Your Input: | |
| | st | Protein scarlet; Part of a membrane-spanning permease system necessary for the transport of pigment precursors into pigment cells responsible for eye color. Scarlet and white complex transports a metabolic intermediate (such as 3-hydroxy kynurenine) from the cytoplasm into the pigment granules. (666 aa) |
| | Afti | Aftiphilin, isoform E; Aftiphilin (Afti) encodes an AP-1 adaptor complex binding protein involved in eye photoreceptor development and intracellular transport. (1161 aa) |
| | Vps24 | Vacuolar protein sorting 24 (Vps24) encodes an essential subunit of ESCRT-III, one of the endosomal sorting complexes required for transport (ESCRT). It is involved in membrane remodeling in diverse cellular processes, such as multi-vesicular body biogenesis, cytokinesis and virus budding. (223 aa) |
| | pHCl-2 | pH-sensitive chloride channel 2 (pHCl-2) encodes a channel involved in chloride transmembrane transport and renal water transport regulation; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (526 aa) |
| | Fuca | alpha-L-fucosidase (Fuca) encodes an enzyme belonging to the family of hydrolases. It has also been identified as a transmembrane protein in the plasma-membrane of spermatozoa. Its roles include N-glycan degradation, glycan structure degradation, and is potentially involved in fertilization, particularly in initial sperm-egg recognition; Belongs to the glycosyl hydrolase 29 family. (494 aa) |
| | Vamp7 | Vesicle-associated membrane protein 7 (Vamp7) encodes an R type SNARE protein. It mediates the fusion of autophagosomes with endosomes and lysosomes by forming a SNARE complex with the products of Syx17 and Snap29. It localizes to endosomes in a Rab21 and Sbf dependent manner; Belongs to the synaptobrevin family. (218 aa) |
| | hemo | Hemotin; Negatively regulates early endosome maturation by binding to and repressing the activity of 14-3-3zeta which prevents the 14-3- 3zeta-mediated activation of phosphoinositide 3-kinase Pi3K68D. This, in turn, inhibits the Pi3K68D-mediated conversion of phosphatidylinositol to phosphatidylinositol-3-phosphate and prevents progression of early endosomes through the maturation process which regulates subsequent steps of phagocytic processing. (88 aa) |
| | Sec13 | Protein SEC13 homolog; Functions as a component of the nuclear pore complex (NPC) and the COPII coat (By similarity). At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles (By similarity). Recruited to transcriptionally active chromatin at the time of transcription initiation by RNA polymerase II. Required for proper expression of ecdysone-responsive genes such as Eip74EF and Eip75B during larval development. Required for reactivation of transcription after heat shock. Required for nuclear import of phosphorylated Mad via importin msk. Has no role i [...] (356 aa) |
| | Sec31 | Secretory 31 (Sec31) encodes a protein involved in the innate immune response. (1260 aa) |
| | Sting | Sting, isoform B; cyclic-di-GMP binding; cyclic-GMP-AMP binding. (343 aa) |
| | CG5946 | FAD binding; cytochrome-b5 reductase activity, acting on NAD(P)H. It is involved in the biological process described with: retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; regulation of lipid storage; oxidation-reduction process; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (330 aa) |
| | Vps4 | Vacuolar protein sorting 4 (Vps4) encodes an AAA family ATPase. It catalyzes the ATP-dependent dissociation of class E VPS proteins from endosomal membranes. It functions in endosomal sorting of cargo into the multivesicular body for lysosomal degradation, abscission during cell division, virus release and nuclear envelope membrane sealing after cell division. (442 aa) |
| | yin | Peptide transporter family 1; Important role in absorption of dietary peptides. High- affinity transporter of alanylalanine. Dipeptide transport activity is proton dependent; Belongs to the PTR2/POT transporter (TC 2.A.17) family. (780 aa) |
| | Sec16 | Secretory 16 (Sec16) encodes a protein involved in the organization of endoplasmic reticulum exit sites. It contributes to stress response to amino-acid starvation, during which it mediates the formation of both Sec bodies and stress granules. (2326 aa) |
| | Sec24AB | Secretory 24AB, isoform A; Zinc ion binding; signal sequence binding. It is involved in the biological process described with: COPII-coated vesicle cargo loading; intracellular protein transport. (1184 aa) |
| | IKKepsilon | I-kappaB kinase epsilon (IKKepsilon) encodes a serine-threonine kinase that targets the inhibitor of apoptosis encoded by Diap1 for degradation. It also negatively regulates protein kinase C and the dynein adaptor encoded nuf. The product of IKKepsilon contributes to the specification of bristle cells, bristle cell morphogenesis, oocyte polarity, and dendrite development. (720 aa) |
| | Lrrk | Leucine-rich repeat kinase (Lrrk) encodes a large Ser/Thr kinase involved in mRNA translational control, cytoskeleton regulation, vesicle trafficking, autophagy, and immune response. (2513 aa) |
| | snky | Protein sneaky; Component of the sperm acrosome membrane. Required for breakdown of the sperm plasma membrane after sperm entry into the egg, which is an essential prerequisite for successful fertilization. (715 aa) |
| | olf413 | MOXD1 homolog 2; Dopamine beta-monooxygenase activity; copper ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen. It is involved in the biological process described with: dopamine catabolic process; oxidation-reduction process; octopamine biosynthetic process; norepinephrine biosynthetic process. (760 aa) |
| | rho | Protein rhomboid; Acts early in embryonic development to establish position along the dorsoventral axis and then again later to specify the fate of neuronal precursor cells. Involved in EGF receptor signaling; cleaves Spitz to release the active growth factor. Belongs to the peptidase S54 family. (355 aa) |
| | Vps60 | Charged multivesicular body protein 5; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and are delivered to lysosomes enabling degradation of membrane proteins (By similarity). Specifically down-regulates Notch signaling activity in the germarium, probably by facilitating Notch en [...] (226 aa) |
| | comm | Protein commissureless 1; Commissureless (comm) product regulates the cell surface localization of Robo axon guidance receptors by intercepting them in the ER/Golgi during exocytosis or removing them from the surface by endocytosis. comm is required for formation of the CNS axon scaffold and synaptogenesis. (370 aa) |
| | nSyb | Neuronal synaptobrevin, isoform J; Neuronal Synaptobrevin (nSyb) encodes a SNAP receptor involved in vesicle fusion. (206 aa) |
| | VGlut | Vesicular glutamate transporter, isoform A. (632 aa) |
| | Dop1R2 | Dopamine receptor 2; Receptor for dopamine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Also capable of generating a calcium signal. In terms of antagonist responses, would be classed with the D1-like dopamine receptor group. This receptor is an attractive candidate for initiating biochemical cascades underlying olfactory learning. (807 aa) |
| | Osi23 | Osiris 23; It is involved in the biological process described with: cuticle development. (255 aa) |
| | gammaCOP | Coatomer subunit gamma; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Required for limiting lipid storage in lipid droplets. Involved in the expansion of luminal extracellular matrices and apical membrane during tubulogenesis. Required [...] (897 aa) |
| | Sec24CD | Secretory 24CD (Sec24CD) encodes a subunit of the coat protein complex of COPII vesicles, which transport cargo from the endoplasmic reticulum to the Golgi apparatus. It is essential for export of membrane and secreted proteins from the endoplasmic reticulum. It is involved in epithelial morphogenesis and differentiation. (1231 aa) |
| | Vps28 | Vacuolar protein sorting 28 (Vps28) encodes a member of the ESCRT-I complex, which sorts certain endocytosed receptors for degradation via the multivesicular body. (210 aa) |
| | Sec22 | Secretory 22, isoform B; Secretory 22 (Sec22) encodes a protein involved in Wnt protein secretion; Belongs to the synaptobrevin family. (213 aa) |
| | Vps13 | Vacuolar protein sorting-associated protein 13; Plays a role in the survival of neurons by maintaining protein homeostasis in the central nervous system. May function as part of a lysosomal degradation pathway. (3321 aa) |
| | b | Black (b) encodes an aspartate 1-decarboxylase. Mutations of b result in viable flies with a cuticular melanization phenotype. (575 aa) |
| | CG4250 | Uncharacterized protein, isoform B. (134 aa) |
| | CG4080 | LD02310p; Zinc ion binding; MHC protein binding; ubiquitin protein ligase activity. It is involved in the biological process described with: immune response; protein polyubiquitination; antigen processing and presentation of peptide antigen via MHC class II. (617 aa) |
| | Sec23 | Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (781 aa) |
| | unc-13 | Unc-13, isoform E; Unc-13 (unc-13) encodes a protein involved in synaptic vesicle exocytosis. (3186 aa) |
| | Vps20 | Vacuolar protein sorting 20 (Vps20) encodes a member of the ESCRT-III complex, which sorts certain endocytosed receptors for degradation via the multivesicular body. As part of this complex, the product of Vps20 is also involved in abscission following cytokinesis. (212 aa) |
| | Ptr | Patched-related, isoform A. (1169 aa) |
| | uif | Uninflatable, isoform C; Uninflatable (uif) encodes a single pass transmembrane protein that localizes to the apical plasma membrane in epithelial cells. It is required for embryonic tracheal maturation and tracheal growth in the larva. (3589 aa) |
| | CG5110 | Ragulator complex protein LAMTOR3 homolog; CG5110 encodes a scaffold protein that associates with the MAP kinase kinase and the MAP kinase encoded by Mekk1 and rl respectively. It regulates the vein promoting function of rl during wing imaginal disc development in third instar larvae; Belongs to the LAMTOR3 family. (124 aa) |
| | Start1 | Steroidogenic acute regulatory protein-like; May bind to and transport cholesterol and may play a role in ecdysteroid biosynthesis. (583 aa) |
| | AP-1sigma | AP complex subunit sigma; Clathrin adaptor activity; clathrin binding; Belongs to the adaptor complexes small subunit family. (157 aa) |
| | Vps37B | Vacuolar protein sorting 37B, isoform A; It is involved in the biological process described with: ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; protein targeting to vacuole; protein targeting to membrane; endosome transport via multivesicular body sorting pathway. (214 aa) |
| | CG42638 | Cation channel activity. (652 aa) |
| | Clc | Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. (219 aa) |
| | Pten | Phosphatase and tensin homolog (Pten) encodes a dual lipid and protein phosphatase that primarily counters the effects of the insulin-regulated lipid kinase, encoded by Pi3K92E. It inhibits cell growth, cell proliferation and cellular events controlling cytoskeletal and junctional rearrangements. (514 aa) |
| | CG5189 | Ragulator complex protein LAMTOR2 homolog; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. Belongs to the GAMAD family. (125 aa) |
| | lqfR | Liquid facets-Related (lqfR) encodes a Golgi protein involved in cell proliferation and oogenesis. (1415 aa) |
| | dsb | Debris buster (dsb) encodes a double-span transmembrane protein of the CD36 family residing in late endosomes and lysosomes. It is required for late stage phagosome maturation; Belongs to the CD36 family. (615 aa) |
| | Atet | ABC transporter expressed in trachea (Atet) encodes a protein that is involved in transmembrane transport. (832 aa) |
| | BORCS7 | GH13245p1. (105 aa) |
| | Syn | Synapsin-1; Synapsin (Syn) encodes a phosphoprotein associated with synaptic vesicles. It interacts with the endocytic scaffolding protein encoded by Dap160. Phosphorylation of synapsin at serine 6 is required for associative short-term learning/memory and short-term olfactory habituation. It is important for outgrowth of synaptic boutons at the larval neuromuscular junction. (1041 aa) |
| | NimB3 | GEO11169p1; It is involved in the biological process described with: defense response to bacterium. (122 aa) |
| | Vmat | Vesicular monoamine transporter (Vmat) encodes a protein responsible for packaging the neurotransmitters dopamine, serotonin and octopamine into secretory vesicles. (646 aa) |
| | Chc | Clathrin heavy chain (Chc) encodes a protein that forms part of the clathrin complex, which is the major component of coated vesicles. (1678 aa) |
| | Pi4KIIalpha | Pi4KIIalpha, isoform A; Pi4KIIalpha (Pi4KIIalpha) encodes a lipid kinase that synthesizes phosphatidylinositol 4-phosphate from phosphatidylinositol. It contributes to membrane trafficking in the larval salivary gland. (710 aa) |
| | Tbh | Tyramine beta-hydroxylase; Converts tyramine into octopamine, a neurotransmitter involved in ovulation and locomotion. Functions in an amine-mediated Bacc-dependent signaling pathway that negatively regulates acute ethanol sensitivity. Belongs to the copper type II ascorbate-dependent monooxygenase family. (670 aa) |
| | AP-2alpha | AP-2 complex subunit alpha; Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. AP- 2alpha is a subunit of the plasma membrane adapter. (952 aa) |
| | Vsp37A | Vacuolar protein sorting 37A, isoform A; It is involved in the biological process described with: endosome transport via multivesicular body sorting pathway; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; protein targeting to vacuole; protein targeting to membrane. (200 aa) |
| | spin | Protein spinster; Probable sphingolipid transporter that plays a central role in endosomes and/or lysosomes storage. Involved in TGF-beta-mediated synaptic growth regulation both pre- and postsynaptically via its function in endosomal storage regulation. Also required during oogenesis by regulating yolk spheres storage. Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family. (630 aa) |
| | Vps25 | Vacuolar protein-sorting-associated protein 25; Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex (By similarity). Seems to function as a tumor suppressor by regulating Notch trafficking, hence preventing non-autonomous overproliferation. May be invo [...] (174 aa) |
| | shrb | GH13992p; Shrub (shrb) encodes Shrub encodes Vps32/Snf7, a filament-forming subunit of the ESCRT-III complex involved in inward membrane budding. It regulates multiple cellular processes involving ESCRTs activity including multivesicular body biogenesis, cytokinesis, membrane repair and regulation of membrane associated signaling. (226 aa) |
| | lambdaTry | Trypsin-lambda; Serine-type endopeptidase activity. It is involved in the biological process described with: proteolysis; Belongs to the peptidase S1 family. (272 aa) |
| | Syx6 | Syntaxin 6, isoform E; SNARE binding; SNAP receptor activity. (339 aa) |
| | Syngr | Synaptogyrin (Syngr) encodes a synaptic vesicle protein implicated in vesicle endocytosis during the bulk endocytosis process. It is the sole Drosopohila homolog of the synaptophysin/synaptogryin synaptic vesicle family of proteins. (241 aa) |
| | VGAT | Vesicular GABA Transporter (VGAT) encodes an essential transporter that is responsible for packaging the neurotransmitter GABA into synaptic vesicles. (549 aa) |
| | HPS4 | Hermansky-Pudlak Syndrome 4 (HPS4) encodes a tethering factor that regulates gene silencing by small RNAs via endosomal trafficking. (858 aa) |
| | Lamp1 | FI04419p; It is involved in the biological process described with: establishment of protein localization to organelle. (318 aa) |
| | Vps2 | Vacuolar protein sorting 2 (Vps2) encodes an ion channel involved in the transmembrane transport of potassium. (256 aa) |
| | Rab7 | Rab7 (Rab7) encodes a small GTPase that contributes to vesicle trafficking regulation. It is involved in endosome maturation and fusion with lysosomes. (207 aa) |
| | AP-2mu | Adaptor Protein complex 2, mu subunit (AP-2mu) encodes a component of the AP-2 adaptor complex, which recruits certain transmembrane proteins into clathrin-coated pits for endocytic internalization. (437 aa) |
| | Sar1 | Secretion-associated Ras-related 1 (Sar1) encodes a small GTPase that is recruited to the endoplasmic reticulum and initiates the recruitment of the COPII subunit complex Sec23/Sec24. (193 aa) |
| | lsn | Vacuolar-sorting protein SNF8; Larsen (lsn), also known as Vacuolar protein sorting 22, encodes a member of the ESCRT-II complex, which sorts certain endocytosed receptors for degradation via the multivesicular body. As part of this complex, it also has a role in bcd RNA localization. (254 aa) |
| | AP-2sigma | Adaptor Protein complex 2, sigma subunit (AP-2sigma) encodes a component of the AP-2 adaptor complex, which recruits certain transmembrane proteins into clathrin-coated pits for endocytic internalization. (142 aa) |
| | Rab11 | Rab11, isoform A; Rab11 (Rab11) encodes a Rab type protein. Rab proteins are ubiquitously expressed family of small monomeric Ras-like GTPases that are key regulators of endomembrane traffiking, regulating exocytosis, endocytosis and membrane recycling processes essential for maintaining various cellular functions. (214 aa) |
| | VAChT | Vesicular acetylcholine transporter (VAChT) encodes a vesicular transport protein necessary for packaging the neurotransmitter acetylcholine into synaptic vesicles; Belongs to the major facilitator superfamily. Vesicular transporter family. (578 aa) |
| | Snap24 | Synaptosomal-associated protein; SNAP receptor activity; syntaxin binding; Belongs to the SNAP-25 family. (212 aa) |
| | AP-1mu | Adaptor Protein complex 1, mu subunit (AP-1mu) encodes a clathrin adaptor involved in intracellular transport. It controls the trafficking of proteins, including the products of N and spdo. (426 aa) |
| | beta'COP | Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity). (914 aa) |
| | PLCXD | Uncharacterized protein, isoform A; Glycosylphosphatidylinositol diacylglycerol-lyase activity; phosphoric diester hydrolase activity. It is involved in the biological process described with: glycerophospholipid metabolic process. (482 aa) |
| | epsilonCOP | Coatomer subunit epsilon; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Belongs to the COPE family. (306 aa) |
| | Itpr | Inositol 1,4,5,-trisphosphate receptor (Itpr) encodes an intracellular ligand gated calcium channel. It functions downstream of G-protein coupled receptors that activate Gq/PLCbeta signaling and generate inositol tris-phosphate. Itpr depletion affects ecdysone release, response to nutritional stress, lipid metabolism and flight; Belongs to the InsP3 receptor family. (2837 aa) |
| | CG5498 | BcDNA.GH08385; It is involved in the biological process described with: late endosome to vacuole transport via multivesicular body sorting pathway; endosomal transport; vesicle budding from membrane. (448 aa) |
| | S | Star (S) encodes a type II transmembrane protein that facilitates trafficking of transmembrane Egfr ligands from the endoplasmic reticulum to the late secretory compartment. It is involved in growth regulation, cell survival and developmental patterning. (597 aa) |
| | Vps29 | Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. (182 aa) |
| | Syt1 | Synaptotagmin 1; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. (474 aa) |
| | FIG4 | FIG4 phosphoinositide 5-phosphatase; Phosphoric ester hydrolase activity. It is involved in the biological process described with: larval locomotory behavior; regulation of lysosome size; compound eye morphogenesis. (858 aa) |
| | CHMP2B | Charged multivesicular body protein 2b (CHMP2B) encodes an ESCRT-III component. It plays an important role in the generation of multivesicular bodies in the endosomal lysosomal pathway. It is also considered to play an important role in autophagosome maturation. (212 aa) |
| | CG6707 | Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (266 aa) |
| | wls | Protein wntless; A segment polarity gene required for wingless (wg)-dependent patterning processes, acting in both wg-sending cells and wg-target cells. In non-neuronal cells wls directs wg secretion. The wls traffic loop encompasses the Golgi, the cell surface, an endocytic compartment and a retrograde route leading back to the Golgi, and involves clathrin-mediated endocytosis and the retromer complex (a conserved protein complex consisting of Vps35 and Vps26). In neuronal cells (the larval motorneuron NMJ), the wg signal moves across the synapse via the release of wls-containing exos [...] (594 aa) |
| | Pi3K68D | Phosphotidylinositol 3 kinase 68D (Pi3K68D) encodes a phosphatidylinositol kinase involved in the organization of the cortical actin cytoskeleton and the regulation of the Egfr signaling pathway; Belongs to the PI3/PI4-kinase family. (1876 aa) |
| | Vps36 | Vacuolar protein-sorting-associated protein 36; Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex (By similarity). ESCRT-II interacts, through the Vps36 subunit, with bicoid mRNA. This interaction is required for the anterior localization of bicoid m [...] (399 aa) |
| | fwe | Calcium channel flower; Flower (fwe) encodes a transmembrane protein with different isoforms expressed in 'loser' and in 'winner' cells to mediate win/lose decisions in cell competition and neuronal culling during development and ageing. (194 aa) |
| | CG5235 | MOXD1 homolog 1; Copper ion binding; dopamine beta-monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen. It is involved in the biological process described with: oxidation-reduction process; norepinephrine biosynthetic process; octopamine biosynthetic process; dopamine catabolic process. (698 aa) |
| | zetaCOP | Coatomer subunit zeta; The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex. (174 aa) |
| | TSG101 | Tumor susceptibility gene 101 (TSG101) encodes an ESCRT-I complex component that acts as an adapter for membrane rearrangements operated by ESCRT-III. Its roles include endosomal sorting of ubiquitinated cargoes, which is important for signaling regulation, cytokinesis, and budding of viruses and exovesicles. (408 aa) |
| | Trpml | Transient receptor potential cation channel, mucolipin (Trpml) encodes a ion channel involved in autophagy, lateral inhibition and TOR signalling regulation. (652 aa) |
| | CG14184 | FI16105p1; Molecular adaptor activity; guanyl-nucleotide exchange factor activity. (180 aa) |
| | AP-1-2beta | Adaptor Protein complex 1/2, beta subunit (AP-1-2beta) encodes a clathrin adaptor involved in vesicle trafficking and autophagy regulation. (921 aa) |
| | betaCOP | Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Required for limiting lipid storage in lipid droplets. (964 aa) |
| | Mvb12 | Multivesicular body subunit 12, isoform A; Ubiquitin binding. It is involved in the biological process described with: virus maturation; viral budding; receptor catabolic process; endosome to lysosome transport via multivesicular body sorting pathway; regulation of epidermal growth factor receptor signaling pathway. (352 aa) |
| | CG9132 | NECAP-like protein CG9132; May be involved in endocytosis; Belongs to the NECAP family. (246 aa) |
| | BORCS5 | LD30509p; It is involved in the biological process described with: lysosome localization; organelle transport along microtubule; positive regulation of anterograde synaptic vesicle transport. (349 aa) |
| | alphaCOP | Coatomer subunit alpha; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. (1234 aa) |
| | Vta1 | Vesicle trafficking 1; ATPase activator activity. It is involved in the biological process described with: endosome transport via multivesicular body sorting pathway; late endosome to vacuole transport via multivesicular body sorting pathway. (316 aa) |
| | ru | Roughoid/rhomboid-3; Roughoid (ru) encodes an intra-membrane serine protease localized in the endoplasmic reticulum. It processes Egfr ligands in specific tissues, most notably the eye; Belongs to the peptidase S54 family. (341 aa) |
| | Vti1a | Vesicle transport through interaction with t-SNAREs 1a (Vti1a) encodes a protein involved in vesicle trafficking. (230 aa) |
| | Rph | Rabphilin, isoform A; Rab GTPase binding; calcium-dependent phospholipid binding. It is involved in the biological process described with: synaptic vesicle exocytosis; exocytosis; intracellular protein transport; neurotransmitter secretion; vesicle-mediated transport. (638 aa) |
| | AP-1gamma | Adaptor Protein complex 1, gamma subunit (AP-1gamma) encodes a clathrin adaptor involved in vesicle trafficking. (982 aa) |
| | CG4557 | FI19713p1; Rab GTPase binding. (933 aa) |
| | w | White (w) encodes a member of the ABCG2 class of transporters, transporting molecules such as cyclic GMP, biogenic amines and pigments including drosopterins and ommochromes. Mutation of w results in viable flies with white eyes. A shortened version of the gene (mini-w) has been widely used in transformation constructs as a selectable marker. (687 aa) |
| | deltaCOP | Coatomer subunit delta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (532 aa) |
