Ubiquitin protein ligase activity; zinc ion binding. It is involved in the biological process described with: intracellular signal transduction; positive regulation of antibacterial peptide biosynthetic process; protein ubiquitination.

Ubiquitin-conjugating enzyme E2-22 kDa; Catalyzes the covalent attachment of ubiquitin to other proteins.

Uncharacterized protein, isoform A; Peptidoglycan transmembrane transporter activity. It is involved in the biological process described with: positive regulation of antimicrobial humoral response; peptidoglycan transport; transmembrane transport; positive regulation of peptidoglycan recognition protein signaling pathway.

Peptidoglycan-recognition protein LC; Major activator of the imd/Relish pathway and is likely to encode a pattern recognition molecule for the humoral immune response. Required for Relish processing and nuclear translocation following proteolytic cleavage. Involved in the response to lipopolysaccharide (LPS) and peptidoglycan of Gram-negative bacteria. The different isoforms probably display different recognition capabilities to various microbial patterns. [Isoform x]: Mediates the response to LPS, peptidoglycan and Gram-negative bacteria; Belongs to the N-acetylmuramoyl-L-alanine amid [...]

LD04951p; Charon (Charon) encodes a nuclear chromatin associated protein that controls Rel-dependent innate immune response and functions as a regulator of antibacterial and antifungal immune defense. It mediates Parp-dependent transcriptional responses downstream of the innate immune pathway.

Inhibitor of nuclear factor kappa-B kinase subunit beta; Required for the activation of the NF-kappa-B factor Relish (Rel) by acting as an essential signaling component in transmitting the lipopolysaccharide (LPS) signal leading to cact degradation, which is required for direct activation of Rel. Phosphorylates inhibitors of NF- kappa-B (cact) thus leading to the dissociation of the inhibitor/NF- kappa-B complex and ultimately the degradation of the NF-kappa-B inhibitor. Essential for antibacterial immune response.

LD04951p; Charon (Charon) encodes a nuclear chromatin associated protein that controls Rel-dependent innate immune response and functions as a regulator of antibacterial and antifungal immune defense. It mediates Parp-dependent transcriptional responses downstream of the innate immune pathway.

Nuclear factor NF-kappa-B p110 subunit; Plays a key role in the humoral immune response. Rel-p68 subunit translocates to the nucleus where it binds to the promoter of the Cecropin A1 gene and probably other antimicrobial peptide genes. I-kappa-B kinase complex (IKKbeta and key) and PGRP-LC are essential signaling components in transmitting the lipopolysaccharide (LPS) signal leading to cact degradation for NF-kappa-B (rel) activation. Part of a Toll-related receptor pathway that functions in the apoptosis of unfit cells during cell competition. May be part of a NF-kappa-B and Tollo sig [...]

LD04951p; Charon (Charon) encodes a nuclear chromatin associated protein that controls Rel-dependent innate immune response and functions as a regulator of antibacterial and antifungal immune defense. It mediates Parp-dependent transcriptional responses downstream of the innate immune pathway.

Nedd8-activating enzyme E1 catalytic subunit; Catalytic subunit of the dimeric Uba3-APP-BP1 E1 enzyme. E1 activates Nedd8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a Nedd8-Uba3 thioester and free AMP. E1 finally transfers Nedd8 to the catalytic cysteine of UbcE2M. Required for Cul1 and Cul3 neddylation. Negatively regulates full-length ci stability and hedgehog signaling.

LD04951p; Charon (Charon) encodes a nuclear chromatin associated protein that controls Rel-dependent innate immune response and functions as a regulator of antibacterial and antifungal immune defense. It mediates Parp-dependent transcriptional responses downstream of the innate immune pathway.

NF-kappa-B essential modulator; Kenny (key) encodes a scaffold protein that is a component of the IKK (IkappaB Kinase) complex, which participates in the activation of the transcription factor Rel in the Imd pathway. This pathway regulates the antibacterial response and other less characterized cellular processes.

Death-associated inhibitor of apoptosis 2; Required for activation of NF-kappaB transcription factors in the immune deficiency (Imd) signaling cascade which is essential for innate immune responses upon infection by Gram-negative bacteria. Promotes cytoplasmic cleavage of Rel and its translocation to the nucleus where it drives expression of antimicrobial peptides. Binds, polyubiquitinates and activates Dredd which is required for Rel- mediated induction of antimicrobial peptides. Anti- apoptotic protein which binds, ubiquitinates and inactivates the effector caspase Drice. Suppresses [...]

Caspase-8 subunit p10; Effector of the programmed cell death (PCD) activators rpr, grim and hid. May play an apoptotic role in the germline as well as soma. Fadd interacts with Dredd to promote cleavage of Dredd and is necessary and sufficient for enhancing Dredd-induced apoptosis. Plays a role in the innate immune response. Required for resistance to Gram-negative bacterial infection. Diap2-mediated ubiquitination of Dredd is critical for processing of imd and rel and the subsequent expression of antimicrobial genes such as DptA. Belongs to the peptidase C14A family.

Death-associated inhibitor of apoptosis 2; Required for activation of NF-kappaB transcription factors in the immune deficiency (Imd) signaling cascade which is essential for innate immune responses upon infection by Gram-negative bacteria. Promotes cytoplasmic cleavage of Rel and its translocation to the nucleus where it drives expression of antimicrobial peptides. Binds, polyubiquitinates and activates Dredd which is required for Rel- mediated induction of antimicrobial peptides. Anti- apoptotic protein which binds, ubiquitinates and inactivates the effector caspase Drice. Suppresses [...]

Fas-associated death domain protein; Component of the IMD signaling pathway and is required for the host defense against Gram-negative bacteria. Interacts with Dredd, promotes cleavage of Dredd and is necessary and sufficient for enhancing Dredd-induced apoptosis.

Death-associated inhibitor of apoptosis 2; Required for activation of NF-kappaB transcription factors in the immune deficiency (Imd) signaling cascade which is essential for innate immune responses upon infection by Gram-negative bacteria. Promotes cytoplasmic cleavage of Rel and its translocation to the nucleus where it drives expression of antimicrobial peptides. Binds, polyubiquitinates and activates Dredd which is required for Rel- mediated induction of antimicrobial peptides. Anti- apoptotic protein which binds, ubiquitinates and inactivates the effector caspase Drice. Suppresses [...]

Inhibitor of nuclear factor kappa-B kinase subunit beta; Required for the activation of the NF-kappa-B factor Relish (Rel) by acting as an essential signaling component in transmitting the lipopolysaccharide (LPS) signal leading to cact degradation, which is required for direct activation of Rel. Phosphorylates inhibitors of NF- kappa-B (cact) thus leading to the dissociation of the inhibitor/NF- kappa-B complex and ultimately the degradation of the NF-kappa-B inhibitor. Essential for antibacterial immune response.

Death-associated inhibitor of apoptosis 2; Required for activation of NF-kappaB transcription factors in the immune deficiency (Imd) signaling cascade which is essential for innate immune responses upon infection by Gram-negative bacteria. Promotes cytoplasmic cleavage of Rel and its translocation to the nucleus where it drives expression of antimicrobial peptides. Binds, polyubiquitinates and activates Dredd which is required for Rel- mediated induction of antimicrobial peptides. Anti- apoptotic protein which binds, ubiquitinates and inactivates the effector caspase Drice. Suppresses [...]

E3 ubiquitin-protein ligase lubel; E3 ubiquitin-protein ligase which conjugates linear 'Met- 1'- and 'Lys-63'-linked polyubiquitin chains to substrates and plays a crucial role in the NF-kappa-B intestinal inflammatory response to oral infection and in the heat stress response. Preferentially interacts with 'Lys-63'-linked, and to a lesser extent 'Lys-48'-linked, polyubiquitin chains. Upon oral infection with a Gram-negative bacterium E.carotovora subsp. carotovora 15, functions with the E2 ubiquitin- conjugating enzyme Ubc10 to mediate the conjugation of 'Lys-63'- and linear 'Met-1'-l [...]

Death-associated inhibitor of apoptosis 2; Required for activation of NF-kappaB transcription factors in the immune deficiency (Imd) signaling cascade which is essential for innate immune responses upon infection by Gram-negative bacteria. Promotes cytoplasmic cleavage of Rel and its translocation to the nucleus where it drives expression of antimicrobial peptides. Binds, polyubiquitinates and activates Dredd which is required for Rel- mediated induction of antimicrobial peptides. Anti- apoptotic protein which binds, ubiquitinates and inactivates the effector caspase Drice. Suppresses [...]

Peptidoglycan-recognition protein LC; Major activator of the imd/Relish pathway and is likely to encode a pattern recognition molecule for the humoral immune response. Required for Relish processing and nuclear translocation following proteolytic cleavage. Involved in the response to lipopolysaccharide (LPS) and peptidoglycan of Gram-negative bacteria. The different isoforms probably display different recognition capabilities to various microbial patterns. [Isoform x]: Mediates the response to LPS, peptidoglycan and Gram-negative bacteria; Belongs to the N-acetylmuramoyl-L-alanine amid [...]

Death-associated inhibitor of apoptosis 2; Required for activation of NF-kappaB transcription factors in the immune deficiency (Imd) signaling cascade which is essential for innate immune responses upon infection by Gram-negative bacteria. Promotes cytoplasmic cleavage of Rel and its translocation to the nucleus where it drives expression of antimicrobial peptides. Binds, polyubiquitinates and activates Dredd which is required for Rel- mediated induction of antimicrobial peptides. Anti- apoptotic protein which binds, ubiquitinates and inactivates the effector caspase Drice. Suppresses [...]

Nuclear factor NF-kappa-B p110 subunit; Plays a key role in the humoral immune response. Rel-p68 subunit translocates to the nucleus where it binds to the promoter of the Cecropin A1 gene and probably other antimicrobial peptide genes. I-kappa-B kinase complex (IKKbeta and key) and PGRP-LC are essential signaling components in transmitting the lipopolysaccharide (LPS) signal leading to cact degradation for NF-kappa-B (rel) activation. Part of a Toll-related receptor pathway that functions in the apoptosis of unfit cells during cell competition. May be part of a NF-kappa-B and Tollo sig [...]

Death-associated inhibitor of apoptosis 2; Required for activation of NF-kappaB transcription factors in the immune deficiency (Imd) signaling cascade which is essential for innate immune responses upon infection by Gram-negative bacteria. Promotes cytoplasmic cleavage of Rel and its translocation to the nucleus where it drives expression of antimicrobial peptides. Binds, polyubiquitinates and activates Dredd which is required for Rel- mediated induction of antimicrobial peptides. Anti- apoptotic protein which binds, ubiquitinates and inactivates the effector caspase Drice. Suppresses [...]

TAK1-associated binding protein 2 (Tab2) encodes a protein with an ubiquitin binding domain. It interacts with the product of Tak1, a MAP kinase kinase kinase involved the activation of the immune deficiency, JNK and Grindelwald-Eiger pathways.

Death-associated inhibitor of apoptosis 2; Required for activation of NF-kappaB transcription factors in the immune deficiency (Imd) signaling cascade which is essential for innate immune responses upon infection by Gram-negative bacteria. Promotes cytoplasmic cleavage of Rel and its translocation to the nucleus where it drives expression of antimicrobial peptides. Binds, polyubiquitinates and activates Dredd which is required for Rel- mediated induction of antimicrobial peptides. Anti- apoptotic protein which binds, ubiquitinates and inactivates the effector caspase Drice. Suppresses [...]

Mitogen-activated protein kinase kinase kinase 7; Component of a protein kinase signal transduction cascade. Mediator of TGF-beta signal transduction. Responsible for activation of the JNK MAPK pathway (basket, bsk and hemipterous, hep) in response to LPS. Component of the NF-kappa-B pathway; relish-mediated JNK inhibition involves proteasomal degradation of Tak1; certain targets of Relish that are induced during immune responses may facilitate destruction of Tak1 and switch off the JNK cascade. Participates in diverse roles such as control of cell shape and regulation of apoptosis.

Death-associated inhibitor of apoptosis 2; Required for activation of NF-kappaB transcription factors in the immune deficiency (Imd) signaling cascade which is essential for innate immune responses upon infection by Gram-negative bacteria. Promotes cytoplasmic cleavage of Rel and its translocation to the nucleus where it drives expression of antimicrobial peptides. Binds, polyubiquitinates and activates Dredd which is required for Rel- mediated induction of antimicrobial peptides. Anti- apoptotic protein which binds, ubiquitinates and inactivates the effector caspase Drice. Suppresses [...]

TNF-receptor-associated factor 6 (Traf6) encodes a protein that belongs to a family of adaptor proteins involved in transducing downstream signaling by interacting with cell surface receptors. It mediates the pro-inflammatory effects of Toll and related receptor signaling, and the cell death induced by JNK activation via the product of egr.

Death-associated inhibitor of apoptosis 2; Required for activation of NF-kappaB transcription factors in the immune deficiency (Imd) signaling cascade which is essential for innate immune responses upon infection by Gram-negative bacteria. Promotes cytoplasmic cleavage of Rel and its translocation to the nucleus where it drives expression of antimicrobial peptides. Binds, polyubiquitinates and activates Dredd which is required for Rel- mediated induction of antimicrobial peptides. Anti- apoptotic protein which binds, ubiquitinates and inactivates the effector caspase Drice. Suppresses [...]

Protein immune deficiency; Essential for the imd/NF-kappa-B (Imd) humoral and epithelial immune response to Gram-negative bacteria. Functions as an adapter protein that transduces immunity signals from the activation of pathogen recognition receptors (PRRs) by bacterial infection to the Imd signaling pathway. Binding of diaminopimelic acid-type (DAP-type) bacterial peptidoglycans (PGN) causes multimerization or clustering of PGRP receptors which activate the Imd cascade probably by recruiting imd, Fadd and Dredd to the receptor complex. Once in proximity, Dredd cleaves imd in a Fadd-de [...]

Death-associated inhibitor of apoptosis 2; Required for activation of NF-kappaB transcription factors in the immune deficiency (Imd) signaling cascade which is essential for innate immune responses upon infection by Gram-negative bacteria. Promotes cytoplasmic cleavage of Rel and its translocation to the nucleus where it drives expression of antimicrobial peptides. Binds, polyubiquitinates and activates Dredd which is required for Rel- mediated induction of antimicrobial peptides. Anti- apoptotic protein which binds, ubiquitinates and inactivates the effector caspase Drice. Suppresses [...]

NF-kappa-B essential modulator; Kenny (key) encodes a scaffold protein that is a component of the IKK (IkappaB Kinase) complex, which participates in the activation of the transcription factor Rel in the Imd pathway. This pathway regulates the antibacterial response and other less characterized cellular processes.

Caspase-8 subunit p10; Effector of the programmed cell death (PCD) activators rpr, grim and hid. May play an apoptotic role in the germline as well as soma. Fadd interacts with Dredd to promote cleavage of Dredd and is necessary and sufficient for enhancing Dredd-induced apoptosis. Plays a role in the innate immune response. Required for resistance to Gram-negative bacterial infection. Diap2-mediated ubiquitination of Dredd is critical for processing of imd and rel and the subsequent expression of antimicrobial genes such as DptA. Belongs to the peptidase C14A family.

Death-associated inhibitor of apoptosis 2; Required for activation of NF-kappaB transcription factors in the immune deficiency (Imd) signaling cascade which is essential for innate immune responses upon infection by Gram-negative bacteria. Promotes cytoplasmic cleavage of Rel and its translocation to the nucleus where it drives expression of antimicrobial peptides. Binds, polyubiquitinates and activates Dredd which is required for Rel- mediated induction of antimicrobial peptides. Anti- apoptotic protein which binds, ubiquitinates and inactivates the effector caspase Drice. Suppresses [...]

Caspase-8 subunit p10; Effector of the programmed cell death (PCD) activators rpr, grim and hid. May play an apoptotic role in the germline as well as soma. Fadd interacts with Dredd to promote cleavage of Dredd and is necessary and sufficient for enhancing Dredd-induced apoptosis. Plays a role in the innate immune response. Required for resistance to Gram-negative bacterial infection. Diap2-mediated ubiquitination of Dredd is critical for processing of imd and rel and the subsequent expression of antimicrobial genes such as DptA. Belongs to the peptidase C14A family.

Fas-associated death domain protein; Component of the IMD signaling pathway and is required for the host defense against Gram-negative bacteria. Interacts with Dredd, promotes cleavage of Dredd and is necessary and sufficient for enhancing Dredd-induced apoptosis.

Caspase-8 subunit p10; Effector of the programmed cell death (PCD) activators rpr, grim and hid. May play an apoptotic role in the germline as well as soma. Fadd interacts with Dredd to promote cleavage of Dredd and is necessary and sufficient for enhancing Dredd-induced apoptosis. Plays a role in the innate immune response. Required for resistance to Gram-negative bacterial infection. Diap2-mediated ubiquitination of Dredd is critical for processing of imd and rel and the subsequent expression of antimicrobial genes such as DptA. Belongs to the peptidase C14A family.

Inhibitor of nuclear factor kappa-B kinase subunit beta; Required for the activation of the NF-kappa-B factor Relish (Rel) by acting as an essential signaling component in transmitting the lipopolysaccharide (LPS) signal leading to cact degradation, which is required for direct activation of Rel. Phosphorylates inhibitors of NF- kappa-B (cact) thus leading to the dissociation of the inhibitor/NF- kappa-B complex and ultimately the degradation of the NF-kappa-B inhibitor. Essential for antibacterial immune response.