ALG-2 interacting protein X (ALiX) encodes an adaptor protein implicated in multiple cellular processes, including positive regulation of mitotic cytokinesis, exosomal secretion and apoptosis.

CIN85 and CD2AP related (cindr) encodes an adaptor protein that links cell surface junctions and adhesion proteins with multiple components of the actin cytoskeleton. It regulates cytoskeletal dynamics, eye patterning and endocytosis. It also cooperates with the product of scra to promote intercellular bridge stability during cytokinesis.

ALG-2 interacting protein X (ALiX) encodes an adaptor protein implicated in multiple cellular processes, including positive regulation of mitotic cytokinesis, exosomal secretion and apoptosis.

GH13992p; Shrub (shrb) encodes Shrub encodes Vps32/Snf7, a filament-forming subunit of the ESCRT-III complex involved in inward membrane budding. It regulates multiple cellular processes involving ESCRTs activity including multivesicular body biogenesis, cytokinesis, membrane repair and regulation of membrane associated signaling.

Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+) (By similarity). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). In photoreceptor cells, light-induced Ca(2+) influx activates calmodulin, which in turn is likely to promote Crag activity in trafficking of newly synthesized ninaE (Rh1) from the trans-Golgi network to rhabdomere membranes. Together with Akap200, regulates PKA activity and ethanol-induced sensitivity and tolerance.

Small ubiquitin-related modifier; Smt3 (smt3) encodes the only Drosophila SUMO family protein. It is required for embryonic patterning and mitosis. It may also have roles in wing patterning, Dpp signaling, and Ras/MAPK signaling. It localizes to the nucleus during interphase and to the kinetochores and midbodies during mitosis; Belongs to the ubiquitin family. SUMO subfamily.

Cdc42-interacting protein 4 (Cip4) encodes an F-BAR protein that functions as an adaptor protein regulating membrane curvature and dynamics.

Syndapin, isoform C; Lipid binding; phospholipid binding; cytoskeletal protein binding; protein binding.

Dynactin 1, p150 subunit (DCTN1-p150) encodes the p150 subunit of the dynactin complex. Dynactin is thought to act as a dynein receptor that modulates binding of dynein to cellular cargoes and enhances the processivity of dynein movement. The roles of the product of DCTN1-p150 include oocyte polarity, mitotic cell division, embryonic development, neuronal transport and neurogenesis.

Toucan, isoform A; Toucan (toc) encodes a protein that associates with spindle microtubules being involved in mitotic spindle organization, mitotic sister chromatid segregation and ovarian follicle cell formation.

Kinesin-like protein at 3A (Klp3A) encodes a microtubule motor protein involved in chromosome segregation and mitotic spindle morphogenesis; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

Aurora B (aurB) encodes a serine-threonine kinase and member of the chromosomal passenger complex. It plays multiple roles in mitosis including the correction of erroneous chromosome-spindle interactions, chromosome condensation, kinetochore assembly, spindle assembly checkpoint and cytokinesis.

Kinesin-like protein at 3A (Klp3A) encodes a microtubule motor protein involved in chromosome segregation and mitotic spindle morphogenesis; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

Protein nessun dorma; Required during male meiosis for completion of spermatocyte cytokinesis and possibly also required in female germline cells. Also involved in ring canal formation in male and female germline cells. Not essential for cleavage furrow ingression but is required for contractile ring stability and the attachment of the furrowing membrane to the actomyosin ring in late telophase. Displays high binding affinity for beta-galactosides.

Kinesin-like protein at 3A (Klp3A) encodes a microtubule motor protein involved in chromosome segregation and mitotic spindle morphogenesis; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

Kinesin-like protein; Pavarotti (pav) encodes a microtubule motor protein from the Kinesin superfamily. It plays important roles during the mitotic cycle including spindle formation, cortical cytoskeleton reorganization and cytokinesis. It also negatively regulates Wnt activity.

Kinesin-like protein at 3A (Klp3A) encodes a microtubule motor protein involved in chromosome segregation and mitotic spindle morphogenesis; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

Serine/threonine-protein kinase polo; May play a role in regulating both nuclear and cytoplasmic aspects of the mitotic cycle. Regulates localization of the augmin complex during mitosis by ensuring its location on mitotic spindles. Also regulates augmin complex localization during male meiosis by promoting its placement at kinetochores while preventing its association with spindle microtubules ; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.

Kinesin-like protein at 3A (Klp3A) encodes a microtubule motor protein involved in chromosome segregation and mitotic spindle morphogenesis; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

Anillin; Required for cytokinesis. Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression and proper formation of the midbody. Required during cellularization of syncytial embryos for the proper formation and function of the furrow canals, the stable inward folds of the plasma membrane which separate the peripheral nuclei. Also required for the formation of the pole cells, the progenitors of the adult germline which are formed by cytokinesis of the cytoplasmic buds at the posterior pole of the syncytial embryo. Essential for embry [...]

Microtubule-associated protein 205 (Map205) encodes a protein that binds and stabilizes microtubules. It also binds, inhibits and stabilizes the product of polo on microtubules during interphase.

Aurora B (aurB) encodes a serine-threonine kinase and member of the chromosomal passenger complex. It plays multiple roles in mitosis including the correction of erroneous chromosome-spindle interactions, chromosome condensation, kinetochore assembly, spindle assembly checkpoint and cytokinesis.

Microtubule-associated protein 205 (Map205) encodes a protein that binds and stabilizes microtubules. It also binds, inhibits and stabilizes the product of polo on microtubules during interphase.

Kinesin-like protein; Pavarotti (pav) encodes a microtubule motor protein from the Kinesin superfamily. It plays important roles during the mitotic cycle including spindle formation, cortical cytoskeleton reorganization and cytokinesis. It also negatively regulates Wnt activity.

Microtubule-associated protein 205 (Map205) encodes a protein that binds and stabilizes microtubules. It also binds, inhibits and stabilizes the product of polo on microtubules during interphase.

Serine/threonine-protein kinase polo; May play a role in regulating both nuclear and cytoplasmic aspects of the mitotic cycle. Regulates localization of the augmin complex during mitosis by ensuring its location on mitotic spindles. Also regulates augmin complex localization during male meiosis by promoting its placement at kinetochores while preventing its association with spindle microtubules ; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.

Nucleoprotein TPR; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC. Plays a role in chromosomal organization and gene expression regulation; stimulates transcription by promoting the formation of an open chromatin environment. Binds chromatin to nucleoporin-associated regions (NARs) that define transcriptionally active regions of the genome. Associates with extended chromosomal regions that alternate between domains of high density binding with those of lo [...]

Aurora B (aurB) encodes a serine-threonine kinase and member of the chromosomal passenger complex. It plays multiple roles in mitosis including the correction of erroneous chromosome-spindle interactions, chromosome condensation, kinetochore assembly, spindle assembly checkpoint and cytokinesis.

Nucleoprotein TPR; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC. Plays a role in chromosomal organization and gene expression regulation; stimulates transcription by promoting the formation of an open chromatin environment. Binds chromatin to nucleoporin-associated regions (NARs) that define transcriptionally active regions of the genome. Associates with extended chromosomal regions that alternate between domains of high density binding with those of lo [...]

Small ubiquitin-related modifier; Smt3 (smt3) encodes the only Drosophila SUMO family protein. It is required for embryonic patterning and mitosis. It may also have roles in wing patterning, Dpp signaling, and Ras/MAPK signaling. It localizes to the nucleus during interphase and to the kinetochores and midbodies during mitosis; Belongs to the ubiquitin family. SUMO subfamily.

Patronin; Involved in mitotic spindle assembly. Regulates microtubule (MT) severing. Antagonizes the activity of the kinesin-13 depolymerase Klp10A thereby switching off the depolymerization of the MTs at their pole-associated minus ends, which turns off poleward flux and induces anaphase B spindle elongation. Involved in asymmetric cell division of sensory organ precursor (SOP) cells by playing a role in the asymmetric localization of Sara-expressing endosomes to the pIIa daughter cell but not to the pIIb cell. Klp98A targets Sara-expressing endosomes to the central spindle which is s [...]

Spaghetti squash (sqh) encodes the regulatory light chain of the nonmuscle type 2 myosin. Its phosphorylation through the Rho-Rho Kinase pathway is predicted to activate myosin motor activity. The product of sqh and myosin function in cellular processes such as cytokinesis, and also contribute to tissue morphogenesis.

Syndapin, isoform C; Lipid binding; phospholipid binding; cytoskeletal protein binding; protein binding.

Cdc42-interacting protein 4 (Cip4) encodes an F-BAR protein that functions as an adaptor protein regulating membrane curvature and dynamics.

Syndapin, isoform C; Lipid binding; phospholipid binding; cytoskeletal protein binding; protein binding.

Anillin; Required for cytokinesis. Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression and proper formation of the midbody. Required during cellularization of syncytial embryos for the proper formation and function of the furrow canals, the stable inward folds of the plasma membrane which separate the peripheral nuclei. Also required for the formation of the pole cells, the progenitors of the adult germline which are formed by cytokinesis of the cytoplasmic buds at the posterior pole of the syncytial embryo. Essential for embry [...]

Aurora B (aurB) encodes a serine-threonine kinase and member of the chromosomal passenger complex. It plays multiple roles in mitosis including the correction of erroneous chromosome-spindle interactions, chromosome condensation, kinetochore assembly, spindle assembly checkpoint and cytokinesis.

Kinesin-like protein at 3A (Klp3A) encodes a microtubule motor protein involved in chromosome segregation and mitotic spindle morphogenesis; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

Aurora B (aurB) encodes a serine-threonine kinase and member of the chromosomal passenger complex. It plays multiple roles in mitosis including the correction of erroneous chromosome-spindle interactions, chromosome condensation, kinetochore assembly, spindle assembly checkpoint and cytokinesis.

Microtubule-associated protein 205 (Map205) encodes a protein that binds and stabilizes microtubules. It also binds, inhibits and stabilizes the product of polo on microtubules during interphase.