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AOX3 AOX3 CG12338 CG12338 AOX2 AOX2 cn cn CG5946 CG5946 Mical Mical ADPS ADPS CG9527 CG9527 CG5009 CG5009 cry cry AOX1 AOX1 AOX4 AOX4 ry ry phr6-4 phr6-4 CG17544 CG17544 CG11236 CG11236 Coq6 Coq6 AIF AIF slgA slgA CG7560 CG7560 CG14997 CG14997 D2hgdh D2hgdh CG4586 CG4586 Acox57D-p Acox57D-p Acox57D-d Acox57D-d Ero1L Ero1L
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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AOX3Aldehyde oxidase 3 (AOX3) encodes a pyridoxal oxidase involved in pyridoxal metabolism. (1254 aa)
CG12338RE49860p; D-amino-acid oxidase activity; FAD binding. It is involved in the biological process described with: oxidation-reduction process; D-amino acid metabolic process. (335 aa)
AOX2Aldehyde oxidase 2 (AOX2) encodes a pyridoxal oxidase involved in pyridoxal metabolism. (1264 aa)
cnKynurenine 3-monooxygenase; Cinnabar (cn) encodes the enzyme that synthesizes 3-hydroxykynurenine (3-HK) as part of the kynurenine pathway of tryptophan degradation. 3-HK is an intermediate product in the formation of ommochromes, the brown pigments in the fly eye, and thus cn loss of function mutant flies exhibit altered eye color. Several kynurenine pathway metabolites are neuroactive and have been linked to the pathogenesis of neurodegenerative disorders. (465 aa)
CG5946FAD binding; cytochrome-b5 reductase activity, acting on NAD(P)H. It is involved in the biological process described with: retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; regulation of lipid storage; oxidation-reduction process; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (330 aa)
Mical[F-actin]-monooxygenase Mical; Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits at 'Met-44' and 'Met-47' through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament disassembly and prevent repolymerization. Plays a key role in semaphorin-plexin repulsive axon guidance and cell morphological changes, probably via its ability to modify and regulate actin. Belongs to the Mical family. (4743 aa)
ADPSAlkyldihydroxyacetonephosphate synthase; Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids; Belongs to the FAD-binding oxidoreductase/transferase type 4 family. (631 aa)
CG9527Acyl-coenzyme A oxidase; Fatty acid binding; FAD binding; acyl-CoA oxidase activity; pristanoyl-CoA oxidase activity; flavin adenine dinucleotide binding. It is involved in the biological process described with: lipid homeostasis; fatty acid beta-oxidation using acyl-CoA oxidase; fatty acid beta-oxidation. (724 aa)
CG5009Probable peroxisomal acyl-coenzyme A oxidase 1; Flavin adenine dinucleotide binding; fatty acid binding; FAD binding; acyl-CoA oxidase activity; Belongs to the acyl-CoA oxidase family. (669 aa)
cryCryptochrome-1; Blue light-dependent regulator that is the input of the circadian feedback loop. Has no photolyase activity for cyclobutane pyrimidine dimers or 6-4 photoproducts. Regulation of expression by light suggests a role in photoreception for locomotor activity rhythms. Functions, together with per, as a transcriptional repressor required for the oscillation of peripheral circadian clocks and for the correct specification of clock cells. Genes directly activated by the transcription factors Clock (Clk) and cycle (cyc) are repressed by cry. Necessary for light-dependent magneto [...] (542 aa)
AOX1Aldehyde oxidase 1 (AOX1) encodes a pyridoxal oxidase involved in pyridoxal metabolism. (1273 aa)
AOX4Aldehyde oxidase 4 (AOX4) encodes an oxidoreductase that catalyzes the oxidation of pyridoxal to pyridoxate with the release of hydrogen peroxide. (1256 aa)
ryXanthine dehydrogenase; Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid (By similarity). (1335 aa)
phr6-4(6-4)-photolyase, isoform A; (6-4)-photolyase (phr6-4) encodes an enzyme that repairs DNA damage induced by ultraviolet light. It uses blue light and cofactor FADH to reverse the pyrimidine(6-4)pyrimidone photoproduct. (540 aa)
CG17544acyl-CoA oxidase activity; fatty acid binding; FAD binding; flavin adenine dinucleotide binding; pristanoyl-CoA oxidase activity. It is involved in the biological process described with: fatty acid beta-oxidation; lipid homeostasis; fatty acid beta-oxidation using acyl-CoA oxidase. (693 aa)
CG11236GH12548p; FAD binding; D-amino-acid oxidase activity. It is involved in the biological process described with: D-amino acid metabolic process; oxidation-reduction process. (341 aa)
Coq6Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. (477 aa)
AIFPutative apoptosis-inducing factor 1, mitochondrial; Probable NADH oxidoreductase (By similarity). Mitochondrial effector of cell death that plays roles in developmentally regulated cell death and normal mitochondrial function. (739 aa)
slgAProline dehydrogenase 1, mitochondrial; Converts proline to delta-1-pyrroline-5-carboxylate. (681 aa)
CG7560GH04035p; FAD binding; methylenetetrahydrofolate reductase (NAD(P)H) activity. It is involved in the biological process described with: methionine biosynthetic process; tetrahydrofolate interconversion; one-carbon metabolic process; oxidation-reduction process. (349 aa)
CG14997GH04863p; FAD binding; sulfide:quinone oxidoreductase activity. It is involved in the biological process described with: sulfide oxidation, using sulfide:quinone oxidoreductase. (457 aa)
D2hgdhD-2-hydroxyglutaric acid dehydrogenase (D2hgdh) encodes an enzyme involved in oxidation-reduction metabolism. (533 aa)
CG4586Acyl-coenzyme A oxidase; Flavin adenine dinucleotide binding; FAD binding; fatty acid binding; acyl-CoA oxidase activity. It is involved in the biological process described with: fatty acid beta-oxidation; lipid homeostasis; fatty acid beta-oxidation using acyl-CoA oxidase. (677 aa)
Acox57D-pAcyl-coenzyme A oxidase; Flavin adenine dinucleotide binding; acyl-CoA oxidase activity; FAD binding; fatty acid binding. It is involved in the biological process described with: fatty acid beta-oxidation; lipid homeostasis; fatty acid beta-oxidation using acyl-CoA oxidase. (677 aa)
Acox57D-dAcyl-coenzyme A oxidase; FAD binding; fatty acid binding; acyl-CoA oxidase activity; flavin adenine dinucleotide binding. It is involved in the biological process described with: fatty acid beta-oxidation; lipid homeostasis; fatty acid beta-oxidation using acyl-CoA oxidase. (677 aa)
Ero1LEro1-like protein; Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes pdi-1, the enzyme catalyzing protein disulfide formation, in order to allow pdi-1 to sustain additional rounds of disulfide formation. Following pdi reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell (By similarity); Belongs to the EROs family. (483 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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