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AGO1 AGO1 Cbp80 Cbp80 AGO2 AGO2 lin-28 lin-28 r2d2 r2d2 loqs loqs Nbr Nbr Cbp20 Cbp20 Dcr-1 Dcr-1 pasha pasha Ars2 Ars2 Dcr-2 Dcr-2 Hen1 Hen1 cuff cuff drosha drosha CG17168 CG17168 Tailor Tailor
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
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gene fusions
gene co-occurrence
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textmining
co-expression
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AGO1Argonaute-1, isoform A; Argonaute-1 (AGO1) encodes an Argonaute/Piwi family protein, which interacts with microRNAs to form miRNA-induced silencing complexes (miRISCs). miRISCs are guided to target and repress mRNAs either by transcript destabilisation, translational inhibition, or both. (984 aa)
Cbp80Nuclear cap-binding protein subunit 1; Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi). The CBC complex is involved in miRNA-mediated RNA interference via its interaction with Ars2 and is required for primary microRNAs (miRNAs) processing. Also involved in innate immunity via the short interfering RNAs (siRNAs) processing machinery by restricting the viral RNA production. In the CBC complex, Cbp80 does not bind directly capped RNAs [...] (800 aa)
AGO2Protein argonaute-2; Essential for RNA interference (RNAi); double-stranded RNA induces potent and specific gene silencing. RNAi is mediated by the RNA-induced silencing complex (RISC), a sequence-specific, multicomponent nuclease that destroys or silences messenger RNAs homologous to the silencing trigger; Belongs to the argonaute family. Ago subfamily. (1217 aa)
lin-28Protein lin-28 homolog; mRNA binding; zinc ion binding; mRNA 3'-UTR binding; Belongs to the lin-28 family. (195 aa)
r2d2R2d2, isoform A; R2d2 (r2d2) encodes a double-stranded RNA-binding protein. It interacts with the product of Dcr-2 to form the core of RISC loading complex, which recruits duplex siRNA to the RISC. (311 aa)
loqsLoquacious, isoform B; Loquacious (loqs) encodes a double-stranded RNA binding protein with multiple splicing isoforms. loqs-PB and loqs-PA associate with the product of Dcr-1 to facilitate processing of precursor miRNA into mature miRNA, whereas loqs-PD interacts with the product of Dcr-2 to enhance processing of dsRNA into siRNA. (465 aa)
NbrExonuclease mut-7 homolog; Possesses 3'-5' exoribonuclease activity. Required for 3'-end trimming of AGO1-bound miRNAs, in particular multiple-isoform miRNAs, which represents a critical step in miRNA maturation. Belongs to the mut-7 family. (625 aa)
Cbp20Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi). The CBC complex is involved in miRNA-mediated RNA interference via its interaction with Ars2 and is required for primary microRNAs (miRNAs) processing. Also involved in innate immunity via the short interfering RNAs (siRNAs) processing machinery by restricting the viral RNA production. In the CBC complex, Cbp20 recognizes and binds capped RNAs [...] (154 aa)
Dcr-1Endoribonuclease Dcr-1; Essential for RNA interference (RNAi); double-stranded RNA (dsRNA) induces potent and specific gene silencing. RNAi is mediated by the RNA-induced silencing complex (RISC), a sequence-specific, multicomponent nuclease that destroys or silences messenger RNAs homologous to the silencing trigger. May carry out the initiation step of RNAi by cleaving dsRNA to produce 22 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs. During embryogenesis, involved in germline fate determination; Belongs to the helicase family. Dicer subfamily. (2249 aa)
pashaPartner of drosha (pasha) encodes a protein involved in oogenesis and miRNA processing. (642 aa)
Ars2Serrate RNA effector molecule homolog; Acts as a mediator between the cap-binding complex (CBC) and RNA-mediated gene silencing (RNAi). Involved in innate immunity via the short interfering RNAs (siRNAs) processing machinery by restricting the viral RNA production. Also involved microRNA (miRNA)-mediated silencing by contributing to the stability and delivery of primary miRNA transcripts to the primary miRNA processing complex containing drosha and pasha; Belongs to the ARS2 family. (943 aa)
Dcr-2Dicer-2, isoform A; Dicer-2 (Dcr-2) encodes a member of the RNase III family of double-stranded RNA-specific endonucleases. It acts in the RNAi pathway by cutting long dsRNA into siRNAs. It helps defend flies against viral infection, particularly RNA viruses. It also processes long, partially double-stranded endogenous transcripts (hairpin RNAs) into endo-siRNAs. (1722 aa)
Hen1Small RNA 2'-O-methyltransferase; Methyltransferase that adds a 2'-O-methyl group at the 3'-end of selected small RNAs. Mediates 2'-O-methylation of piRNAs, single- stranded siRNAs and long hairpin RNA genes (hpRNAs). Methylation protects the 3'-end of small RNAs from tailing and trimming and could constitute a recognition signal for appropriate argonaute machineries. (391 aa)
cuffCutoff (cuff) encodes a protein that interacts with the products of rhi and del in a germline complex that allows noncanonical transcription of dual-strand piRNA clusters. The product of cuff is therefore an integral part of the piRNA response to transposon activity in the germline. In its absence, a DNA damage checkpoint is activated leading to ventralization of the egg and embryo. (384 aa)
droshaRibonuclease; Drosha (drosha) encodes a protein that contributes to miRNA processing. It is involved in salivary gland histolysis and oocyte development. (1327 aa)
CG17168RE68879p; RNA binding; mRNA binding. It is involved in the biological process described with: production of miRNAs involved in gene silencing by miRNA. (421 aa)
TailorTailor (Tailor) encodes a cytoplasmic RNA-specific terminal uridylyltransferase. It acts as part of the terminal RNA uridylation-mediated processing (TRUMP) complex, marking RNA species for 3'-to-5' exoribonucleolytic decay by the product of Dis3l2. The product of Tailor regulates microRNA biogenesis by targeting precursor-microRNAs (predominantly mirtron hairpins) and targets unprocessed RNA polymerase III transcripts for degradation in a cytoplasmic RNA surveillance pathway. (563 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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