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ifc ifc Klp67A Klp67A ncd ncd wisp wisp Nup154 Nup154 Synd Synd gammaTub37C gammaTub37C wac wac SRPK SRPK mud mud larp larp mtsh mtsh sau sau Incenp Incenp sub sub fest fest mgr mgr Grip71 Grip71 Grip75 Grip75 Cks30A Cks30A polo polo Grip128 Grip128 nod nod Klp10A Klp10A
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
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textmining
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ifcSphingolipid delta-4 desaturase activity. It is involved in the biological process described with: spermatogenesis; spindle assembly involved in male meiosis; ceramide biosynthetic process; Belongs to the fatty acid desaturase type 1 family. DEGS subfamily. (321 aa)
Klp67AKinesin-like protein at 67A (Klp67A) encodes a microtubule motor protein involved in chromosome congression and mitotic spindle morphogenesis; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (814 aa)
ncdProtein claret segregational; Non-claret disjunctional (ncd) encodes a minus-end-directed kinesin microtubule motor protein and the sole member of the kinesin-14 motor family. It is required for spindle assembly in oocytes and chromosome attachment to spindles in early embryos; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. NCD subfamily. (700 aa)
wispPoly(A) RNA polymerase gld-2 homolog B; Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific maternal RNAs (bcd, Tl, and tor), forming a poly(A) tail, during late oogenesis and early embryogenesis. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs. Required for localization of mRNAs to both poles of the egg, to recruit or maintain known centrosomal proteins with two types of microtubule organizing centers (MTOCs): the central MTOC that forms between the meiosis II tandem spindles and [...] (1373 aa)
Nup154Nuclear pore complex protein Nup154; Component of the nuclear pore complex. Has a role in the organization of the inner nuclear membrane proteins at the nuclear envelope. In germ cells, plays a role in the nuclear localization of components of the dpp signaling pathways, such as Medea and phosphorylated Mad. Binds to chromatin, and together with Nup62 and Nup93-1, contributes to karyosome morphology and chromatin organization including attachment to the nuclear envelope in oocytes and nurse cells. Has a role in female fertility including egg chamber development; in nurse cells, has a r [...] (1365 aa)
SyndSyndapin, isoform C; Lipid binding; phospholipid binding; cytoskeletal protein binding; protein binding. (495 aa)
gammaTub37CTubulin gamma-2 chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly. Required for oocyte activation and consequently for organization of the female meiotic spindle. Essential for centrosome organization and assembly of biastral mitotic spindles in embryos. Plays a role in stabilizing the augmin complex on the meiotic spindle. (457 aa)
wacAugmin complex subunit wac; As part of the augmin complex, plays a role in centrosome- independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules. wac is dispensable for somatic mitosis and for assembly of spindle microtubules in oocytes during female meiosis but is required during female meiosis for chromosome alignment and segregation. It is required for microtubule assembly near spindle poles in oocytes. It is also required for acentrosomal microtubule nucleation and [...] (163 aa)
SRPKSR Protein Kinase (SRPK) encodes a protein involved in spindle microtubule assembly and karyosome formation in oocytes. (939 aa)
mudMushroom body defect (mud) encodes regulates spindle orientation via interactions with the dynein complex. (2567 aa)
larpLa-related protein 1; RNA-binding protein required during male meiosis and development of the syncytial embryo. Binds poly-(A) tails of mRNAs and regulates their expression by regulating their stability or translation. (1673 aa)
mtshMitoshell (mtsh) encodes a protein with a bromodomain-related region. It is required during spermatogenesis for proper temporal coordination of meiotic divisions with the morphogenetic events that usually follow meiosis. (649 aa)
sauGolgi phosphoprotein 3 homolog sauron; Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (By similarity). May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion (By similarity). Also involved in the control of the local [...] (294 aa)
IncenpInner centromere protein (Incenp) encodes a component of the chromosomal passenger complex, acting as a subunit that targets and activates the product of aurB. It controls different processes during cell division, including regulation of chromosome structure, kinetochore-microtubule error correction, chromosome segregation and cytokinesis. (755 aa)
subKinesin-like protein subito; Subito (sub) encodes a kinesin-6 homolog. Kinesin-6 proteins are known to bundle antiparallel microtubules. The product of sub is required for cytokinesis in mitosis and spindle organization and chromosome segregation in female meiosis; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (628 aa)
festWurstfest, isoform A; It is involved in the biological process described with: spindle assembly involved in male meiosis I; multicellular organism reproduction. (513 aa)
mgrPrefoldin subunit 3; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity). Required for tubulin stability and spindle and centrosome formation in cooperation with Vhl. (194 aa)
Grip71Grip71; Gamma-tubulin binding. It is involved in the biological process described with: centrosome cycle; protein localization to centrosome; regulation of cell cycle; spindle assembly involved in female meiosis I; mitotic cell cycle. (646 aa)
Grip75Gamma-tubulin complex component 4 homolog; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family. (650 aa)
Cks30ACyclin-dependent kinase subunit 30A (Cks30A) encodes a protein that promotes progression through female meiosis and the mitotic divisions of the early embryo. It interacts with the product of Cdk1 and is required in prometaphase for spindle assembly, and at the metaphase to anaphase transition for the destruction of the cyclin encoded by CycA. (74 aa)
poloSerine/threonine-protein kinase polo; May play a role in regulating both nuclear and cytoplasmic aspects of the mitotic cycle. Regulates localization of the augmin complex during mitosis by ensuring its location on mitotic spindles. Also regulates augmin complex localization during male meiosis by promoting its placement at kinetochores while preventing its association with spindle microtubules ; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily. (576 aa)
Grip128Grip128 (Grip128) encodes a component of the Gamma-tubulin ring complex, which is a potent microtubule nucleator in eukaryotic cells essential for successful chromosome segregation and cell division. (1092 aa)
nodKinesin-like protein Nod; No distributive disjunction (nod) encodes a kinesin-like protein that is important for nonexchange chromosome biology. The nod product is necessary for chromosome segregation during meiosis and for proper chromosome alignment along the meiotic spindle. (666 aa)
Klp10AKinesin-like protein Klp10A; Required during anaphase to drive sister chromatid separation to promote flux by actively depolymerizing kinetochore microtubules at their pole-associated minus ends, thereby moving chromatids through a 'poleward flux'. Involved in asymmetric cell division of sensory organ precursor (SOP) cells by playing a role in the asymmetric localization of Sara- expressing endosomes to the pIIa daughter cell but not to the pIIb cell. Klp98A targets Sara-expressing endosomes to the central spindle which is symmetrically arranged in early cell division. During late cyto [...] (805 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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