RE59221p; It is involved in the biological process described with: apoptotic DNA fragmentation; DNA catabolic process, endonucleolytic.

Uncharacterized protein; It is involved in the biological process described with: apoptotic DNA fragmentation; DNA catabolic process, endonucleolytic.

Uncharacterized protein; It is involved in the biological process described with: apoptotic DNA fragmentation; DNA catabolic process, endonucleolytic.

RE59221p; It is involved in the biological process described with: apoptotic DNA fragmentation; DNA catabolic process, endonucleolytic.

Deoxyribonuclease II (DNaseII) encodes an ubiquitous endonuclease that hydrolyzes DNA without sequence specificity, generating nucleotides with 3'-phosphate. It is localized in lysosomes, and essential for degrading nuclear DNA of the engulfed apoptotic cells. DNase II is also responsible to digest mitochondrial DNA during autophagy.

DNAation factor-related protein 1, isoform B; DNA fragmentation factor-related protein 1 (Drep1) encodes a protein that regulates apoptosis.

Deoxyribonuclease II (DNaseII) encodes an ubiquitous endonuclease that hydrolyzes DNA without sequence specificity, generating nucleotides with 3'-phosphate. It is localized in lysosomes, and essential for degrading nuclear DNA of the engulfed apoptotic cells. DNase II is also responsible to digest mitochondrial DNA during autophagy.

Endonuclease G (EndoG) encodes an enzyme with endodeoxyribonuclease and endoribonuclease activity. It is involved in germ cell programmed cell death, mitochondrion inheritance and spermatid development.

Death associated molecule related to Mch2 caspase (Damm) encodes one of the seven members of the caspase family of cysteine proteases. Damm overexpression induces cell death; Belongs to the peptidase C14A family.

Caspase-1 subunit p13; Death caspase-1 (Dcp-1) encodes an effector caspase that cleaves specific proteins during apoptosis. It typically acts downstream of the initiator caspase encoded by Dronc. It is also involved in non-apoptotic processes such as autophagy.

Death associated molecule related to Mch2 caspase (Damm) encodes one of the seven members of the caspase family of cysteine proteases. Damm overexpression induces cell death; Belongs to the peptidase C14A family.

Death executioner caspase related to Apopain/Yama (Decay) encodes one of the seven members of the caspase family of cysteine proteases. It has substrate specificity similar to the effector caspases encoded by Drice and Dcp-1; Belongs to the peptidase C14A family.

Death associated molecule related to Mch2 caspase (Damm) encodes one of the seven members of the caspase family of cysteine proteases. Damm overexpression induces cell death; Belongs to the peptidase C14A family.

Caspase subunit p12; Death related ICE-like caspase (Drice) encodes a major effector apoptotic caspase. It is essential for both developmental and damaged induced cell death, as well as several non-apoptotic vital cellular processes. It is activated by the product of Dark and the initiator caspase encoded by Dronc and is inhibited by the inhibitor of apoptosis encoded by Diap1; Belongs to the peptidase C14A family.

Death associated molecule related to Mch2 caspase (Damm) encodes one of the seven members of the caspase family of cysteine proteases. Damm overexpression induces cell death; Belongs to the peptidase C14A family.

Caspase Nc subunit 1; Involved in the activation cascade of caspases responsible for apoptosis execution. Effector of steroid-mediated apoptosis during insect metamorphosis. Overexpression promotes programmed cell death. Interaction with Diap1 is required to suppress Dronc-mediated cell death; via Diap1-mediated ubiquitination of Dronc. Rate-limiting caspase in rpr and hid death pathway.

Death associated molecule related to Mch2 caspase (Damm) encodes one of the seven members of the caspase family of cysteine proteases. Damm overexpression induces cell death; Belongs to the peptidase C14A family.

Ser/Thr-rich caspase (Strica) encodes a member of initiator caspases. It contributes, redundantly or cooperatively with the product of Dronc, to the apoptosis of selective larval neurons during metamorphosis and nurse cells during oogenesis, and competitive apoptosis of heterozygous mutant cells; Belongs to the peptidase C14A family.

Caspase-1 subunit p13; Death caspase-1 (Dcp-1) encodes an effector caspase that cleaves specific proteins during apoptosis. It typically acts downstream of the initiator caspase encoded by Dronc. It is also involved in non-apoptotic processes such as autophagy.

Death associated molecule related to Mch2 caspase (Damm) encodes one of the seven members of the caspase family of cysteine proteases. Damm overexpression induces cell death; Belongs to the peptidase C14A family.

Caspase-1 subunit p13; Death caspase-1 (Dcp-1) encodes an effector caspase that cleaves specific proteins during apoptosis. It typically acts downstream of the initiator caspase encoded by Dronc. It is also involved in non-apoptotic processes such as autophagy.

Death executioner caspase related to Apopain/Yama (Decay) encodes one of the seven members of the caspase family of cysteine proteases. It has substrate specificity similar to the effector caspases encoded by Drice and Dcp-1; Belongs to the peptidase C14A family.

Caspase-1 subunit p13; Death caspase-1 (Dcp-1) encodes an effector caspase that cleaves specific proteins during apoptosis. It typically acts downstream of the initiator caspase encoded by Dronc. It is also involved in non-apoptotic processes such as autophagy.

Caspase subunit p12; Death related ICE-like caspase (Drice) encodes a major effector apoptotic caspase. It is essential for both developmental and damaged induced cell death, as well as several non-apoptotic vital cellular processes. It is activated by the product of Dark and the initiator caspase encoded by Dronc and is inhibited by the inhibitor of apoptosis encoded by Diap1; Belongs to the peptidase C14A family.

Caspase-1 subunit p13; Death caspase-1 (Dcp-1) encodes an effector caspase that cleaves specific proteins during apoptosis. It typically acts downstream of the initiator caspase encoded by Dronc. It is also involved in non-apoptotic processes such as autophagy.

Caspase Nc subunit 1; Involved in the activation cascade of caspases responsible for apoptosis execution. Effector of steroid-mediated apoptosis during insect metamorphosis. Overexpression promotes programmed cell death. Interaction with Diap1 is required to suppress Dronc-mediated cell death; via Diap1-mediated ubiquitination of Dronc. Rate-limiting caspase in rpr and hid death pathway.

Caspase-1 subunit p13; Death caspase-1 (Dcp-1) encodes an effector caspase that cleaves specific proteins during apoptosis. It typically acts downstream of the initiator caspase encoded by Dronc. It is also involved in non-apoptotic processes such as autophagy.

Endonuclease G (EndoG) encodes an enzyme with endodeoxyribonuclease and endoribonuclease activity. It is involved in germ cell programmed cell death, mitochondrion inheritance and spermatid development.

Caspase-1 subunit p13; Death caspase-1 (Dcp-1) encodes an effector caspase that cleaves specific proteins during apoptosis. It typically acts downstream of the initiator caspase encoded by Dronc. It is also involved in non-apoptotic processes such as autophagy.

Ser/Thr-rich caspase (Strica) encodes a member of initiator caspases. It contributes, redundantly or cooperatively with the product of Dronc, to the apoptosis of selective larval neurons during metamorphosis and nurse cells during oogenesis, and competitive apoptosis of heterozygous mutant cells; Belongs to the peptidase C14A family.

Endoribonuclease Dcr-1; Essential for RNA interference (RNAi); double-stranded RNA (dsRNA) induces potent and specific gene silencing. RNAi is mediated by the RNA-induced silencing complex (RISC), a sequence-specific, multicomponent nuclease that destroys or silences messenger RNAs homologous to the silencing trigger. May carry out the initiation step of RNAi by cleaving dsRNA to produce 22 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs. During embryogenesis, involved in germline fate determination; Belongs to the helicase family. Dicer subfamily.

Dicer-2, isoform A; Dicer-2 (Dcr-2) encodes a member of the RNase III family of double-stranded RNA-specific endonucleases. It acts in the RNAi pathway by cutting long dsRNA into siRNAs. It helps defend flies against viral infection, particularly RNA viruses. It also processes long, partially double-stranded endogenous transcripts (hairpin RNAs) into endo-siRNAs.

Dicer-2, isoform A; Dicer-2 (Dcr-2) encodes a member of the RNase III family of double-stranded RNA-specific endonucleases. It acts in the RNAi pathway by cutting long dsRNA into siRNAs. It helps defend flies against viral infection, particularly RNA viruses. It also processes long, partially double-stranded endogenous transcripts (hairpin RNAs) into endo-siRNAs.

Endoribonuclease Dcr-1; Essential for RNA interference (RNAi); double-stranded RNA (dsRNA) induces potent and specific gene silencing. RNAi is mediated by the RNA-induced silencing complex (RISC), a sequence-specific, multicomponent nuclease that destroys or silences messenger RNAs homologous to the silencing trigger. May carry out the initiation step of RNAi by cleaving dsRNA to produce 22 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs. During embryogenesis, involved in germline fate determination; Belongs to the helicase family. Dicer subfamily.

Dicer-2, isoform A; Dicer-2 (Dcr-2) encodes a member of the RNase III family of double-stranded RNA-specific endonucleases. It acts in the RNAi pathway by cutting long dsRNA into siRNAs. It helps defend flies against viral infection, particularly RNA viruses. It also processes long, partially double-stranded endogenous transcripts (hairpin RNAs) into endo-siRNAs.

Death executioner caspase related to Apopain/Yama (Decay) encodes one of the seven members of the caspase family of cysteine proteases. It has substrate specificity similar to the effector caspases encoded by Drice and Dcp-1; Belongs to the peptidase C14A family.

Dicer-2, isoform A; Dicer-2 (Dcr-2) encodes a member of the RNase III family of double-stranded RNA-specific endonucleases. It acts in the RNAi pathway by cutting long dsRNA into siRNAs. It helps defend flies against viral infection, particularly RNA viruses. It also processes long, partially double-stranded endogenous transcripts (hairpin RNAs) into endo-siRNAs.

Stress induced DNase (Sid) encodes a protein belonging to an evolutionarily conserved enzyme family that degrades both single and double stranded nucleic acids. Sid expression is highly induced by bacterial infection and oxidative stress. Its apparent role is to protect from the toxic effects of excess DNA/RNA released by a vigorous immune response.

Death executioner caspase related to Apopain/Yama (Decay) encodes one of the seven members of the caspase family of cysteine proteases. It has substrate specificity similar to the effector caspases encoded by Drice and Dcp-1; Belongs to the peptidase C14A family.

Death associated molecule related to Mch2 caspase (Damm) encodes one of the seven members of the caspase family of cysteine proteases. Damm overexpression induces cell death; Belongs to the peptidase C14A family.