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CG12402 CG12402 CG5003 CG5003 CG14317 CG14317 Fbxl7 Fbxl7 FipoQ FipoQ Cul2 Cul2 CG11044 CG11044 CG5961 CG5961 fsd fsd Fsn Fsn SkpB SkpB Fbl6 Fbl6 Cul1 Cul1 SkpA SkpA CG9003 CG9003 CG12520 CG12520 CG34025 CG34025 CG32221 CG32221 dmpd dmpd Roc1a Roc1a CG6758 CG6758 CG9316 CG9316 CG13085 CG13085 CG14937 CG14937 CG13088 CG13088 Rca1 Rca1 CG31633 CG31633 Fbw5 Fbw5 jet jet Skp2 Skp2 CG7148 CG7148 morgue morgue pall pall CG32085 CG32085 CG11658 CG11658 Cul6 Cul6 CG7707 CG7707 SkpE SkpE SkpC SkpC SkpD SkpD Fbxl4 Fbxl4 CG2247 CG2247 ago ago ntc ntc Roc1b Roc1b SkpF SkpF slmb slmb CG8272 CG8272 Ppa Ppa FBXO11 FBXO11 Kdm2 Kdm2 Cks85A Cks85A CG30466 CG30466 CG13766 CG13766 CG4911 CG4911
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CG12402Uncharacterized protein, isoform C; It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; ubiquitin-dependent protein catabolic process. (671 aa)
CG5003FI05230p; It is involved in the biological process described with: regulation of cell cycle; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; G2/M transition of mitotic cell cycle. (713 aa)
CG14317MIP30824p1; It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. (448 aa)
Fbxl7F-box and leucine-rich repeat protein 7 (Fbxl7) encodes a ubiquitin ligase that regulates Hippo signaling. (772 aa)
FipoQUncharacterized protein, isoform A; It is involved in the biological process described with: positive regulation of protein ubiquitination; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. (515 aa)
Cul2Cullin 2 (Cul2) encodes a protein that plays important roles during oogenesis. Reduction of the product of Cul2 in somatic cells produces tumorous germaria with excess germline stem cell-like cells due to the elevation of Dpp signaling in the niche; Belongs to the cullin family. (753 aa)
CG11044F-box domain-containing protein; It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. (511 aa)
CG5961LD45245p; It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. (442 aa)
fsdFates-shifted (fsd) encodes an F-box protein with a role in the gradient formation of the product of bcd and fatemap specification through targeting bcd protein for ubiquitination and degradation. (312 aa)
FsnF-box/SPRY domain-containing protein 1; Required in the presynaptic motoneuron to down-regulate the levels of wnd and restrain synaptic terminal growth at the neuromuscular junction (NMJ). Negatively regulates the localization of vas to the posterior pole of the oocyte. Involved in primordial germ cell formation; Belongs to the FBXO45/Fsn family. (255 aa)
SkpBCullin family protein binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. (161 aa)
Fbl6F-box and leucine-rich repeat protein 6, isoform A; SAM domain binding. It is involved in the biological process described with: positive regulation of ubiquitin-dependent protein catabolic process; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; regulation of protein stability; ubiquitin-dependent protein catabolic process. (720 aa)
Cul1Cullin homolog 1; Core component of multiple SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin- conjugating enzyme. During early metamorphosis, part of the SCF-slmb complex that negatively regulates the InR/PI3K/TOR pathway to activate the pruning of unnecessary larv [...] (774 aa)
SkpASKP1-related A (SkpA) encodes a subunit of Skp, Cullin, F-box (SCF)-containing ubiquitin ligase complexes. It regulates centrosome duplication, chromatin condensation, cell cycle progression, cell polarity, dendrite pruning and endoreduplication. (162 aa)
CG9003Uncharacterized protein, isoform B; It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; response to endoplasmic reticulum stress. (651 aa)
CG12520Uncharacterized protein, isoform B; It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. (371 aa)
CG34025F-box domain-containing protein; It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. (325 aa)
CG32221GM18426p; It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. (432 aa)
dmpdDampened, isoform A; Dampened (dmpd) encodes a nuclear F-box protein that acts as a co-activator of the product of bcd in modulating the expression level of its target gene hb. (603 aa)
Roc1aRING-box protein 1A; Core component of multiple SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Required for the specific SCF-dependent proteolysis of CI, but not that of ARM, suggesting that it also participates in the selection of substrates inside the SCF complex. During early metamorphosis, part of [...] (136 aa)
CG6758GH02866p; It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. (667 aa)
CG9316Uncharacterized protein; It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; ubiquitin-dependent protein catabolic process. (448 aa)
CG13085Uncharacterized protein, isoform A; It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. (240 aa)
CG14937RE59904p; It is involved in the biological process described with: G2/M transition of mitotic cell cycle; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; regulation of cell cycle. (445 aa)
CG13088AT02038p; It is involved in the biological process described with: G2/M transition of mitotic cell cycle; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; regulation of cell cycle. (401 aa)
Rca1Regulator of cyclin A1 (Rca1) encodes an anaphase-promoting complex/cyclosome inhibitor. It contributes to mitotic G1/S transition and cyclin degradation. (411 aa)
CG31633LD20162p; It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. (408 aa)
Fbw5F-box and WD repeat domain containing 5 (Fbw5) encodes a protein that targets proteins for destruction via its role as a substrate receptor for the CRL4 E3 ubiquitin ligase. A key target of the product of Fbw5 is the subunit of the tuberous sclerosis complex encoded by gig, an important negative regulator of cellular growth via inhibition of the TOR kinase pathway. (656 aa)
jetJetlag, isoform A; Jetlag (jet) encodes an F-box protein that is a component of an SCF E3 ubiquitin ligase complex. It targets the product of tim for degradation upon light exposure, and is essential for photic entrainment of the circadian clock. (319 aa)
Skp2S-phase kinase-associated protein 2 (Skp2) encodes the substrate recognizing component of the SCF-Skp2 ubiquitin ligase. It functions with the product of Cks85A to target the product of dap for destruction. It is required for larval growth and to maintain diploidy in imaginal tissues. (559 aa)
CG7148GH10766p; It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. (454 aa)
morgueModifier of rpr and grim, ubiquitously expressed (morgue) encodes an F box/ubiquitin conjugase domain protein. It regulates cell death by controlling the levels of the apoptosis inhibitor encoded by Diap1. (491 aa)
pallPallbearer (pall) encodes an F-Box protein. In response to apoptosis, it translocates from the nucleus to the cytoplasm of macrophages to promote apoptotic cell clearance by degrading the product of RpS6, and promote actin remodeling through activation of the product of Rac2. (314 aa)
CG32085FI04525p; It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; ubiquitin-dependent protein catabolic process. (666 aa)
CG11658LD30288p; It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. (351 aa)
Cul6Cullin 6; Ubiquitin-protein transferase activity; ubiquitin protein ligase binding; Belongs to the cullin family. (670 aa)
CG7707AT02411p; It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. (320 aa)
SkpECullin family protein binding. It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; ubiquitin-dependent protein catabolic process; Belongs to the SKP1 family. (167 aa)
SkpCCullin family protein binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; Belongs to the SKP1 family. (158 aa)
SkpDCullin family protein binding. It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; ubiquitin-dependent protein catabolic process; Belongs to the SKP1 family. (158 aa)
Fbxl4F box and leucine-rich-repeat gene 4; It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; protein polyubiquitination; negative regulation of synaptic transmission, GABAergic; negative regulation of circadian sleep/wake cycle, sleep; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. (669 aa)
CG2247LD23158p; It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; defense response to bacterium. (1048 aa)
agoF-box/WD repeat-containing protein 7; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Probably recognizes and binds to phosphorylated target proteins (By similarity). In the wing and eye, negatively regulates cell growth and proliferation by mediating the degradation of Myc and cyclin E, respectively. Required for endocycles, but not mitosis in follicle cell epithelium. (1326 aa)
ntcProtein nutcracker; Functions together with PI31 to control non-apoptotic caspase activation during sperm individualization. Positively regulates PI31 stability. (314 aa)
Roc1bRING-box protein 1B; Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate (By similarity). Belongs to the RING-box family. (122 aa)
SkpFCullin family protein binding. It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; ubiquitin-dependent protein catabolic process; Belongs to the SKP1 family. (171 aa)
slmbSupernumerary limbs (slmb) encodes an essential, conserved F-box protein and a component of the SCF (Skp/Cullin/F-box) E3 ubiquitin-ligase, providing substrate specificity to the SCF. It negatively regulates multiple signaling pathways and cellular processes by promoting the proteasome-mediated degradation or cleavage of its targets, including the products of arm and ci (Wg and Hh signaling), SAK, per and Cap-H2. (597 aa)
CG8272Uncharacterized protein, isoform B; It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. (710 aa)
PpaPartner of paired, isoform B; Partner of paired (Ppa) encodes a protein involved in response to oxidative stress. (562 aa)
FBXO11F-box protein 11 (FBXO11) encodes a subunit of a SCF-like E3 ubiquitin ligase involved in gene silencing mediated by both siRNAs and miRNAs.s. (1182 aa)
Kdm2JmjC domain-containing histone demethylation protein 1; Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. (1345 aa)
Cks85ACyclin-dependent kinase subunit 85A (Cks85A) encodes a small protein that interacts with the products of Cdk1 and Cdk2. It also functions with the product of Skp2 to target specific substrates for destruction, including the product of dap. It is required for larval growth and to maintain diploidy in imaginal tissues. (96 aa)
CG30466Uncharacterized protein, isoform B; It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. (405 aa)
CG13766Uncharacterized protein, isoform A; It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. (315 aa)
CG4911LD04326p; It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. (450 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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