(21 nodes) Ciliary transition zone network (Drosophila melanogaster)

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second shell of interactors

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proteins of unknown 3D structure

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	Mks1	Meckel syndrome type 1 protein homolog; Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia. Required for ciliary structure and function. (699 aa)
	Fam92	GH04442p; It is involved in the biological process described with: negative regulation of protein secretion. (395 aa)
	CG11760	GEO13292p1; It is involved in the biological process described with: non-motile cilium assembly; cilium assembly. (149 aa)
	B9d1	B9 domain-containing protein 1; Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia. Required for ciliary structure and function. (241 aa)
	DZIP1	Uncharacterized protein, isoform A; Nucleic acid binding. It is involved in the biological process described with: cilium assembly. (737 aa)
	eve	Segmentation protein even-skipped; May play a role in determining neuronal identity. May be directly involved in specifying identity of individual neurons. Pair- rule protein required for segmentation; involved in transforming the broad, spatial, aperiodic expression patterns of the gap genes into a system of precise periodic expression patterns of the pair-rule and segmentary polarity genes; Belongs to the even-skipped homeobox family. (376 aa)
	Kap3	Kinesin associated protein 3 (Kap3) encodes the non-motor accessory subunit of the heterotrimeric kinesin-2. It associates to the coiled-coil stalk domain of the products of Klp68D andKlp64D. It plays an essential role in sensory cilia assembly and axonal transport. (1038 aa)
	TMEM216	Transmembrane protein 216, isoform A; It is involved in the biological process described with: non-motile cilium assembly; cilium assembly. (136 aa)
	Cby	Chibby, isoform E; Chibby (Cby) encodes a protein involved in ciliogenesis and basal body transition zone formation. (132 aa)
	B9d2	B9 domain-containing protein 2; Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia. Has a role in ciliary structure and function. (177 aa)
	tctn	Tectonic; Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia. Has a role in ciliary structure and function. (657 aa)
	Cep135	Centrosomal protein 135kDa (Cep135) encodes a microtubule binding protein important for centriole elongation and stability. It promotes centrosome asymmetry and spindle orientation in neuroblasts and it is required for male fertility. (1065 aa)
	crb	Protein crumbs; Plays a central role in cell polarity establishment. Participates in the assembly, positioning and maintenance of adherens junctions via its interaction with the SAC complex. Controls the coalescence of the spots of zonula adherens (ZA) into a adhesive ring around the cells. It may act as a signal. Involved in morphogenesis of the photoreceptor rhabdomere, for positioning and growth of rhabdomere and AJ during the crucial period of photoreceptor extension along the proximodistal axis of the retina. Component of the crb-galla-Xpd (CGX) complex which is essential for prop [...] (2253 aa)
	Cc2d2a	Coiled-coil and C2 domain-containing protein 2A; Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia (Probable). Required for ciliary structure and function (By similarity). (1336 aa)
	dila	Centrosomal protein of 131 kDa; Cilium-specific protein with a role in cilium/flagellum formation. May be involved in transport of components into the growing cilium. In germ cells and sensory neurons, plays a role with Cby in the building of the transition zone necessary for the formation of the ciliary cap and for the correct elongation of the axoneme. (1155 aa)
	robo2	Roundabout 2 (robo2) encodes a member of the Robo receptor family that responds to the ligand encoded by sli as a repulsive cue in axons, dendrites, muscles, trachea and heart development. It can also inhibit robo1 signaling, likely explaining why the product of robo2 can appear to be an attractive receptor in certain contexts. (1519 aa)
	CG15923	Uncharacterized protein, isoform C; It is involved in the biological process described with: cilium assembly; negative regulation of centrosome duplication. (984 aa)
	kek1	Kekkon 1 (kek1) encodes a transmembrane protein that acts in a negative feedback loop to modulate the activity of the product of Egfr in a number of tissues, including follicle cells and imaginal discs. It also plays a role in axonal outgrowth in the central nervous system. (880 aa)
	cep290	Centrosomal protein cep290; Essential for ciliogenesis in sensory neurons and germ cells. During neuron and spermatocyte ciliogenesis, plays a role in transition zone assembly where it is required for the formation of diverse connections between microtubules and between microtubules and the membrane. (1978 aa)
	unc-5	Netrin receptor unc-5; Receptor for netrin required for motor axon guidance. Mediates both short- and long-range axon motor repulsion in the developing nervous system upon ligand binding. Also involved in glial migration. While short-range repulsion requires both fra and unc-5, long-range repulsion only requires unc-5. (1072 aa)
	unc	Uncoordinated, isoform A; Uncoordinated (unc) encodes a basal body-associated protein that is required for normal ciliogenesis. unc depletion results in spermatids with defective flagella and truncated cilia in mechanosensory and chemosensory neurons. Its name arises from the severe uncoordination phenotype due to a lack of proprioceptive sensory feedback. (1386 aa)

Your Current Organism:

Drosophila melanogaster

NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B9d1	B9d2	FBpp0082599	FBpp0292197	B9 domain-containing protein 1; Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia. Required for ciliary structure and function.	B9 domain-containing protein 2; Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia. Has a role in ciliary structure and function.	0.998
B9d1	CG11760	FBpp0082599	FBpp0081390	B9 domain-containing protein 1; Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia. Required for ciliary structure and function.	GEO13292p1; It is involved in the biological process described with: non-motile cilium assembly; cilium assembly.	0.424
B9d1	CG15923	FBpp0082599	FBpp0303061	B9 domain-containing protein 1; Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia. Required for ciliary structure and function.	Uncharacterized protein, isoform C; It is involved in the biological process described with: cilium assembly; negative regulation of centrosome duplication.	0.765
B9d1	Cby	FBpp0082599	FBpp0312613	B9 domain-containing protein 1; Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia. Required for ciliary structure and function.	Chibby, isoform E; Chibby (Cby) encodes a protein involved in ciliogenesis and basal body transition zone formation.	0.449
B9d1	Cc2d2a	FBpp0082599	FBpp0298338	B9 domain-containing protein 1; Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia. Required for ciliary structure and function.	Coiled-coil and C2 domain-containing protein 2A; Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia (Probable). Required for ciliary structure and function (By similarity).	0.997
B9d1	Mks1	FBpp0082599	FBpp0073500	B9 domain-containing protein 1; Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia. Required for ciliary structure and function.	Meckel syndrome type 1 protein homolog; Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia. Required for ciliary structure and function.	0.987
B9d1	TMEM216	FBpp0082599	FBpp0289770	B9 domain-containing protein 1; Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia. Required for ciliary structure and function.	Transmembrane protein 216, isoform A; It is involved in the biological process described with: non-motile cilium assembly; cilium assembly.	0.979
B9d1	cep290	FBpp0082599	FBpp0304992	B9 domain-containing protein 1; Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia. Required for ciliary structure and function.	Centrosomal protein cep290; Essential for ciliogenesis in sensory neurons and germ cells. During neuron and spermatocyte ciliogenesis, plays a role in transition zone assembly where it is required for the formation of diverse connections between microtubules and between microtubules and the membrane.	0.971
B9d1	dila	FBpp0082599	FBpp0301614	B9 domain-containing protein 1; Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia. Required for ciliary structure and function.	Centrosomal protein of 131 kDa; Cilium-specific protein with a role in cilium/flagellum formation. May be involved in transport of components into the growing cilium. In germ cells and sensory neurons, plays a role with Cby in the building of the transition zone necessary for the formation of the ciliary cap and for the correct elongation of the axoneme.	0.689
B9d1	tctn	FBpp0082599	FBpp0292198	B9 domain-containing protein 1; Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia. Required for ciliary structure and function.	Tectonic; Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia. Has a role in ciliary structure and function.	0.993
B9d2	B9d1	FBpp0292197	FBpp0082599	B9 domain-containing protein 2; Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia. Has a role in ciliary structure and function.	B9 domain-containing protein 1; Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia. Required for ciliary structure and function.	0.998
B9d2	CG11760	FBpp0292197	FBpp0081390	B9 domain-containing protein 2; Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia. Has a role in ciliary structure and function.	GEO13292p1; It is involved in the biological process described with: non-motile cilium assembly; cilium assembly.	0.581
B9d2	CG15923	FBpp0292197	FBpp0303061	B9 domain-containing protein 2; Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia. Has a role in ciliary structure and function.	Uncharacterized protein, isoform C; It is involved in the biological process described with: cilium assembly; negative regulation of centrosome duplication.	0.626
B9d2	Cby	FBpp0292197	FBpp0312613	B9 domain-containing protein 2; Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia. Has a role in ciliary structure and function.	Chibby, isoform E; Chibby (Cby) encodes a protein involved in ciliogenesis and basal body transition zone formation.	0.467
B9d2	Cc2d2a	FBpp0292197	FBpp0298338	B9 domain-containing protein 2; Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia. Has a role in ciliary structure and function.	Coiled-coil and C2 domain-containing protein 2A; Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia (Probable). Required for ciliary structure and function (By similarity).	0.990
B9d2	Mks1	FBpp0292197	FBpp0073500	B9 domain-containing protein 2; Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia. Has a role in ciliary structure and function.	Meckel syndrome type 1 protein homolog; Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia. Required for ciliary structure and function.	0.974
B9d2	TMEM216	FBpp0292197	FBpp0289770	B9 domain-containing protein 2; Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia. Has a role in ciliary structure and function.	Transmembrane protein 216, isoform A; It is involved in the biological process described with: non-motile cilium assembly; cilium assembly.	0.962
B9d2	cep290	FBpp0292197	FBpp0304992	B9 domain-containing protein 2; Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia. Has a role in ciliary structure and function.	Centrosomal protein cep290; Essential for ciliogenesis in sensory neurons and germ cells. During neuron and spermatocyte ciliogenesis, plays a role in transition zone assembly where it is required for the formation of diverse connections between microtubules and between microtubules and the membrane.	0.929
B9d2	dila	FBpp0292197	FBpp0301614	B9 domain-containing protein 2; Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia. Has a role in ciliary structure and function.	Centrosomal protein of 131 kDa; Cilium-specific protein with a role in cilium/flagellum formation. May be involved in transport of components into the growing cilium. In germ cells and sensory neurons, plays a role with Cby in the building of the transition zone necessary for the formation of the ciliary cap and for the correct elongation of the axoneme.	0.669
B9d2	tctn	FBpp0292197	FBpp0292198	B9 domain-containing protein 2; Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia. Has a role in ciliary structure and function.	Tectonic; Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia. Has a role in ciliary structure and function.	0.993