STRINGSTRING
Moe Moe Slik Slik pav pav sstn sstn pbl pbl Sep1 Sep1 Arf79F Arf79F Lrch Lrch Cen Cen Sgt1 Sgt1 Rab11 Rab11 Rab1 Rab1 Hil Hil Arf51F Arf51F tum tum Amph Amph pnut pnut scra scra sau sau dunk dunk Cip4 Cip4 Spt Spt slam slam dia dia nuf nuf Arl4 Arl4 vib vib cindr cindr Tl Tl step step Synd Synd sqh sqh Graf Graf Sry-alpha Sry-alpha Apc2 Apc2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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MoeMoesin/ezrin/radixin homolog 1; Involved in connections of major cytoskeletal structures to the plasma membrane. Together with wgn, involved in control of axon targeting of R8 and R2-R5 photoreceptors, independent of egr. In the nucleus, recruited to sites of active transcription by RNA polymerase II where it has a role in nuclear mRNA export together with the mRNA export factor PCID2 and other messenger ribonucleoprotein (mRNP) particles. (649 aa)
SlikSterile20-like kinase (Slik) encodes a member of the Sterile-20 kinase family. It acts via Raf to promote cell proliferation in imaginal disc epithelia. Independently, Slik acts via the product of Moe to support epithelial integrity. (1703 aa)
pavKinesin-like protein; Pavarotti (pav) encodes a microtubule motor protein from the Kinesin superfamily. It plays important roles during the mitotic cycle including spindle formation, cortical cytoskeleton reorganization and cytokinesis. It also negatively regulates Wnt activity. (887 aa)
sstnStepping stone (sstn) encodes an adaptor protein that forms a complex with the plasma membrane encoded by step through direct coil-coil domain interactions. It functions with the product of step to antagonize actomyosin networks during cleavage of the Drosophila embryo. (635 aa)
pblPebble, isoform B; Pebble (pbl) encodes a Rho guanine nucleotide exchange factor that contributes to multiple processes involving actin cytoskeleton reorganization, including cytokinesis, axogenesis and wound healing as well as cell shape regulation and cell migration during gastrulation. (1311 aa)
Sep1Septin-1; Involved in cytokinesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (361 aa)
Arf79FADP-ribosylation factor 1; GTP-binding protein involved in protein trafficking; has a role in Golgi organization and may modulate vesicle budding and uncoating within the Golgi apparatus (Probable). Has a role in eye development. Required for cleavage furrow ingression in embryonic cells. (182 aa)
LrchLeucine-rich-repeats and calponin homology domain protein (Lrch) encodes a scaffold protein well conserved across animals that associates with actin-rich structures during cell division. Lack of Lrch results in a reduction of fertility and fitness. (1135 aa)
CenCentrocortin, isoform A; Centrocortin (Cen) encodes a protein that regulates cleavage furrow assembly in the early embryo. It localizes to centrosomes asymmetrically, and to cortical actin structures. (790 aa)
Sgt1suppressor-of-G2-allele-of-skp1 (Sgt1) encodes a protein required for the stability of the kinase encoded by polo and has a role in centrosome maturation and function. (178 aa)
Rab11Rab11, isoform A; Rab11 (Rab11) encodes a Rab type protein. Rab proteins are ubiquitously expressed family of small monomeric Ras-like GTPases that are key regulators of endomembrane traffiking, regulating exocytosis, endocytosis and membrane recycling processes essential for maintaining various cellular functions. (214 aa)
Rab1FI01544p; Rab1 (Rab1) encodes a small GTPase which regulates endoplasmic reticulum to Golgi and intra Golgi trafficking through different effectors. It has been involved in Notch signaling, cell migration, autophagy and cytokinesis. (205 aa)
HilHillarin (Hil) encodes a W180-domain protein that affects cytokinesis through interactions with the Septin family member encoded by pnut in the developing nervous system; Belongs to the transglutaminase-like superfamily. (818 aa)
Arf51FADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus (By similarity). Promotes cell movement and remodeling of the actin cytoskeleton during compound eye morphogenesis. Required for normal ethanol-induced tolerance and preference. Probably after Efa6-mediated activation, counteracts ethanol-induced sedation. (175 aa)
tumTumbleweed (tum) encodes a GTPase activating protein for Rho family GTPases involved in Wnt signalling regulation. (625 aa)
AmphAmphiphysin, isoform A; Amphiphysin (Amph) encodes a BAR and SH3 domain containing protein that regulates muscle transverse tubule formation. It exhibits post-synaptic localization at the neuromuscular junction and its mutants show locomotion defects. (602 aa)
pnutPeanut (pnut) encodes a protein that belongs to the septin family of polymerizing GTPases. Together with the products of Sep1 and Sep2, it forms the septin complex. It participates in cytokinesis and other processes that involve organization of the cell cortex. (539 aa)
scraAnillin; Required for cytokinesis. Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression and proper formation of the midbody. Required during cellularization of syncytial embryos for the proper formation and function of the furrow canals, the stable inward folds of the plasma membrane which separate the peripheral nuclei. Also required for the formation of the pole cells, the progenitors of the adult germline which are formed by cytokinesis of the cytoplasmic buds at the posterior pole of the syncytial embryo. Essential for embry [...] (1239 aa)
sauGolgi phosphoprotein 3 homolog sauron; Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (By similarity). May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion (By similarity). Also involved in the control of the local [...] (294 aa)
dunkDisrupted underground network, isoform A; It is involved in the biological process described with: syncytial embryo cellularization. (246 aa)
Cip4Cdc42-interacting protein 4 (Cip4) encodes an F-BAR protein that functions as an adaptor protein regulating membrane curvature and dynamics. (665 aa)
SptSpitting Image (Spt) encodes an F-actin binding and stabilizing protein. Spt and Sry-alpha represent a novel clade of the Vinculin/alpha-Catenin superfamily. The product of Spt is maternally provided in early embryos, and it positively regulates F-actin levels during cellularization. (591 aa)
slamSlow as molasses, isoform B; Slow as molasses (slam) encodes a protein involved in cortical polarization and furrow invagination during cellularization, as well in germ cell migration during later embryogenesis. slam RNA co-localizes and forms a complex with its encoded protein, which is needed for full expression and subcellular localization. (1173 aa)
diaProtein diaphanous; Required for cytokinesis in both mitosis and meiosis. Has a role in actin cytoskeleton organization and is essential for many, if not all, actin-mediated events involving membrane invagination. May serve as a mediator between signaling molecules and actin organizers at specific phases of the cell cycle. Possible component of the contractile ring or may control its function. (1098 aa)
nufNuclear fallout, isoform J; Nuclear fallout (nuf) encodes a cytoplasmic, coiled-coil protein that acts as an adaptor between the product of Rab11 and motor proteins in the recycling endosome pathway. It is required for early embryo cellularization, and for subsequent Rab11-dependent processes. (541 aa)
Arl4ADP ribosylation factor-like 4, isoform B; GTP binding. It is involved in the biological process described with: vesicle-mediated transport; intracellular protein transport. (313 aa)
vibVibrator, isoform B; Vibrator (vib) is an essential gene that encodes a conserved phosphatidylinositol transfer protein. The vib protein is enriched at the cleavage furrow and it is required for cytokinesis. (273 aa)
cindrCIN85 and CD2AP related (cindr) encodes an adaptor protein that links cell surface junctions and adhesion proteins with multiple components of the actin cytoskeleton. It regulates cytoskeletal dynamics, eye patterning and endocytosis. It also cooperates with the product of scra to promote intercellular bridge stability during cytokinesis. (941 aa)
TlProtein toll; Receptor for the cleaved activated form of spz, spaetzle C- 106. Binding to spaetzle C-106 activates the Toll signaling pathway and induces expression of the antifungal peptide drosomycin. Component of the extracellular signaling pathway that establishes dorsal-ventral polarity in the embryo. Promotes heterophilic cellular adhesion. Involved in synaptic targeting of motoneurons RP5 and V to muscle 12 (M12); functions as a repulsive cue inhibiting motoneuron synapse formation on muscle 13 (M13) to guide RP5 and V to the neighboring M12, where its expression is repressed by [...] (1117 aa)
stepSteppke, isoform C; Steppke (step) encodes a member of the cytohesin family of guanine nucleotide exchange factors, which regulate small GTPases of the ADP-ribosylation factor (ARF) family. It contributes to multiple signaling pathways, such as Egfr, MAPK, PI3K and insulin signaling. It is involved in wing and eye development, germ cell segregation and cell growth. (727 aa)
SyndSyndapin, isoform C; Lipid binding; phospholipid binding; cytoskeletal protein binding; protein binding. (495 aa)
sqhSpaghetti squash (sqh) encodes the regulatory light chain of the nonmuscle type 2 myosin. Its phosphorylation through the Rho-Rho Kinase pathway is predicted to activate myosin motor activity. The product of sqh and myosin function in cellular processes such as cytokinesis, and also contribute to tissue morphogenesis. (174 aa)
GrafGTPase regulator associated with FAK, isoform G; Phospholipid binding; ubiquitin-dependent protein binding; GTPase activator activity. It is involved in the biological process described with: Rho protein signal transduction; negative regulation of epidermal growth factor receptor signaling pathway; positive regulation of receptor internalization. (1025 aa)
Sry-alphaSerendipity locus protein alpha; Required for the cellularization of the syncytial blastoderm embryo. Involved in the localization of the actin filaments just prior to and during plasma membrane invagination. Sry-alpha together with nullo and bnk may provide auxiliary functions, by acting both to stabilize a large and dynamic microfilament structure and regulate its functions. (530 aa)
Apc2Adenomatous polyposis coli 2 (Apc2) encodes one of two Drosophila APC family proteins. It is a key negative regulator of Wingless signaling, as a critical component of the destruction complex that phosphorylates beta-catenin and thus targets it for ubiquitination and proteasomal destruction. It is the primary APC family member during embryonic development, and functions redundantly with the product of Apc in adult development. (1067 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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