RE48077p; It is involved in the biological process described with: mitochondrial outer membrane permeabilization; regulation of programmed cell death; positive regulation of apoptotic process.

Death executioner Bcl-2 (Debcl) encodes a pro-apoptotic member of the Bcl-2 family involved in programmed cell death.

AT16536p; Buffy (Buffy) encodes one of the two Bcl-2 family members in Drosophila (the other being the product of Debcl). Its loss has been linked to altered energy metabolism in larvae.

Death executioner Bcl-2 (Debcl) encodes a pro-apoptotic member of the Bcl-2 family involved in programmed cell death.

AT16536p; Buffy (Buffy) encodes one of the two Bcl-2 family members in Drosophila (the other being the product of Debcl). Its loss has been linked to altered energy metabolism in larvae.

Caspase Nc subunit 1; Involved in the activation cascade of caspases responsible for apoptosis execution. Effector of steroid-mediated apoptosis during insect metamorphosis. Overexpression promotes programmed cell death. Interaction with Diap1 is required to suppress Dronc-mediated cell death; via Diap1-mediated ubiquitination of Dronc. Rate-limiting caspase in rpr and hid death pathway.

AT16536p; Buffy (Buffy) encodes one of the two Bcl-2 family members in Drosophila (the other being the product of Debcl). Its loss has been linked to altered energy metabolism in larvae.

Cell death protein Grim; Grim (grim) encodes a member of the inhibitor of apoptotic protein antagonists. In response to death signals, it induces apoptosis of cells in the central nervous system. It is important particularly for the apoptosis of specific juvenile neurons during metamorphosis.

AT16536p; Buffy (Buffy) encodes one of the two Bcl-2 family members in Drosophila (the other being the product of Debcl). Its loss has been linked to altered energy metabolism in larvae.

Cell death protein rpr; Reaper (rpr) encodes Reaper, Hid, Grim (RHG) protein. It contributes to the caspase dependent apoptosis by inhibiting the anti-apoptotic protein encoded by Diap1.

Cyclin-dependent kinase 5 (Cdk5) encodes a protein serine-threonine kinase of the cyclin-dependent kinase family whose activity is largely restricted to post-mitotic neurons. It is required for synaptic homeostasis and fidelity of axon patterning, and altered activity causes adult-onset neurodegeneration.

Cdk5 activator-like protein (Cdk5alpha) encodes the sole, essential stimulatory subunit for the kinase encoded by Cdk5. The Cdk5/Cdk5alpha complex is active in post-mitotic neurons. It is required for synaptic homeostasis and fidelity of axon patterning, and altered activity causes adult-onset neurodegeneration.

Cyclin-dependent kinase 5 (Cdk5) encodes a protein serine-threonine kinase of the cyclin-dependent kinase family whose activity is largely restricted to post-mitotic neurons. It is required for synaptic homeostasis and fidelity of axon patterning, and altered activity causes adult-onset neurodegeneration.

Death executioner Bcl-2 (Debcl) encodes a pro-apoptotic member of the Bcl-2 family involved in programmed cell death.

Cyclin-dependent kinase 5 (Cdk5) encodes a protein serine-threonine kinase of the cyclin-dependent kinase family whose activity is largely restricted to post-mitotic neurons. It is required for synaptic homeostasis and fidelity of axon patterning, and altered activity causes adult-onset neurodegeneration.

P53 protein long form variant 1; P53 (p53) encodes a transcriptional factor required for adaptive responses to genotoxic stress, including cell death, compensatory proliferation and DNA repair.

Cdk5 activator-like protein (Cdk5alpha) encodes the sole, essential stimulatory subunit for the kinase encoded by Cdk5. The Cdk5/Cdk5alpha complex is active in post-mitotic neurons. It is required for synaptic homeostasis and fidelity of axon patterning, and altered activity causes adult-onset neurodegeneration.

Cyclin-dependent kinase 5 (Cdk5) encodes a protein serine-threonine kinase of the cyclin-dependent kinase family whose activity is largely restricted to post-mitotic neurons. It is required for synaptic homeostasis and fidelity of axon patterning, and altered activity causes adult-onset neurodegeneration.

Cdk5 activator-like protein (Cdk5alpha) encodes the sole, essential stimulatory subunit for the kinase encoded by Cdk5. The Cdk5/Cdk5alpha complex is active in post-mitotic neurons. It is required for synaptic homeostasis and fidelity of axon patterning, and altered activity causes adult-onset neurodegeneration.

P53 protein long form variant 1; P53 (p53) encodes a transcriptional factor required for adaptive responses to genotoxic stress, including cell death, compensatory proliferation and DNA repair.

Death executioner Bcl-2 (Debcl) encodes a pro-apoptotic member of the Bcl-2 family involved in programmed cell death.

RE48077p; It is involved in the biological process described with: mitochondrial outer membrane permeabilization; regulation of programmed cell death; positive regulation of apoptotic process.

Death executioner Bcl-2 (Debcl) encodes a pro-apoptotic member of the Bcl-2 family involved in programmed cell death.

AT16536p; Buffy (Buffy) encodes one of the two Bcl-2 family members in Drosophila (the other being the product of Debcl). Its loss has been linked to altered energy metabolism in larvae.

Death executioner Bcl-2 (Debcl) encodes a pro-apoptotic member of the Bcl-2 family involved in programmed cell death.

Cyclin-dependent kinase 5 (Cdk5) encodes a protein serine-threonine kinase of the cyclin-dependent kinase family whose activity is largely restricted to post-mitotic neurons. It is required for synaptic homeostasis and fidelity of axon patterning, and altered activity causes adult-onset neurodegeneration.

Death executioner Bcl-2 (Debcl) encodes a pro-apoptotic member of the Bcl-2 family involved in programmed cell death.

Caspase Nc subunit 1; Involved in the activation cascade of caspases responsible for apoptosis execution. Effector of steroid-mediated apoptosis during insect metamorphosis. Overexpression promotes programmed cell death. Interaction with Diap1 is required to suppress Dronc-mediated cell death; via Diap1-mediated ubiquitination of Dronc. Rate-limiting caspase in rpr and hid death pathway.

Death executioner Bcl-2 (Debcl) encodes a pro-apoptotic member of the Bcl-2 family involved in programmed cell death.

Fas-associated death domain protein; Component of the IMD signaling pathway and is required for the host defense against Gram-negative bacteria. Interacts with Dredd, promotes cleavage of Dredd and is necessary and sufficient for enhancing Dredd-induced apoptosis.

Death executioner Bcl-2 (Debcl) encodes a pro-apoptotic member of the Bcl-2 family involved in programmed cell death.

Inositol-requiring enzyme-1 (Ire1) encodes a transmembrane protein that mediates the unfolded protein response. Misfolded peptides in the endoplasmic reticulum activate the RNase activity of the product of Ire1, thereby promoting the cleavage of its downstream substrates, such as Xbp1 mRNA. The product of Ire1 is also required for photoreceptor differentiation.

Death executioner Bcl-2 (Debcl) encodes a pro-apoptotic member of the Bcl-2 family involved in programmed cell death.

Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Milt and Miro form an essential protein complex that links Khc to mitochondria for light chain-independent, anterograde transport of mitochondria. Required for axonal transport to synapses within nerve terminals. Required presynaptically but not postsynaptically at neuromuscular junctions (NMJs).

Death executioner Bcl-2 (Debcl) encodes a pro-apoptotic member of the Bcl-2 family involved in programmed cell death.

Cell death protein Grim; Grim (grim) encodes a member of the inhibitor of apoptotic protein antagonists. In response to death signals, it induces apoptosis of cells in the central nervous system. It is important particularly for the apoptosis of specific juvenile neurons during metamorphosis.

Death executioner Bcl-2 (Debcl) encodes a pro-apoptotic member of the Bcl-2 family involved in programmed cell death.

P53 protein long form variant 1; P53 (p53) encodes a transcriptional factor required for adaptive responses to genotoxic stress, including cell death, compensatory proliferation and DNA repair.

Death executioner Bcl-2 (Debcl) encodes a pro-apoptotic member of the Bcl-2 family involved in programmed cell death.

Cell death protein rpr; Reaper (rpr) encodes Reaper, Hid, Grim (RHG) protein. It contributes to the caspase dependent apoptosis by inhibiting the anti-apoptotic protein encoded by Diap1.