node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Had1 | Had2 | FBpp0311907 | FBpp0086628 | Beta hydroxy acid dehydrogenase 1, isoform A; NAD+ binding; L-gulonate 3-dehydrogenase activity; 3-hydroxyacyl-CoA dehydrogenase activity. It is involved in the biological process described with: oxidation-reduction process; fatty acid metabolic process. | Beta hydroxy acid dehydrogenase 2; 3-hydroxyacyl-CoA dehydrogenase activity. It is involved in the biological process described with: fatty acid metabolic process; oxidation-reduction process. | 0.902 |
Had1 | Mtpalpha | FBpp0311907 | FBpp0079454 | Beta hydroxy acid dehydrogenase 1, isoform A; NAD+ binding; L-gulonate 3-dehydrogenase activity; 3-hydroxyacyl-CoA dehydrogenase activity. It is involved in the biological process described with: oxidation-reduction process; fatty acid metabolic process. | Mitochondrial trifunctional protein alpha subunit (Mtpalpha) encodes a subunit of the mitochondrial trifunctional protein. It possesses 3-enoyl-CoA hydratase and 3-hydroxyacyl-CoA dehydrogenase activities, which catalyze the second and third steps,respectively, of the beta-oxidation of long-chain fatty acids. | 0.670 |
Had2 | Had1 | FBpp0086628 | FBpp0311907 | Beta hydroxy acid dehydrogenase 2; 3-hydroxyacyl-CoA dehydrogenase activity. It is involved in the biological process described with: fatty acid metabolic process; oxidation-reduction process. | Beta hydroxy acid dehydrogenase 1, isoform A; NAD+ binding; L-gulonate 3-dehydrogenase activity; 3-hydroxyacyl-CoA dehydrogenase activity. It is involved in the biological process described with: oxidation-reduction process; fatty acid metabolic process. | 0.902 |
Had2 | Mtpalpha | FBpp0086628 | FBpp0079454 | Beta hydroxy acid dehydrogenase 2; 3-hydroxyacyl-CoA dehydrogenase activity. It is involved in the biological process described with: fatty acid metabolic process; oxidation-reduction process. | Mitochondrial trifunctional protein alpha subunit (Mtpalpha) encodes a subunit of the mitochondrial trifunctional protein. It possesses 3-enoyl-CoA hydratase and 3-hydroxyacyl-CoA dehydrogenase activities, which catalyze the second and third steps,respectively, of the beta-oxidation of long-chain fatty acids. | 0.667 |
Mtpalpha | Had1 | FBpp0079454 | FBpp0311907 | Mitochondrial trifunctional protein alpha subunit (Mtpalpha) encodes a subunit of the mitochondrial trifunctional protein. It possesses 3-enoyl-CoA hydratase and 3-hydroxyacyl-CoA dehydrogenase activities, which catalyze the second and third steps,respectively, of the beta-oxidation of long-chain fatty acids. | Beta hydroxy acid dehydrogenase 1, isoform A; NAD+ binding; L-gulonate 3-dehydrogenase activity; 3-hydroxyacyl-CoA dehydrogenase activity. It is involved in the biological process described with: oxidation-reduction process; fatty acid metabolic process. | 0.670 |
Mtpalpha | Had2 | FBpp0079454 | FBpp0086628 | Mitochondrial trifunctional protein alpha subunit (Mtpalpha) encodes a subunit of the mitochondrial trifunctional protein. It possesses 3-enoyl-CoA hydratase and 3-hydroxyacyl-CoA dehydrogenase activities, which catalyze the second and third steps,respectively, of the beta-oxidation of long-chain fatty acids. | Beta hydroxy acid dehydrogenase 2; 3-hydroxyacyl-CoA dehydrogenase activity. It is involved in the biological process described with: fatty acid metabolic process; oxidation-reduction process. | 0.667 |
Sirt1 | Sirt4 | FBpp0080015 | FBpp0070817 | NAD-dependent histone deacetylase sirtuin-1; NAD-dependent histone deacetylase involved in heterochromatic silencing. Mildly suppresses the heterochromatin-mediated silencing phenomenon known as position-effect variegation (PEV). Required for epigenetic silencing of the polycomb group proteins. Has histone H4 deacetylase activity in vitro. Required maternally for establishing proper segmentation of the embryo. Involved in sex determination. May be involved in the regulation of life span. | NAD-dependent protein deacylase Sirt4; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues. | 0.680 |
Sirt1 | Sirt6 | FBpp0080015 | FBpp0293897 | NAD-dependent histone deacetylase sirtuin-1; NAD-dependent histone deacetylase involved in heterochromatic silencing. Mildly suppresses the heterochromatin-mediated silencing phenomenon known as position-effect variegation (PEV). Required for epigenetic silencing of the polycomb group proteins. Has histone H4 deacetylase activity in vitro. Required maternally for establishing proper segmentation of the embryo. Involved in sex determination. May be involved in the regulation of life span. | Sirtuin 6 (Sirt6) encodes an NAD-dependent histone deacetylase in the class IV of the Sirtuin family. It is involved in chromatin silencing and determination of adult lifespan. | 0.805 |
Sirt1 | Sirt7 | FBpp0080015 | FBpp0084733 | NAD-dependent histone deacetylase sirtuin-1; NAD-dependent histone deacetylase involved in heterochromatic silencing. Mildly suppresses the heterochromatin-mediated silencing phenomenon known as position-effect variegation (PEV). Required for epigenetic silencing of the polycomb group proteins. Has histone H4 deacetylase activity in vitro. Required maternally for establishing proper segmentation of the embryo. Involved in sex determination. May be involved in the regulation of life span. | NAD-dependent protein deacetylase Sirt7; NAD-dependent protein deacetylase. | 0.992 |
Sirt2 | Sirt4 | FBpp0310647 | FBpp0070817 | NAD-dependent protein deacetylase Sirt2; NAD-dependent protein deacetylase (By similarity). May be involved in the regulation of life span; Belongs to the sirtuin family. Class I subfamily. | NAD-dependent protein deacylase Sirt4; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues. | 0.687 |
Sirt2 | Sirt6 | FBpp0310647 | FBpp0293897 | NAD-dependent protein deacetylase Sirt2; NAD-dependent protein deacetylase (By similarity). May be involved in the regulation of life span; Belongs to the sirtuin family. Class I subfamily. | Sirtuin 6 (Sirt6) encodes an NAD-dependent histone deacetylase in the class IV of the Sirtuin family. It is involved in chromatin silencing and determination of adult lifespan. | 0.725 |
Sirt2 | Sirt7 | FBpp0310647 | FBpp0084733 | NAD-dependent protein deacetylase Sirt2; NAD-dependent protein deacetylase (By similarity). May be involved in the regulation of life span; Belongs to the sirtuin family. Class I subfamily. | NAD-dependent protein deacetylase Sirt7; NAD-dependent protein deacetylase. | 0.668 |
Sirt4 | Sirt1 | FBpp0070817 | FBpp0080015 | NAD-dependent protein deacylase Sirt4; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues. | NAD-dependent histone deacetylase sirtuin-1; NAD-dependent histone deacetylase involved in heterochromatic silencing. Mildly suppresses the heterochromatin-mediated silencing phenomenon known as position-effect variegation (PEV). Required for epigenetic silencing of the polycomb group proteins. Has histone H4 deacetylase activity in vitro. Required maternally for establishing proper segmentation of the embryo. Involved in sex determination. May be involved in the regulation of life span. | 0.680 |
Sirt4 | Sirt2 | FBpp0070817 | FBpp0310647 | NAD-dependent protein deacylase Sirt4; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues. | NAD-dependent protein deacetylase Sirt2; NAD-dependent protein deacetylase (By similarity). May be involved in the regulation of life span; Belongs to the sirtuin family. Class I subfamily. | 0.687 |
Sirt4 | Sirt6 | FBpp0070817 | FBpp0293897 | NAD-dependent protein deacylase Sirt4; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues. | Sirtuin 6 (Sirt6) encodes an NAD-dependent histone deacetylase in the class IV of the Sirtuin family. It is involved in chromatin silencing and determination of adult lifespan. | 0.879 |
Sirt4 | Sirt7 | FBpp0070817 | FBpp0084733 | NAD-dependent protein deacylase Sirt4; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues. | NAD-dependent protein deacetylase Sirt7; NAD-dependent protein deacetylase. | 0.686 |
Sirt6 | Sirt1 | FBpp0293897 | FBpp0080015 | Sirtuin 6 (Sirt6) encodes an NAD-dependent histone deacetylase in the class IV of the Sirtuin family. It is involved in chromatin silencing and determination of adult lifespan. | NAD-dependent histone deacetylase sirtuin-1; NAD-dependent histone deacetylase involved in heterochromatic silencing. Mildly suppresses the heterochromatin-mediated silencing phenomenon known as position-effect variegation (PEV). Required for epigenetic silencing of the polycomb group proteins. Has histone H4 deacetylase activity in vitro. Required maternally for establishing proper segmentation of the embryo. Involved in sex determination. May be involved in the regulation of life span. | 0.805 |
Sirt6 | Sirt2 | FBpp0293897 | FBpp0310647 | Sirtuin 6 (Sirt6) encodes an NAD-dependent histone deacetylase in the class IV of the Sirtuin family. It is involved in chromatin silencing and determination of adult lifespan. | NAD-dependent protein deacetylase Sirt2; NAD-dependent protein deacetylase (By similarity). May be involved in the regulation of life span; Belongs to the sirtuin family. Class I subfamily. | 0.725 |
Sirt6 | Sirt4 | FBpp0293897 | FBpp0070817 | Sirtuin 6 (Sirt6) encodes an NAD-dependent histone deacetylase in the class IV of the Sirtuin family. It is involved in chromatin silencing and determination of adult lifespan. | NAD-dependent protein deacylase Sirt4; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues. | 0.879 |
Sirt7 | Sirt1 | FBpp0084733 | FBpp0080015 | NAD-dependent protein deacetylase Sirt7; NAD-dependent protein deacetylase. | NAD-dependent histone deacetylase sirtuin-1; NAD-dependent histone deacetylase involved in heterochromatic silencing. Mildly suppresses the heterochromatin-mediated silencing phenomenon known as position-effect variegation (PEV). Required for epigenetic silencing of the polycomb group proteins. Has histone H4 deacetylase activity in vitro. Required maternally for establishing proper segmentation of the embryo. Involved in sex determination. May be involved in the regulation of life span. | 0.992 |