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Had1 Had1 Sirt2 Sirt2 Sirt6 Sirt6 Had2 Had2 Sirt7 Sirt7 Sirt1 Sirt1 Mtpalpha Mtpalpha Uxs Uxs Sirt4 Sirt4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Had1Beta hydroxy acid dehydrogenase 1, isoform A; NAD+ binding; L-gulonate 3-dehydrogenase activity; 3-hydroxyacyl-CoA dehydrogenase activity. It is involved in the biological process described with: oxidation-reduction process; fatty acid metabolic process. (315 aa)
Sirt2NAD-dependent protein deacetylase Sirt2; NAD-dependent protein deacetylase (By similarity). May be involved in the regulation of life span; Belongs to the sirtuin family. Class I subfamily. (355 aa)
Sirt6Sirtuin 6 (Sirt6) encodes an NAD-dependent histone deacetylase in the class IV of the Sirtuin family. It is involved in chromatin silencing and determination of adult lifespan. (325 aa)
Had2Beta hydroxy acid dehydrogenase 2; 3-hydroxyacyl-CoA dehydrogenase activity. It is involved in the biological process described with: fatty acid metabolic process; oxidation-reduction process. (315 aa)
Sirt7NAD-dependent protein deacetylase Sirt7; NAD-dependent protein deacetylase. (771 aa)
Sirt1NAD-dependent histone deacetylase sirtuin-1; NAD-dependent histone deacetylase involved in heterochromatic silencing. Mildly suppresses the heterochromatin-mediated silencing phenomenon known as position-effect variegation (PEV). Required for epigenetic silencing of the polycomb group proteins. Has histone H4 deacetylase activity in vitro. Required maternally for establishing proper segmentation of the embryo. Involved in sex determination. May be involved in the regulation of life span. (823 aa)
MtpalphaMitochondrial trifunctional protein alpha subunit (Mtpalpha) encodes a subunit of the mitochondrial trifunctional protein. It possesses 3-enoyl-CoA hydratase and 3-hydroxyacyl-CoA dehydrogenase activities, which catalyze the second and third steps,respectively, of the beta-oxidation of long-chain fatty acids. (783 aa)
UxsUDP-xylose synthase; NAD+ binding; UDP-glucuronate decarboxylase activity. (441 aa)
Sirt4NAD-dependent protein deacylase Sirt4; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues. (312 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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