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cora cora Gli Gli Nrg Nrg Galphao Galphao Gbeta13F Gbeta13F Ggamma1 Ggamma1 Lac Lac nrv2 nrv2 Cont Cont sinu sinu prc prc Nrx-IV Nrx-IV
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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coraProtein 4.1 homolog; An integral component of the septate junction. May play a role in cell-cell interactions that are necessary for proper development. Vital for embryonic development. (1698 aa)
GliGliotactin, isoform A; Gliotactin (Gli) encodes a transmembrane protein localized at tricellular junctions that is necessary for septate junction and permeability barrier formation. (956 aa)
NrgNeuroglian; The long isoform may play a role in neural and glial cell adhesion in the developing embryo. The short isoform may be a more general cell adhesion molecule involved in other tissues and imaginal disk morphogenesis. Vital for embryonic development. Essential for septate junctions. Septate junctions, which are the equivalent of vertebrates tight junctions, are characterized by regular arrays of transverse structures that span the intermembrane space and form a physical barrier to diffusion. Required for the blood-brain barrier formation. (1309 aa)
GalphaoG protein alpha o subunit (Galphao) encodes the most abundant G protein in the nervous tissue and is involved in signaling by a variety of GPCRs. It contributes to heart development, axonogenesis, neuro-muscular junction formation, asymmetric cell division, planar cell polarity, blood-brain barrier establishment, Wnt signaling, and gustatory and olfactory sensory perception; Belongs to the G-alpha family. G(i/o/t/z) subfamily. (354 aa)
Gbeta13FGuanine nucleotide-binding protein subunit beta-1; G protein beta-subunit 13F (Gbeta13F) encodes an ubiquitous, maternal product required for gastrulation movements of early embryo and regulating medial (mesoderm and ectoderm) and junctional Myosin II (ectoderm) via RhoI pathway. The product of Gbeta13F is detected apically and at adherens junctions. (340 aa)
Ggamma1Guanine nucleotide-binding protein subunit gamma-1; G protein gamma 1 (Ggamma1) encodes a protein involved in the G-protein coupled receptor signaling pathway. Ggamma1-product regulates actomyosin dynamics and contributes to heart morphogenesis, asymmetric neuroblast division and convergent extension movements during gastrulation. (70 aa)
LacLachesin (Lac) encodes a cell surface protein that belongs to the Ig superfamily. It is required for the proper ultrastructural organisation of septate junctions. Lac is required for tracheal system morphogenesis and for muscle contractions associated with peristalsis. (359 aa)
nrv2Sodium/potassium-transporting ATPase subunit beta-2; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. (323 aa)
ContContactin; Required for organization of septate junctions and paracellular barrier functions. Septate junctions, which are the equivalent of vertebrates tight junctions, are characterized by regular arrays of transverse structures that span the intermembrane space and form a physical barrier to diffusion. (1390 aa)
sinuSinuous (sinu) encodes a claudin that contributes to the assembly of septate junctions. It is involved in the development of heart, tracheal tree and the glial blood-brain barrier. (247 aa)
prcPericardin (prc) encodes a type IV collagen-like extracellular matrix protein involved in heart development. (1713 aa)
Nrx-IVNeurexin-4; Seems to play a role in the formation and function of septate junctions. Septate junctions, which are the equivalent of vertebrates tight junctions, are characterized by regular arrays of transverse structures that span the intermembrane space and form a physical barrier to diffusion. Required for the blood-brain barrier formation. Belongs to the neurexin family. (1284 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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