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| | bnl | Branchless (bnl) encodes a Fibroblast Growth Factor (FGF) receptor for secreted FGF ligands that utilizes the intracellular Ras-MAP kinase pathway. It contributes to embryonic tracheal migration; Belongs to the heparin-binding growth factors family. (770 aa) |
| | htl | Fibroblast growth factor receptor homolog 1; Heartless (htl) encodes a transmembrane tyrosine kinase receptor for secreted FGF ligands that utilizes the intracellular Ras-MAP kinase pathway. It contributes to embryonic mesoderm migration and the specification of several mature mesodermal cell derivatives; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily. (729 aa) |
| | Lgr1 | Leucine-rich repeat-containing G protein-coupled receptor 1 (Lgr1) encodes a Leucine-rich repeat-containing G protein-coupled receptor (LGR type A) that shows highest similarity with vertebrate glycoprotein hormone (TSH and Thyrostimulin, FSH, LH ) receptors. (831 aa) |
| | Dad | Mothers against decapentaplegic homolog; Daughters against dpp (Dad) encodes the inhibitory SMAD in the BMP/Dpp pathway. It is involved in growth regulation and developmental patterning. (568 aa) |
| | Der-2 | Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family. (261 aa) |
| | Akt1 | RAC serine/threonine-protein kinase; Serine/threonine kinase involved in various developmental processes. During early embryogenesis, acts as a survival protein. During mid-embryogenesis, phosphorylates and activates trh, a transcription factor required for tracheal cell fate determination. Also regulates tracheal cell migration. Later in development, acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and antagonizing FOXO transcription factor. Controls follicle cell size during oogenesis. M [...] (611 aa) |
| | Fkbp39 | 39 kDa FK506-binding nuclear protein; PPIases accelerate the folding of proteins. May function in a signal transduction cascade during early development. (357 aa) |
| | CG5038 | Protein O-mannosyl-transferase TMTC4; Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. (705 aa) |
| | Hsc70-4 | Heat shock protein cognate 4 (Hsc70-4) encodes a protein involved in protein folding. It contributes to clathrin-mediated endocytosis, neurotransmitter exocytosis and RNAi response. (651 aa) |
| | GlyS | Glycogen synthase (GlyS) encodes a glycosyltransferase that catalyzes linkage of glucose monomers into glycogen. Regulation of the product of GlyS activity by glucose 6-phosphate and phosphorylation helps control cellular glycogen levels. (709 aa) |
| | Crz | Corazonin (Crz) encodes a neuropeptide expressed in specific groups of neurons. It functions as a neurohormone and neuromodulator, which involves a G-protein-coupled receptor. Its roles include ethanol and trehalose metabolism, and male reproductive activity. (154 aa) |
| | CG3061 | RH07106p; Hsp70 protein binding. It is involved in the biological process described with: ubiquitin-dependent ERAD pathway; chaperone cofactor-dependent protein refolding; cellular response to misfolded protein. (370 aa) |
| | CG8141 | RING-type domain-containing protein; Ubiquitin protein ligase activity; zinc ion binding; ubiquitin-like protein conjugating enzyme binding. It is involved in the biological process described with: ER-associated misfolded protein catabolic process; ubiquitin-dependent protein catabolic process. (239 aa) |
| | Hsc70-2 | Heat shock protein cognate 2 (Hsc70-2) encodes a member of the heat shock protein 70 family. It functions as chaperone protein in facilitating the proper folding of proteins. (633 aa) |
| | Hsp70Ba | Heat-shock-protein-70Ba (Hsp70Ba) encodes a protein involved in response to heat shock and hypoxia. (641 aa) |
| | Hsp70Bc | Heat-shock-protein-70Bc (Hsp70Bc) encodes a protein involved in response to heat shock, hypoxia and drugs. (641 aa) |
| | Hsp70Bb | Heat-shock-protein-70Bb (Hsp70Bb) encodes a protein involved in response to hypoxia heat shock and. (641 aa) |
| | Hsp70Bbb | Hsp70Bbb (Hsp70Bbb) encodes a protein involved in response to heat shock and hypoxia. (641 aa) |
| | Hsp70Aa | Heat-shock-protein-70Aa (Hsp70Aa) encodes a protein involved in response to heat shock and hypoxia. (642 aa) |
| | Hsp70Ab | Heat-shock-protein-70Ab (Hsp70Ab) encodes a protein involved in response to heat shock and hypoxia. (642 aa) |
| | Ras85D | Ras-like protein 1; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays a role in eye development by regulating cell growth, survival of postmitotic ommatidial cells and differentiation of photoreceptor cells. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis. (189 aa) |
| | RagA-B | Ras-related GTP binding A/B (RagA-B) encodes a Ras family GTPase that forms a heterodimer with the product of RagC-D. The heterodimer localizes on the lysosome surface and functions to relay amino acid signals to activate the product of Tor by recruiting it to the lysosome. (311 aa) |
| | tgo | Aryl hydrocarbon receptor nuclear translocator homolog; Heterodimers of tgo/trh are involved in the control of breathless expression. Plays a role in the cellular or tissue response to oxygen deprivation. (642 aa) |
| | mAChR-B | Muscarinic Acetylcholine Receptor, B-type (mAChR-B) encodes a G protein-coupled receptor activated by acetylcholine; Belongs to the G-protein coupled receptor 1 family. (1019 aa) |
| | Hr39 | Hormone receptor-like in 39 (Hr39) encodes a nuclear hormone receptor protein in subfamily 5. It is a master regulator of female reproductive gland development from the bipotential genital disc, and in adults is required for reproductive gland secretion, ovulation and additional functions. (808 aa) |
| | Hr38 | Hormone receptor-like in 38 (Hr38) encodes a protein that can heterodimerize with the U adult cuticle and for the proper uptake and storage of glycogen in larvae; Belongs to the nuclear hormone receptor family. NR4 subfamily. (1078 aa) |
| | rk | Rickets (rk) encodes a G-protein coupled receptor that signals intracellularly using the second messenger cAMP. It binds the heterodimeric hormone bursicon and is developmentally important for molting-related behaviors. It is also required after adult emergence for cuticle hardening and melanization. (1360 aa) |
| | Sos | Protein son of sevenless; Promotes the exchange of Ras-bound GDP by GTP. Functions in signaling pathways initiated by the sevenless and epidermal growth factor receptor tyrosine kinases; implies a role for the ras pathway in neuronal development. (1596 aa) |
| | Hsp60D | Heat shock protein 60D (Hsp60D) encodes a protein involved in caspase-mediated apoptosis and polyQ-mediated neurodegeneration; Belongs to the chaperonin (HSP60) family. (558 aa) |
| | Edem2 | alpha-1,2-Mannosidase; ER degradation enhancer, mannosidase alpha-like 2 (Edem2) encodes a lectin involved in the degradation of proteins during endoplasmic reticulum (ER) stress, which is generated by the presence of unfolded proteins in the ER; Belongs to the glycosyl hydrolase 47 family. (801 aa) |
| | Sirt1 | NAD-dependent histone deacetylase sirtuin-1; NAD-dependent histone deacetylase involved in heterochromatic silencing. Mildly suppresses the heterochromatin-mediated silencing phenomenon known as position-effect variegation (PEV). Required for epigenetic silencing of the polycomb group proteins. Has histone H4 deacetylase activity in vitro. Required maternally for establishing proper segmentation of the embryo. Involved in sex determination. May be involved in the regulation of life span. (823 aa) |
| | CG6766 | FI04402p; It is involved in the biological process described with: retrograde protein transport, ER to cytosol; ubiquitin-dependent ERAD pathway. (525 aa) |
| | Utx | Utx histone demethylase (Utx) encodes a Jumonji C containing protein that catalyzes the removal of methyl groups from Histone H3 lysine 27. Together with the products of trr and Lpt, it is thought to regulate chromatin structure at transcriptional enhancers. (1136 aa) |
| | STUB1 | Carboxy terminus of Hsp70-interacting protein; STIP1 homology and U-box containing protein 1 (STUB1) encodes a ubiquitin protein ligase involved in insulin signaling pathway regulation and protein ubiquitination. (289 aa) |
| | Hnf4 | Transcription factor HNF-4 homolog; Hepatocyte nuclear factor 4 (Hnf4) encodes a protein that regulates lipid mobilization and fatty acid beta-oxidation during larval stages. Its expression increases greatly at the onset of adulthood when it promotes glucose-stimulated ILP secretion from the insulin-producing cells, maintains glucose homeostasis, and supports mitochondrial function; Belongs to the nuclear hormone receptor family. NR2 subfamily. (732 aa) |
| | Akap200 | A-kinase anchor protein 200; Scaffolding protein involved in the regulation of PKA signaling and anchoring to the actin cytoskeleton integrating signals propagated by cAMP, diacylglycerol and calcium. Contributes to the maintenance and regulation of cytoskeletal structures in germline via PKA-mediated signaling. As part of ethanol response in the glia, mediates ethanol-induced structural remodeling of actin cytoskeleton and perineurial membrane topology by anchoring PKA to the membrane of perineurial glia. In specific tissues such as eye and thorax, promotes N/Notch protein stability b [...] (837 aa) |
| | smt3 | Small ubiquitin-related modifier; Smt3 (smt3) encodes the only Drosophila SUMO family protein. It is required for embryonic patterning and mitosis. It may also have roles in wing patterning, Dpp signaling, and Ras/MAPK signaling. It localizes to the nucleus during interphase and to the kinetochores and midbodies during mitosis; Belongs to the ubiquitin family. SUMO subfamily. (90 aa) |
| | Hsp60C | Heat shock protein 60C (Hsp60C) encodes one of the four Hsp60 family chaperone proteins. It is widely expressed and essential for embryonic viability and tracheal formation. It has essential roles in spermatogenesis and oogenesis, possibly through interaction with F-Actin. (576 aa) |
| | tkv | Receptor protein serine/threonine kinase; Thickveins (tkv) encodes a transforming growth factor beta type I receptor. Together with the product of put, it functions as a receptor of the product of dpp and therefore contributes to the BMP signaling pathway; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (575 aa) |
| | srl | Spargel, isoform B; Transcription coregulator activity; mRNA binding; nuclear receptor transcription coactivator activity; transcription factor binding; nucleic acid binding. (1067 aa) |
| | 5-HT2A | 5-hydroxytryptamine (serotonin) receptor 2A (5-HT2A) encodes a 5-hydroxytryptamine (serotonin) GPCR that belongs to the Class A GPCR family. They bind and transmit the signal from the neurotransmitter 5-HT (serotonin). The family can be subdivided into several subclasses based on pharmacology, signal transduction and structure. There are 5 genes encoding serotonin receptors in the Drosophila melanogaster genome: 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, and 5-HT7. (930 aa) |
| | PEK | Eukaryotic translation initiation factor 2-alpha kinase; Pancreatic eIF-2alpha kinase (PEK) encodes an endoplasmic reticulum (ER) transmembrane kinase and a component of the integrated stress response. During ER stress the product of PEK phosphorylates the translation initiation factor encoded by eIF2alpha resulting in the inhibition of most cap-dependent translation. This is especially important during the development of secretory tissues and the response to cellular stress; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily. (1162 aa) |
| | Rheb | GTP-binding protein Rheb homolog; Binds GTP and exhibits intrinsic GTPase activity (By similarity). Activates the protein kinase activity of TORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K through activation of TORC1 signaling. May also have a role in activating TORC2 signaling. (182 aa) |
| | Itpr | Inositol 1,4,5,-trisphosphate receptor (Itpr) encodes an intracellular ligand gated calcium channel. It functions downstream of G-protein coupled receptors that activate Gq/PLCbeta signaling and generate inositol tris-phosphate. Itpr depletion affects ecdysone release, response to nutritional stress, lipid metabolism and flight; Belongs to the InsP3 receptor family. (2837 aa) |
| | pzg | Putzig, isoform A; Putzig (pzg) encodes a nuclear protein that is involved in chromatin activation of replication related genes and signalling pathways including Notch, Ecdysone and JAK/STAT. It regulates growth, cell death and various developmental processes. (996 aa) |
| | CG5199 | FI02826p; Proteasome-nuclear membrane anchor activity. It is involved in the biological process described with: proteasome localization; proteasome localization to nuclear periphery; nuclear protein quality control by the ubiquitin-proteasome system. (382 aa) |
| | Spp | Signal peptide peptidase; Aspartic endopeptidase activity, intramembrane cleaving. It is involved in the biological process described with: signal peptide processing; cellular response to unfolded protein; membrane protein proteolysis. (389 aa) |
| | Hsp60B | 60 kDa heat shock protein homolog 1, mitochondrial; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. Belongs to the chaperonin (HSP60) family. (648 aa) |
| | GlyP | Glycogen phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity). Required for glycogen breakdown in skeletal muscle. (844 aa) |
| | dpp | Protein decapentaplegic; Required during oogenesis for eggshell patterning and dorsal/ventral patterning of the embryo. Acts as a morphogen during embryogenesis to pattern the dorsal/ventral axis, specifying dorsal ectoderm and amnioserosa cell fate within the dorsal half of the embryo; this activity is antagonized by binding to sog and tsg. Induces the formation of visceral mesoderm and the heart in early embryos. Required later in embryogenesis for dorsal closure and patterning of the hindgut. Also functions postembryonically as a long-range morphogen during imaginal disk development [...] (588 aa) |
| | CG15399 | Uncharacterized protein; GTPase activity. (242 aa) |
| | Thor | 4E-binding protein THOR; Thor (Thor) encodes a eukaryotic translation initiation factor 4E binding protein that is controlled by the product of tor. It contributes to translation regulation, response to environmental stress and cell growth regulation. (117 aa) |
| | Rab10 | LD39986p; Rab10 (Rab10) encodes a small GTPase that contributes to vesicle trafficking regulation. It is involved in basement membrane organization. (204 aa) |
| | Tak1 | Mitogen-activated protein kinase kinase kinase 7; Component of a protein kinase signal transduction cascade. Mediator of TGF-beta signal transduction. Responsible for activation of the JNK MAPK pathway (basket, bsk and hemipterous, hep) in response to LPS. Component of the NF-kappa-B pathway; relish-mediated JNK inhibition involves proteasomal degradation of Tak1; certain targets of Relish that are induced during immune responses may facilitate destruction of Tak1 and switch off the JNK cascade. Participates in diverse roles such as control of cell shape and regulation of apoptosis. (678 aa) |
| | Ir64a | Ionotropic receptor 64a (Ir64a) encodes a member of the Ionotropic Receptor (IR) family of variant ionotropic glutamate receptors. It is part of a broad-specificity acid sensor that mediates avoidance behavior. (859 aa) |
| | Lkr | Leucokinin receptor (Lkr) encodes a 7-transmembrane domain G-protein-coupled receptor (GPCR) with the product of Lk as a ligand. It signals through intracellular calcium, and is implicated in ion regulation by the Malpighian tubules and in feeding control. (542 aa) |
| | sfl | Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in diffusion of morphogen wingless (wg) via its role in heparan sulfate proteoglycans (HSPGs) biosynthesis, HSPGs being required for movement of wg morphogens. Required for wg signaling dur [...] (1048 aa) |
| | sgl | UDP-glucose 6-dehydrogenase; Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate and heparan sulfate. Required for wingless signaling in different tissues; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (476 aa) |
| | pbl | Pebble, isoform B; Pebble (pbl) encodes a Rho guanine nucleotide exchange factor that contributes to multiple processes involving actin cytoskeleton reorganization, including cytokinesis, axogenesis and wound healing as well as cell shape regulation and cell migration during gastrulation. (1311 aa) |
| | ERR | Estrogen-related receptor (ERR) encodes a protein that directly induces a transcriptional switch in mid-embryogenesis, up-regulating the genes that act in biosynthetic pathways associated with aerobic glycolysis. This nuclear receptor establishes the metabolic state that supports growth during larval stages. (496 aa) |
| | BI-1 | Bax inhibitor 1; Suppressor of apoptosis (By similarity). Modulates unfolded protein response signaling. Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation. (245 aa) |
| | Shc | SHC-adaptor protein (Shc) encodes a protein involved in receptor tyrosine kinase signalling. It regulates anti-parasitoid immune response and tracheal development. (409 aa) |
| | Ilp3 | Insulin-like peptide 3 (Ilp3) encodes a peptide involved in the insulin signaling pathway, the sugar-mediated activation of TOR signaling, sleep and mating behavior in females. (120 aa) |
| | Ilp4 | Insulin-like peptide 4 (Ilp4) encodes a protein involved in larval feeding behavior; Belongs to the insulin family. (134 aa) |
| | Ilp2 | Probable insulin-like peptide 2 A chain; Plays a role in regulating body size by increasing cell size and cell number of individual organs. Probably mediates its growth effects by acting as a ligand for the insulin receptor and transducing a signal via the Chico/PI3K/Akt(PKB) pathway. (137 aa) |
| | Ilp1 | Probable insulin-like peptide 1 A chain; Insulin receptor binding; hormone activity. It is involved in the biological process described with: insulin receptor signaling pathway. (154 aa) |
| | Ufd1-like | Ubiquitin fusion degradation protein 1 homolog; Functions at a post-ubiquitation step in the ubiquitin fusion degradation (UFD) pathway; Belongs to the UFD1 family. (316 aa) |
| | btl | Fibroblast growth factor receptor homolog 2; May be required for patterning of muscle precursor cells: generation of mesodermal and endodermal layers, invaginations of various types of cells, and CNS formation. Essential for the ability of the migrating tracheal and midline cells to recognize external guiding cues. (1052 aa) |
| | Hsc70-1 | Heat shock 70 kDa protein cognate 1. (641 aa) |
| | CG32847 | GEO10296p1; Ubiquitin-like protein conjugating enzyme binding; ubiquitin-protein transferase activity; zinc ion binding; ubiquitin protein ligase activity. It is involved in the biological process described with: ER-associated misfolded protein catabolic process; protein ubiquitination; ubiquitin-dependent protein catabolic process. (164 aa) |
| | Galphaf | G protein alpha f subunit (Galphaf) encodes a transcriptional target of the JAK/STAT pathway in blood cells where it regulates cell shape and function; Belongs to the G-alpha family. (399 aa) |
| | ftz-f1 | Nuclear hormone receptor FTZ-F1; Acts as a cofactor to fushi tarazu (ftz). Facilitates the binding of ftz to DNA. Binds the sequence element 5'-YCYYGGYCR-3' in the zebra element of ftz. Probably also functions as a receptor for a yet unknown ligand; Belongs to the nuclear hormone receptor family. NR5 subfamily. (1027 aa) |
| | Uggt | UDP-glucose-glycoprotein glucosyltransferase (Uggt) encodes an enzyme that recognizes glycoproteins with folding defects and adds glucose to N-glycans near the misfolded part of the protein. Uggt product is a component of the calnexin cycle and promotes protein folding in the endoplasmic reticulum along with the protein encoded by Cnx99A and Calr; Belongs to the glycosyltransferase 8 family. (1548 aa) |
| | CG14184 | FI16105p1; Molecular adaptor activity; guanyl-nucleotide exchange factor activity. (180 aa) |
| | Ir76b | Ionotropic receptor 76b (Ir76b) encodes a member of the Ionotropic Receptor (IR) family of variant ionotropic glutamate receptors. It functions in chemosensory detection of various amines and salt, as a probable co-receptor subunit. (636 aa) |
| | gig | Gigas, isoform A; Gigas (gig) encodes a tumour suppressor protein that, together with with the product of Tsc1, controls cellular growth via antagonizing insulin and TOR signalling pathways. (1847 aa) |
| | dome | Cytokine receptor; Critical for epithelial morphogenesis during oogenesis; border cell migration. Required in the germarium for the polarization of follicle cells during encapsulation of germline cells. Required for embryonic segmentation and trachea specification. Essential receptor molecule for upd and JAK/STAT signaling during oogenesis. (1282 aa) |
| | rictor | Rapamycin-insensitive companion of Tor (rictor) encodes an essential component of TOR complex 2 where it controls phosphorylation of protein kinases, such as those encoded by Akt1 and trc. The product of rictor contributes to the regulation of tissue growth, dendritic tiling, long term memory, tolerance to heat stress, and mitochondrial quality control. (1936 aa) |
| | wgn | Tumor necrosis factor receptor superfamily member wengen; Receptor for egr. Involved in induction of apoptosis by triggering JNK signaling. Mediates the tumor suppressor activity of egr which eliminates oncogenic cells from epithelia, thereby maintaining epithelial integrity. Following UV-induced epidermal damage, binds to egr released from apoptotic epidermal cells and plays a role in development of thermal allodynia, a responsiveness to subthreshold thermal stimuli which are not normally perceived as noxious. Together with Moe, involved in control of axon targeting of R8 and R2-R5 ph [...] (343 aa) |
| | CG4880 | LD20971p1; ATPase activity; ATP binding. It is involved in the biological process described with: cellular response to misfolded protein. (351 aa) |
| | Traf-like | TNF-receptor-associated factor-like, isoform A; Protein binding. It is involved in the biological process described with: positive regulation of lipophagy. (474 aa) |
| | CG8974 | GH14055p; Ubiquitin protein ligase activity; ubiquitin-like protein conjugating enzyme binding; zinc ion binding; ubiquitin-protein transferase activity. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; protein ubiquitination; ER-associated misfolded protein catabolic process. (277 aa) |
| | CG32581 | RE35552p; Ubiquitin protein ligase activity; ubiquitin-protein transferase activity; zinc ion binding; ubiquitin-like protein conjugating enzyme binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; ER-associated misfolded protein catabolic process; protein ubiquitination. (283 aa) |
| | Set2 | Probable histone-lysine N-methyltransferase CG1716; Probable histone methyltransferase. Histone methylation gives specific tags for epigenetic transcriptional activation or repression (By similarity). (2362 aa) |
| | hep | Dual specificity mitogen-activated protein kinase kinase hemipterous; Required for the epithelial cell sheet movement called dorsal closure (DC), which allows establishment of the dorsal epidermis. Controls the expression in the dorsal epithelium edges of another dorsal closure gene, puckered (puc). Phosphorylates and activates the MAP kinase bsk; bsk signal transduction pathway mediates an immune response and morphogenesis; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. (1178 aa) |
| | CG32641 | annotation not available (132 aa) |
| | CG32640 | J domain-containing protein. (132 aa) |
| | lic | Licorne (lic) encodes a serine/threonine kinase that phosphorylates p38 MAP kinases. (334 aa) |
| | Hsc70-3 | Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen. Involved in the correct folding of proteins and degradation of misfolded proteins (By similarity). Acts as a key repressor of the unfolded protein response (UPR) (By similarity). (656 aa) |
| | hop | Tyrosine-protein kinase hopscotch; Tyrosine kinase of the non-receptor type, phosphorylates the marelle protein. Required maternally for the establishment of the normal array of embryonic segments: involved in the control of pair- rule gene transcription in a stripe-specific manner. Together with Hsp83 and piwi, mediates canalization, also known as developmental robustness, likely via epigenetic silencing of existing genetic variants and suppression of transposon-induced new genetic variation. (1177 aa) |
| | Hsp60A | Heat shock protein 60A; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. Belongs to the chaperonin (HSP60) family. (573 aa) |
| | Rab9Fa | Rab at 9Fa; GTP binding; GTPase activity. (197 aa) |
| | Rab9Fb | Rab at 9Fb; GTPase activity; GTP binding. (214 aa) |
| | Chd64 | Transgelin; Chd64 (Chd64) encodes a protein involved in the juvenile hormone mediated signaling pathway; Belongs to the calponin family. (188 aa) |
| | Ack | Activated Cdc42 kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1073 aa) |
| | CG32276 | GEO09675p1; It is involved in the biological process described with: endoplasmic reticulum unfolded protein response; protein glycosylation. (64 aa) |
| | wfs1 | Wolframin; Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store (By similarity). In neurons and glial cells, has a role in maintaining neuronal function and integrity during aging. (853 aa) |
| | Gba1a | Glucosylceramidase; Hydrolase activity; glucosylceramidase activity; glucosyltransferase activity. (561 aa) |
| | Nup98-96 | Nuclear pore complex protein Nup98-Nup96; Part of the nuclear pore complex (NPC). Required for MAD import as part of the Nup107-160 complex and required for nuclear export of Moe probably via its association with Rae1. Plays a role in nuclear mRNA export. Promotes cell antiviral response by upregulating FoxK-dependent antiviral gene transcription. In germline stem cells, involved in their maintenance and division together with the TGF-Beta and EGFR signaling pathways. In larval lymph glands, has a role in the maintenance of hematopoiesis by regulating Pvr expression. [Nuclear pore comp [...] (1960 aa) |
| | Tsc1 | LD23779p; Tsc1 (Tsc1) encodes a tumour suppressor protein that forms a complex with the product of gig. They control cellular growth via antagonizing insulin and TOR signalling pathways. (1100 aa) |
| | Hsp68 | Heat shock protein 68 (Hsp68) encodes a protein involved in lifespan determination and response to heat shock and starvation. (635 aa) |
| | RabX4 | RabX4; GTPase activity; GTP binding. (213 aa) |
| | Vps33B | Vacuolar protein sorting 33B (Vps33B) encodes a member of the family of SM proteins, which in conjunction with SNARE proteins catalyze membrane fusion events. The product of Vps33B, together with its binding partner encoded by Vps16B, forms a complex that is necessary for fusions between phagosomes and lysosomes; Belongs to the STXBP/unc-18/SEC1 family. (640 aa) |
| | Lgr3 | Leucine-rich repeat-containing G protein-coupled receptor 3 (Lgr3) encodes a protein activated by the relaxin-like hormone encoded by Ilp8, which coordinates organ growth. (765 aa) |
| | pll | Serine/threonine-protein kinase pelle; Plays an essential role in the Tl receptor signaling pathway that establishes embryonic dorsoventral polarity; the signal directs import of dl into ventral and ventrolateral nuclei, thereby establishing dorsoventral polarity. Tub recruits pll to the plasma membrane and protein-protein interaction activates pll. (501 aa) |
| | Vps16B | Vacuolar protein sorting 16B (Vps16B) encodes a protein that, together with its binding partner encoded by Vps33B, forms a distinct complex necessary for fusions between phagosomes and lysosomes. (447 aa) |
| | Tace | ADAM 17-like protease; Tace (Tace) encodes a transmembrane anchored, cell surface metalloprotease and member of the ADAM family of proteins. The product of Tace, along with the related ADAM protease encoded by kuz, performs ectodomain shedding by cleaving cell surface receptors and/or ligands to affect cell-cell signaling or adhesion. Both proteases are implicated in the Notch signaling pathway. (732 aa) |
| | Atf6 | Atf6, isoform C; DNA-binding transcription factor activity. It is involved in the biological process described with: regulation of transcription, DNA-templated. (741 aa) |
| | Trap1 | Trap1, isoform A; Trap1 (Trap1) encodes a mitochondrial chaperone protein of the heat shock protein (HSP90) family. It shows an ATPase activity and is involved in neurodegeneration associated with mitochondrial dysfunction. (691 aa) |
| | Toll-7 | Toll-like receptor 7; Toll-related receptor which binds to the neurotrophins NT1 and spz5. Essential for antiviral autophagy, it detects and binds to the vesicular stomatitis virus (vsv) following infection. This role is likely to be independent of the canonical Toll, immune deficiency, and JAK-STAT signaling pathways. Functions in olfactory circuit assembly by promoting synaptic partner matching between olfactory receptor neurons (ORN) axons and projection neurons (PN) dendrites partners in the antennal lobe. Function in the Va1d ORNs is necessary and sufficient for correct targeting [...] (1446 aa) |
| | Pepck2 | Phosphoenolpyruvate carboxykinase (GTP) activity; manganese ion binding; GTP binding. (638 aa) |
| | Pepck1 | Phosphoenolpyruvate carboxykinase 1 (Pepck1) encodes an enzyme that converts oxaloacetate into phosphoenolpyruvate. It catalyzes the first committed step in gluconeogenesis and thus plays an essential role in glucose metabolism. (647 aa) |
| | Gbp1 | Growth-blocking peptide 1 (Gbp1) encodes a cytokine that regulates the humoral immune response. (118 aa) |
| | Parp16 | Protein mono-ADP-ribosyltransferase Parp16; Intracellular mono-ADP-ribosyltransferase that may play a role in different processes through the mono-ADP-ribosylation of proteins involved in those processes. Required for amino acid starvation-induced mono-ADP-ribosylation and subsequent formation of Sec bodies - which are stress assemblies that promote cell survival by preserving components of the ER exit sites (ERES) during amino-acid starvation. Catalyzes the mono-ADP-ribosylation of Sec16 which is essential for Sec body formation. (359 aa) |
| | Dh44-R1 | Diuretic hormone 44 receptor 1 (Dh44-R1) encodes a G-Protein Coupled Receptor of the Family B class of GPCRs (Secretin Receptor-like). It is involved in regulation of diuresis, sperm storage in females and circadian control of locomotion. (504 aa) |
| | Sin1 | Stress-activated map kinase-interacting protein 1; Component of a multiprotein complex that phosphorylates Akt1, a protein that regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. (569 aa) |
| | Hsc70-5 | Heat shock 70 kDa protein cognate 5. (686 aa) |
| | drk | Protein enhancer of sevenless 2B; Downstream of receptor kinase (drk) encodes an adaptor protein that recognizes phosphorylated tyrosine residues of membrane receptors and triggers the Ras/Raf/MAPK pathway. drk product contributes to the regulation of cytoskeletal organization and participates in developmental and cognitive processes (associative learning, anesthesia resistant memory). (211 aa) |
| | Iswi | Chromatin-remodeling complex ATPase chain Iswi; Energy-transducing component of the chromatin-remodeling complexes NURF (nucleosome-remodeling factor), ACF (ATP-utilizing chromatin assembly and remodeling factor), and CHRAC (chromatin accessibility complex). NURF catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. It is required for homeotic gene expression, proper larval blood cell development, normal male X chromosome morphology, ecdysteroid signaling and metamorphosis. (1027 aa) |
| | ths | Thisbe, isoform A; Thisbe (ths) encodes is a Fibroblast growth factor (FGF) and ligand for the FGF receptor encoded by htl. It regulates the development of somatic and visceral muscle in the mesoderm, cardioblasts and glial cells. Its roles include acting as a chemoattractant in directional cell migration, and regulating adhesion, differentiation, and cell survival. (748 aa) |
| | nclb | Periodic tryptophan protein 1 homolog; Chromatin-associated factor that regulates transcription. Regulates Pol I-mediated rRNA biogenesis and, probably, Pol III-mediated transcription. Regulates the localization to the nucleolus of Cdk7, a regulator of the Pol I- elongation factor TFIIH. Acts as regulator of cell proliferation and tissue growth as part of the TORC1 and Myc signaling pathway in response to nutrients. Required in males for both germline stem cell (GSC) maintenance and early stages of germ cell differentiation of germ cell cysts. Not required for female germline stem cell [...] (459 aa) |
| | egr | Protein eiger, membrane form; Cytokine which acts as a ligand for wgn. Also acts as a ligand for grnd. Induces apoptosis by triggering JNK signaling. Required for JNK-dependent non-autonomous apoptosis through release from apoptotic cells and activation of apoptosis in neighboring cells. Required for JNK-independent damage-induced apoptosis in the embryonic central nervous system through regulation of the pro-apoptotic gene hid. Involved in the innate immune response to extracellular pathogens. Plays a role in the melanization immune response through its involvement in the rupture of c [...] (415 aa) |
| | Pka-R2 | cAMP-dependent protein kinase type II regulatory subunit; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Mediates membrane association by binding to anchoring proteins, such as Akap200. Might play an essential role in the regulation of neuronal activity in the brain. (377 aa) |
| | babo | Receptor protein serine/threonine kinase; Baboon (babo) encodes the type I receptor for the activin-like ligands encoded by daw, Actbeta and myo. There are three isoforms of the product of babo that differ only in their extracellular domain likely resulting in different ligand binding specificity. It can form a complex with the type II receptors put or wit in the presence of an activin like ligand. This results in the transcriptional regulation of activin responsive genes; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (622 aa) |
| | sand | RE21922p; Potassium ion leak channel activity; potassium channel activity. It is involved in the biological process described with: negative regulation of membrane potential; negative regulation of circadian sleep/wake cycle, sleep; stabilization of membrane potential; potassium ion transmembrane transport; cellular response to dopamine; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (395 aa) |
| | RagC-D | Protein heterodimerization activity; GTP binding; GTPase activity. It is involved in the biological process described with: regulation of autophagy; positive regulation of TOR signaling; cellular response to starvation; positive regulation of TORC1 signaling; cellular response to amino acid stimulus. (385 aa) |
| | ACC | Acetyl-CoA carboxylase (ACC) encodes a ubiquitous metabolic enzyme. It catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting substrate for fatty acid synthesis. It is essential in the embryo and in the oenocytes (specialized abdominal cells) for the watertightness of the respiratory system. It is required in the fat body for triglyceride storage and in the muscles for locomotor activity. (2482 aa) |
| | Drat | Death resistor Adh domain containing target (Drat) encodes a member of the zinc-dependent ADH-like family that is an effector of ethanol-induced apoptosis. (434 aa) |
| | mav | Maverick (mav) encodes a protein involved in the BMP signaling pathway. (701 aa) |
| | PGRP-LC | Peptidoglycan-recognition protein LC; Major activator of the imd/Relish pathway and is likely to encode a pattern recognition molecule for the humoral immune response. Required for Relish processing and nuclear translocation following proteolytic cleavage. Involved in the response to lipopolysaccharide (LPS) and peptidoglycan of Gram-negative bacteria. The different isoforms probably display different recognition capabilities to various microbial patterns. [Isoform x]: Mediates the response to LPS, peptidoglycan and Gram-negative bacteria; Belongs to the N-acetylmuramoyl-L-alanine amid [...] (520 aa) |
| | Sh | Potassium voltage-gated channel protein Shaker; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Forms rapidly inactivating tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient and may contribute to A- type currents. Plays a role in the regulation of sleep need or efficiency ; Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) s [...] (655 aa) |
| | pnt | ETS-like protein pointed; ETS transcription factor with a prominent role during development of the eye and the nervous system. Required for glial- neuronal cell interactions at the ventral midline which are necessary for the proper elaboration of commissures in the embryonic CNS. [Isoform P1]: Required for normal EGFR-induced photoreceptor development. Following transcriptional activation by isoform P2, acts as a constitutive activator of transcription, leading to induction of target genes essential for photoreceptor development. In larval brains, involved in the maintenance of type II [...] (718 aa) |
| | AstC-R1 | Allatostatin C receptor 1 (AstC-R1) encodes G-protein coupled receptor for the neuropeptide encoded by AstC. (483 aa) |
| | gro | Groucho (gro) encodes a global developmental co-repressor in conjunction with manifold DNA-binding repressor partner proteins, which tether it to target promoters. It functions downstream of key signaling pathways such as Wg/Wnt and Dpp/TGF-beta. Notably, phosphorylation of the product of gro in response to MAPK activation weakens its repressor capacity. (730 aa) |
| | cact | NF-kappa-B inhibitor cactus; Involved in the formation of the dorsoventral pattern. It inhibits nuclear translocation of the dorsal morphogen in the dorsal region of the embryo. Acts as a negative regulator of the NF-kappa-B (rel) signaling pathway. Cact is degraded by IKKbeta, this is essential for NF-kappa-B (rel) activation. (500 aa) |
| | Pka-C1 | cAMP-dependent protein kinase catalytic subunit 1; Serine/threonine-protein kinase involved in memory formation. Promotes long-term memory by phosphorylating meng and by regulating CrebB protein stability and activity. As part of ethanol response in the glia, mediates ethanol-induced structural remodeling of actin cytoskeleton and perineurial membrane topology when anchored to the membrane. (353 aa) |
| | DopEcR | Dopamine/Ecdysteroid receptor (DopEcR) encodes a GPCR that shows ligand-biased activation. It can be activated by dopamine to increase cyclic AMP levels and by the insect steroid ecdysone to activate the MAPKinase pathway. It is widely expressed in the nervous system and can modulate a wide variety of complex behaviors including male courtship, locomotion, the response to stressful social interactions and the regulation of appetite. (322 aa) |
| | rdx | Protein roadkill; Involved in segment polarity. In complex with gft/CUL3, promotes ubiquitination of ci and its subsequent degradation by the proteasome, which results in hh signaling attenuation. This regulation may be important during eye formation for proper packing of ommatidia into a hexagonal array. (829 aa) |
| | CG17760 | SD21019p; GTPase activity; G protein-coupled receptor binding; guanyl nucleotide binding; G-protein beta/gamma-subunit complex binding. It is involved in the biological process described with: adenylate cyclase-modulating G protein-coupled receptor signaling pathway; phospholipase C-activating dopamine receptor signaling pathway. (353 aa) |
| | Pdxk | Pyridoxal kinase (Pdxk) encodes the enzyme that generates Pyridoxal-5-phosphate, the metabolically active form of vitamin B6. It contributes to chromosome integrity and glucose homeostasis. (304 aa) |
| | pyr | Pyramus (pyr) encodes a Fibroblast growth factor (FGF) and ligand for the FGF receptor encoded by htl. It regulates the development of somatic and visceral muscle in the mesoderm, cardioblasts and glial cells. Its roles include acting as a chemoattractant in directional cell migration, and regulating adhesion, differentiation, and cell survival. (766 aa) |
| | Dh44-R2 | Diuretic hormone 44 receptor 2 (Dh44-R2) encodes a protein that exhibits diuretic hormone receptor activity. It is involved in G protein-coupled receptor signaling pathways, hormone-mediated signaling pathways, and response to salt stress. (476 aa) |
| | Sesn | Sestrin (Sesn) encodes a stress-inducible protein that suppresses accumulation of reactive oxygen species and inhibits the TORC1 signaling pathway, which allows it to regulate oxidative damage. (497 aa) |
| | Ire1 | Inositol-requiring enzyme-1 (Ire1) encodes a transmembrane protein that mediates the unfolded protein response. Misfolded peptides in the endoplasmic reticulum activate the RNase activity of the product of Ire1, thereby promoting the cleavage of its downstream substrates, such as Xbp1 mRNA. The product of Ire1 is also required for photoreceptor differentiation. (1074 aa) |
| | CG32335 | RE72485p; Hydrolase activity, acting on ester bonds; zinc ion binding. (322 aa) |
| | Ilp8 | Insulin-like peptide 8 (Ilp8) encodes a divergent member of the insulin/IGF/relaxin-like family that acts through the relaxin receptor encoded by Lgr3. It coordinates growth status of tissues with developmental timing. (150 aa) |
| | grh | Protein grainyhead; Grainy head (grh) encodes the founding member of a highly conserved family of transcription factors essential for embryonic development. It is both a transcriptional activator and repressor, responsible for the proper expression of many genes primarily involved in epithelial cell fate, barrier formation, wound healing, tube morphogenesis and proliferation of larval neuroblasts; Belongs to the grh/CP2 family. Grainyhead subfamily. (1333 aa) |
| | CG5189 | Ragulator complex protein LAMTOR2 homolog; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. Belongs to the GAMAD family. (125 aa) |
| | Duox | Dual oxidase; Plays a role in innate immunity limiting microbial proliferation in the gut. Acts downstream of a hh-signaling pathway to induce the production of reactive oxygen species (ROS) in response to intestinal bacterial infection. May generate antimicrobial oxidative burst through its peroxidase-like domain. (1537 aa) |
| | CG32638 | FI19011p1; It is involved in the biological process described with: angiotensin-activated signaling pathway. (159 aa) |
| | Cul3 | Cullin 3, isoform F; Ubiquitin protein ligase binding; molecular adaptor activity; ubiquitin-protein transferase activity; protein binding; Belongs to the cullin family. (934 aa) |
| | bsk | Stress-activated protein kinase JNK; Responds to activation by environmental stress by phosphorylating a number of transcription factors, primarily components of AP-1 such as Jra and also the transcriptional repressor aop, and thus regulates transcriptional activity. Component of the immune response activated by bacterial infection, and is involved in wound healing and in dorsal closure, a morphogenetic movement during embryogenesis. Functions in the systematic response to wounding acting downstream of the Hayan-phenoloxidase PPO1 cascade. Exhibits cytoprotective activity in neuronal c [...] (372 aa) |
| | CG30054 | Uncharacterized protein, isoform E; Guanyl nucleotide binding; G-protein beta/gamma-subunit complex binding; GTPase activity; G protein-coupled receptor binding. It is involved in the biological process described with: adenylate cyclase-modulating G protein-coupled receptor signaling pathway; phospholipase C-activating dopamine receptor signaling pathway. (353 aa) |
| | EcR | Ecdysone receptor (EcR) encodes a protein that interacts with the product of usp to form the nuclear ecdysone receptor heterodimer, which modulates, in conjunction with co-activators and co-repressors, the activities of hundreds of genes in a tissue- and stage-specific way. EcR is widely expressed in embryonic and larval tissues and in some adult tissues where its activities (modulated by the hormone ecdysone) trigger both molting and metamorphosis. (878 aa) |
| | Rap1 | Ras-related protein Rap1; Rap1 GTPase (Rap1) encodes a small GTPase in the Ras superfamily. When GTP bound, it binds to a number of different effectors, one of which is the product of scno. Together they regulate many morphogenetic movements including mesoderm invagination and dorsal closure, help establish apical-basal polarity during cellularization, regulate macrophage migration, help define neuroblast asymmetric division, and play a role in planar cell polarity in the imaginal discs. (184 aa) |
| | gce | Germ cell-expressed bHLH-PAS (gce) encodes a bHLH-PAS domain transcription factor paralogous to the product of Met. It is a receptor for the sesquiterpenoid juvenile hormone. (959 aa) |
| | Lpin | Lipin, isoform A; Lipin (Lpin) encodes a protein that plays a central role in fat body function and energy metabolism. It works as a phosphatidate phosphatase required for normal insulin pathway signaling. (1089 aa) |
| | slpr | Mitogen-activated protein kinase kinase kinase; Activates the JUN N-terminal pathway during dorsal closure. (1155 aa) |
| | Sik3 | ATP binding; protein serine/threonine kinase activity. (1471 aa) |
| | Nup358 | E3 SUMO-protein ligase RanBP2; E3 SUMO-protein ligase (By similarity). Component of the nuclear pore complex (NPC), a complex required for trafficking across the nuclear envelope. Required for nuclear import of nuclear localization signal (NLS)-containing proteins in an importin alpha/importin beta-dependent manner, but also for the nuclear import of specific proteins such as phosphorylated Mad or the sesquiterpenoid juvenile hormone receptor Met as part of the juvenile hormone signal transduction pathway. Plays a role in nuclear mRNA export by recruiting the mRNA transport complex com [...] (2718 aa) |
| | Cam | Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+) (By similarity). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). In photoreceptor cells, light-induced Ca(2+) influx activates calmodulin, which in turn is likely to promote Crag activity in trafficking of newly synthesized ninaE (Rh1) from the trans-Golgi network to rhabdomere membranes. Together with Akap200, regulates PKA activity and ethanol-induced sensitivity and tolerance. (149 aa) |
| | tai | Taiman, isoform G; Taiman (tai) encodes an ecdysone receptor co-activator related to mammalian steroid receptor coactivator (SRC) proteins. It contributes to border cell migration. (2047 aa) |
| | foxo | Forkhead box protein O; Transcription factor involved in the regulation of the insulin signaling pathway. Consistently activates both the downstream target Thord4EBP and the feedback control target InR. Involved in negative regulation of the cell cycle, modulating cell growth and proliferation. In response to cellular stresses, such as nutrient deprivation or increased levels of reactive oxygen species, foxo is activated and inhibits growth through the action of target genes such as Thor. Foxo activated in the adult fat body can regulate lifespan in adults; an insulin peptide itself m [...] (622 aa) |
| | Tab2 | TAK1-associated binding protein 2 (Tab2) encodes a protein with an ubiquitin binding domain. It interacts with the product of Tak1, a MAP kinase kinase kinase involved the activation of the immune deficiency, JNK and Grindelwald-Eiger pathways. (831 aa) |
| | Lst | Limostatin, isoform B; Limostatin (Lst) encodes a peptide hormone produced by endocrine corpora cardiaca cells during starvation. It suppresses insulin production and secretion from insulin-producing cells by signaling through the G-protein coupled receptor encoded by PK1-R. (152 aa) |
| | CG5110 | Ragulator complex protein LAMTOR3 homolog; CG5110 encodes a scaffold protein that associates with the MAP kinase kinase and the MAP kinase encoded by Mekk1 and rl respectively. It regulates the vein promoting function of rl during wing imaginal disc development in third instar larvae; Belongs to the LAMTOR3 family. (124 aa) |
| | Toll-6 | Toll-like receptor 6; Toll-related receptor which binds to the neurotrophin spz5. Functions in olfactory circuit assembly by promoting synaptic partner matching between olfactory receptor neurons (ORN) axons and projection neurons (PN) dendrites partners in the antennal lobe. Involved in the targeting of specific classes of PN dendrites (Va1d, Va1v, DC3 and DA1). Functions with Toll-7 to regulate motor axon targeting and neuronal survival in the central nervous system (CNS). Possibly functions with 18w and Toll-8 during convergent extension, to help direct proper planar cell polarity, [...] (1514 aa) |
| | Eip75B | Ecdysone-induced protein 75B (Eip75B) encodes a nuclear receptor that interacts with the receptor encoded by Hr3. The product of Eip75B regulates feeding behavior, fat deposition, and developmental timing in response to nitric oxide (NO) signaling. It also acts downstream from NO in the nervous system, where it controls neuronal remodeling. (1412 aa) |
| | DOR | Diabetes and obesity regulated (DOR) encodes a transcriptional coactivator of ecdysone receptor signaling required during metamorphosis. It is antagonized by insulin signaling via the product of foxo in the fat body and forms part of a feed-forward mechanism whereby ecdysone potentiates its own signaling. The product of DOR also regulates autophagosome formation and protein degradation via ecdysone signaling. (417 aa) |
| | Hydr2 | Abhydrolase domain-containing protein 2; Alpha/beta hydrolase2 (Hydr2) encodes a lipase involved in lipid metabolism; Belongs to the AB hydrolase superfamily. AB hydrolase 4 family. (398 aa) |
| | et | Eye transformer (et) encodes a type 1 cytokine receptor in the JAK/STAT pathway that behaves as a dominant negative receptor. It plays a key role in the larval hematopoietic organ the lymph gland under wasp parasitism. (645 aa) |
| | sax | Receptor protein serine/threonine kinase; Saxophone (sax) encodes a type I BMP receptor. Together with the BMP receptors encoded by tkv and put, it transduces signaling of the BMP ligands encoded by dpp, gbb and scw, in a wide variety of developmental processes including embryonic and imaginal disc patterning; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (582 aa) |
| | lwr | Lesswright (lwr) encodes Ubc9, a SUMO conjugating enzyme that accepts SUMO from the SUMO activating enzyme and hands it off to the SUMO conjugation target. It has documented biological functions in innate immunity, meiosis, and anterior patterning of the embryo. (159 aa) |
| | Xbp1 | X box binding protein-1 (Xbp1) encodes a transcription factor that mediates the unfolded protein response. Xbp1 mRNA undergoes splicing after being cleaved by the product of Ire1, inducing the expression of ER quality control transcripts. Xbp1 mutants fail to develop beyond the 2nd instar larval stage, indicative of a requirement to resolve inherent ER stress during normal development. (498 aa) |
| | 5-HT1B | 5-hydroxytryptamine (serotonin) receptor 1B (5-HT1B) encodes a 5-hydroxytryptamine (serotonin) GPCR that belongs to the Class A GPCR family. They bind and transmit the signal from the neurotransmitter 5-HT (serotonin). The family can be subdivided into several subclasses based on pharmacology, signal transduction and structure. There are 5 genes encoding serotonin receptors in the Drosophila melanogaster genome: 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, and 5-HT7. (629 aa) |
| | CrzR | Corazonin receptor (CrzR) encodes a member of the Class A family of G-protein-coupled receptor that transduces the siganl of the neuropeptide encoded by Crz. It is involved in ethanol-induced behavior and ethanol metabolism. (644 aa) |
| | wit | Receptor protein serine/threonine kinase; Wishful thinking (wit) encodes a BMP Type II Receptor that, upon binding of the ligand encoded by gbb, makes a complex with either tkv or sax encoding BMP type I receptors. This complex initiates phosphorylation and nuclear translocation of the transcription factor encoded by Mad. wit product controls synaptic homeostasis and neurotransmission at the neuromusclular junction during larval development. It also regulates the peptidergic phenotype of several neurosecretory cells; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase [...] (913 aa) |
| | CG14977 | Ragulator complex protein LAMTOR4 homolog; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. (164 aa) |
| | kek6 | Kekkon 6, isoform B; Neurotrophin binding; neurotrophin receptor activity. It is involved in the biological process described with: regulation of synaptic plasticity. (843 aa) |
| | sip3 | E3 ubiquitin-protein ligase HRD1; Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin- dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins. Protects cells from ER stress-induced apoptosis. Sequesters p53 in the cytoplasm and pro [...] (626 aa) |
| | 5-HT2B | 5-hydroxytryptamine (serotonin) receptor 2B (5-HT2B) encodes a 5-hydroxytryptamine (serotonin) GPCR that belongs to the Class A GPCR family. They bind and transmit the signal from the neurotransmitter 5-HT (serotonin). The family can be subdivided into several subclasses based on pharmacology, signal transduction and structure. There are 5 genes encoding serotonin receptors in the Drosophila melanogaster genome: 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, and 5-HT7. (947 aa) |
| | CG4603 | Ubiquitin thioesterase OTU1; Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. (371 aa) |
| | Tl | Protein toll; Receptor for the cleaved activated form of spz, spaetzle C- 106. Binding to spaetzle C-106 activates the Toll signaling pathway and induces expression of the antifungal peptide drosomycin. Component of the extracellular signaling pathway that establishes dorsal-ventral polarity in the embryo. Promotes heterophilic cellular adhesion. Involved in synaptic targeting of motoneurons RP5 and V to muscle 12 (M12); functions as a repulsive cue inhibiting motoneuron synapse formation on muscle 13 (M13) to guide RP5 and V to the neighboring M12, where its expression is repressed by [...] (1117 aa) |
| | Crtc | CREB-regulated transcription coactivator (Crtc) encodes a highly conserved transcriptional coactivator of cAMP-response element-binding protein (CREB). Its nuclear localization is regulated by several factors including intracellular cAMP or calcium levels, or calcineurin. Sik family kinases also phosphorylate to inhibit the product of Crtc and, consequently, control energy homeostais and lipid metabolism. (889 aa) |
| | put | Serine/threonine-protein kinase receptor; Punt (put) encodes a transforming growth factor beta type II receptor that functions in both Dpp/BMP and Activin signaling. Pathway specificity in signaling output is determined by which type I receptor (Dpp/BMP or Activin one) is engaged in the complex with the product of put; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (520 aa) |
| | Dop1R2 | Dopamine receptor 2; Receptor for dopamine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Also capable of generating a calcium signal. In terms of antagonist responses, would be classed with the D1-like dopamine receptor group. This receptor is an attractive candidate for initiating biochemical cascades underlying olfactory learning. (807 aa) |
| | fkh | Fork head (fkh) encodes a winged-helix nuclear transcription factor most studied for its role in salivary gland formation, where it is required for salivary gland viability, invagination, and maintaining expression of other early-expressed salivary gland transcription factors. It works with the product of sage to activate expression of salivary gland specific gene products, such as secreted proteins and their modifying enzymes. (692 aa) |
| | br | Broad-complex core protein isoform 6; Broad-complex proteins are required for puffing and transcription of salivary gland late genes during metamorphosis. (1011 aa) |
| | shn | Schnurri, isoform F; Schnurri (shn) encodes a zinc finger C2H2 transcription factor involved in Dpp signaling. It contributes to multiple processes including ectoderm and midgut development, wing disc patterning and morphogenesis of Malpighian tubules and dendrites. (2587 aa) |
| | aop | Ets DNA-binding protein pokkuri; Anterior open (aop) encodes a transcriptional repressor of the ETS family. It acts downstream of receptor tyrosine kinase signaling to regulate cell fate transitions critical to the development of many tissues including the nervous system, heart, trachea and eye. (732 aa) |
| | Dop1R1 | Dopamine receptor 1; Receptor for dopamine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Might be involved in the processing of visual information and/or visual learning. Important for Pavlovian conditioning: required in the mushroom body as a receptor conveying unconditional stimuli information, has a role in memory formation for aversive and appetitive learning. Sleep-deprivation-induced impairments in learning can be partially explained through alterations in dopamine signaling, Dop1R1 expression levels are reduced; sleep may have a role i [...] (560 aa) |
| | Oamb | Octopamine receptor Oamb; Receptor for octopamine (OA) which is a neurotransmitter, neurohormone and neuromodulator in invertebrates. Stimulates intracellular accumulation of cAMP and Ca(2+) following ligand binding. Required for ovulation. Following activation on mature follicle cells by OA, induces activity of the metalloprotease Mmp2 which leads to breakdown of the posterior follicle wall, resulting in ovulation. Ligand binding probably also leads to activation of CamKII which is also required for ovulation. Modulates sleep/wake behavior by acting in neurons of the pars intercerebra [...] (751 aa) |
| | Dh31-R | Diuretic hormone 31 Receptor (Dh31-R) encodes a protein that exhibits diuretic hormone receptor activity. It is involved in G protein-coupled receptor signaling pathwayS; Belongs to the G-protein coupled receptor 2 family. (604 aa) |
| | Pi3K21B | Pi3K21B, isoform B; Pi3K21B (Pi3K21B) encodes an adaptor protein (p60) that binds the product of Pi3K92E to form the functional cllass IA phosphoinositide 3-kinase. This heterodimeric kinase is involved in phosphatidylinositol phosphorylation and regulates cell size and proliferation. (496 aa) |
| | Myc | Myc protein; Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence CAC[GA]TG. Seems to activate the transcription of growth-related genes; required for cellular proliferation and growth. Functions in the TORC2-mediated regulation of cell growth, acting downstream of the TORC2 complex. Inhibits the demethylase activity of Lid. Activates transcription of mbm. Has a role in ribosome biogenesis and endoreplication in fat body cells by activating the transcription of LTV1. Able to induce the SCF E3 ubiqui [...] (717 aa) |
| | Blimp-1 | Blimp-1, isoform B; Blimp-1 (Blimp-1) encodes a zinc finger transcription repressor that is induced by 20-hydroxylecdysone and plays important roles for metamorphosis. It also contributes to embryonic trachea formation. (1216 aa) |
| | CG13398 | FI23523p1. (442 aa) |
| | crc | Cryptocephal, isoform A; Cryptocephal (crc) encodes a protein that belongs to a member of the CREB/ATF family of basic-leucine zipper transcription factors. It serves as an coactivator of the product EcR of to promote expression the molting peptide hormone encoded by ETH. It also acts as an unfolded protein response transcription factor to regulate glycolytic genes in response to ER stress. (381 aa) |
| | E(bx) | Nucleosome-remodeling factor subunit NURF301; Histone-binding component of NURF (nucleosome remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. Required for homeotic gene expression, proper larval blood cell development, normal male X chromosome morphology, ecdysteroid signaling and metamorphosis. Belongs to the BPTF family. (2761 aa) |
| | grnd | Grindelwald (grnd) encodes a receptor of the TNF superfamily ligand encoded by egr, which activates the intracellular JNK pathway. It is involved in apoptosis and neoplastic growth. (241 aa) |
| | Mad | Mothers against dpp (Mad) encodes the primary transcription factor that mediates cellular response to the BMP like ligands encoded by dpp, scw and gbb. Upon phosphorylation by either the products of sax or tkv (type I BMP receptors), it forms a complex with the product of Med and translocates to the nucleus where, together with cofactors, it regulates expression of BMP response target genes; Belongs to the dwarfin/SMAD family. (525 aa) |
| | Edem1 | alpha-1,2-Mannosidase; ER degradation enhancer, mannosidase alpha-like 1 (Edem1) encodes a lectin in the endoplasmic reticulum (ER) lumen that helps to recognize specific misfolded glycoproteins in this cellular compartment for retro-translation to the cytoplasm and ubiquitin-mediated degradation. This process is referred to as "ER-Associated Degradation"; Belongs to the glycosyl hydrolase 47 family. (1004 aa) |
| | G9a | G9a, isoform B; G9a (G9a) encodes a histone-lysine methyltransferase involved in epigenetic regulation. It contributes to multiple processes including gene expression, dendrite morphogenesis, larval locomotory behavior as well as short and long-term memory. (1657 aa) |
| | Galphaq | G protein alpha q subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Could be the transducin analog, an amplifier and one of the transducers of a visual impulse that performs the coupling between opsin and cGMP-phosphodiesterase. Could mediate a subset of olfactory and gustatory responses. (396 aa) |
| | Pdk1 | 3-phosphoinositide-dependent protein kinase 1; Serine/threonine kinase required for embryonic development. Inhibits apoptosis. Acts in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and activating Akt1 and S6k. May be involved in axonal pathfinding and synaptogenesis, and in spermatogenesis. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily. (836 aa) |
| | dsf | Dissatisfaction, isoform A; Dissatisfaction (dsf) encodes a nuclear receptor that regulates hemocyte proliferation, courtship behavior and neural differentiation. (691 aa) |
| | S6k | Ribosomal protein S6 kinase (S6k) encodes an important component of the target of rapamycin pathway. It is involved in the control of synapse development, autophagy and cell size. (490 aa) |
| | HDAC4 | Histone deacetylase 4, isoform G; Histone deacetylase 4 (HDAC4) encodes a Class IIa histone deacetylase that modulates gene expression by associating with transcriptional factors. It is regulated by nucleocytoplasmic shuttling and contributes to embryogenesis, muscle development, circadian function, energy balance and memory. (1269 aa) |
| | chico | Insulin receptor substrate 1; Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity). May mediate the control of various cellular processes by insulin-like peptides. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains. Involved in control of cell proliferation, cell size, and body and organ growth throughout development. Also has a role in a signaling pathway controlling the physiological response required to endure periods of low nutrient conditions. Insulin/insulin-like growth fac [...] (968 aa) |
| | CG14812 | EG:131F2.3 protein; Guanyl-nucleotide exchange factor activity. It is involved in the biological process described with: negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; cellular response to amino acid stimulus; positive regulation of TORC1 signaling; viral genome replication; positive regulation of TOR signaling. (100 aa) |
| | usp | Protein ultraspiracle; Receptor for ecdysone. May be an important modulator of insect metamorphosis. Plays an important part in embryonic and post- embryonic development. Binds to ecdysone response elements (ECRES) such as in the promoter region of s15 chorion gene; Belongs to the nuclear hormone receptor family. NR2 subfamily. (508 aa) |
| | Snmp1 | Sensory neuron membrane protein 1; Plays an olfactory role that is not restricted to pheromone sensitivity. Has a role in detection and signal transduction of the fatty-acid-derived male pheromone 11-cis vaccenyl acetate (cVA). Not required for sensitivity to general odorants. Acts in concert with Or67d and lush to capture cVA molecules on the surface of Or67d expressing olfactory dendrites and facilitate their transfer to the odorant-receptor Orco complex. Essential for the electrophysiological responses of these olfactory sensory neurons (OSNs) to cVA. Not required for the developmen [...] (551 aa) |
| | Mkk4 | MAP kinase kinase 4 (Mkk4) encodes a mitogen activated protein kinase kinase (MAPKK) involved in the Jun kinase (JNK) pathway. It is directly activated by the MAPKKK encoded by Tak1. Mkk4 product roles include activation of intracellular JNK signalling upon the TNF family ligand encoded by egr and regulation of axon stability. (424 aa) |
| | 5-HT7 | 5-hydroxytryptamine (serotonin) receptor 7 (5-HT7) encodes a 5-hydroxytryptamine (serotonin) GPCR that belongs to the Class A GPCR family. They bind and transmit the signal from the neurotransmitter 5-HT (serotonin). The family can be subdivided into several subclasses based on pharmacology, signal transduction and structure. There are 5 genes encoding serotonin receptors in the Drosophila melanogaster genome: 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, and 5-HT7. The product of 5-HT7 is involved in olfactory learning and memory, and courtship behaviors. (564 aa) |
| | Stat92E | Signal-transducer and activator of transcription protein at 92E (Stat92E) encodes a transcription factor that shuttles between the cytosol and nucleus and functions in the JAK/STAT pathway. Its roles include proliferation, growth control, organismal metabolism, cell competition, stem cell self-renewal, immunity and developmental patterning. (818 aa) |
| | Pi3K92E | Phosphoinositide 3-kinase, Dp110; Pi3K92E (Pi3K92E) encodes the catalytic subunit of a class I phosphatidylinositol 3-kinase that functions downstream of the product of InR and other receptors during several processes, including cell and tissue growth; Belongs to the PI3/PI4-kinase family. (1088 aa) |
| | Snmp2 | Sensory neuron membrane protein 2; Plays an olfactory role that is not restricted to pheromone sensitivity; Belongs to the CD36 family. (556 aa) |
| | Der-1 | Derlin-1; May be involved in the degradation process of specific misfolded endoplasmic reticulum (ER) luminal proteins. May also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. (245 aa) |
| | Gba1b | Glucosylceramidase; Glucocerebrosidase 1b (Gba1b) encodes a lysosomal acid beta glucocerebrosidase that catalyzes the hydrolysis of glucosylceramide to ceramide and glucose. (566 aa) |
| | stumps | Stumps, isoform E; Stumps (stumps) encodes a fibroblast growth factor (FGF) scaffolding protein. Upon FGF receptor activation, it mediates the recruitment of the phosphatase encoded by csw, which is essential for the activation of the MAPK pathway. (1220 aa) |
| | daw | Dawdle, isoform A; Dawdle (daw) encodes an Activin- like ligand of the TGF beta superfamily that is required for proper tricarboxylic acid cycle function in the fat body and also regulates insulin release from IPC neurons. (586 aa) |
| | FASN2 | Fatty acid synthase 2 (FASN2) encodes an enzyme required for the synthesis of branched/methylated long chain fatty acids that are the precursors of methylated cuticular hydrocarbons. (2410 aa) |
| | FASN1 | Fatty acid synthase 1 (FASN1) encodes a fatty acid synthase involved in glycogen metabolism and triglyceride biosynthesis. (2540 aa) |
| | Tor | Serine/threonine-protein kinase Tor; Promotes cell and tissue growth, maintains tissue homeostatis and controls responses to environmental stress and aging. Regulates growth during animal development by coupling growth factor signaling to nutrient availability. Central regulators of autophagy. May be involved in atg1 phosphorylation. May also be involved, directly or indirectly, in the control of neuronal function. Phosphorylates S6K/p70S6K, in vitro. May regulate the activity of S6K. Overexpression inhibits growth and reduces cell size. Affects the timing of neuronal cell differentiat [...] (2471 aa) |
| | CG30156 | AT29763p; Hsp70 protein binding. It is involved in the biological process described with: chaperone cofactor-dependent protein refolding; cellular response to misfolded protein; ubiquitin-dependent ERAD pathway. (358 aa) |
| | Ir92a | Ionotropic receptor 92a (Ir92a) encodes a member of the Ionotropic Receptor (IR) family of variant ionotropic glutamate receptors. It functions in detection of ammonia and amines to mediate attraction behavior. (678 aa) |
| | Med | Mothers against decapentaplegic homolog; Medea (Med) encodes a protein that belongs to the highly conserved Smad family. It can bind its siblings encoded by Mad or Smox to facilitate signal transduction for the product of dpp or Activin ligands in the TGF-beta family. Med-complexes function as transcriptional regulators. Many developmental roles include dorsal-ventral patterning, patterning and proliferation of the wing disc and gene expression in the mushroom body of the larval brain. (771 aa) |
| | CG15537 | IP18706p; Hormone binding; corticotropin-releasing hormone binding. It is involved in the biological process described with: negative regulation of corticotropin-releasing hormone receptor activity; negative regulation of corticotropin secretion; hormone-mediated signaling pathway; hormone metabolic process. (353 aa) |
| | Lnk | Lnk, isoform D; Lnk (Lnk) encodes a member of the SH2B family of adaptor proteins. It functions within the insulin signalling pathway as an intracellular adaptor for the insulin receptor. It stabilises the interaction between the activated insulin receptor and the insulin receptor substrate, which are encoded by InR and chico respectively. (728 aa) |
| | CG12290 | Orphan GPCR CG12290; Alpha1-adrenergic receptor activity; G protein-coupled receptor activity. (798 aa) |
| | Smox | Mothers against decapentaplegic homolog; Smad on X (Smox) encodes the primary transcription factor that mediates Activin signalling. Upon phosphorylation by the receptor encoded by babo, it forms a complex with the co-Smad protein encoded by Med. This complex translocates to the nucleus where it regulates expression of target genes. (486 aa) |
| | cnk | Connector enhancer of KSR protein CNK; Enzyme regulator activity; MAP-kinase scaffold activity; receptor tyrosine kinase binding; mitogen-activated protein kinase kinase kinase binding; protein binding. (1557 aa) |
| | Lgr4 | Leucine-rich repeat-containing G protein-coupled receptor 4 (Lgr4) encodes a protein that shows highest similarity with vertebrate receptors for relaxin-like peptides. (809 aa) |
| | PICK1 | Membrane curvature sensor activity; phospholipid binding; protein kinase C binding; protein domain specific binding. (577 aa) |
| | Dop2R | Dopamine 2-like receptor (Dop2R) encodes a G protein-coupled receptor that is activated by dopamine. Postulated Dop2R-mediated functions include regulation of: aggression, cardiac function, feeding, levels of juvenile hormone and 20-hydroxyecdysone, lifespan, locomotor activity, nocturnal activity, olfactory associative learning, response to stress, sleep and sucrose acceptance. (905 aa) |
| | Herp | It is involved in the biological process described with: endoplasmic reticulum unfolded protein response. (465 aa) |
| | scw | Screw (scw) encodes a BMP-type ligand that forms a heterodimer with the product of dpp. The heterodimer is required to achieve the peak levels of BMP signal in the dorsal-most cells of the early blastoderm embryo that are necessary to specify the amnioserosa. (400 aa) |
| | Raf | Raf homolog serine/threonine-protein kinase Raf; Serine/threonine kinase required in the early embryo for the formation of terminal structure. Also required during the proliferation of imaginal cells. May act downstream of Ras85D in the tor signal transduction pathway. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily. (739 aa) |
| | ksr | Kinase suppressor of ras (ksr) encodes a MAP-kinase scaffold protein. It mediates the activation of the serine/threonine kinase encoded by Dsor1. (966 aa) |
| | Dh44 | Diuretic hormone 44, isoform A; Hormone activity; G protein-coupled receptor binding; diuretic hormone activity; neuropeptide hormone activity. It is involved in the biological process described with: locomotor rhythm; G protein-coupled receptor signaling pathway; neuropeptide signaling pathway; body fluid secretion; hormone-mediated signaling pathway. (356 aa) |
| | sima | Protein similar; Functions as a transcriptional regulator of the adaptive response to hypoxia. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. (1593 aa) |
| | TyrRII | Tyramine receptor II (TyrRII) encodes a Tyramine 3 class receptor. When heterologously expressed it shows a high affinity for both tyramine and phenylethylamine, and a lower affinity for a range of other related biogenic amines, in both the inhibition of adenylyl cyclase activity and in the release of calcium from internal stores; Belongs to the G-protein coupled receptor 1 family. (586 aa) |
| | Gr43a | Gustatory receptor for sugar taste 43a; Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. Gr43a is the main sugar receptor in larvae. Functions as a narrowly tuned fructose receptor in taste neurons but also as a fructose receptor in the brain. Necessary and sufficient to sense hemolymph fructose and promote feeding in hungry flies but suppress feeding in satiated flies. (453 aa) |
| | Oatp74D | Solute carrier organic anion transporter family member 74D; Transporter that mediates the cellular uptake of ecdysteroids, including ecdysone, from the hemolymph. Belongs to the organo anion transporter (TC 2.A.60) family. (819 aa) |
| | rl | Mitogen-activated protein kinase ERK-A; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway to regulate poliferation, differentiation and effect cell fate decisions in various tissues. Required downstream of phl/Raf in the sev/sevenless, tor/torso, and EGF receptor homolog Egfr signal transduction pathways. Required for embryonic epithelial tissue repair. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis. (376 aa) |
| | CG7182 | LD21269p; Belongs to the heat shock protein 70 family. (513 aa) |
| | Torsin | Torsin-like protein; Torsin (Torsin) encodes an AAA-ATPase that is implicated in the export of large ribonuclear protein particles through the nuclear membrane. It regulates dopamine levels; Belongs to the ClpA/ClpB family. Torsin subfamily. (340 aa) |
| | raptor | Raptor, isoform B; Raptor (raptor) encodes a crucial component of target of rapamycin (TOR) complex 1, which is a conserved regulator of cell growth and metabolism. (1621 aa) |
| | Sec13 | Protein SEC13 homolog; Functions as a component of the nuclear pore complex (NPC) and the COPII coat (By similarity). At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles (By similarity). Recruited to transcriptionally active chromatin at the time of transcription initiation by RNA polymerase II. Required for proper expression of ecdysone-responsive genes such as Eip74EF and Eip75B during larval development. Required for reactivation of transcription after heat shock. Required for nuclear import of phosphorylated Mad via importin msk. Has no role i [...] (356 aa) |
| | TyrR | Tyramine receptor (TyrR) encodes a Tyramine 2 class receptor. When heterologously expressed it shows a very high specificity for the release of intercellular calcium by tyramine; Belongs to the G-protein coupled receptor 1 family. (631 aa) |
| | JhI-21 | Juvenile hormone Inducible-21, isoform A; L-amino acid transmembrane transporter activity. It is involved in the biological process described with: cellular response to leucine; defense response to fungus; L-leucine import across plasma membrane; positive regulation of insulin secretion; carbohydrate homeostasis. (500 aa) |
| | AstC-R2 | Allatostatin C receptor 2 (AstC-R2) encodes G-protein coupled receptor for the neuropeptide encoded by AstC. (593 aa) |
| | PRAS40 | Proline-rich Akt substrate 40 kDa (PRAS40) encodes a protein that functions to link Insulin/IGF signaling and the activation of the product of Tor in a tissue-specific manner, affecting the activity of the product of Tor in the ovary but not in other fly tissues. (562 aa) |
| | CG34308 | RING-type domain-containing protein; Ubiquitin-like protein conjugating enzyme binding; ubiquitin protein ligase activity; metal ion binding. It is involved in the biological process described with: ER-associated misfolded protein catabolic process; ubiquitin-dependent protein catabolic process. (194 aa) |
| | Ilp5 | Insulin-like peptide 5 (Ilp5) encodes a peptide involved in the insulin signaling pathway, sleep and mating behavior in females; Belongs to the insulin family. (108 aa) |
| | 5-HT1A | 5-hydroxytryptamine (serotonin) receptor 1A (5-HT1A) encodes a 5-hydroxytryptamine (serotonin) GPCR that belongs to the Class A GPCR family. They bind and transmit the signal from the neurotransmitter 5-HT (serotonin). The family can be subdivided into several subclasses based on pharmacology, signal transduction and structure. There are 5 genes encoding serotonin receptors in the Drosophila melanogaster genome: 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, and 5-HT7. The product of 5-HT1A has been implicated in several aspects of adult behavior, including baseline sleep, aggression, courtship, as w [...] (846 aa) |
| | csw | Tyrosine-protein phosphatase corkscrew; Required in all receptor tyrosine kinase signaling pathways. Functions downstream of the receptor tyrosine kinase torso, acting in concert with D-Raf via tailless. Also functions downstream of Egfr (epidermal growth factor receptor) and btl (fibroblast growth factor receptor). The SH2 domain suggests that csw effects its role by mediating heteromeric protein interactions. Maternally required for normal determination of cell fates at the termini of the embryo. Required for cell fate specification of the ventral ectoderm, in the developing embryoni [...] (945 aa) |
| | Sik2 | Salt-inducible kinase 2 (Sik2) encodes a serine/threonine kinase that is activated by the product of Lkb1. It regulates lipid storage and energy homeostasis by controlling the activity of cAMP-response element-binding protein (CREB)-regulated transcription coactivator (CRTC). (1398 aa) |
| | AdipoR | Adiponectin receptor (AdipoR) encodes a membrane protein that regulates glucose and lipid metabolism by controlling insulin signaling. It also maintains germ line stem cells via an insulin-independent mechanism. (444 aa) |
| | msn | Misshapen, isoform A; Misshapen (msn) encodes a Sterile 20 MAP kinase kinase kinase. (1504 aa) |
| | mAChR-A | Muscarinic acetylcholine receptor DM1; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. May have a role in the processing of olfactory and mechanosensory signals; regulation of neurosecretion. (805 aa) |
| | Nurf-38 | Inorganic pyrophosphatase; Component of NURF (nucleosome remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. NURF is required for homeotic gene expression, proper larval blood cell development, normal male X chromosome morphology, ecdysteroid signaling and metamorphosis. Nurf-38 may have adapted to deliver pyrophosphatase to chromatin to assist in replication or transcription by efficient removal of the inhibitory metabolite; Belongs to the PPase family. (338 aa) |
| | Galphas | G protein alpha s subunit (Galphas) encodes an alpha subunit of the class of heterotrimeric G proteins, found on the cytosolic face of the plasma membrane. An inactive GDP-bound form forms a heterotrimer with beta and gamma subunits. On activation by a 7-TM receptor, the product of Galphas exchanges GDP for GTP, dissociates from the trimer, and activates adenylyl cyclase, thus initiating cAMP signaling. Galphas roles include neurophysiology, and behaviors including learning; Belongs to the G-alpha family. G(s) subfamily. (385 aa) |
| | Lpt | Lost PHDs of trr (Lpt) encodes a core component of COMPASS-like nuclear receptor coactivator complexes. It is involved in histone methylation and dpp/BMP signaling regulation. (1482 aa) |
| | gbb | Protein 60A; Glass bottom boat (gbb) encodes a BMP ligand in the TGF-beta/BMP family of dimeric signaling molecules. It binds to a receptor complex to transduce signal through phosphorylation of the product of Mad. It contributes to maintain stem cell populations, control cell fate specification, proliferation, synapse growth and neuropeptide release. (455 aa) |
| | Rab9Db | Rab at 9Db; GTP binding; GTPase activity. (197 aa) |
| | Rab9E | Rab at 9E; GTPase activity; GTP binding. (197 aa) |
| | Rab9D | Rab at 9D; GTPase activity; GTP binding. (197 aa) |
| | RabX2 | CG2885; GTP binding; GTPase activity. (195 aa) |
| | Zpr1 | LD37736p; Zpr1 (Zpr1) encodes a protein that functions downstream of the EGFR and other tyrosine kinase receptors. It also contributes to the assembly of spliceosome snRNPs. In the developing tracheal system it is required for terminal cell lumen formation. (457 aa) |
| | InR | Insulin-like receptor subunit beta 1; Has a ligand-stimulated tyrosine-protein kinase activity. Required for cell survival. Regulates body size and organ size by altering cell number and cell size in a cell-autonomous manner. Involved in the development of the embryonic nervous system, and is necessary for axon guidance and targeting in the visual system. Also plays a role in life-span determination. (2144 aa) |
| | Ir8a | Ionotropic receptor 8a (Ir8a) encodes a member of the Ionotropic Receptor (IR) family of variant ionotropic glutamate receptors. It functions as a co-receptor together with ligand-specific IRs (in a probable heterotetrameric complex) to detect diverse organic acids; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (936 aa) |
| | Dsor1 | Dual specificity mitogen-activated protein kinase kinase dSOR1; Required downstream of Raf in the sevenless (sev), torso (tor), and Drosophila EGF receptor homolog (DER) signal transduction pathways. Involved in both positive regulation (at the posterior terminus) and negative regulation (at the anterior domain) of tll, as in other terminal class gene products, maybe via the ERK-A kinase. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. (396 aa) |
| | Gbeta5 | RH17413p; GTPase activator activity; G-protein gamma-subunit binding. It is involved in the biological process described with: G protein-coupled receptor signaling pathway; dopamine receptor signaling pathway; positive regulation of GTPase activity. (358 aa) |
| | Traf6 | TNF-receptor-associated factor 6 (Traf6) encodes a protein that belongs to a family of adaptor proteins involved in transducing downstream signaling by interacting with cell surface receptors. It mediates the pro-inflammatory effects of Toll and related receptor signaling, and the cell death induced by JNK activation via the product of egr. (475 aa) |
| | Ilp7 | Insulin-like peptide 7 (Ilp7) encodes a secreted insulin-like peptide that binds to the receptor encoded by InR to activate the insulin signaling pathway. It is expressed by small populations of neurons and plays roles in female egg-site selection, sleep duration, and nutrient-dependent food intake and tracheal growth. (159 aa) |
| | Ilp6 | Insulin-like peptide 6 (Ilp6) encodes a protein that promotes growth during starvation. (107 aa) |
