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| | CG33303 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] (458 aa) |
| | Calr | Calreticulin; Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (By similarity). (406 aa) |
| | Der-1 | Derlin-1; May be involved in the degradation process of specific misfolded endoplasmic reticulum (ER) luminal proteins. May also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. (245 aa) |
| | PIG-H | Phosphatidylinositol glycan anchor biosynthesis class H, isoform A; It is involved in the biological process described with: GPI anchor biosynthetic process. (221 aa) |
| | tw | Protein O-mannosyl-transferase 2; Twisted (tw) encodes a protein that transfers a mannose to the Ser/Thr residues of dystroglycan, via forming an heterodimer with the product of rt. Its roles include myogenesis, muscle architecture and cell adhesion. (765 aa) |
| | Orai | Calcium release-activated calcium channel protein 1; Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores. Regulates transcription factor NFAT nuclear import. (507 aa) |
| | CG14671 | GEO12035p1; Unfolded protein binding. It is involved in the biological process described with: vacuolar proton-transporting V-type ATPase complex assembly. (155 aa) |
| | CG30495 | Uncharacterized protein, isoform B; NADP-retinol dehydrogenase activity. (331 aa) |
| | CG2070 | LP06328p; NADP-retinol dehydrogenase activity; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (325 aa) |
| | CG2065 | RH23455p; NADP-retinol dehydrogenase activity; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (300 aa) |
| | EMC2B | GH23451p. (282 aa) |
| | cni | Protein cornichon; Acts as cargo receptor necessary for the transportation of gurken (grk) to a transitional endoplasmic reticulum (tER) site and promotes its incorporation into coat protein complex II (COPII) vesicles. Associated with gurken, produces a signal received by torpedo resulting in a signaling pathway that first establishes posterior follicle cell fates and normal localization of the anterior and posterior determinants, later they act in a signaling event inducing dorsal follicle cell fates and regulating the dorsal-ventral pattern of egg and embryo. (144 aa) |
| | PIG-V | GPI mannosyltransferase 2; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis. Transfers the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly. Required for the GPI-mediated endoplasmic reticulum exit and proper targeting to the cell surface of chp. Required for GPI-mediated membrane attachment of chp, qsm and Cont. Essential for microvillar stability in the rhabdomere; Belongs to the PIGV family. (449 aa) |
| | PIG-S | Phosphatidylinositol glycan anchor biosynthesis class S (PIG-S) encodes a subunit of glycosylphosphatidylinositol (GPI) transamidase, which mediates GPI anchoring in the endoplasmic reticulum. GPI anchor attachment serves as a general mechanism for linking proteins to the cell surface membrane. (536 aa) |
| | CG1941 | RE04845p; O-acyltransferase activity; diacylglycerol O-acyltransferase activity. It is involved in the biological process described with: lipid metabolic process; triglyceride biosynthetic process. (352 aa) |
| | CG34293 | MIP14036p. (84 aa) |
| | CG9855 | FI03672p; Ubiquitin protein ligase activity; ubiquitin-protein transferase activity; zinc ion binding. It is involved in the biological process described with: protein polyubiquitination. (382 aa) |
| | EMC1 | ER Membrane protein Complex 1 (EMC1) encodes a subunit of the ER membrane protein complex (EMC). In fly retinas, EMC has been shown to be essential for the biosynthesis of multi-pass membrane proteins, but not for single-pass membrane proteins and secretory proteins. (915 aa) |
| | CG34194 | FI16908p1. (104 aa) |
| | CG6870 | GEO08203p1; Heme binding; electron transfer activity; Belongs to the cytochrome b5 family. (137 aa) |
| | PIG-A | Phosphatidylinositol glycan anchor biosynthesis class A, isoform A; Phosphatidylinositol N-acetylglucosaminyltransferase activity. It is involved in the biological process described with: GPI anchor biosynthetic process. (479 aa) |
| | Spase25 | Signal peptidase complex subunit 2; Microsomal signal peptidase is a membrane-bound endoproteinase that removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. (199 aa) |
| | PIG-Q | Phosphatidylinositol glycan anchor biosynthesis class Q (PIG-Q) encodes a protein required for the biosynthesis of glycosylphosphatidylinositol, which is a component for anchoring eukaryotic proteins to membranes. (481 aa) |
| | Sec61gamma | Protein transport protein Sec61 gamma-2 subunit; Necessary for protein translocation in the endoplasmic reticulum. (68 aa) |
| | Pld3 | GM01519p; Catalytic activity. (494 aa) |
| | Sting | Sting, isoform B; cyclic-di-GMP binding; cyclic-GMP-AMP binding. (343 aa) |
| | Sec61alpha | Sec61 alpha subunit (Sec61alpha) encodes a subunit of the the translocon, a protein-conducting channel that mediates the co-translational transport of nascent polypeptides into the endoplasmic reticulum. It is a subunit of the Sec61 heterotrimer that forms the core of translocon channel. (476 aa) |
| | Stt3A | Catalytic subunit 3A of the oligosaccharyltransferase complex, isoform A; Dolichyl-diphosphooligosaccharide-protein glycotransferase activity. It is involved in the biological process described with: protein N-linked glycosylation via asparagine; post-translational protein modification. (713 aa) |
| | CG4960 | Receptor expression-enhancing protein; It is involved in the biological process described with: endoplasmic reticulum tubular network organization; regulation of intracellular transport. (174 aa) |
| | RpS26 | 40S ribosomal protein S26; mRNA binding; structural constituent of ribosome. It is involved in the biological process described with: cytoplasmic translation. (114 aa) |
| | EMC4 | ER membrane protein complex subunit 4; Belongs to the EMC4 family. (166 aa) |
| | PIG-C | Phosphatidylinositol glycan anchor biosynthesis class C (PIG-C) encodes a subunit of GPI-GlcNAc transferase, which catalyzes the first reaction in the biosynthesis of the glycosylphosphatidylinositol (GPI)-anchor. (312 aa) |
| | PIG-K | Putative GPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein (By similarity); Belongs to the peptidase C13 family. (355 aa) |
| | Seipin | Seipin; Is a regulator of lipid catabolism essential for adipocyte differentiation. May also be involved in the central regulation of energy homeostasis (By similarity). Necessary for correct lipid storage and lipid droplets maintenance; plays a tissue-autonomous role in controlling lipid storage in adipocytes and in preventing ectopic lipid droplet formation in non-adipose tissues. May participate in phosphatidic acid metabolism and subsequently down-regulate lipogenesis. (370 aa) |
| | GAA1 | Glycosylphosphatidylinositol anchor attachment 1 (GAA1) encodes a subunit of glycosylphosphatidylinositol (GPI) transamidase, which mediates GPI anchoring in the endoplasmic reticulum. GPI anchor attachment serves as a general mechanism for linking proteins to the cell surface membrane. (674 aa) |
| | xit | Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase; Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol (By similarity). Functions in developmental processes such as germband extension, the apical constriction of mesoderm precursor cells and ventral furrow formation in early embryogenesis prior to gastrulation. Involved in the glycosylation and intracellular distribution of shg ( [...] (511 aa) |
| | sws | Neuropathy target esterase sws; Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain. Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain; Belongs to the NTE family. (1425 aa) |
| | PIG-T | Phosphatidylinositol glycan anchor biosynthesis class T; GPI-anchor transamidase activity. It is involved in the biological process described with: attachment of GPI anchor to protein. (633 aa) |
| | CG10761 | AT07234p; Zinc ion binding; ubiquitin-protein transferase activity; ubiquitin protein ligase activity. It is involved in the biological process described with: protein polyubiquitination. (323 aa) |
| | Erk7 | Extracellular signal-regulated kinase 7; Atypical MAPK protein that regulates protein secretion in a kinase activity-dependent manner. In response to starvation regulates protein secretion by mediating transitional endoplasmic reticulum site disassembly. Mediates inhibition of insulin-like peptide secretion upon disturbed ribosome biogenesis and acts as a downstream effector of TP53. (916 aa) |
| | Ost48 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across t [...] (449 aa) |
| | Tango11 | Transport and Golgi organization protein 11; May play a role in mitochondrial and peroxisomal fission. Belongs to the Tango11 family. (277 aa) |
| | GlcT | Glucosylceramide synthase (GlcT) encodes an enzyme that catalyzes the formation of glucosylceramide, the core component of glycosphingolipids. It regulates lipid energy metabolism in fat body and plays critical roles in embryo survival and development. (440 aa) |
| | EMC8-9 | ER Membrane protein Complex 8-9 (EMC8-9) encodes a subunit of the ER membrane protein complex (EMC). In fly retinas, EMC has been shown to be essential for the biosynthesis of multi-pass membrane proteins, but not for single-pass membrane proteins and secretory proteins. (203 aa) |
| | Xxylt | UDP-xylosyltransferase activity. It is involved in the biological process described with: protein O-linked glycosylation; negative regulation of Notch signaling pathway. (458 aa) |
| | SERCA | Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type; Sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) encodes an endoplasmic reticulum (ER) calcium pump with roles in ER calcium homeostasis and lipid storage. (1020 aa) |
| | emc | Protein extra-macrochaetae; Participates in sensory organ patterning by antagonizing the neurogenic activity of the Achaete-scute complex (AS-C). It lacks a basic DNA-binding domain but is able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. May sequester proneural proteins in complexes inefficient for DNA interaction. EMC also affects vein differentiation. Inhibits the activity of AS-C proteins by forming an non-DNA binding heterodimer. (199 aa) |
| | CG1317 | FI03626p; Ubiquitin protein ligase activity; zinc ion binding; ubiquitin-protein transferase activity. It is involved in the biological process described with: protein ubiquitination; ubiquitin-dependent ERAD pathway. (988 aa) |
| | SrpRalpha | Signal recognition particle receptor subunit alpha homolog; Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (By similarity). May have a role in axonogenesis. (614 aa) |
| | CG1924 | Calcium ion binding; unfolded protein binding. It is involved in the biological process described with: protein folding; endoplasmic reticulum unfolded protein response. (570 aa) |
| | Alg14 | ALG14, UDP-N-acetylglucosaminyltransferase subunit; N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity. It is involved in the biological process described with: dolichol-linked oligosaccharide biosynthetic process. (191 aa) |
| | Cnx14D | Calnexin 14D; Calcium ion binding; unfolded protein binding. It is involved in the biological process described with: endoplasmic reticulum unfolded protein response; protein folding. (639 aa) |
| | por | Protein-serine O-palmitoleoyltransferase porcupine; Protein-serine O-palmitoleoyltransferase that acts as a key regulator of the Wnt signaling pathway by mediating the attachment of palmitoleate, a 16-carbon monounsaturated fatty acid (C16:1), to Wnt proteins. Serine palmitoleylation of Wnt proteins is required for efficient binding to frizzled receptors (By similarity). Also facilitates the glycosylation of Wnt family members, including wg and Wnt5. The cotranslational disulfide bond formation of wg competes with the N-glycosylation. Porc stimulates the post-translational N- glycosyla [...] (525 aa) |
| | SREBP | Sterol regulatory element binding protein (SREBP) encodes a membrane protein that functions as a master-regulator of lipogenesis. It activates transcription of lipogenic genes upon reduction of lipid or cholesterol levels. (1113 aa) |
| | kud | Transmembrane protein 258; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are requ [...] (78 aa) |
| | Baldspot | Elongation of very long chain fatty acids protein; Baldspot (Baldspot) encodes a protein involved in spermatogenesis. (316 aa) |
| | rt | Protein O-mannosyltransferase 1; Rotated abdomen (rt) encodes a protein that transfers a mannose to the Ser/Thr residues of the product of Dg, via forming an heterodimer with the product of tw. Its roles include myogenesis, muscle architecture and cell adhesion. (886 aa) |
| | Alg10 | Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase; Adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol (By similarity). Belongs to the ALG10 glucosyltransferase family. (449 aa) |
| | wls | Protein wntless; A segment polarity gene required for wingless (wg)-dependent patterning processes, acting in both wg-sending cells and wg-target cells. In non-neuronal cells wls directs wg secretion. The wls traffic loop encompasses the Golgi, the cell surface, an endocytic compartment and a retrograde route leading back to the Golgi, and involves clathrin-mediated endocytosis and the retromer complex (a conserved protein complex consisting of Vps35 and Vps26). In neuronal cells (the larval motorneuron NMJ), the wg signal moves across the synapse via the release of wls-containing exos [...] (594 aa) |
| | Ufd1-like | Ubiquitin fusion degradation protein 1 homolog; Functions at a post-ubiquitation step in the ubiquitin fusion degradation (UFD) pathway; Belongs to the UFD1 family. (316 aa) |
| | CG8009 | Nuclear envelope phosphatase-regulatory subunit 1 homolog; May form with the serine/threonine protein phosphatase l(1)G0269 an active complex dephosphorylating and activating lipin-like phosphatases. Lipins are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels (By similarity). (131 aa) |
| | ghi | Ghiberti (ghi) encodes a protein homologous to the mammalian small regulatory subunit of serine palmitoyltransferase. Mutations in ghi affect the first steps of sphingolipids biosynthesis and disrupt meiotic cytokinesis of males. (81 aa) |
| | Use1 | Vesicle transport protein USE1; SNARE that may be involved in targeting and fusion of Golgi- derived retrograde transport vesicles with the ER (By similarity). Required for protein secretion. (250 aa) |
| | Sec63 | Secretory 63; Protein transmembrane transporter activity; RNA binding. It is involved in the biological process described with: SRP-dependent cotranslational protein targeting to membrane; posttranslational protein targeting to endoplasmic reticulum membrane; posttranslational protein targeting to membrane, translocation. (753 aa) |
| | SMSr | Sphingomyelin synthase-related 1; Sphingomyelin synthases synthesize sphingolipids through transfer of a phosphatidyl head group on to the primary hydroxyl of ceramide. SAMD8 is an endoplasmic reticulum (ER) transferase that has no sphingomyelin synthase activity but can convert phosphatidylethanolamine (PE) and ceramide to ceramide phosphoethanolamine (CPE) albeit with low product yield. Appears to operate as a ceramide sensor to control ceramide homeostasis in the endoplasmic reticulum rather than a converter of ceramides. Seems to be critical for the integrity of the early secretory [...] (600 aa) |
| | Fitm | Fat storage-inducing transmembrane protein; Plays an important role in lipid droplet accumulation. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for correct morphology of nociceptive multi-dendritic sensory neurons. Required for normal mechanical amplification in hearing. (480 aa) |
| | Dd | CTD nuclear envelope phosphatase 1 homolog; Serine/threonine protein phosphatase that may dephosphorylate and activate lipin-like phosphatases. Lipins are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol (By similarity). Belongs to t [...] (243 aa) |
| | S | Star (S) encodes a type II transmembrane protein that facilitates trafficking of transmembrane Egfr ligands from the endoplasmic reticulum to the late secretory compartment. It is involved in growth regulation, cell survival and developmental patterning. (597 aa) |
| | ninaA | Peptidyl-prolyl cis-trans isomerase, rhodopsin-specific isozyme; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts on the folding of rhodopsin RH1 and RH2 (but not RH3) and is required for visual transduction. Belongs to the cyclophilin-type PPIase family. (237 aa) |
| | Spp | Signal peptide peptidase; Aspartic endopeptidase activity, intramembrane cleaving. It is involved in the biological process described with: signal peptide processing; cellular response to unfolded protein; membrane protein proteolysis. (389 aa) |
| | ORMDL | ORM1-like protein; Negative regulator of sphingolipid synthesis. (154 aa) |
| | Ssl1 | General transcription factor IIH subunit; Zinc ion binding; nucleic acid binding. (438 aa) |
| | jagn | Jagunal (jagn) encodes a conserved protein that is located in the endoplasmic reticulum membrane. It contributes to oocyte growth by organizing the endoplasmic reticulum. It is also involved in bristle growth. (197 aa) |
| | Itpr | Inositol 1,4,5,-trisphosphate receptor (Itpr) encodes an intracellular ligand gated calcium channel. It functions downstream of G-protein coupled receptors that activate Gq/PLCbeta signaling and generate inositol tris-phosphate. Itpr depletion affects ecdysone release, response to nutritional stress, lipid metabolism and flight; Belongs to the InsP3 receptor family. (2837 aa) |
| | PEK | Eukaryotic translation initiation factor 2-alpha kinase; Pancreatic eIF-2alpha kinase (PEK) encodes an endoplasmic reticulum (ER) transmembrane kinase and a component of the integrated stress response. During ER stress the product of PEK phosphorylates the translation initiation factor encoded by eIF2alpha resulting in the inhibition of most cap-dependent translation. This is especially important during the development of secretory tissues and the response to cellular stress; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily. (1162 aa) |
| | Ostgamma | Oligosaccharide transferase gamma subunit (Ostgamma) encodes a subunit of the oligosaccharyltransferase complex involved in cell migration and cellular encapsulation response. (330 aa) |
| | PIG-U | Phosphatidylinositol glycan anchor biosynthesis class U (PIG-U) encodes a subunit of glycosylphosphatidylinositol (GPI) transamidase, which mediates GPI anchoring in the endoplasmic reticulum. GPI anchor attachment serves as a general mechanism for linking proteins to the cell surface membrane. (426 aa) |
| | Dad1 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the [...] (112 aa) |
| | jp | Junctophilin, isoform A; Junctophilin (jp) belongs to a gene family encoding proteins anchored to the endoplasmic reticulum through a transmembrane region. The product of jp contributes to the formation and maintenance of junctional membrane complexes. It serves as a physical bridge between the plasma membrane and the endoplasmic reticulum in excitable cells, allowing the functional crosstalk between ion channels. It is necessary for calcium signalling in muscle contraction and neuronal communication. (1054 aa) |
| | EMC3 | ER Membrane protein Complex 3 (EMC3) encodes a subunit of the ER membrane protein complex (EMC). In fly retinas, EMC has been shown to be essential for the biosynthesis of multi-pass membrane proteins, but not for single-pass membrane proteins and secretory proteins. (247 aa) |
| | CG6230 | Cation-transporting ATPase; Ion transmembrane transporter activity, phosphorylative mechanism; nucleotide binding; ATPase activity. It is involved in the biological process described with: cellular calcium ion homeostasis; cation transport; transmembrane transport; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1225 aa) |
| | Alg7 | GH19029p; phospho-N-acetylmuramoyl-pentapeptide-transferase activity; UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity. It is involved in the biological process described with: protein N-linked glycosylation; dolichyl diphosphate biosynthetic process. (409 aa) |
| | lace | Lace, isoform A; Lace (lace) encodes a serine C-palmitoyltransferase involved in sphingolipid biosynthesis. (597 aa) |
| | EMC5 | GEO07313p1; Inorganic cation transmembrane transporter activity. (109 aa) |
| | CG10029 | MIP10555p; Protein disulfide isomerase activity; peptide disulfide oxidoreductase activity. It is involved in the biological process described with: protein folding; cell redox homeostasis. (410 aa) |
| | twr | Signal peptidase complex catalytic subunit SEC11; Serine-type peptidase activity; peptidase activity. It is involved in the biological process described with: signal peptide processing. (185 aa) |
| | ELOVL | Elongation of very long chain fatty acids protein; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. (329 aa) |
| | ATP6AP2 | ATPase H(+)-transporting accessory protein 2 C-terminal fragment; Multifunctional protein which functions as transmembrane receptor in the planar cell polarity (PCP) and is involved in the assembly of the proton-transporting vacuolar (V)-ATPase protein pump. As transmembrane receptor mediates fz/PCP signaling through interaction with fz and stabilizes asymmetric PCP domains through its interaction with stan. Also mediates Wnt/beta-cat signaling through interaction with fz/fz2. Probably by controlling the assembly of the V-ATPase pump and thus the acidification of the endo-lysosomal sys [...] (320 aa) |
| | Der-2 | Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family. (261 aa) |
| | EMC2A | LD10670p. (282 aa) |
| | CG5823 | HL05730p; Ubiquitin-protein transferase activity; ubiquitin conjugating enzyme activity. It is involved in the biological process described with: protein ubiquitination; ubiquitin-dependent ERAD pathway; protein polyubiquitination. (283 aa) |
| | Xport-A | Exit protein of rhodopsin and TRP A (Xport-A) encodes a TRP channel chaperone. It mediates the transport to the plasma membrane of the products of ninaE and trp. (116 aa) |
| | atl | Atlastin; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate microtubule polymerization and Golgi biogenesis. Required for dopaminergic neurons survival and the growth of muscles and synapses at neuromuscular junctions. (541 aa) |
| | Stt3B | Catalytic subunit 3B of the oligosaccharyltransferase complex; Dolichyl-diphosphooligosaccharide-protein glycotransferase activity. It is involved in the biological process described with: protein N-linked glycosylation via asparagine; post-translational protein modification. (774 aa) |
| | EMC6 | Uncharacterized protein; It is involved in the biological process described with: autophagosome assembly. (113 aa) |
| | Npl4 | Nuclear protein localization protein 4 homolog; May be part of a complex that binds ubiquitinated proteins and that is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. Belongs to the NPL4 family. (652 aa) |
| | PIG-P | Phosphatidylinositol glycan anchor biosynthesis class P; Phosphatidylinositol N-acetylglucosaminyltransferase activity. It is involved in the biological process described with: GPI anchor biosynthetic process. (158 aa) |
| | CG17991 | AT21004p; Ubiquitin protein ligase activity; zinc ion binding; ubiquitin-protein transferase activity. It is involved in the biological process described with: protein polyubiquitination. (294 aa) |
| | superdeath | Aminopeptidase; Zinc ion binding; peptide binding; metalloaminopeptidase activity. It is involved in the biological process described with: peptide catabolic process; proteolysis. (999 aa) |
| | Alg13 | Glyco_tran_28_C domain-containing protein; N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity. It is involved in the biological process described with: dolichol-linked oligosaccharide biosynthetic process. (171 aa) |
| | Spase12 | Signal peptidase complex subunit 1; Microsomal signal peptidase is a membrane-bound endoproteinase that removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. (98 aa) |
| | Cnx99A | Calnexin 99A (Cnx99A) encodes an endoplasmic reticulum chaperone that colocalizes and genetically interacts with the sodium channel subunit encoded by para. (605 aa) |
| | nero | Deoxyhypusine hydroxylase; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L- lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor (By similarity). Essential for organismal viability and plays a role in a wide number of important processes such as cell growth and proliferation, and regulates induction of autophagy and protein synthesis. Has a role in eIF-5A-mediated translational control; Belongs to the deoxyhypusine hydroxylase family. (302 aa) |
| | SCAP | SREBP cleavage activating protein; Sterol binding. It is involved in the biological process described with: sterol regulatory element binding protein cleavage; protein processing; SREBP signaling pathway. (1276 aa) |
| | Atf6 | Atf6, isoform C; DNA-binding transcription factor activity. It is involved in the biological process described with: regulation of transcription, DNA-templated. (741 aa) |
| | PGAP3 | Post-GPI attachment to proteins 3 (PGAP3) encodes a protein involved in the lipid remodeling steps of glycosylphosphatidylinositol (GPI)-anchor maturation. Lipid remodeling consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchored proteins. The product of PGAP3 is required for the phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling. (330 aa) |
| | CG13426 | P-P-bond-hydrolysis-driven protein transmembrane transporter activity; protein transmembrane transporter activity. It is involved in the biological process described with: posttranslational protein targeting to membrane, translocation. (105 aa) |
| | EMC7 | DUF2012 domain-containing protein; Carbohydrate binding. (245 aa) |
| | Sec61beta | Sec61 beta subunit (Sec61beta) encodes a protein involved in the regulation of autophagy. (100 aa) |
| | Spt-I | Pyridoxal phosphate binding; serine C-palmitoyltransferase activity. It is involved in the biological process described with: positive regulation of sphingolipid biosynthetic process; ceramide biosynthetic process; sphingosine biosynthetic process. (468 aa) |
| | CG8860 | Protein transport protein Sec61 gamma-1 subunit; Necessary for protein translocation in the endoplasmic reticulum. (68 aa) |
| | CG8237 | LD27256p. (325 aa) |
| | CG30491 | AT09608p; NADP-retinol dehydrogenase activity; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (331 aa) |
| | CG2064 | Uncharacterized protein; NADP-retinol dehydrogenase activity; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (330 aa) |
| | CG1946 | IP08359p; O-acyltransferase activity; diacylglycerol O-acyltransferase activity. It is involved in the biological process described with: triglyceride biosynthetic process; lipid metabolic process. (349 aa) |
| | OstDelta | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] (634 aa) |
| | rho-5 | Inactive rhomboid protein 1; Rhomboid protease-like protein which has no protease activity but regulates the secretion of several ligands of the epidermal growth factor receptor. Indirectly activates the epidermal growth factor receptor signaling pathway and may thereby regulate sleep, cell survival, proliferation and migration. (1429 aa) |
| | CG3566 | Uncharacterized protein, isoform B; Heme binding; electron transfer activity; Belongs to the cytochrome b5 family. (117 aa) |
| | Trc8 | Protein TRC8 homolog; Plays a role in growth inhibition that is dependent upon COP9 signalosome subunits CSN5 and CSN6. May modulate signalosome levels or compartmentalization. Probably functions in the same or a related pathway to VHL during early midline development. (809 aa) |
| | Vkor | Vitamin-K epoxide reductase (Vkor) encodes an enzyme that converts Vitamin-K 2,3-epoxide back to the active form of Vitamin-K by de-epoxidation. (152 aa) |
| | CG41106 | MIP26267p; It is involved in the biological process described with: positive regulation of protein dephosphorylation. (123 aa) |
| | Ire1 | Inositol-requiring enzyme-1 (Ire1) encodes a transmembrane protein that mediates the unfolded protein response. Misfolded peptides in the endoplasmic reticulum activate the RNase activity of the product of Ire1, thereby promoting the cleavage of its downstream substrates, such as Xbp1 mRNA. The product of Ire1 is also required for photoreceptor differentiation. (1074 aa) |
| | meigo | Solute carrier family 35 member B1 homolog; Medial glomeruli (meigo) encodes an evolutionarily conserved, multi-membrane pass protein that is mainly localized at the endoplasmic reticulum. meigo genetically interacts with Ephrin in dendrite targeting of olfactory projection neurons. (338 aa) |
| | shams | IP22168p; Shams (shams) encodes a xylosyltransferase involved in protein O-linked glycosylation and Notch signalling regulation. (362 aa) |
| | THADA | Thyroid adenoma-associated protein homolog; Plays a key role in energy homeostasis by regulating the balance between energy storage and heat production. Functions by negatively regulating Ca(2+) signaling pathways that are involved in heat production and maintaining correct lipid storage in the fat body. Regulates Ca(2+) signaling pathways by reducing the activity of the calcium-transporting ATPase SERCA possibly by promoting uncoupling of SERCA ATP hydrolysis from calcium pumping. May also function in the nervous system to control feeding behavior. (1746 aa) |
| | CG9592 | IP08778p; Unfolded protein binding. It is involved in the biological process described with: vacuolar proton-transporting V-type ATPase complex assembly. (152 aa) |
| | EMC10 | Uncharacterized protein, isoform C. (227 aa) |
| | Dpm2 | Dolichol phosphate-mannose biosynthesis regulatory protein; Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization. Belongs to the DPM2 family. (81 aa) |
| | SppL | Signal peptide peptidase-like, isoform D; Aspartic endopeptidase activity, intramembrane cleaving. It is involved in the biological process described with: membrane protein proteolysis; signal peptide processing. (422 aa) |
| | hob | Hobbit, isoform B; It is involved in the biological process described with: positive regulation of intracellular transport. (2300 aa) |
| | RyR | Ryanodine receptor (RyR) encodes an intracellular calcium channel localized in the sarcoplasmic reticulum of muscles and the endoplasmic reticulum of neurons and other cell types. It regulates the release of intracellular calcium stores and has a key role in muscle contraction. (5134 aa) |
| | Spase22-23 | Signal peptidase complex subunit 3; Component of the microsomal signal peptidase complex which removes signal peptides and other N-terminal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. (179 aa) |
| | Xbp1 | X box binding protein-1 (Xbp1) encodes a transcription factor that mediates the unfolded protein response. Xbp1 mRNA undergoes splicing after being cleaved by the product of Ire1, inducing the expression of ER quality control transcripts. Xbp1 mutants fail to develop beyond the 2nd instar larval stage, indicative of a requirement to resolve inherent ER stress during normal development. (498 aa) |
| | CG16781 | Uncharacterized protein, isoform B; Zinc ion binding; ubiquitin-protein transferase activity; ubiquitin protein ligase activity. It is involved in the biological process described with: protein polyubiquitination. (386 aa) |
| | Xport-B | Exit protein of rhodopsin and TRP B, isoform A; It is involved in the biological process described with: protein localization to rhabdomere. (113 aa) |
| | Mctp | Multiple C2 and transmembrane domain-containing protein; Calcium sensor which is essential for the stabilization of normal baseline neurotransmitter release and for the induction and long-term maintenance of presynaptic homeostatic plasticity. (982 aa) |
| | CG3842 | GH10714p; NADP-retinol dehydrogenase activity. (406 aa) |
| | crc | Cryptocephal, isoform A; Cryptocephal (crc) encodes a protein that belongs to a member of the CREB/ATF family of basic-leucine zipper transcription factors. It serves as an coactivator of the product EcR of to promote expression the molting peptide hormone encoded by ETH. It also acts as an unfolded protein response transcription factor to regulate glycolytic genes in response to ER stress. (381 aa) |
| | SrpRbeta | Signal recognition particle receptor beta (SrpRbeta) encodes a protein that contributes to cuticle secretion by epidermal cells. (244 aa) |
