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nAChRbeta1 nAChRbeta1 Stim Stim ppk28 ppk28 Trpml Trpml GluRIA GluRIA nAChRbeta3 nAChRbeta3 Itpr Itpr Nmdar1 Nmdar1 Orco Orco GluRIIA GluRIIA ppk7 ppk7 ppk ppk ppk13 ppk13 GluRIID GluRIID KaiR1D KaiR1D nAChRbeta2 nAChRbeta2 ppk21 ppk21 ppk19 ppk19 ppk20 ppk20 ppk3 ppk3 ppk24 ppk24 ppk25 ppk25 ppk6 ppk6 GluRIIB GluRIIB ppk10 ppk10 ppk11 ppk11 ppk16 ppk16 GluRIIE GluRIIE clumsy clumsy Ekar Ekar ppk9 ppk9 ppk23 ppk23 ppk15 ppk15 ppk31 ppk31 ppk22 ppk22 ppk29 ppk29 nAChRalpha4 nAChRalpha4 nAChRalpha7 nAChRalpha7 CG42638 CG42638 CngA CngA ppk27 ppk27 RyR RyR rpk rpk ppk5 ppk5 ppk8 ppk8 Cngl Cngl ppk30 ppk30 ppk26 ppk26 CG11155 CG11155 Grik Grik ppk18 ppk18 Irk1 Irk1 GluRIIC GluRIIC Trpm Trpm Irk2 Irk2 Irk3 Irk3 sei sei ppk17 ppk17 ppk14 ppk14 Nach Nach CG42260 CG42260 nAChRalpha5 nAChRalpha5 ppk12 ppk12 CngB CngB Nmdar2 Nmdar2
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
Predicted Interactions
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nAChRbeta1Acetylcholine receptor subunit beta-like 1; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. (521 aa)
StimStromal interaction molecule (Stim) encodes an endomasplic reticulum-membrane protein that is an essential component of the store-operated calcium entry mechanism, which in neurons regulates flight. (570 aa)
ppk28Pickpocket protein 28; Osmosensitive ion channel that mediates the cellular and behavioral response to water. Plays an essential role in gustatory water reception. Part of a complex that plays a role in tracheal liquid clearance. Probable role in sodium transport. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (606 aa)
TrpmlTransient receptor potential cation channel, mucolipin (Trpml) encodes a ion channel involved in autophagy, lateral inhibition and TOR signalling regulation. (652 aa)
GluRIAGlutamate receptor 1; Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists (By similarity). Forms ligand-gated ion channels which are activated by kainate; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (991 aa)
nAChRbeta3Nicotinic acetylcholine receptor beta 3 (Dbeta3) subunit; Transmembrane signaling receptor activity; acetylcholine-gated cation-selective channel activity; neurotransmitter receptor activity. (441 aa)
ItprInositol 1,4,5,-trisphosphate receptor (Itpr) encodes an intracellular ligand gated calcium channel. It functions downstream of G-protein coupled receptors that activate Gq/PLCbeta signaling and generate inositol tris-phosphate. Itpr depletion affects ecdysone release, response to nutritional stress, lipid metabolism and flight; Belongs to the InsP3 receptor family. (2837 aa)
Nmdar1Glutamate [NMDA] receptor subunit 1; NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors. Plays a role in associative learning and in long-term memory consolidation. (997 aa)
OrcoOdorant receptor coreceptor; Odorant coreceptor which complexes with conventional odorant receptors (ORs) to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Orco is a universal and integral part of the functional odorant receptor, involved in the dendritic localization of other olfactory receptors. Expression of Orco alone leads to formation of rapid and transient ion channels not directly responding to odorants, but directly activated by intracellular cAMP or cGMP. Snmp, Or67d and lush act in concert to capture fatty-acid-deriv [...] (486 aa)
GluRIIAGlutamate receptor IIA (GluRIIA) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. (907 aa)
ppk7Pickpocket 7; Sodium channel activity. It is involved in the biological process described with: sodium ion transport; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (573 aa)
ppkAmiloride-sensitive Na+ channel; Pickpocket (ppk) encodes an acid-sensing sodium channel from the degenerin/epithelial sodium channel (DEG/ENaC) family. It contributes to mechanical nociception, larval behavior and dendrite morphogenesis. (606 aa)
ppk13Pickpocket 13; Sodium channel activity. It is involved in the biological process described with: sodium ion transport; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (460 aa)
GluRIIDGlutamate receptor IID (GluRIID) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. (902 aa)
KaiR1DKainate-type ionotropic glutamate receptor subunit 1D; It is involved in the biological process described with: calcium ion import across plasma membrane; regulation of synaptic activity; synaptic transmission, glutamatergic; positive regulation of neuromuscular synaptic transmission; modulation of chemical synaptic transmission. (853 aa)
nAChRbeta2Nicotinic Acetylcholine Receptor beta2 (nAChRbeta2) encodes a subunit of the nicotinic acetylcholine receptor, which is part of the superfamily of ligand-gated ion channels. These channels open to facilitate the passage of cations across synaptic membranes in response to the binding of their native ligand, acetylcholine. Mutations in nAChRbeta2 have been associated with resistance phenotypes to several neonicotinoid insecticides. (519 aa)
ppk21Pickpocket 21, isoform A; Sodium channel activity. It is involved in the biological process described with: sodium ion transport; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (550 aa)
ppk19Pickpocket 19 (ppk19) encodes a predicted member of the Degenerin/Epithelial Sodium Channel family protein. In the larval stage, it is expressed in the terminal organ for salt taste and tracheal cells for liquid clearance. In the adult stage it functions in salt taste likely through its expression in the chemical-sensing epithelia in the leg segment and wing blade. (511 aa)
ppk20Pickpocket 20, isoform A; Sodium channel activity. It is involved in the biological process described with: sodium ion transport; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (587 aa)
ppk3Pickpocket 3; Sodium channel activity. It is involved in the biological process described with: sodium ion transport; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (535 aa)
ppk24Pickpocket 24; Sodium channel activity. It is involved in the biological process described with: sodium ion transport; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (595 aa)
ppk25Pickpocket 25 (ppk25) encodes a DEG/ENaC channel subunit involved in male courtship behavior and pheromone detection; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (451 aa)
ppk6Pickpocket 6 (ppk6) encodes a member of the DEG/ENaC family, whose members act as non-voltage-gated cation channels. DEG/ENaC family members have been implicated in the maintenance of sodium gradients across epithelial membranes, as well as in diverse sensory modalities, which include gustatory chemosensation, mechanosensation, hygrosensation, and nociception; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (498 aa)
GluRIIBGlutamate receptor IIB (GluRIIB) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. (913 aa)
ppk10Pickpocket 10; Sodium channel activity. It is involved in the biological process described with: sodium ion transport; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (485 aa)
ppk11Pickpocket 11 (ppk11) encodes a predicted member of the Degenerin/Epithelial Sodium Channel family. In the larval stage, it is expressed in the terminal organ for salt taste and tracheal cells for liquid clearance. It functions in salt taste in adult flies; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (516 aa)
ppk16Pickpocket 16; Sodium channel activity. It is involved in the biological process described with: regulation of synaptic activity; sodium ion transport; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (531 aa)
GluRIIEGlutamate receptor IIE (GluRIIE) encodes an ion channel subunit involved in calcium ion transport. (897 aa)
clumsyClumsy, isoform B; Glutamate receptor activity; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential; ligand-gated ion channel activity; signaling receptor activity; kainate selective glutamate receptor activity. It is involved in the biological process described with: ion transport; modulation of chemical synaptic transmission; synaptic transmission, glutamatergic; regulation of synaptic activity. (1002 aa)
EkarEye-enriched kainate receptor, isoform B; Eye-enriched kainate receptor (Ekar) encodes an ionotropic receptor that responds to the neurotransmitter glutamate. (899 aa)
ppk9Pickpocket 9, isoform A; Sodium channel activity. It is involved in the biological process described with: sodium ion transport; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (599 aa)
ppk23Pickpocket 23 (ppk23) encodes a gustatory-specific putative non-voltage gated cation channel that belongs to the Degenerin/Epithelial sodium channel (DEG/ENaC) family. It contributes to pheromone perception and male courtship behavior. (591 aa)
ppk15Pickpocket 15; Sodium channel activity. It is involved in the biological process described with: sodium ion transport; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (483 aa)
ppk31Pickpocket 31; Sodium channel activity. It is involved in the biological process described with: sodium ion transport; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (421 aa)
ppk22Pickpocket 22, isoform B; Sodium channel activity. It is involved in the biological process described with: sodium ion transport; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (561 aa)
ppk29Pickpocket 29 (ppk29) encodes a putative non-voltage gated cation channel that belongs to the Degenerin/Epithelial sodium channel (DEG/ENaC) family. It contributes to pheromone signaling and neuronal excitability. (425 aa)
nAChRalpha4Nicotinic Acetylcholine Receptor alpha4 (nAChRalpha4) encodes a four-pass transmembrane channel that is part of a nicotinic acetycholine receptor complex. It promotes sleep and its expression level peaks when sleep need is high. Its activity is inhibited by the product of qvr. (539 aa)
nAChRalpha7Nicotinic Acetylcholine Receptor alpha7 (nAChRalpha7) encodes a subunit of the nicotinic acetylcholine receptor, a pentameric neurotransmitter-gated ion channel. (564 aa)
CG42638Cation channel activity. (652 aa)
CngACyclic nucleotide-gated ion channel subunit A (CngA) encodes a non-selective cation channel related to the superfamily of voltage-gated ion channels. It is involved in both excitation and adaptation of sensory cells, as well as in Ca[2+] response in the mushroom bodies. (840 aa)
ppk27Pickpocket 27; Sodium channel activity. It is involved in the biological process described with: sodium ion transport; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (422 aa)
RyRRyanodine receptor (RyR) encodes an intracellular calcium channel localized in the sarcoplasmic reticulum of muscles and the endoplasmic reticulum of neurons and other cell types. It regulates the release of intracellular calcium stores and has a key role in muscle contraction. (5134 aa)
rpkRipped pocket, isoform B; Ripped pocket (rpk) encodes a sodium channel in the Degenerin/Epithelial Sodium Channel/Acid Sensing Ion Channel (Deg/ENaC/ASIC) family. Expression of rpk in the larval multidendritic neurons is required for the detection of gentle touch stimuli. (568 aa)
ppk5Pickpocket 5, isoform B; Sodium channel activity. It is involved in the biological process described with: sodium ion transport; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (474 aa)
ppk8Pickpocket 8, isoform H; Sodium channel activity. It is involved in the biological process described with: sodium ion transport; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (569 aa)
CnglIntracellular cyclic nucleotide activated cation channel activity. It is involved in the biological process described with: cyclic-nucleotide-mediated signaling; transmembrane transport; cation transport. (1970 aa)
ppk30Pickpocket 30, isoform A; Sodium channel activity. It is involved in the biological process described with: sodium ion transport; regulation of terminal button organization; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (457 aa)
ppk26Pickpocket 26 (ppk26) encodes a member of the Degenerin/epithelial sodium channel family. In the larva, it regulates locomotion behavior and participates in mechanical nociception together with the product of ppk. (597 aa)
CG11155FI01405p; Kainate selective glutamate receptor activity; signaling receptor activity; ligand-gated ion channel activity. It is involved in the biological process described with: ion transport; regulation of synaptic activity. (910 aa)
GrikGrik, isoform C; Transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential; glutamate receptor activity; signaling receptor activity; kainate selective glutamate receptor activity; ligand-gated ion channel activity. It is involved in the biological process described with: ion transport; modulation of chemical synaptic transmission; synaptic transmission, glutamatergic; regulation of synaptic activity. (907 aa)
ppk18Pickpocket 18; Sodium channel activity. It is involved in the biological process described with: sodium ion transport; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (553 aa)
Irk1Inwardly rectifying potassium channel 1 (Irk1) encodes a K[+] channel involved in transepithelial ion transport in the renal tubule and in regulating excitability of the LNv subset of circadian pacemaker neurons. (652 aa)
GluRIICGlutamate receptor IIC (GluRIIC) encodes a subunit of the muscle glutamate receptor that responds to neurotransmitter at the neuromuscular junction. It is required for the synaptic localization of the products of GluRIIA and GluRIIB and for synaptic transmission. (940 aa)
TrpmTransient receptor potential cation channel trpm; Calcium channel mediating constitutive calcium ion entry. Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. (2023 aa)
Irk2Inwardly rectifying potassium channel 2 (Irk2) encodes a protein that is required in transepithelial fluid secretion and potassium transport in the Malpighian tubule. It contributes to wing patterning, through the regulation of release of the product of dpp. (454 aa)
Irk3Inwardly rectifying potassium channel 3 (Irk3) encodes a protein involved in wing disc development. (446 aa)
seiPutative potassium channel subunit homolog; Seizure (sei) encodes a protein involved in sound perception. (855 aa)
ppk17Pickpocket 17, isoform A; Sodium channel activity. It is involved in the biological process described with: sodium ion transport; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (431 aa)
ppk14Pickpocket 14; Sodium channel activity. It is involved in the biological process described with: sodium ion transport; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (504 aa)
NachSodium channel protein Nach; Nach (Nach) encodes a predicted member of the Degenerin/Epithelial Sodium Channel family of proteins. It is mainly expressed in the tracheal system and functions in liquid clearance during tracheal development; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (553 aa)
CG42260Uncharacterized protein, isoform E; CG42260 encodes a protein predicted to form the beta subunit of a cyclic nucleotide-gated ion channel. It could form a functional channel as a heterodimer with either the products of CngA or Cngl. (1269 aa)
nAChRalpha5Nicotinic Acetylcholine Receptor alpha5 (nAChRalpha5) encodes a subunit of the nicotinic acetylcholine receptor, which is a pentameric neurotransmitter-gated ion channel. (837 aa)
ppk12Pickpocket 12; Sodium channel activity. It is involved in the biological process described with: sodium ion transport; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (569 aa)
CngBCyclic nucleotide-gated ion channel subunit B, isoform A; cGMP binding; intracellular cAMP-activated cation channel activity; intracellular cGMP-activated cation channel activity; intracellular cyclic nucleotide activated cation channel activity. It is involved in the biological process described with: cation transport; cation transmembrane transport; cyclic-nucleotide-mediated signaling. (1040 aa)
Nmdar2NMDA receptor 2, isoform C; Ligand-gated ion channel activity; signaling receptor activity; NMDA glutamate receptor activity; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential; glutamate receptor activity. (1083 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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