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RpL5 RpL5 RpL22 RpL22 RpL36 RpL36 RpL35 RpL35 RpL17 RpL17 RpL29 RpL29 RpL23 RpL23 RpL37b RpL37b RpL22-like RpL22-like RpL12 RpL12 RpL39 RpL39 RpL19 RpL19 RpL8 RpL8 RpLP0-like RpLP0-like RpLP2 RpLP2 RpL18A RpL18A RpL6 RpL6 RpL32 RpL32 RpL4 RpL4 RpL34a RpL34a RpL10Aa RpL10Aa RpL24-like RpL24-like RpL34b RpL34b RpL35A RpL35A RpL13A RpL13A RpL28 RpL28 RpL37a RpL37a RpL10Ab RpL10Ab RpL14 RpL14 RpL23A RpL23A RpL26 RpL26 RpL36A RpL36A RpL7 RpL7 RpL7A RpL7A RpL24 RpL24 RpL11 RpL11 RpL30 RpL30 RpL9 RpL9 RpL3 RpL3 RpL27A RpL27A RpL38 RpL38 RpL40 RpL40 RpLP0 RpLP0 RpL10 RpL10 RpL18 RpL18 RpLP1 RpLP1 RpL27 RpL27 RpL21 RpL21 RpL13 RpL13 RpL37A RpL37A RpL15 RpL15 RpL7-like RpL7-like RpL41 RpL41 RpL31 RpL31
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RpL560S ribosomal protein L5; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] (299 aa)
RpL22Ribosomal protein L22 (RpL22) encodes a member of the eukaryotic ribosomal protein eL22 family. It is ubiquitously expressed, forms part of the large ribosomal subunit and is involved in protein synthesis. (299 aa)
RpL3660S ribosomal protein L36; Component of the large ribosomal subunit. (115 aa)
RpL35Ribosomal protein L35, isoform A; mRNA binding; structural constituent of ribosome. It is involved in the biological process described with: cytoplasmic translation; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); translation. (123 aa)
RpL1760S ribosomal protein L17; Structural constituent of ribosome. It is involved in the biological process described with: cytoplasmic translation; Belongs to the universal ribosomal protein uL22 family. (186 aa)
RpL2960S ribosomal protein L29; Chromatin binding; structural constituent of ribosome. It is involved in the biological process described with: cytoplasmic translation; Belongs to the eukaryotic ribosomal protein eL29 family. (76 aa)
RpL2360S ribosomal protein L23; Large ribosomal subunit rRNA binding; structural constituent of ribosome; myosin binding. It is involved in the biological process described with: translation; cytoplasmic translation; Belongs to the universal ribosomal protein uL14 family. (140 aa)
RpL37bProbable 60S ribosomal protein L37-B; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL37 family. (89 aa)
RpL22-likeRibosomal protein L22-like (RpL22-like) encodes a eukaryotic-specific component of the large ribosomal subunit involved in protein synthesis. (312 aa)
RpL12Ribosomal protein L12 (RpL12) encodes a protein of the large subunit of the ribosome. It regulates transcription of ribosomal proteins and ribosome biogenesis genes as well as interacting with the Enhancer of Trithorax and Polycomb protein encoded by corto. (165 aa)
RpL3960S ribosomal protein L39; Structural constituent of ribosome. It is involved in the biological process described with: cytoplasmic translation; translation; Belongs to the eukaryotic ribosomal protein eL39 family. (51 aa)
RpL19Ribosomal protein L19 (RpL19) encodes a ribosomal structural constituent; Belongs to the eukaryotic ribosomal protein eL19 family. (203 aa)
RpL8Ribosomal protein L8 (RpL8) encodes a ribosomal structural constituent. (256 aa)
RpLP0-likeRibosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (256 aa)
RpLP260S acidic ribosomal protein P2; Plays an important role in the elongation step of protein synthesis; Belongs to the eukaryotic ribosomal protein P1/P2 family. (113 aa)
RpL18A60S ribosomal protein L18a; Structural constituent of ribosome. It is involved in the biological process described with: translation; cytoplasmic translation; Belongs to the eukaryotic ribosomal protein eL20 family. (177 aa)
RpL6Ribosomal protein L6, isoform B; RNA binding; structural constituent of ribosome. It is involved in the biological process described with: cytoplasmic translation; ribosomal large subunit assembly. (262 aa)
RpL3260S ribosomal protein L32; Structural constituent of ribosome. It is involved in the biological process described with: translation; cytoplasmic translation. (147 aa)
RpL460S ribosomal protein L4; Structural constituent of ribosome; RNA binding. It is involved in the biological process described with: cytoplasmic translation; translation; Belongs to the universal ribosomal protein uL4 family. (401 aa)
RpL34aRibosomal protein L34a, isoform A; Structural constituent of ribosome; myosin binding. It is involved in the biological process described with: translation; ribosome biogenesis; cytoplasmic translation. (162 aa)
RpL10AaRibosomal protein L10Aa (RpL10Aa) encodes a component of the large ribosomal subunit. It is likely a retrogene derived from RpL10Ab and, unlike RpL10Ab, the expression of RpL10Aa is low in most tissues/developmental stages but enriched in the adult testis. (216 aa)
RpL24-likeProbable ribosome biogenesis protein RLP24; Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of NOG1 to pre-60S particles (By similarity). (191 aa)
RpL34bRibosomal protein L34b (RpL34b) encodes a ribosomal structural constituent. (168 aa)
RpL35ARibosomal protein L35A; Structural constituent of ribosome. It is involved in the biological process described with: cytoplasmic translation; ribosomal large subunit biogenesis. (157 aa)
RpL13ARibosomal protein L13A (RpL13A) encodes a component of the large ribosomal subunit, and thus involved in mRNA translation. Mutations in genes encoding ribosomal proteins affect fertility, viability and other Drosophila phenotypes, described as Minute; Belongs to the universal ribosomal protein uL13 family. (205 aa)
RpL2860S ribosomal protein L28; Structural constituent of ribosome. It is involved in the biological process described with: cytoplasmic translation; translation; Belongs to the eukaryotic ribosomal protein eL28 family. (144 aa)
RpL37aProbable 60S ribosomal protein L37-A; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL37 family. (93 aa)
RpL10AbRibosomal protein L10Ab (RpL10Ab) is an essential gene during oogenesis that encodes a ribosomal protein of the large ribosome subunit; Belongs to the universal ribosomal protein uL1 family. (217 aa)
RpL14Ribosomal protein L14 (RpL14) encodes a component of the large subunit of cytoplasmic ribosomes, which translate mRNAs encoded by the nuclear genome. RpL14 is haploinsufficient - heterozygous mutants display the 'Minute' phenotype, characterized by a slower developmental rate and small adult bristles. (166 aa)
RpL23ARibosomal protein L23A (RpL23A) encodes an essential ribosomal RNA binding protein of the large ribosomal subunit involved in protein synthesis; Belongs to the universal ribosomal protein uL23 family. (277 aa)
RpL26Ribosomal protein L26 (RpL26) encodes a protein component of large ribosomal subunits. (149 aa)
RpL36ARibosomal protein L36A, isoform A; Structural constituent of ribosome. It is involved in the biological process described with: translation; cytoplasmic translation; Belongs to the eukaryotic ribosomal protein eL42 family. (104 aa)
RpL760S ribosomal protein L7; Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs (By similarity). (252 aa)
RpL7ARibosomal protein L7A (RpL7A) encodes a ribosomal structural constituent; Belongs to the eukaryotic ribosomal protein eL8 family. (271 aa)
RpL2460S ribosomal protein L24; Structural constituent of ribosome; RNA binding. It is involved in the biological process described with: cytoplasmic translation; assembly of large subunit precursor of preribosome; translation; ribosomal large subunit assembly; Belongs to the eukaryotic ribosomal protein eL24 family. (155 aa)
RpL1160S ribosomal protein L11; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] (184 aa)
RpL30Ribosomal protein L30, isoform B; RNA binding; structural constituent of ribosome. It is involved in the biological process described with: cytoplasmic translation; translation. (111 aa)
RpL9Ribosomal protein L9 (RpL9) encodes a ribosomal structural constituent; Belongs to the universal ribosomal protein uL6 family. (190 aa)
RpL360S ribosomal protein L3; The L3 protein is a component of the large subunit of cytoplasmic ribosomes. (416 aa)
RpL27ARibosomal protein L27A (RpL27A) encodes a ribosomal structural constituent; Belongs to the universal ribosomal protein uL15 family. (149 aa)
RpL38Ribosomal protein L38 (RpL38) encodes a component of the large subunit of cytoplasmic ribosomes, which translate mRNAs encoded by the nuclear genome. RpL38 is haploinsufficient - heterozygous mutants display the 'Minute' phenotype, characterized by a slower developmental rate and small adult bristles. (70 aa)
RpL40Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is invol [...] (128 aa)
RpLP060S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10; Belongs to the universal ribosomal protein uL10 family. (317 aa)
RpL1060S ribosomal protein L10; Structural constituent of ribosome. It is involved in the biological process described with: translation; ribosomal large subunit assembly; cytoplasmic translation. (218 aa)
RpL1860S ribosomal protein L18; Structural constituent of ribosome; RNA binding. It is involved in the biological process described with: cytoplasmic translation; translation. (188 aa)
RpLP1Ribosomal protein LP1 (RpLP1) encodes a member of the cytoplasmic large ribosomal protein family. (112 aa)
RpL2760S ribosomal protein L27; Structural constituent of ribosome. It is involved in the biological process described with: translation; cytoplasmic translation; Belongs to the eukaryotic ribosomal protein eL27 family. (135 aa)
RpL21Ribosomal protein L21, isoform A; Structural constituent of ribosome. It is involved in the biological process described with: translation; cytoplasmic translation. (159 aa)
RpL13Ribosomal protein L13 (RpL13) encodes a ribosomal structural constituent; Belongs to the eukaryotic ribosomal protein eL13 family. (218 aa)
RpL37A60S ribosomal protein L37a; Structural constituent of ribosome. It is involved in the biological process described with: cytoplasmic translation; translation; Belongs to the eukaryotic ribosomal protein eL43 family. (92 aa)
RpL1560S ribosomal protein L15; Structural constituent of ribosome; RNA binding. It is involved in the biological process described with: cytoplasmic translation; Belongs to the eukaryotic ribosomal protein eL15 family. (204 aa)
RpL7-likeRibosomal protein L7-like, isoform A; Structural constituent of ribosome; RNA binding. It is involved in the biological process described with: maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); cytoplasmic translation. (257 aa)
RpL41Structural constituent of ribosome. It is involved in the biological process described with: cytoplasmic translation; translation. (25 aa)
RpL3160S ribosomal protein L31; Structural constituent of ribosome. It is involved in the biological process described with: cytoplasmic translation; Belongs to the eukaryotic ribosomal protein eL31 family. (124 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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