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| | RpS21 | 40S ribosomal protein S21; May be an associated component of the ribosome rather than a core structural subunit. May act as a translation initiation factor. Has a role in regulation of cell proliferation in the hematopoietic organs and the imaginal disks of larva. (83 aa) |
| | Rpp30 | RNaseP protein p30 (Rpp30) encodes a protein involved in tRNA processing. (297 aa) |
| | Snp | Snipper, isoform D; Snipper (Snp) encodes a non-essential exonuclease in the DnaQ-H family. (281 aa) |
| | CG5645 | Protein KRI1 homolog; It is involved in the biological process described with: endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); Belongs to the KRI1 family. (855 aa) |
| | ldbr | Lariat debranching enzyme; Cleaves the 2'-5' phosphodiester linkage at the branch point of lariat intron pre-mRNAs after splicing and converts them into linear molecules that are subsequently degraded. It thereby facilitates ribonucleotide turnover. It may also participate in retrovirus replication via an RNA lariat intermediate in cDNA synthesis (By similarity); Belongs to the lariat debranching enzyme family. (534 aa) |
| | Cpsf6 | Cleavage and polyadenylation specificity factor subunit CG7185; May play a role in pre-mRNA 3'-processing; Belongs to the RRM CPSF6/7 family. (652 aa) |
| | RNaseX25 | Endoribonuclease activity; RNA binding; ribonuclease T2 activity; ribonuclease activity. It is involved in the biological process described with: RNA catabolic process; multicellular organism reproduction; Belongs to the RNase T2 family. (325 aa) |
| | Rexo5 | RNA exonuclease 5, isoform A; Nucleic acid binding; 3'-5'-exoribonuclease activity; exonuclease activity. It is involved in the biological process described with: snoRNA 3'-end processing; rRNA 3'-end processing. (681 aa) |
| | CG32409 | Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (349 aa) |
| | Tengl1 | Testis EndoG-Like 1; It is involved in the biological process described with: apoptotic DNA fragmentation; DNA catabolic process, endonucleolytic. (319 aa) |
| | Tengl2 | Endonuclease; It is involved in the biological process described with: DNA catabolic process, endonucleolytic; apoptotic DNA fragmentation. (318 aa) |
| | Tengl3 | Testis EndoG-Like 3; It is involved in the biological process described with: DNA catabolic process, endonucleolytic; apoptotic DNA fragmentation. (337 aa) |
| | CG44249 | RRM domain-containing protein; mRNA binding; nucleic acid binding; 3'-5'-exoribonuclease activity. It is involved in the biological process described with: DNA metabolic process; DNA catabolic process, exonucleolytic; mRNA splicing, via spliceosome; exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). (407 aa) |
| | Clp | Cleavage and polyadenylation specificity factor subunit 4; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity. Binds RNA polymers with a preference for G- and/or C-rich clusters. Binds single-stranded DNA non-specifically. (296 aa) |
| | CG13690 | Ribonuclease H2 subunit A; Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes (By similarity). (347 aa) |
| | Tsr1 | Pre-rRNA-processing protein TSR1 homolog; Required during maturation of the 40S ribosomal subunit in the nucleolus; Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. TSR1 subfamily. (814 aa) |
| | Fip1 | Factor interacting with poly(A) polymerase 1; Myosin binding. It is involved in the biological process described with: mRNA polyadenylation; positive regulation of transcription by RNA polymerase II; pre-mRNA cleavage required for polyadenylation; mRNA 3'-end processing by stem-loop binding and cleavage. (701 aa) |
| | CG9117 | FI02812p. (228 aa) |
| | Rat1 | Rat1 5'-3' exoribonuclease (Rat1) encodes a member of the 5'-3' exonuclease family. It is required for mRNA processing and mutations cause phenotypes in various cell types, including the nervous system. (908 aa) |
| | CG12375 | Beta-lactamase-like protein 2 homolog; Single-stranded RNA binding; endoribonuclease activity; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. (292 aa) |
| | pelo | Protein pelota; Required prior to the first meiotic division for spindle formation and nuclear envelope breakdown during spermatogenesis. It is also required for normal eye patterning and for mitotic divisions in the ovary. Required for ovarian germ line stem cell self-renewal. May play a role in regulating translation. May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. May have ribonuclease activity (Potential). (395 aa) |
| | aub | Protein aubergine; Acts via the piwi-interacting RNA (piRNA) metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. In ovary, associates predominantly with antisense piRNAs that contain uridine at their 5' end. In testis, associates with [...] (866 aa) |
| | piwi | Protein piwi; Acts via the piwi-interacting RNA (piRNA) metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. In ovarian somatic cells, mediates silencing of transposable elements at the transcriptional level in a mael-dependent manner. [...] (843 aa) |
| | zuc | Mitochondrial cardiolipin hydrolase; Cardiolipin hydrolase present at the mitochondrial outer membrane required for piRNA metabolic process. Acts by catalyzing the hydrolysis of cardiolipin (diphosphatidylglycerol) to form phosphatidate (phosphatidic acid or PA) at the mitochondrial outer membrane surface, promoting the piRNA metabolic process. Plays a key role in primary biogenesis of piRNAs and is required during oogenesis to repress transposable elements and prevent their mobilization. piRNAs mediate the repression of transposable elements during meiosis by forming complexes compose [...] (253 aa) |
| | Nbr | Exonuclease mut-7 homolog; Possesses 3'-5' exoribonuclease activity. Required for 3'-end trimming of AGO1-bound miRNAs, in particular multiple-isoform miRNAs, which represents a critical step in miRNA maturation. Belongs to the mut-7 family. (625 aa) |
| | CG16790 | U6 snRNA phosphodiesterase; Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA. (258 aa) |
| | Tengl4 | Testis EndoG-Like 4; It is involved in the biological process described with: apoptotic DNA fragmentation; DNA catabolic process, endonucleolytic. (378 aa) |
| | Exd2 | Exonuclease 3'-5' domain-containing protein 2; 3'-5' exoribonuclease required for mitochondrial metabolism. (583 aa) |
| | CG8461 | LD29276p; It is involved in the biological process described with: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); cleavage involved in rRNA processing. (244 aa) |
| | EndoU | Endoribonuclease U-specific (EndoU) encodes a endoribonuclease belonging to the eukaryotic endoU ribonuclease family. It is essential for viability and plays a crucial role in the nervous system, contributing to complex neuronal networks largely dependent on cholinergic neurons. (322 aa) |
| | CstF64 | Cleavage stimulation factor 64 kD subunit (CstF64) encodes an RNA-binding protein that is part of the cleavage stimulation factor (CstF) complex. As part of the CstF complex, it interacts with the polyadenylation protein encoded bysu(f). The product of CstF64 is necessary for the cleavage and polyadenylation of most mRNAs and for 3' end processing of mRNAs that encode the replication-dependent histones. (419 aa) |
| | Cpsf73 | Cleavage and polyadenylation specificity factor 73; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity and functions as mRNA 3'- end-processing endonuclease. Required for the cotranscriptional processing of 3'-ends of polyadenylated and histone pre-mRNA. Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lacta [...] (684 aa) |
| | Regnase-1 | LD08718p; Endoribonuclease activity; mRNA binding; metal ion binding. It is involved in the biological process described with: RNA phosphodiester bond hydrolysis, endonucleolytic. (540 aa) |
| | RpI12 | DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (120 aa) |
| | Dcr-1 | Endoribonuclease Dcr-1; Essential for RNA interference (RNAi); double-stranded RNA (dsRNA) induces potent and specific gene silencing. RNAi is mediated by the RNA-induced silencing complex (RISC), a sequence-specific, multicomponent nuclease that destroys or silences messenger RNAs homologous to the silencing trigger. May carry out the initiation step of RNAi by cleaving dsRNA to produce 22 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs. During embryogenesis, involved in germline fate determination; Belongs to the helicase family. Dicer subfamily. (2249 aa) |
| | CG10214 | Probable oligoribonuclease; 3'-to-5' exoribonuclease specific for small oligoribonucleotides. (211 aa) |
| | twin | Twin, isoform C; Twin (twin) encodes the CCR4 deadenylase, one of two enzymes in the CCR4-NOT complex that degrade mRNA poly(A) tails. It is required during oogenesis in germline stem cell self-renewal, synchronous germ cell division and prevention of cell death, as well as in early embryonic patterning through the deadenylation of specific maternal mRNAs. (567 aa) |
| | Dis3 | Dis3, isoform A; Dis3 (Dis3) encodes an exoribonuclease that forms part of the RNA processing exosome complex. It is involved in the regulation of cell cycle progresion, microRNA expression and mRNA surveillance; Belongs to the RNR ribonuclease family. (982 aa) |
| | Smg6 | GH14566p; Smg6 (Smg6) encodes an RNA endonuclease that is required for nonsense mediated mRNA decay (NMD). Upon recognition of an NMD-targeted transcript, it cleaves the mRNA in the vicinity of the termination codon, exposing free 5' and 3' ends leading to the complete exonucleolytic degradation of the target. (948 aa) |
| | Sid | Stress induced DNase (Sid) encodes a protein belonging to an evolutionarily conserved enzyme family that degrades both single and double stranded nucleic acids. Sid expression is highly induced by bacterial infection and oxidative stress. Its apparent role is to protect from the toxic effects of excess DNA/RNA released by a vigorous immune response. (370 aa) |
| | CG14062 | LP23408p; It is involved in the biological process described with: DNA catabolic process, endonucleolytic; apoptotic DNA fragmentation. (346 aa) |
| | Cpsf100 | Probable cleavage and polyadenylation specificity factor subunit 2; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Required for the cotranscriptional processing of 3'- ends of polyadenylated and histone pre-mRNA. (756 aa) |
| | IntS11 | Integrator complex subunit 11; Catalytic component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box-dependent processing (By similarity). Mediates the snRNAs 3' cleavage (By similarity). Involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5. May mediate recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (By similarity); Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lactamase-like family. INT [...] (597 aa) |
| | CG33785 | DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (108 aa) |
| | Dcr-2 | Dicer-2, isoform A; Dicer-2 (Dcr-2) encodes a member of the RNase III family of double-stranded RNA-specific endonucleases. It acts in the RNAi pathway by cutting long dsRNA into siRNAs. It helps defend flies against viral infection, particularly RNA viruses. It also processes long, partially double-stranded endogenous transcripts (hairpin RNAs) into endo-siRNAs. (1722 aa) |
| | Fen1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (385 aa) |
| | Rrp42 | IP10364p; AU-rich element binding. (296 aa) |
| | CG8414 | Polynucleotide 5'-hydroxyl-kinase NOL9; Polynucleotide 5'-kinase involved in rRNA processing. Belongs to the Clp1 family. NOL9/GRC3 subfamily. (995 aa) |
| | EndoG | Endonuclease G (EndoG) encodes an enzyme with endodeoxyribonuclease and endoribonuclease activity. It is involved in germ cell programmed cell death, mitochondrion inheritance and spermatid development. (310 aa) |
| | RNaseZ | Ribonuclease Z, mitochondrial; Ribonuclease Z (RNaseZ) is a highly conserved gene that encodes the endoribonuclease RNase Z, which cleaves pre-tRNA molecules directly 3' to the discriminator. It has at least two biological roles - nuclear pre-tRNA processing and mitochondrial primary transcript processing. (766 aa) |
| | CG1671 | LD47550p; U3 snoRNA binding. It is involved in the biological process described with: endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). (787 aa) |
| | PAN2 | PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...] (1241 aa) |
| | drosha | Ribonuclease; Drosha (drosha) encodes a protein that contributes to miRNA processing. It is involved in salivary gland histolysis and oocyte development. (1327 aa) |
| | rnh1 | Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (333 aa) |
| | CG11123 | RH42110p; RNA binding. (665 aa) |
| | CG7206 | FI16522p1. (404 aa) |
| | CG2972 | RNA-binding protein NOB1; May play a role in mRNA degradation. Belongs to the NOB1 family. (472 aa) |
| | Rrp45 | Rrp45, isoform A; AU-rich element binding. (412 aa) |
| | Pop2 | Pop2, isoform E; Pop2 (Pop2) encodes a poly(A)-specific ribonuclease involved in translation inhibition. (361 aa) |
| | Pop1 | Lethal (1) G0045; Ribonuclease P activity; ribonuclease MRP activity. It is involved in the biological process described with: tRNA processing; rRNA processing; tRNA 5'-leader removal; RNA phosphodiester bond hydrolysis, endonucleolytic. (857 aa) |
| | CG32708 | RRM domain-containing protein; RNA binding. It is involved in the biological process described with: endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); small-subunit processome assembly. (239 aa) |
| | CG32706 | RRM domain-containing protein; RNA binding. It is involved in the biological process described with: endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); small-subunit processome assembly; defense response to bacterium; endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA). (230 aa) |
| | CG6999 | CG6999; RNA binding. It is involved in the biological process described with: regulation of alternative mRNA splicing, via spliceosome; endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); small-subunit processome assembly. (233 aa) |
| | CG11269 | FI15737p1; Endoribonuclease activity. It is involved in the biological process described with: nucleic acid phosphodiester bond hydrolysis. (107 aa) |
| | angel | Protein angel; 3'-5'-exoribonuclease activity; Belongs to the CCR4/nocturin family. (354 aa) |
| | Rrp4 | Rrp4, isoform A; Rrp4 (Rrp4) encodes a protein involved in gene expression regulation. (298 aa) |
| | Dis3l2 | Dis3 like 3'-5' exoribonuclease 2 (Dis3l2) encodes a 3'-5'-exoribonuclease involved in catabolism of miRNA and tRNA; Belongs to the RNR ribonuclease family. (1044 aa) |
| | CG2145 | Poly(U)-specific endoribonuclease homolog; Endoribonuclease; Belongs to the ENDOU family. (592 aa) |
| | Rtc1 | Probable RNA 3'-terminal phosphate cyclase-like protein; Does not have cyclase activity. Plays a role in 40S- ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA (By similarity); Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily. (384 aa) |
| | CG10993 | GH23064p; RNA binding. It is involved in the biological process described with: small-subunit processome assembly; endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA). (210 aa) |
| | Rai1 | Decapping nuclease DXO homolog; Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping and pyrophosphohydrolase activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5' end triphosphate to release pyrophosphates (By similarity). Belongs to the DXO/Dom3Z family. (375 aa) |
| | CG6839 | Uncharacterized protein; It is involved in the biological process described with: apoptotic DNA fragmentation; DNA catabolic process, endonucleolytic. (430 aa) |
| | CG7728 | LD38375p; GTP binding; U3 snoRNA binding; GTPase activity. It is involved in the biological process described with: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). (1159 aa) |
| | AGO2 | Protein argonaute-2; Essential for RNA interference (RNAi); double-stranded RNA induces potent and specific gene silencing. RNAi is mediated by the RNA-induced silencing complex (RISC), a sequence-specific, multicomponent nuclease that destroys or silences messenger RNAs homologous to the silencing trigger; Belongs to the argonaute family. Ago subfamily. (1217 aa) |
| | CG14120 | Uncharacterized protein; It is involved in the biological process described with: apoptotic DNA fragmentation; DNA catabolic process, endonucleolytic. (1371 aa) |
| | Rrp40 | Ribosomal RNA processing 40 (Rrp40) encodes a protein involved in gene expression regulation. (232 aa) |
| | Rpp20 | Ribonuclease P protein subunit p20; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP complex, which cleaves pre-rRNA sequences (By similarity). (167 aa) |
| | Rrp6 | Rrp6, isoform B; Rrp6 (Rrp6) encodes an exoribonuclease that forms part of the RNA processing exosome complex. It is involved in the regulation of cell cycle progresion and mRNA surveillance. (900 aa) |
| | RpII15 | DNA-directed RNA polymerase II subunit RPB9; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template (By similarity); Belongs to the archaeal RpoM [...] (129 aa) |
| | CG40813 | RRM domain-containing protein; RNA binding. It is involved in the biological process described with: endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); small-subunit processome assembly; endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA). (213 aa) |
| | Trax | Translin associated factor X (Trax) encodes a protein that, together with the product of trsn, forms the trsn/Trax complex, a ribonuclease that facilitates RNA-induced silencing complex (RISC) activation and has been implicated in many different processes, including starvation-induced sleep suppression. (298 aa) |
| | Cpsf160 | Cleavage and polyadenylation specificity factor subunit 1; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction (By similarity); Belongs to the CPSF1 family. (1455 aa) |
| | CG4266 | Uncharacterized protein, isoform B; mRNA binding; nucleic acid binding. (1306 aa) |
| | CG14118 | MIP11263p; It is involved in the biological process described with: DNA catabolic process, endonucleolytic; apoptotic DNA fragmentation. (439 aa) |
| | cu | Nocturnin; Phosphatase which catalyzes the conversion of NADP(+) to NAD(+) and of NADPH to NADH. Shows a small preference for NADPH over NADP(+). Because of its association with the CCR4-NOT complex, has a role in mRNA deadenylation and decay. Required at the pupal stage for proper wing morphogenesis after eclosion. [Isoform D]: In dorsal neurons, contributes to the light- mediated behavioral response; Belongs to the CCR4/nocturin family. (642 aa) |
| | Ire1 | Inositol-requiring enzyme-1 (Ire1) encodes a transmembrane protein that mediates the unfolded protein response. Misfolded peptides in the endoplasmic reticulum activate the RNase activity of the product of Ire1, thereby promoting the cleavage of its downstream substrates, such as Xbp1 mRNA. The product of Ire1 is also required for photoreceptor differentiation. (1074 aa) |
| | CG41562 | MIP26132p1; RNA binding. It is involved in the biological process described with: endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); small-subunit processome assembly. (213 aa) |
| | Tsen2 | Uncharacterized protein; tRNA-intron endonuclease activity; nucleic acid binding. It is involved in the biological process described with: tRNA-type intron splice site recognition and cleavage. (233 aa) |
| | CG31759 | Uncharacterized protein, isoform C; 3'-5'-exoribonuclease activity. It is involved in the biological process described with: nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay. (564 aa) |
| | CG12917 | IP10440p; It is involved in the biological process described with: DNA catabolic process, endonucleolytic; apoptotic DNA fragmentation. (356 aa) |
| | AGO3 | Protein argonaute-3; Acts via the piwi-interacting RNA (piRNA) metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Associates predominantly with sense piRNAs that contain adenine at nucleotide 10, but shows no preference for uridine at [...] (867 aa) |
| | CG42360 | RNase_Zc3h12a domain-containing protein. (496 aa) |
| | PNPase | Polynucleotide phosphorylase (PNPase) encodes an enzyme involved in the regulation of mitochondrial mRNA stability. (771 aa) |
| | pcm | 5'-3' exoribonuclease 1; Pacman (pcm) encodes an exoribonuclease that degrades decapped mRNA. It is involved in epithelial closure, male fertility, apoptosis and growth control. (1613 aa) |
| | Pcf11 | Protein 1 of cleavage and polyadenylation factor 1 (Pcf11) encodes an RNA binding protein involved in RNA splicing regulation. (1953 aa) |
| | Tsen34 | tRNA-splicing endonuclease subunit Sen34; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structura [...] (276 aa) |
| | CG33346 | Endonuclease; It is involved in the biological process described with: DNA catabolic process, endonucleolytic; apoptotic DNA fragmentation. (364 aa) |
| | mldr | Mulder, isoform A; Mulder (mldr) encodes a protein involved in mitochondrial tRNA processing. (544 aa) |
| | AGO1 | Argonaute-1, isoform A; Argonaute-1 (AGO1) encodes an Argonaute/Piwi family protein, which interacts with microRNAs to form miRNA-induced silencing complexes (miRISCs). miRISCs are guided to target and repress mRNAs either by transcript destabilisation, translational inhibition, or both. (984 aa) |
| | CG18809 | GH15549p; 3'-5' exonuclease activity; 5'-3' exonuclease activity. It is involved in the biological process described with: RNA phosphodiester bond hydrolysis, exonucleolytic; determination of adult lifespan. (362 aa) |
| | mtRNApol | DNA-directed RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the phage and mitochondrial RNA polymerase family. (1369 aa) |
| | NHP2 | H/ACA ribonucleoprotein complex subunit 2-like protein; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity). (160 aa) |
| | CG3819 | RE59221p; It is involved in the biological process described with: apoptotic DNA fragmentation; DNA catabolic process, endonucleolytic. (423 aa) |
| | RNASEK | Ribonuclease kappa (RNASEK) encodes a protein involved in clathrin-mediated endocytosis of large cargo, such as viruses. (95 aa) |
