: cilium assembly; Belongs to the TTC36 family. (185 aa) |
| | Zmynd10 | Zinc finger MYND domain-containing protein 10 homolog; Plays a role in axonemal structure organization and motility. May be involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility; Belongs to the ZMYND10 family. (451 aa) |
| | CCDC151 | Coiled-coil domain containing protein 151; It is involved in the biological process described with: axonemal dynein complex assembly; cilium movement; negative gravitaxis. (614 aa) |
| | CG5964 | Uncharacterized protein; It is involved in the biological process described with: cilium assembly; establishment of epithelial cell polarity. (928 aa) |
| | CG14838 | Uncharacterized protein; Dynein heavy chain binding; dynein light chain binding. It is involved in the biological process described with: microtubule-based movement; outer dynein arm assembly; cilium movement. (1132 aa) |
| | BBS1 | Bardet-Biedl syndrome 1; Patched binding; smoothened binding. It is involved in the biological process described with: protein localization to cilium; non-motile cilium assembly; cilium assembly. (605 aa) |
| | CG10064 | WD_REPEATS_REGION domain-containing protein. (742 aa) |
| | Rsph3 | GH13213p. (659 aa) |
| | Klp64D | Kinesin-like protein at 64D (Klp64D) encodes the kinesin-2alpha motor subunit of the heterotrimeric kinesin-2. It associates with the products of Klp68D and Kap3. It plays an essential role in sensory cilia assembly and axonal transport; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (677 aa) |
| | tilB | Protein tilB; Touch insensitive larva B (tilB) encodes a protein required for the assembly and/or transport to the cilium of axonemal dynein arms. tilB depletion results in deafness and male sterility because it specifically affects chordotonal neurons and spermatids, the only fly motile cilia cells. It interacts with the product of Zmynd10, which has a similar distribution and mutant phenotype. (395 aa) |
| | Cluap1 | Clusterin associated protein 1; It is involved in the biological process described with: cilium assembly. (530 aa) |
| | IFT57 | Intraflagellar transport protein 57 homolog; Required for the formation of cilia; Belongs to the IFT57 family. (405 aa) |
| | BBS8 | Bardet-Biedl syndrome 8; It is involved in the biological process described with: cilium assembly; non-motile cilium assembly. (549 aa) |
| | rempA | Reduced mechanoreceptor potential A (rempA) encodes the IFT140 subunit of the IFT-A subcomplex. As such, it is a component of the conserved intraflagellar transport (IFT) mechanism and is needed to extend cilia above the cell surface. (1503 aa) |
| | CG13693 | DUF4201 domain-containing protein. (443 aa) |
| | in | Inturned (in) encodes a cytoplasmic protein that functions as a downstream member of the fz-stan planar cell polarity pathway, which controls hair and bristle polarity in the adult. In directly binds with the products of fy, frtz and mwh and accumulates on the proximal side of wing cells. (869 aa) |
| | atk | Artichoke (atk) encodes a leucine-rich-repeat extracellular matrix protein secreted by accessory cells in ciliated sensory organs. It surrounds the tip of the cilium, and contributes to its assembly. Its roles include cilium integrity, chemosensation and proprioception. (1535 aa) |
| | CG13251 | CCDC66 domain-containing protein; Microtubule binding. It is involved in the biological process described with: retinal rod cell development. (1088 aa) |
| | CG10510 | FI07739p; It is involved in the biological process described with: cilium-dependent cell motility; axonemal dynein complex assembly; regulation of cilium movement. (523 aa) |
| | SAK | Serine/threonine-protein kinase PLK4; Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the mother centriole cylinder, using mother centriole as a platform, leading to the recruitment of centriole biogenesis proteins such as Sas-6. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Centrosome amplification following overexpression can initiate tumorigenesis, highlighting [...] (769 aa) |
| | asl | Asterless (asl) encodes a component of the centriole that is required for centrosome function. It contributes to asymmetric cell division, sperm development and centriole replication and elongation. (994 aa) |
| | BBS5 | Bardet-Biedl syndrome 5; Phosphatidylinositol-3-phosphate binding. It is involved in the biological process described with: cilium assembly; intracellular transport. (381 aa) |
| | CG17387 | FI16519p1; It is involved in the biological process described with: cilium-dependent cell motility; cilium movement; inner dynein arm assembly; epithelial cilium movement involved in determination of left/right asymmetry. (967 aa) |
| | CG13999 | GEO13394p1; It is involved in the biological process described with: cilium assembly. (165 aa) |
| | TTLL3A | Tubulin glycylase 3A; Polylycylase which modifies alpha- and beta-tubulin, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Involved both in the side-chain initiation and elongation steps of the polyglycylation reaction by adding a single glycine chain to generate monoglycine side chains and by elongating monoglycine side chains to polyglycine side chains. (992 aa) |
| | IFT52 | Intraflagellar transport 52. (410 aa) |
| | fy | Protein fuzzy; Plays a role in the organization of cell polarity via a planar cell polarity (PCP) cascade. Involved in the development of the hairs on the wings. Specify the correct orientation of the hair by limiting the site of prehair initiation to the distal vertex of the wing cells. Controls wing cell hair number by maintaining the integrity of the cytoskeletal components that direct hair development. Belongs to the fuzzy family. (416 aa) |
| | CG3769 | IP11319p; Dynein heavy chain binding; ATP-dependent microtubule motor activity, minus-end-directed. It is involved in the biological process described with: intraciliary retrograde transport; intraciliary transport involved in cilium assembly. (368 aa) |
| | Bug22 | Cilia- and flagella-associated protein 20; Basal body up regulated gene 22 (Bug22) encodes a ciliary protein involved in cilium organization and assembly. It contributes to multiple processes during spermatogenesis including tubulin polyglycylation, axoneme assembly, sperm individualization and motility. It also contributes to locomotion, dendrite morphogenesis and neuron and muscle development; Belongs to the CFAP20 family. (199 aa) |
| | CG17118 | DUF667 domain-containing protein; It is involved in the biological process described with: positive regulation of cell motility; cilium assembly; regulation of cilium beat frequency involved in ciliary motility. (281 aa) |
| | Fam92 | GH04442p; It is involved in the biological process described with: negative regulation of protein secretion. (395 aa) |
| | Rsph1 | AT19426p; It is involved in the biological process described with: axoneme assembly. (344 aa) |
| | CG10859 | GH14707p; Dynein light chain binding; dynein heavy chain binding. It is involved in the biological process described with: microtubule-based movement; cilium movement; outer dynein arm assembly. (627 aa) |
| | Rsph9 | AT29119p; It is involved in the biological process described with: axoneme assembly; cilium movement involved in cell motility; motile cilium assembly. (281 aa) |
| | IFT46 | Intraflagellar transport 46; It is involved in the biological process described with: intraciliary transport; cilium assembly. (416 aa) |
| | CG10137 | GH24474p. (941 aa) |
| | dtr | Dynein assembly factor 1, axonemal homolog; Cilium-specific protein required for cilia structures. Belongs to the DNAAF1 family. (1483 aa) |
| | alphaTub84D | Tubulin alpha-3 chain; alpha-Tubulin at 84D (alphaTub84D) encodes a protein involved in major cellular mechanisms such as formation of spindle apparatus or microtubular threads for transport of proteins or organelles. (450 aa) |
| | Sas-4 | Spindle assembly abnormal 4 (Sas-4) encodes a centriole protein that is essential for centriole assembly. It is recruited to centrioles through an interaction with the centriole protein encoded by ana2, and it helps recruit microtubules to the centriole. (901 aa) |
| | Mst84Da | Male-specific sperm protein Mst84Da; It is involved in the biological process described with: sperm axoneme assembly; spermatogenesis. (63 aa) |
| | Mst84Db | It is involved in the biological process described with: spermatogenesis; sperm axoneme assembly. (74 aa) |
| | Mst84Dc | Male-specific sperm protein Mst84Dc; It is involved in the biological process described with: sperm axoneme assembly; spermatogenesis. (55 aa) |
| | Mst84Dd | Male-specific sperm protein Mst84Dd; It is involved in the biological process described with: sperm axoneme assembly; spermatogenesis; Belongs to the MST(3)CGP family. (72 aa) |
| | CG11760 | GEO13292p1; It is involved in the biological process described with: non-motile cilium assembly; cilium assembly. (149 aa) |
| | Dnali1 | Putative inner dynein arm light chain, axonemal; May play a dynamic role in flagellar motility. (250 aa) |
| | Rsbp15 | AT09290p. (421 aa) |
| | Past1 | Putative Achaete Scute Target 1 (Past1) encodes a protein that associates predominantly with the plasma membrane and genetically interacts with N. It contributes to endocytosis, male sterility, temperature sensitivity, life span and differentiation of photoreceptors R1/R6/R7 and cone cells; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (540 aa) |
| | CG14367 | ARL2_Bind_BART domain-containing protein; It is involved in the biological process described with: cilium assembly. (310 aa) |
| | IFT54 | Intraflagellar transport 54; Microtubule binding. It is involved in the biological process described with: regulation of microtubule cytoskeleton organization; intraciliary transport; cilium assembly. (588 aa) |
| | HEATR2 | Dynein assembly factor 5, axonemal; Cytoplasmic protein involved in the delivery of the dynein machinery to the motile cilium. It is required for the assembly of the axonemal dynein inner and outer arms, two structures attached to the peripheral outer doublet A microtubule of the axoneme, that play a crucial role in cilium motility. (845 aa) |
| | B9d1 | B9 domain-containing protein 1; Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia. Required for ciliary structure and function. (241 aa) |
| | Ttc26 | Tetratricopeptide repeat domain 26; Intraciliary transport particle B binding. It is involved in the biological process described with: cilium assembly; intraciliary anterograde transport; intraciliary transport involved in cilium assembly. (570 aa) |
| | CG5614 | FI08029p; It is involved in the biological process described with: cilium assembly. (358 aa) |
| | CG31294 | TPR_REGION domain-containing protein. (225 aa) |
| | CG14905 | Uncharacterized protein. (473 aa) |
| | hmw | Protein hemingway; Involved in assembly and/or maintenance of motile cilia. Required during spermatogenesis for axoneme elongation. Necessary for optimal function of the chordotonal (hearing) organs. (604 aa) |
| | CG15498 | AT03531p. (281 aa) |
| | dnd | Dead end (dnd) encodes an Arf-like3 GTPase that controls the targeting of exocytosis machinery to specific apical domains in fusion cells during the tracheal branch fusion process. (179 aa) |
| | CG13855 | Uncharacterized protein. (706 aa) |
| | CG17083 | AT03545p. (550 aa) |
| | DZIP1 | Uncharacterized protein, isoform A; Nucleic acid binding. It is involved in the biological process described with: cilium assembly. (737 aa) |
| | CG6980 | GH10293p. (250 aa) |
| | Efhc1.2 | EF-hand domain containing 1.2; It is involved in the biological process described with: regulation of neuron projection development; cilium assembly. (765 aa) |
| | Oseg6 | Outer segment 6; It is involved in the biological process described with: intraciliary retrograde transport; cilium assembly; non-motile cilium assembly. (1366 aa) |
| | Arl6 | ADP ribosylation factor-like 6, isoform A; GTP binding; GTPase activity. It is involved in the biological process described with: vesicle-mediated transport; intracellular protein transport; intracellular transport; cilium assembly; protein localization to cilium; Belongs to the small GTPase superfamily. Arf family. (202 aa) |
| | CG17669 | Dynein assembly factor 3, axonemal homolog; Required for the assembly of axonemal inner and outer dynein arms; Belongs to the DNAAF3 family. (540 aa) |
| | CG15701 | RE36115p; Dynein heavy chain binding; dynein light chain binding. It is involved in the biological process described with: microtubule-based movement; positive regulation of ATP-dependent microtubule motor activity, plus-end-directed; transport along microtubule. (1051 aa) |
| | bug | Bunker gear; It is involved in the biological process described with: cilium assembly. (295 aa) |
| | Cep89 | Protein Cep89 homolog; Required for mitochondrial complex IV activity. May be involved in non-associative learning. (476 aa) |
| | shot | Short stop (shot) encodes a member of the spectraplakin family of large cytoskeletal linker molecules. It binds both actin and microtubules, as well as scaffold proteins, certain signalling factors and calcium. It plays developmental and maintenance roles in the nervous system, the epidermis, at muscle attachments, the foregut, the wing, tracheae and oocytes. (8805 aa) |
| | CG4714 | DUF4201 domain-containing protein. (732 aa) |
| | CG4712 | FI19336p1. (674 aa) |
| | CG13202 | Dynein_attach_N domain-containing protein; Protein homodimerization activity. It is involved in the biological process described with: cilium movement; inner dynein arm assembly; epithelial cilium movement involved in extracellular fluid movement; determination of left/right symmetry. (81 aa) |
| | BBS4 | Bardet-Biedl syndrome 4 protein homolog; May be required for microtubule anchoring at the centrosome. Required for ciliogenesis (By similarity); Belongs to the BBS4 family. (486 aa) |
| | CG8800 | Uncharacterized protein; Motor activity; alpha-tubulin binding; dynein heavy chain binding. It is involved in the biological process described with: outer dynein arm assembly. (188 aa) |
| | pnut | Peanut (pnut) encodes a protein that belongs to the septin family of polymerizing GTPases. Together with the products of Sep1 and Sep2, it forms the septin complex. It participates in cytokinesis and other processes that involve organization of the cell cortex. (539 aa) |
| | Nop17l | Protein kintoun; Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment. Belongs to the PIH1 family. Kintoun subfamily. (834 aa) |
| | CG34107 | GEO10781p1. (114 aa) |
| | CG34124 | FI23230p1; It is involved in the biological process described with: cilium assembly; cilium-dependent cell motility; sperm axoneme assembly. (2003 aa) |
| | CG34274 | IP18157p. (250 aa) |
| | CG34297 | RT07743p; Molecular adaptor activity. It is involved in the biological process described with: response to heat. (233 aa) |
| | CG34425 | Uncharacterized protein; It is involved in the biological process described with: cilium movement; cilium assembly. (532 aa) |
| | CG34457 | IP12443p. (308 aa) |
| | l(2)41Ab | Lethal (2) 41Ab, isoform A; It is involved in the biological process described with: cilium movement; axonemal dynein complex assembly. (890 aa) |
| | CG42231 | Uncharacterized protein; It is involved in the biological process described with: cilium assembly. (242 aa) |
| | btv | Beethoven (btv) encodes the minor cytoplasmic dynein heavy chain, which is the retrograde motor for intraflagellar transport. It is required for the proper assembly of the sensory cilia in chordotonal organs. It contributes to hearing and other chordotonal-dependent functions such as larval locomotion. (4236 aa) |
| | Kap3 | Kinesin associated protein 3 (Kap3) encodes the non-motor accessory subunit of the heterotrimeric kinesin-2. It associates to the coiled-coil stalk domain of the products of Klp68D andKlp64D. It plays an essential role in sensory cilia assembly and axonal transport. (1038 aa) |
| | Oseg5 | Outer segment 5; It is involved in the biological process described with: non-motile cilium assembly; cilium assembly. (775 aa) |
| | IFT20 | Intraflagellar transport 20; It is involved in the biological process described with: centrosome localization; intraciliary transport; cilium assembly; protein localization to cilium. (131 aa) |
| | CG42366 | Uncharacterized protein, isoform A; Protein kinase activity; MAP kinase activity; ATP binding. It is involved in the biological process described with: cilium assembly; intraciliary transport; intracellular signal transduction; protein phosphorylation; regulation of gene expression. (706 aa) |
| | TTLL3B | Tubulin glycylase 3B; Essential glycylase which modifies both tubulin and non- tubulin proteins, generating side chains of glycine on the gamma- carboxyl groups of specific glutamate residues of target proteins. Monoglycylates alpha-tubulin by adding a single glycine chain to generate monoglycine side chains, but is not involved in elongation step to generate polyglycine side chains on alpha-tubulin. Has the ability to both mono- and polyglycylate non-tubulin proteins such as up (Troponin T). Required for early steps of spermatogenesis. (756 aa) |
| | IFT43 | Intraflagellar transport 43; It is involved in the biological process described with: cilium assembly; positive regulation of canonical Wnt signaling pathway; intraciliary retrograde transport. (229 aa) |
| | BBS9 | Bardet-Biedl syndrome 9; It is involved in the biological process described with: cilium assembly. (957 aa) |
| | TMEM216 | Transmembrane protein 216, isoform A; It is involved in the biological process described with: non-motile cilium assembly; cilium assembly. (136 aa) |
| | BBIP1 | BBSome interacting protein 1; It is involved in the biological process described with: cilium assembly; receptor localization to non-motile cilium. (76 aa) |
| | CG42699 | LD45147p. (897 aa) |
| | B9d2 | B9 domain-containing protein 2; Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia. Has a role in ciliary structure and function. (177 aa) |
| | tctn | Tectonic; Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia. Has a role in ciliary structure and function. (657 aa) |
| | Cep135 | Centrosomal protein 135kDa (Cep135) encodes a microtubule binding protein important for centriole elongation and stability. It promotes centrosome asymmetry and spindle orientation in neuroblasts and it is required for male fertility. (1065 aa) |
| | CG10839 | IP06404p; Motor activity; dynein heavy chain binding; alpha-tubulin binding. It is involved in the biological process described with: outer dynein arm assembly. (182 aa) |
| | Cc2d2a | Coiled-coil and C2 domain-containing protein 2A; Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia (Probable). Required for ciliary structure and function (By similarity). (1336 aa) |
| | Fmr1 | Synaptic functional regulator FMR1; Polyribosome-associated RNA-binding protein that plays a role in neuronal development and synaptic plasticity through the regulation of protein synthesis of mRNAs. Plays a role as a negative translational regulator of specific mRNAs. Represses translation of the microtubule-associated protein futsch mRNA to regulate microtubule-dependent synaptic growth and function. May also be involved in microRNA (miRNA)-mediated translational suppression as part of the RNA-induced silencing complex (RISC). Required for stability of the central pair of microtubule [...] (729 aa) |
| | dila | Centrosomal protein of 131 kDa; Cilium-specific protein with a role in cilium/flagellum formation. May be involved in transport of components into the growing cilium. In germ cells and sensory neurons, plays a role with Cby in the building of the transition zone necessary for the formation of the ciliary cap and for the correct elongation of the axoneme. (1155 aa) |
| | CG3085 | CG3085 protein; Structural constituent of cytoskeleton. It is involved in the biological process described with: microtubule nucleation; cilium assembly; cilium movement involved in cell motility. (432 aa) |
| | Poc1 | Proteome of centrioles 1 (Poc1) encodes a cytoplasmic protein located in the sperm giant centriole and proximal centriole-like structure (PCL), which assists in the elongation of the giant centrioles and recruitment of centriolar proteins to the PCL. It contributes to sperm motility and fertility. (403 aa) |
| | CG14020 | Uncharacterized protein, isoform B; It is involved in the biological process described with: cilium assembly; regulation of protein localization. (343 aa) |
| | CG15923 | Uncharacterized protein, isoform C; It is involved in the biological process described with: cilium assembly; negative regulation of centrosome duplication. (984 aa) |
| | CG7568 | Uncharacterized protein, isoform E. (482 aa) |
| | CG10874 | Uncharacterized protein, isoform D; It is involved in the biological process described with: cilium assembly. (317 aa) |
| | Tektin-A | Tektin A, isoform A; It is involved in the biological process described with: cilium movement involved in cell motility; cilium assembly. (585 aa) |
| | Tektin-C | Tektin C, isoform A; It is involved in the biological process described with: cilium movement involved in cell motility; cilium assembly. (421 aa) |
| | Rilpl | RILP-like protein homolog; May have a role in lysosome distribution by interacting with Arl8; Belongs to the RILPL family. (486 aa) |
| | Oseg2 | Intraflagellar transport protein 172 homolog; Required for the maintenance and formation of cilia. Belongs to the IFT172 family. (1754 aa) |
| | cep290 | Centrosomal protein cep290; Essential for ciliogenesis in sensory neurons and germ cells. During neuron and spermatocyte ciliogenesis, plays a role in transition zone assembly where it is required for the formation of diverse connections between microtubules and between microtubules and the membrane. (1978 aa) |
| | Dnai2 | Dynein, axonemal, intermediate chain 2 (Dnai2) encodes a subunit of the axonemal dynein complex. It is involved in the perception of sound and sperm competititon. (585 aa) |
| | LRR | Leucine-rich repeat, isoform F; Leucine-rich repeat (LRR) encodes a protein that contributes to the response to insecticides. It regulates the immune response and NIK/NF-kappaB signaling. (1486 aa) |
| | ana1 | Anastral spindle 1 (ana1) encodes a cytoplasmic protein located in the centrioles, including the sperm giant centriole and proximal centriole-like structure, which assists in centrioles formation. Its roles include coordinated movement behavior, sperm motility, and fertility. (1729 aa) |
| | Efa6 | PH and SEC7 domain-containing protein; Guanine nucleotide exchange factor for Arf6. Regulates axon growth and branching by inhibiting microtubule polymerisation at the cortex. Together with shot, promotes axonal microtubule bundle integrity. Required for normal ethanol-induced tolerance and preference. Probably by activating Arf6, counteracts ethanol-induced sedation. (1601 aa) |
| | Ttc30 | Tetratricopeptide repeat protein 30 homolog; Required for polyglutamylation of axonemal tubulin in sensory cilia. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip; Belongs to the TTC30/dfy-1/fleer family. (655 aa) |
| | unc | Uncoordinated, isoform A; Uncoordinated (unc) encodes a basal body-associated protein that is required for normal ciliogenesis. unc depletion results in spermatids with defective flagella and truncated cilia in mechanosensory and chemosensory neurons. Its name arises from the severe uncoordination phenotype due to a lack of proprioceptive sensory feedback. (1386 aa) |
| | CG6614 | GH18077p. (1058 aa) |
| | nompB | No mechanoreceptor potential B (nompB) encodes an essential component of the conserved intraflagellar transport mechanism, which is needed to extend cilia above the cell surface. nompB mutants have truncated, nonfunctional sensory cilia with consequent mechanosensory deficits. (857 aa) |
| | CG9313 | Uncharacterized protein, isoform B; Dynein light chain binding; dynein heavy chain binding. It is involved in the biological process described with: cilium movement; outer dynein arm assembly; microtubule-based movement; sensory perception of sound. (740 aa) |
| | cdc14 | Cell division cycle 14, isoform A; Protein tyrosine/serine/threonine phosphatase activity; protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity. (1052 aa) |
| | Oseg1 | Outer segment 1 (Oseg1) encodes a protein required for ciliogenesis. (1169 aa) |
| | nsr | Novel spermatogenesis regulator, isoform A; RNA binding; mRNA binding. It is involved in the biological process described with: regulation of alternative mRNA splicing, via spliceosome; posttranscriptional regulation of gene expression; sperm axoneme assembly; sperm individualization. (340 aa) |
| | CG15824 | Uncharacterized protein, isoform B. (1957 aa) |
| | unc-119 | Protein unc-119 homolog; Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. (265 aa) |
| | kl-3 | Male fertility factor kl3 (kl-3) encodes a dynein heavy chain that is a component of a microtubule motor complex. This motor activity is essential only for spermatogenesis. Lack of kl-3 results in loss of the axonemal out dynein arms in the spermatid tail. (4593 aa) |
| | Cby | Chibby, isoform E; Chibby (Cby) encodes a protein involved in ciliogenesis and basal body transition zone formation. (132 aa) |
| | orb2 | Translational regulator orb2; Required in mushroom body gamma neurons for long-term memory in male courtship. Binds to mRNA 3'- UTRs. In its monomeric form, acts as a translational repressor of genes involved in neuronal growth, synapse formation and protein turnover. In its amyloid- like oligomeric form, acts as a translational activator. The monomeric form reduces poly(A) tail length and destabilizes mRNA while the oligomeric form protects and elongates the poly(A) tail and stabilizes mRNA. Isoform A is required for initial memory acquisition and, following subsequent late dopaminerg [...] (769 aa) |
