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| | Vha16-1 | Vacuolar H[+] ATPase 16kD subunit 1 (Vha16-1) encodes the proteolipid component of V-ATPase, which is a multi-functional channel protein. It contributes to vesicle-membrane fusion, hydrophilic molecule transport and intercellular communication. (159 aa) |
| | Seipin | Seipin; Is a regulator of lipid catabolism essential for adipocyte differentiation. May also be involved in the central regulation of energy homeostasis (By similarity). Necessary for correct lipid storage and lipid droplets maintenance; plays a tissue-autonomous role in controlling lipid storage in adipocytes and in preventing ectopic lipid droplet formation in non-adipose tissues. May participate in phosphatidic acid metabolism and subsequently down-regulate lipogenesis. (370 aa) |
| | VhaAC39-1 | V-type proton ATPase subunit d 1; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity); Belongs to the V-ATPase V0D/AC39 subunit family. (350 aa) |
| | fh | Frataxin homolog, mitochondrial; Promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+). May be able to store large amounts of the metal in the form of a ferrihydrite mineral by oligomerization. Required for ecdysteroidogenesis in the prothoracic gland which is necessary for larval to pupal transition. Belongs to the frataxin family. (190 aa) |
| | SERCA | Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type; Sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) encodes an endoplasmic reticulum (ER) calcium pump with roles in ER calcium homeostasis and lipid storage. (1020 aa) |
| | Letm1 | Mitochondrial proton/calcium exchanger protein; Mitochondrial proton/calcium antiporter that mediates proton- dependent calcium efflux from mitochondrion. Belongs to the LETM1 family. (1013 aa) |
| | ABCB7 | ATP binding cassette subfamily B member 7 (ABCB7) encodes a transporter that likely dimerizes to form a functional transporter. It may act in the mitochondria to transport substrates necessary for the maturation of ICS proteins, which are involved in iron homeostasis. (743 aa) |
| | sesB | ADP,ATP carrier protein; Catalyzes the exchange of ADP and ATP across the mitochondrial inner membrane. (312 aa) |
| | SelG | Selenoprotein G (SelG) encodes a type III Golgi apparatus transmembrane protein. It is implicated in the release of Ca[2+] from the endoplasmic reticulum to the cytosol by regulating the expression of genes participating in the inositol 1,4,5-tris-phosphate pathway. (110 aa) |
| | CG1840 | LD12750p; It is involved in the biological process described with: calcium ion transport; endoplasmic reticulum calcium ion homeostasis. (118 aa) |
| | CG10362 | LD34222p; Lipid binding. It is involved in the biological process described with: intracellular signal transduction; mitochondrial calcium ion homeostasis; mitochondrion-endoplasmic reticulum membrane tethering. (1037 aa) |
| | Fer3HCH | Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Belongs to the ferritin family. (186 aa) |
| | Stim | Stromal interaction molecule (Stim) encodes an endomasplic reticulum-membrane protein that is an essential component of the store-operated calcium entry mechanism, which in neurons regulates flight. (570 aa) |
| | Mco4 | Multicopper oxidase 4; Ferroxidase activity; copper ion binding. It is involved in the biological process described with: iron ion homeostasis; iron ion transport; oxidation-reduction process; Belongs to the multicopper oxidase family. (645 aa) |
| | Trpml | Transient receptor potential cation channel, mucolipin (Trpml) encodes a ion channel involved in autophagy, lateral inhibition and TOR signalling regulation. (652 aa) |
| | scaf6 | SR-related CTD associated factor 6, isoform A; RNA binding. It is involved in the biological process described with: cellular calcium ion homeostasis; RNA processing. (960 aa) |
| | CG7638 | RE42071p. (496 aa) |
| | Ae2 | Inorganic anion exchanger activity. It is involved in the biological process described with: intracellular pH reduction; regulation of intracellular pH; bicarbonate transport. (1268 aa) |
| | CG7194 | IP12463p; It is involved in the biological process described with: copper ion homeostasis. (346 aa) |
| | ZnT77C | Zinc transporter 77C (ZnT77C) encodes a protein involved in zinc detoxification and zinc transmembrane import. (513 aa) |
| | park | Parkin (park) encodes an E3 ubiquitin ligase with a key role in protein ubiquitination. It is involved in mitochondrion organization, oxidative stress and locomotion; Belongs to the RBR family. Parkin subfamily. (482 aa) |
| | CG11367 | LD47277p. (362 aa) |
| | Itpr | Inositol 1,4,5,-trisphosphate receptor (Itpr) encodes an intracellular ligand gated calcium channel. It functions downstream of G-protein coupled receptors that activate Gq/PLCbeta signaling and generate inositol tris-phosphate. Itpr depletion affects ecdysone release, response to nutritional stress, lipid metabolism and flight; Belongs to the InsP3 receptor family. (2837 aa) |
| | Nmdar1 | Glutamate [NMDA] receptor subunit 1; NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors. Plays a role in associative learning and in long-term memory consolidation. (997 aa) |
| | NKCC | Sodium:potassium:chloride symporter activity; potassium:chloride symporter activity; sodium ion transmembrane transporter activity; sodium:chloride symporter activity; amino acid transmembrane transporter activity. (1068 aa) |
| | CG14036 | FI16614p1; It is involved in the biological process described with: copper ion homeostasis. (93 aa) |
| | Scox | Synthesis of cytochrome c oxidase (Scox) encodes a protein involved in cytochrome complex assembly and regulation of ATP biosynthesis. (251 aa) |
| | nrv2 | Sodium/potassium-transporting ATPase subunit beta-2; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. (323 aa) |
| | nrv1 | Sodium/potassium-transporting ATPase subunit beta-1; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. (309 aa) |
| | MME1 | Mitochondrial magnesium exporter 1; Mediates efflux of magnesium ions from mitochondria, suggesting a role in magnesium homeostasis. (299 aa) |
| | CG6230 | Cation-transporting ATPase; Ion transmembrane transporter activity, phosphorylative mechanism; nucleotide binding; ATPase activity. It is involved in the biological process described with: cellular calcium ion homeostasis; cation transport; transmembrane transport; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1225 aa) |
| | Vha68-2 | Vacuolar H[+] ATPase 68 kDa subunit 2 (Vha68-2) encodes a component of the V1 subunit of the vacuolar ATPase, which acidifies endosomal compartments including the lysosome and influences the activity of several signaling pathways. (614 aa) |
| | Vha68-1 | V-type proton ATPase catalytic subunit A isoform 1; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (614 aa) |
| | CG6523 | LD40224p; Protein disulfide oxidoreductase activity; electron transfer activity. It is involved in the biological process described with: cellular iron ion homeostasis; cell redox homeostasis. (216 aa) |
| | ZnT35C | Zinc transporter 35C (ZnT35C) encodes a protein involved in cellular and organismal zinc efflux that plays a major role in the detoxification of zinc excess. ZnT35C is a target of the metal-responsive transcription factor encoded by MTF-1. (472 aa) |
| | Syx5 | Syntaxin-5; Syntaxin 5 (Syx5) encodes a type II transmembrane protein in the Q-SNARE family that forms hetero tetramers required for membrane function in the early secretory pathway (ER and Golgi). It has been involved in cytokinesis during spermatogenesis. (467 aa) |
| | Catsup | Protein catecholamines up; Negatively regulates tyrosine hydroxylase activity; Belongs to the ZIP transporter (TC 2.A.5) family. KE4/Catsup subfamily. (449 aa) |
| | CG10470 | Calcium load-activated calcium channel; Calcium-selective channel required to prevent calcium stores from overfilling. (183 aa) |
| | Ctr1B | Copper transporter 1B (Ctr1B) encodes a protein that ensures copper uptake in the intestine. Ctr1B transcription is upregulated under conditions of copper depletion via the metal-responsive transcription factor encoded by MTF-1. (174 aa) |
| | IscU | Iron-sulfur cluster assembly enzyme; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. (154 aa) |
| | Irp-1B | Iron regulatory protein 1B (Irp-1B) encodes a cytosolic aconitase highly homologous to the product of Irp-1A; Belongs to the aconitase/IPM isomerase family. (899 aa) |
| | ZnT86D | Zinc transporter 86D (ZnT86D) encodes a transporter involved in zinc detoxification. (366 aa) |
| | Ho | Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (296 aa) |
| | CG6908 | Uncharacterized protein, isoform A; It is involved in the biological process described with: copper ion homeostasis. (449 aa) |
| | Cpn | Calphotin (Cpn) encodes a glutamic acid-rich protein with a strong negative charge and a highly hydrophobic amino acid composition. It functions as an immobile Ca[2+] buffer along the base of the photoreceptor's microvilli. It protects the photoreceptor cells from Ca[2+] overload and light induced degeneration. (864 aa) |
| | Vha55 | V-type proton ATPase subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells; Belongs to the ATPase alpha/beta chains family. (490 aa) |
| | Vha100-2 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (834 aa) |
| | Vha100-4 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (844 aa) |
| | CG5250 | AT04468p; ATPase activator activity; sodium:potassium-exchanging ATPase activity. It is involved in the biological process described with: cellular potassium ion homeostasis; cellular sodium ion homeostasis; potassium ion import across plasma membrane; sodium ion export across plasma membrane. (311 aa) |
| | CG11703 | Na/K-ATPase beta subunit isoform 4; Sodium:potassium-exchanging ATPase activity; ATPase activator activity. It is involved in the biological process described with: cellular sodium ion homeostasis; sodium ion export across plasma membrane; potassium ion import across plasma membrane; cellular potassium ion homeostasis. (353 aa) |
| | MtnC | Metallothionein-3; Metallothionein C (MtnC) encodes a member of the Metallothionein family whose transcription is strongly inducible by copper and cadmium ions. Its induction depends on the transcription factor encoded by MTF-1; Belongs to the metallothionein superfamily. Type 5 family. (43 aa) |
| | Irp-1A | Iron regulatory protein 1A (Irp-1A) encodes a cytosolic aconitase that under iron deficiency (or if cytosolic superoxide is present) loses its iron-sulfur cluster, changes confirmation and binds iron regulatory elements (so far identified on the products of SdhB and Fer1HCH mRNAs); Belongs to the aconitase/IPM isomerase family. (902 aa) |
| | wfs1 | Wolframin; Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store (By similarity). In neurons and glial cells, has a role in maintaining neuronal function and integrity during aging. (853 aa) |
| | VhaAC39-2 | Probable V-type proton ATPase subunit d 2; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system; Belongs to the V-ATPase V0D/AC39 subunit family. (350 aa) |
| | Mco3 | Multicopper oxidase 3 (Mco3) encodes a multi-copper oxidase enzyme that is located in the cellular secretory pathway. It is developmentally regulated and has been proposed to affect iron and copper homeostasis. (677 aa) |
| | boss | Protein bride of sevenless; Acts as a ligand for sevenless tyrosine-kinase receptor during eye development. (896 aa) |
| | mfrn | Mitoferrin; Mitochondrial iron transporter that mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly; Belongs to the mitochondrial carrier (TC 2.A.29) family. (379 aa) |
| | Vha100-1 | Vacuolar H[+] ATPase 100kD subunit 1 (Vha100-1) encodes a subunit of the V0 domain of V-ATPase, which acidifies autophagosomes and lysosomes in neurons. The product of Vha100-1 is involved in autophagosome maturation, tracheal branching and eye development. (855 aa) |
| | Cisd2 | CDGSH iron-sulfur domain-containing protein 2 homolog; 2 iron, 2 sulfur cluster binding; Belongs to the CISD protein family. CISD2 subfamily. (133 aa) |
| | trp | Transient receptor potential protein; A light-sensitive calcium channel that is required for inositide-mediated Ca(2+) entry in the retina during phospholipase C (PLC)-mediated phototransduction. Ca(2+) influx may then feed back and inhibit PLC, thereby facilitating phosphatidylinositol 4,5 bisphosphate (PIP2) recycling. Trp and trpl act together in the light response, though it is unclear whether as heteromultimers or as distinct units, and are activated by fatty acids and metabolic stress. Also required for olfactory adaptation and may be involved in olfactory system development. Bel [...] (1275 aa) |
| | Ctr1C | Copper transporter 1C (Ctr1C) is expressed in the male gonad. The autosomal gene seems to have originated as a retrogene copy of the X-linked Ctr1A, thus maintaining copper delivery during male spermatogenesis when the X chromosome is inactive. (270 aa) |
| | Zip42C.1 | Zinc/iron regulated transporter-related protein 42C.1 (Zip42C.1) encodes a plasma membrane resident zinc transporter belonging to the Zinc-Iron Permease family. It works together with the products of Zip42C.2 and Zip89B in dietary zinc absorption. (352 aa) |
| | Vha100-3 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (904 aa) |
| | EMRE | Essential MCU regulator, mitochondrial; Essential regulatory subunit of the mitochondrial calcium uniporter MCU channel, a protein that mediates calcium uptake into mitochondria. (97 aa) |
| | Cbp53E | Calbindin-32; Calbindin 53E (Cbp53E) encodes a 6 EF-hand domain-containing protein that regulates neuronal development. (310 aa) |
| | GPHR | Golgi pH Regulator (GPHR) encodes an anion channel that regulates Golgi luminal pH. It is expressed in both ER and Golgi apparatus and is necessary for proper function of the secretory pathway. (455 aa) |
| | AGBE | 1,4-Alpha-Glucan Branching Enzyme (AGBE) encodes a protein that is inferred to be a hydrolase involved in glycogen synthesis and hypoxia, based on the function of its orthologs. It contributes to the determination of lifespan. (685 aa) |
| | CG33672 | GEO02273p1; Iron-sulfur cluster binding. It is involved in the biological process described with: cellular iron ion homeostasis; [2Fe-2S] cluster assembly. (86 aa) |
| | CG13223 | Uncharacterized protein; Calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential; cation transmembrane transporter activity. It is involved in the biological process described with: transmembrane transport; cellular calcium ion homeostasis; cation transport; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (527 aa) |
| | Fbl6 | F-box and leucine-rich repeat protein 6, isoform A; SAM domain binding. It is involved in the biological process described with: positive regulation of ubiquitin-dependent protein catabolic process; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; regulation of protein stability; ubiquitin-dependent protein catabolic process. (720 aa) |
| | trpl | Transient-receptor-potential-like protein; A light-sensitive calcium channel that is required for inositide-mediated Ca(2+) entry in the retina during phospholipase C (PLC)-mediated phototransduction. Required for vision in the dark and in dim light. Binds calmodulin. Trp and trpl act together in the light response, although it is unclear whether as heteromultimers or distinct units. Also forms a functional cation channel with Trpgamma. Activated by fatty acids, metabolic stress, inositols and GTP-binding proteins. (1124 aa) |
| | VhaAC45 | V-type proton ATPase subunit S1; Accessory subunit of the proton-transporting vacuolar (V)- ATPase protein pump, which is required for luminal acidification of secretory vesicles. (379 aa) |
| | CG12376 | GH07338p; Cation transmembrane transporter activity; calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential. It is involved in the biological process described with: transmembrane transport; cellular calcium ion homeostasis; cation transport; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (617 aa) |
| | CG14757 | Succinate dehydrogenase assembly factor 2-A, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer. (163 aa) |
| | Atpalpha | Sodium/potassium-transporting ATPase subunit alpha; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. (1041 aa) |
| | Zip99C | Zinc/iron regulated transporter-related protein 99C (Zip99C) encodes an iron transporter located on the Golgi and endoplasmic reticulum that moves iron from the cytoplasm into the secretory compartments; Belongs to the ZIP transporter (TC 2.A.5) family. KE4/Catsup subfamily. (355 aa) |
| | CG31030 | Uncharacterized protein, isoform B; Proton-transporting ATPase activity, rotational mechanism; proton-transporting ATP synthase activity, rotational mechanism. It is involved in the biological process described with: regulation of cellular pH. (423 aa) |
| | MICU1 | Calcium uptake protein 1 homolog, mitochondrial; Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains (Probable). During development, required in alpha/beta or gamma mushroom body neurons to support olfactory intermediate-term memory in the adult ; Belongs to the MICU1 family. MICU1 subfamily. (525 aa) |
| | Amt | Ammonium transporter (Amt) encodes a protein required for ammonia detection. (562 aa) |
| | MTF-1 | Metal response element-binding Transcription Factor-1 (MTF-1) encodes a zinc finger protein that primarily controls the homeostasis of physiological trace metals, such as zinc and copper, and the detoxification of non-essential, toxic heavy metals, such as cadmium, mercury, and silver. It activates a number of genes in response to heavy metal load but also induces transcription of the copper importer encoded by Ctr1B upon copper depletion. Variations in the DNA binding site can affect its response to a specific metal. (1006 aa) |
| | anne | Nucleotide binding; ATPase activity. It is involved in the biological process described with: cellular calcium ion homeostasis; cation transport; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1451 aa) |
| | Nhe3 | Sodium/hydrogen exchanger; Sodium:proton antiporter activity; potassium:proton antiporter activity. It is involved in the biological process described with: regulation of intracellular pH; potassium ion transmembrane transport; sodium ion import across plasma membrane; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (711 aa) |
| | THADA | Thyroid adenoma-associated protein homolog; Plays a key role in energy homeostasis by regulating the balance between energy storage and heat production. Functions by negatively regulating Ca(2+) signaling pathways that are involved in heat production and maintaining correct lipid storage in the fat body. Regulates Ca(2+) signaling pathways by reducing the activity of the calcium-transporting ATPase SERCA possibly by promoting uncoupling of SERCA ATP hydrolysis from calcium pumping. May also function in the nervous system to control feeding behavior. (1746 aa) |
| | Ndae1 | Na[+]-driven anion exchanger 1 (Ndae1) encodes an intrinsic membrane protein that reversibly mediates the exchange of 1 Na[+] and 2 HCO[[3]][-] for 1 Cl[-] at basolateral membranes of gut and renal epithelia as well as CNS neurons. In the CNS, the product of Ndae1 can lower resting intracellular Cl[-] controlling GABA(A) Cl-channel activity. (1190 aa) |
| | Nhe2 | Na[+]/H[+] hydrogen exchanger 2 (Nhe2) encodes a Na-H exchanger of the SLC family 9A that increases intracellular pH. The product of Nhe2 activity promotes proliferation, morphogenesis and planar cell polarity, and contributes to oncogene-induced metastatic cell behaviors; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (1322 aa) |
| | stw | Straw, isoform E; Oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor; ferroxidase activity; copper ion binding. It is involved in the biological process described with: oxidation-reduction process; chitin-based cuticle development; iron ion homeostasis; iron ion transport. (784 aa) |
| | CG17167 | RE48874p; Calcium, potassium:sodium antiporter activity; calcium channel activity. It is involved in the biological process described with: calcium ion transmembrane transport; cellular calcium ion homeostasis; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (522 aa) |
| | CG42542 | Uncharacterized protein, isoform D; Calcium ion transmembrane transporter activity; manganese ion transmembrane transporter activity; metal ion transmembrane transporter activity. It is involved in the biological process described with: calcium ion transmembrane transport; Golgi calcium ion transport; Golgi calcium ion homeostasis; manganese ion transmembrane transport. (503 aa) |
| | zyd | Zydeco, isoform F; Zydeco (zyd) encodes a potassium-dependent sodium/calcium exchanger found in cortex glia. It is thought to serve as a key calcium export pathway to control calcium oscillations that occur in membrane microdomains of the glial cell; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (542 aa) |
| | Nhe1 | Sodium/hydrogen exchanger; Sodium:proton antiporter activity; potassium:proton antiporter activity. It is involved in the biological process described with: sodium ion transport; regulation of intracellular pH; potassium ion transmembrane transport; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (649 aa) |
| | uex | Unextended, isoform E; Transmembrane transporter activity. It is involved in the biological process described with: cellular ion homeostasis. (834 aa) |
| | CG42638 | Cation channel activity. (652 aa) |
| | ZnT33D | Zinc ion transmembrane transporter activity. (701 aa) |
| | Rbcn-3A | Rabconnectin-3A (Rbcn-3A) encodes a protein that is part of a regulatory subunit of the Vacuolar H[+] ATPase required for acidification of intracellular vesicles and the lysosome. It is involved in endocytic trafficking and lysosome function, and mutations block Notch signaling in follicle cells and imaginal disc cells. (3426 aa) |
| | Mco1 | Multicopper oxidase 1 (Mco1) encodes a plasma membrane-bound multicopper oxidase that is positioned to oxidize substrates in the hemolymph, such as ascorbate, and its biological role is unknown. (959 aa) |
| | Nckx30C | Sodium/potassium/calcium exchanger Nckx30C; May function in the removal and maintenance of calcium homeostasis during signaling in the adult and in signaling events during embryogenesis and patterning of imaginal disks. Transports one Ca(2+) and 1 K(+) in exchange for 4 Na(+). Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily. (881 aa) |
| | PMCA | Plasma membrane calcium ATPase (PMCA) encodes a P-type ion pump found in the plasma membrane. It functions as a low-capacity, high-affinity Ca[2+]-extrusion mechanism, which is required for maintaining resting Ca[2+] levels in all cells. In the larval neuromuscular junction it plays an important role in restoring resting Ca[2+] levels after pre- or post-synaptic Ca[2+] influx. (1255 aa) |
| | RyR | Ryanodine receptor (RyR) encodes an intracellular calcium channel localized in the sarcoplasmic reticulum of muscles and the endoplasmic reticulum of neurons and other cell types. It regulates the release of intracellular calcium stores and has a key role in muscle contraction. (5134 aa) |
| | Cib2 | Calcium and integrin binding family member 2; Calcium ion binding; calcium-dependent protein serine/threonine phosphatase activity. It is involved in the biological process described with: calcium ion homeostasis; phototransduction. (189 aa) |
| | CG5348 | Uncharacterized protein, isoform B; Cation transmembrane transporter activity; calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential. It is involved in the biological process described with: cation transport; cellular calcium ion homeostasis; transmembrane transport; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (625 aa) |
| | CG43321 | Uncharacterized protein; It is involved in the biological process described with: mitochondrial calcium ion transmembrane transport; mitochondrial calcium ion homeostasis; calcium import into the mitochondrion. (65 aa) |
| | CG14743 | Uncharacterized protein; Calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential; cation transmembrane transporter activity. It is involved in the biological process described with: transmembrane transport; cation transport; cellular calcium ion homeostasis; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (611 aa) |
| | CG14744 | Uncharacterized protein, isoform C; Cation transmembrane transporter activity; calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential. It is involved in the biological process described with: cellular calcium ion homeostasis; cation transport; transmembrane transport; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (620 aa) |
| | MCU | Calcium uniporter protein, mitochondrial; Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes a pore- forming and calcium-conducting subunit. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Together with Itpr, has a role in oxidative stress-induced ER-mitochondria calcium transfer. During pupation, required for memory function in mushroom body neurons. Belongs to the MCU (TC 1.A.77) family. (457 aa) |
| | MtnD | Metallothionein-4; Metallothionein D (MtnD) encodes a member of the Metallothionein family whose transcription is strongly inducible by copper and cadmium ions. Its induction depends on the transcription factor encoded by MTF-1; Belongs to the metallothionein superfamily. Type 5 family. (44 aa) |
| | Pdfr | PDF receptor; Pigment-dispersing factor receptor (Pdfr) encodes a G-Protein Coupled Receptor in the Family B class of GPCRs (Secretin Receptor-like) that can be activated by the product of Pdf. It has been implicated in regulation of circadian physiology, development of the flight motor system, and regulation of mating. (738 aa) |
| | Ctr1A | Copper transporter 1A (Ctr1A) encodes a plasma membrane protein that functions as a copper transporter. It is required to drive neuropeptide maturation during normal growth and development. (241 aa) |
| | Grx1 | Glutaredoxin 1 (Grx1) encodes a protein involved in copper ion homeostasis. (114 aa) |
| | up | Troponin T, skeletal muscle; Upheld (up) encodes the striated muscle protein Troponin T. Troponins T, C and I form a regulatory complex with Tropomyosin that is found at regular intervals along the thin (F-actin) filaments of the muscle sarcomere. (397 aa) |
| | CG11825 | Uncharacterized protein, isoform C; It is involved in the biological process described with: mitochondrial respirasome assembly; copper ion homeostasis. (136 aa) |
| | DAT | Sodium-dependent dopamine transporter; Sodium-dependent dopamine transporter which terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals. Also transports tyramine and norepinephrine, shows less efficient transport of octopamine and does not transport serotonin. Plays a role in the regulation of the rest/activity cycle. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (644 aa) |
| | Mvl | Malvolio (Mvl) encodes a member of the SLC11 family of metal ion transporters that transports divalent metal cations, including Mn[2+] and Fe[2+]. Its function has been linked to feeding-related decisions, possibly via modulation of dopaminergic signaling. (639 aa) |
| | ZnT63C | Zinc transporter 63C, isoform F; Zinc transporter 63C (ZnT63C) encodes a plasma membrane resident zinc transporter belonging to the zinc transporter family that is mainly responsible for zinc export from the cell or into organelles. It plays a key role in effluxing zinc from enterocytes into circulation during dietary zinc absorption. (545 aa) |
| | Atox1 | Antioxidant 1 copper chaperone (Atox1) null mutants are unable to develop on low-copper food. Furthermore, the intestinal copper importer encoded by Ctr1B, which is regulated by copper demand, fails to be induced upon copper starvation in Atox1 mutant larvae, while intestinal metallothionein is upregulated. This suggests intestinal copper accumulation, combined with insufficient delivery to the rest of the body. (89 aa) |
| | Dop1R2 | Dopamine receptor 2; Receptor for dopamine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Also capable of generating a calcium signal. In terms of antagonist responses, would be classed with the D1-like dopamine receptor group. This receptor is an attractive candidate for initiating biochemical cascades underlying olfactory learning. (807 aa) |
| | Wdr24 | GATOR complex protein WDR24; An essential component of the GATOR subcomplex GATOR2 which functions as an activator of the amino acid-sensing branch of the TORC1 signaling pathway. The two GATOR subcomplexes, GATOR1 and GATOR2, regulate the TORC1 pathway in order to mediate metabolic homeostasis, female gametogenesis and the response to amino acid limitation and complete starvation. GATOR2 activates the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex, controlling the switch to cell proliferation and growth under nutrient replete conditions and during female oocyt [...] (777 aa) |
| | Dop1R1 | Dopamine receptor 1; Receptor for dopamine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Might be involved in the processing of visual information and/or visual learning. Important for Pavlovian conditioning: required in the mushroom body as a receptor conveying unconditional stimuli information, has a role in memory formation for aversive and appetitive learning. Sleep-deprivation-induced impairments in learning can be partially explained through alterations in dopamine signaling, Dop1R1 expression levels are reduced; sleep may have a role i [...] (560 aa) |
| | Oamb | Octopamine receptor Oamb; Receptor for octopamine (OA) which is a neurotransmitter, neurohormone and neuromodulator in invertebrates. Stimulates intracellular accumulation of cAMP and Ca(2+) following ligand binding. Required for ovulation. Following activation on mature follicle cells by OA, induces activity of the metalloprotease Mmp2 which leads to breakdown of the posterior follicle wall, resulting in ovulation. Ligand binding probably also leads to activation of CamKII which is also required for ovulation. Modulates sleep/wake behavior by acting in neurons of the pars intercerebra [...] (751 aa) |
| | VGlut | Vesicular glutamate transporter, isoform A. (632 aa) |
| | Rh50 | Rh50, isoform B; Ammonium transmembrane transporter activity. It is involved in the biological process described with: ammonium transmembrane transport; Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily. (460 aa) |
| | SPoCk | Secretory Pathway Calcium atpase (SPoCk) encodes a transporting ATPase with roles in the maintenance of cellular Ca2+ homeostasis; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (1062 aa) |
| | Fer2LCH | Ferritin 2 light chain homologue (Fer2LCH) encodes one of two subunits of the major iron storage complex, the ferritin molecule. In insects, ferritin is assembled from 12 Fer1HCH and 12 Fer2LCH subunits and can be found in the secretory pathway of cells and in hemolymph. The product of Fer2LCH provides iron nucleation sites in the internal cavity of the complex required for iron mineralization and is essential for embryogenesis. (236 aa) |
| | Fer1HCH | Ferritin 1 heavy chain homologue (Fer1HCH) encodes one of two subunits of the major iron storage complex, the ferritin molecule. In insects, ferritin is assembled from 12 Fer1HCH and 12 Fer2LCH subunits and can be found in the secretory pathway of cells and in hemolymph. The product of Fer1HCH has ferroxidase activity required for iron loading into ferritin and is essential for embryogenesis. (245 aa) |
| | CG12061 | Uncharacterized protein, isoform D; Calcium, potassium:sodium antiporter activity; calcium channel activity. It is involved in the biological process described with: calcium ion transmembrane transport; cellular calcium ion homeostasis; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (441 aa) |
| | CG5421 | Uncharacterized protein, isoform A; Proton-transporting ATP synthase activity, rotational mechanism; proton-transporting ATPase activity, rotational mechanism. It is involved in the biological process described with: regulation of cellular pH. (426 aa) |
| | CG17593 | FI04424p; Calcium ion binding. (476 aa) |
| | nrv3 | Nervana 3 (nrv3) encodes one of three beta subunits of the sodium-potassium pump (ATPalpha). nrv3 is expressed in the nervous system, including subsets of the CNS and Johnston's organ neurons, and is required for hearing. (313 aa) |
| | ClC-c | Chloride channel-c (ClC-c) encodes an intracellular chloride transporter that is involved in endosomal lumen acidification. (893 aa) |
| | Cln3 | Battenin. (422 aa) |
| | Ncc69 | Sodium chloride cotransporter 69 (Ncc69) encodes a member of the SLC12 family of Na[+]/K[+]/2Cl[-] cotransporters (NKCC). (1207 aa) |
| | ATP7 | ATP7, isoform B; ATP7 (ATP7) encodes a copper transmembrane transporter involved in cuticle pigmentation, copper homeostasis and larval development. (1254 aa) |
| | MtnA | Metallothionein-1; Metallothionein A (MtnA) encodes a member of the Metallothionein family whose transcript level is higher than that of the other four Drosophila metallothioneins. Transcription is strongly induced by copper and cadmium ions and this induction depends on the transcription factor encoded by MTF-1; Belongs to the metallothionein superfamily. Type 5 family. (40 aa) |
| | MICU3 | Uncharacterized protein, isoform D; Calcium ion binding. It is involved in the biological process described with: mitochondrial calcium ion transmembrane transport. (524 aa) |
| | Trpgamma | Transient receptor potential-gamma protein; A light-sensitive calcium channel that is required for inositide-mediated Ca(2+) entry in the retina during phospholipase C (PLC)-mediated phototransduction (By similarity). Forms a regulated cation channel when heteromultimerized with trpl; Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. (1188 aa) |
| | CG1090 | Probable sodium/potassium/calcium exchanger CG1090; May function in the removal and maintenance of calcium homeostasis. Transports one Ca(2+) and 1 K(+) in exchange for 4 Na(+) (By similarity). (633 aa) |
| | Vha100-5 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (814 aa) |
| | Trpm | Transient receptor potential cation channel trpm; Calcium channel mediating constitutive calcium ion entry. Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. (2023 aa) |
| | CG30377 | MIP13269p; It is involved in the biological process described with: copper ion homeostasis. (897 aa) |
| | CG4704 | Uncharacterized protein, isoform A; Calcium ion binding. It is involved in the biological process described with: mitochondrial calcium ion transmembrane transport. (354 aa) |
| | wash | WASH complex subunit 1; Acts as a nucleation-promoting factor by activating the Arp2/3 complex to induce actin polymerization. Participates in both linear- and branched-actin networks. Functions in linear-filament (bundled F-actin) by acting downstream of Rho1 and regulating actin and microtubule organization during oogenesis. Nucleates actin in an Arp2/3-dependent manner and exhibits F-actin and microtubule bundling and cross-linking activity in the egg chamber. During embryogenesis, acts downstream of Rho1 to activate the Arp2/3 complex which is necessary for the developmental migrat [...] (499 aa) |
| | CG12773 | EG:8D8.3 protein; Potassium:chloride symporter activity; amino acid transmembrane transporter activity. (712 aa) |
| | kcc | Kazachoc, isoform G; Kazachoc (kcc) encodes a potassium:chloride symporter that contributes to seizure susceptibility. (1077 aa) |
| | CG33310 | Uncharacterized protein; ATPase activator activity; sodium:potassium-exchanging ATPase activity. It is involved in the biological process described with: cellular potassium ion homeostasis; cellular sodium ion homeostasis; sodium ion export across plasma membrane; potassium ion import across plasma membrane. (876 aa) |
| | CG10413 | GH08340p; Potassium:chloride symporter activity. It is involved in the biological process described with: chloride ion homeostasis; cell volume homeostasis; chloride transmembrane transport; potassium ion homeostasis; potassium ion import across plasma membrane. (941 aa) |
| | Raf | Raf homolog serine/threonine-protein kinase Raf; Serine/threonine kinase required in the early embryo for the formation of terminal structure. Also required during the proliferation of imaginal cells. May act downstream of Ras85D in the tor signal transduction pathway. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily. (739 aa) |
| | Shawn | Shawn, isoform B; Shawn (Shawn) encodes a mitochondrial carrier involved in metal homeostasis; Belongs to the mitochondrial carrier (TC 2.A.29) family. (387 aa) |
| | Rbcn-3B | Rabconnectin-3B, isoform A; Rabconnectin-3B (Rbcn-3B) encodes a protein that is part of a regulatory subunit of the Vacuolar H[+] ATPase required for acidification of intracellular vesicles and the lysosome. It involved in endocytic trafficking and lysosome function, and mutations block Notch signaling in follicle cells and imaginal disc cells. (1525 aa) |
| | CG45062 | Uncharacterized protein, isoform A; ATPase activity; nucleotide binding; calcium transmembrane transporter activity, phosphorylative mechanism; proton-exporting ATPase activity, phosphorylative mechanism. It is involved in the biological process described with: calcium ion transmembrane transport; cellular calcium ion homeostasis. (794 aa) |
| | foi | Zinc transporter foi; Required for the normal migration of longitudinal and peripheral glial cells. During larval development, required for the migration of the subretinal glia into the eye disk. During embryonic development, also controls the migration of muscle cells toward their attachment sites. Required in the mesoderm for the correct morphogenesis of embryonic gonad and for tracheal branch fusion during tracheal development. Shg may be cooperating with foi to mediate a common mechanism for gonad and tracheal morphogenesis. Acts as a zinc transporter in both yeast and mammalian cells. (706 aa) |
| | CG33932 | GEO12594p1; It is involved in the biological process described with: cellular calcium ion homeostasis. (148 aa) |
| | MtnB | Metallothionein-2; Metallothionein B (MtnB) encodes one of the five metallothioneins. They are metal-binding polypeptides that coordinate both physiological and xenobiotic metal ions, either for homeostasis or detoxification purposes. The product of MtnB shows a preference towards divalent metal ion binding. (43 aa) |
| | JYalpha | Sodium/potassium-transporting ATPase subunit alpha; JYalpha (JYalpha) is a gene essential for male fertility as mutants produce immotile sperm. (1009 aa) |
| | Zip71B | Zinc/iron regulated transporter-related protein 71B (Zip71B) encodes a protein involved in zinc detoxification and zinc transmembrane import. (572 aa) |
