(5 nodes) Regulation of production of small RNA involved in gene silencing by RNA network (Drosophila melanogaster)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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Known Interactions

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Predicted Interactions

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protein homology

Your Input:
	CRIF	CR6-interacting factor (CRIF) encodes a protein that may play a role in regulating the RNAi pathway by stabilizing the RNAase III enzyme encoded by Dcr-2. (232 aa)
	loqs	Loquacious, isoform B; Loquacious (loqs) encodes a double-stranded RNA binding protein with multiple splicing isoforms. loqs-PB and loqs-PA associate with the product of Dcr-1 to facilitate processing of precursor miRNA into mature miRNA, whereas loqs-PD interacts with the product of Dcr-2 to enhance processing of dsRNA into siRNA. (465 aa)
	r2d2	R2d2, isoform A; R2d2 (r2d2) encodes a double-stranded RNA-binding protein. It interacts with the product of Dcr-2 to form the core of RISC loading complex, which recruits duplex siRNA to the RISC. (311 aa)
	lin-28	Protein lin-28 homolog; mRNA binding; zinc ion binding; mRNA 3'-UTR binding; Belongs to the lin-28 family. (195 aa)
	CG11342	Probable RNA methyltransferase CG11342; Probable RNA methyltransferase. (238 aa)

Your Current Organism:

Drosophila melanogaster

NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
loqs	r2d2	FBpp0080076	FBpp0079112	Loquacious, isoform B; Loquacious (loqs) encodes a double-stranded RNA binding protein with multiple splicing isoforms. loqs-PB and loqs-PA associate with the product of Dcr-1 to facilitate processing of precursor miRNA into mature miRNA, whereas loqs-PD interacts with the product of Dcr-2 to enhance processing of dsRNA into siRNA.	R2d2, isoform A; R2d2 (r2d2) encodes a double-stranded RNA-binding protein. It interacts with the product of Dcr-2 to form the core of RISC loading complex, which recruits duplex siRNA to the RISC.	0.921
r2d2	loqs	FBpp0079112	FBpp0080076	R2d2, isoform A; R2d2 (r2d2) encodes a double-stranded RNA-binding protein. It interacts with the product of Dcr-2 to form the core of RISC loading complex, which recruits duplex siRNA to the RISC.	Loquacious, isoform B; Loquacious (loqs) encodes a double-stranded RNA binding protein with multiple splicing isoforms. loqs-PB and loqs-PA associate with the product of Dcr-1 to facilitate processing of precursor miRNA into mature miRNA, whereas loqs-PD interacts with the product of Dcr-2 to enhance processing of dsRNA into siRNA.	0.921