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fbl fbl Ppat-Dpck Ppat-Dpck iPLA2-VIA iPLA2-VIA Ilp2 Ilp2 hep hep CPT2 CPT2 Mondo Mondo PK1-R PK1-R Lst Lst NLaz NLaz Ppcs Ppcs Lztr1 Lztr1 FASN1 FASN1 Fatp2 Fatp2 Lnk Lnk snz snz ktub ktub Torsin Torsin Fatp1 Fatp1 cue cue Fatp3 Fatp3 bmm bmm AkhR AkhR Dark Dark hppy hppy Hr96 Hr96 AdipoR AdipoR wrd wrd Gnmt Gnmt Desat1 Desat1 hll hll mag mag InR InR
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
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fblFumble, isoform E; Fumble (fbl) encodes an enzyme that phosphorylates pantothenate (vitamin B5), which is one of the early steps of the Coenzyme A de novo biosynthesis pathway. (512 aa)
Ppat-DpckBifunctional Phosphopantetheine adenylyltransferase - Dephospho-CoA kinase (Ppat-Dpck) encodes a bifunctional enzyme that carries out the last two steps of the canonical Coenzyme A (CoA) biosynthesis pathway. The Ppat part converts 4'-phosphopantetheine into dephospho-CoA and subsequently the Dpck part phosphorylates dephospho-CoA to form CoA. (518 aa)
iPLA2-VIACalcium-independent phospholipase A2 VIA (iPLA2-VIA) encodes a protein that localizes to cytosol and mitochondria involved in repairing oxidized mitochondrial lipids, such as cardiolipin, and thus preventing cytochrome c release. It is partially responsible for cardiolipin depletion and monolysocardiolipin accumulation in Taz-deficient flies, which is a model of Barth syndrome. (887 aa)
Ilp2Probable insulin-like peptide 2 A chain; Plays a role in regulating body size by increasing cell size and cell number of individual organs. Probably mediates its growth effects by acting as a ligand for the insulin receptor and transducing a signal via the Chico/PI3K/Akt(PKB) pathway. (137 aa)
hepDual specificity mitogen-activated protein kinase kinase hemipterous; Required for the epithelial cell sheet movement called dorsal closure (DC), which allows establishment of the dorsal epidermis. Controls the expression in the dorsal epithelium edges of another dorsal closure gene, puckered (puc). Phosphorylates and activates the MAP kinase bsk; bsk signal transduction pathway mediates an immune response and morphogenesis; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. (1178 aa)
CPT2Carnitine palmitoyltransferase 2 (CPT2) encodes an enzyme required for the beta-oxidation of long-chain fatty acids; Belongs to the carnitine/choline acetyltransferase family. (667 aa)
MondoMlx interactor alpha; Mondo (Mondo) encodes a basic helix-loop-helix-leucine zipper transcription factor involved in lipid and carbohydrate metabolism. Together with its binding partner encoded by bigmax, it controls sugar-dependent gene expression, including activation of genes involved in lipogenesis. Mondo mutants are intolerant to dietary sugars and have impaired muscle function. (1119 aa)
PK1-RPyrokinin-1 receptor; Receptor for the neuropeptide CAP-3/pyrokinin-1 (TGPSASSGLWFGPRL-amide). Also activated weakly by other neuropeptides terminating in the sequence PRL-amide including pyrokinin-2, Hug-gamma, and ecdysis-triggering-hormone-1. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. (430 aa)
LstLimostatin, isoform B; Limostatin (Lst) encodes a peptide hormone produced by endocrine corpora cardiaca cells during starvation. It suppresses insulin production and secretion from insulin-producing cells by signaling through the G-protein coupled receptor encoded by PK1-R. (152 aa)
NLazNeural lazarillo, isoform B; Neural Lazarillo (NLaz) encodes an extracellular lipid binding protein of the Lipocalin family. It is regulated by JNK signaling and negatively regulates the IIS pathway. It contributes to longevity, stress resistance, and behavior. (245 aa)
PpcsPhosphopantothenoylcysteine synthetase, isoform C; Phosphopantothenate--cysteine ligase activity. (373 aa)
Lztr1Leucine-zipper-like transcriptional regulator 1 homolog; Inhibitor of Ras signaling. Acts as a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin- protein ligase complex that mediates ubiquitination of Ras (By similarity); Belongs to the LZTR1 family. (998 aa)
FASN1Fatty acid synthase 1 (FASN1) encodes a fatty acid synthase involved in glycogen metabolism and triglyceride biosynthesis. (2540 aa)
Fatp2Long-chain fatty acid-CoA ligase activity; fatty acid transmembrane transporter activity; long-chain fatty acid transporter activity; very long-chain fatty acid-CoA ligase activity. It is involved in the biological process described with: fatty acid biosynthetic process; fatty acid transport; triglyceride homeostasis. (714 aa)
LnkLnk, isoform D; Lnk (Lnk) encodes a member of the SH2B family of adaptor proteins. It functions within the insulin signalling pathway as an intracellular adaptor for the insulin receptor. It stabilises the interaction between the activated insulin receptor and the insulin receptor substrate, which are encoded by InR and chico respectively. (728 aa)
snzSnazarus, isoform A; Snazarus (snz) encodes a sorting nexin protein involved in lifespan. (1117 aa)
ktubProtein king tubby; Functions in regulating protein trafficking, retinal maintenance and lipid storage. Protects photoreceptor cells R1 to R6 against light-induced retinal degeneration by stimulating norpA- mediated endocytosis of the rhodopsin ninaE (Rh1). In the auditory receptor neurons, functions as a cilia trafficking regulator of various transient receptor potential (TRP) channel components including iav and nompC. Likely to deliver pre-ciliary vesicles containing membrane proteins such as iav and nompC to the intraflagellar transport complex (IFT) at the cilia base. Plays a role [...] (469 aa)
TorsinTorsin-like protein; Torsin (Torsin) encodes an AAA-ATPase that is implicated in the export of large ribonuclear protein particles through the nuclear membrane. It regulates dopamine levels; Belongs to the ClpA/ClpB family. Torsin subfamily. (340 aa)
Fatp1Fatty acid transport protein 1 (Fatp1) encodes a transmembrane protein with acyl-CoA synthetase activity required for photoreceptor survival. It is involved in the cellular uptake of long-chain fatty acids with a role in the catabolism of fatty acids as well as synthesis of triglycerides. (746 aa)
cueProtein cueball; Has a role in spermatogenesis and oogenesis. Might have a role in triglyceride homeostasis. Probably by regulating lipid storage and catabolism, plays a role in neuronal function. (644 aa)
Fatp3Fatty acid transport protein 3, isoform A; Long-chain fatty acid-CoA ligase activity; very long-chain fatty acid-CoA ligase activity; long-chain fatty acid transporter activity. It is involved in the biological process described with: fatty acid biosynthetic process; triglyceride homeostasis. (687 aa)
bmmBrummer, isoform B; Brummer (bmm) encodes a triglyceride lipase involved in glycerolipid metabolism, regulation of lipid storage and triglyceride homeostasis. (553 aa)
AkhRAdipokinetic hormone receptor (AkhR) encodes a G protein-coupled receptor for the hormone encoded by Akh. It modulates both lipid and carbohydrate homeostasis. (455 aa)
DarkDeath-associated APAF1-related killer, isoform B; Death-associated APAF1-related killer (Dark) encodes an essential component of the apoptosome. The products of Dark and Dronc form a pivotal holoenzyme required for apoptotic cell death with the products of Dark acting as an adaptor of the multimeric complex. (1440 aa)
hppyHappyhour, isoform A; Happyhour (hppy) encodes the Drosophila orthologue of MAP4K3, a Ser/Thr Kinase belonging to the Germinal Center Kinase I family of Ste20-related kinases. The function of hppy has being linked to the Egfr, Hippo and Tor signalling pathways. (1218 aa)
Hr96Hormone receptor-like in 96 (Hr96) encodes a protein that binds cholesterol as a ligand and is required to maintain cholesterol and lipid homeostasis; Belongs to the nuclear hormone receptor family. NR1 subfamily. (723 aa)
AdipoRAdiponectin receptor (AdipoR) encodes a membrane protein that regulates glucose and lipid metabolism by controlling insulin signaling. It also maintains germ line stem cells via an insulin-independent mechanism. (444 aa)
wrdWell-rounded, isoform B; Well-rounded (wrd) encodes one of the two regulatory B' subunits of the protein phosphatase PP2A. It influences metabolism and growth via negative regulation of the InR/TOR signalling network. (984 aa)
GnmtGlycine N-methyltransferase (Gnmt) encodes an enzyme that catalyzes the methylation reaction of glycine to generate sarcosine (N-methylglycine). It is abundantly expressed in the fat body and controls the amount of methyl donor S-adenosylmethionine; Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family. (289 aa)
Desat1Desaturase 1 (Desat1) encodes a transmembrane fatty acid desaturase that utilizes myristate and stearate (C16:0 and C18:0) to synthesize myristoleic and oleic acids (C16:1 and C18:1). It is involved in the synthesis of unsaturated fatty acids. (383 aa)
hllLong-chain-fatty-acid--CoA ligase heimdall; Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Probably by regulating lipid storage and catabolism, plays a role in neuronal function ; Belongs to the ATP-dependent AMP-binding enzyme family. Bubblegum subfamily. (681 aa)
magLipase; Magro (mag) encodes a lipase induced by the product of Hr96 in the intestine, where it acts in the lumen to degrade dietary triglycerides for fatty acid absorption. (399 aa)
InRInsulin-like receptor subunit beta 1; Has a ligand-stimulated tyrosine-protein kinase activity. Required for cell survival. Regulates body size and organ size by altering cell number and cell size in a cell-autonomous manner. Involved in the development of the embryonic nervous system, and is necessary for axon guidance and targeting in the visual system. Also plays a role in life-span determination. (2144 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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