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wds wds Atac3 Atac3 Ada2b Ada2b Sgf11 Sgf11 Nipped-A Nipped-A Atxn7 Atxn7 Sf3b3 Sf3b3 e(y)2 e(y)2 e(y)1 e(y)1 Spt7 Spt7 Taf6 Taf6 Ada2a Ada2a Sgf29 Sgf29 Ada3 Ada3 not not Hcf Hcf Spt20 Spt20 Gcn5 Gcn5 Spt3 Spt3 wda wda Mocs2B Mocs2B Chrac-14 Chrac-14 Taf10 Taf10 Taf10b Taf10b Saf6 Saf6 Atac1 Atac1 D12 D12 Ada1-2 Ada1-2 Ada1-1 Ada1-1 NC2beta NC2beta Atac2 Atac2 Sf3b5 Sf3b5 Taf12 Taf12
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
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textmining
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wdsProtein will die slowly; Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at 'Lys-4'. (361 aa)
Atac3Ada2a-containing complex component 3 (Atac3) encodes a protein involved in chromatin remodeling and histone acetylation. (583 aa)
Ada2bTranscriptional adapter 2B; Required for the function of some acidic activation domains, which activate transcription from a distant site. Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. (555 aa)
Sgf11SAGA-associated factor 11 homolog; Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Binds independently on SAGA to promoters in an RNA- dependent manner. Bind [...] (196 aa)
Nipped-ATranscription-associated protein 1; Part of the Tip60 chromatin-remodeling complex which is involved in DNA repair. Upon induction of DNA double- strand breaks, this complex acetylates phosphorylated H2AV in nucleosomes and exchanges it with unmodified H2AV. During wing development, required for activity of Notch and its coactivator mam. Function in promoting mam function is likely to involve both the Tip60 and SAGA complexes. (3790 aa)
Atxn7Ataxin 7 (Atxn7) encodes a component of the SAGA chromatin modifying complex, which is responsible for acetylation of histones and deubiquitination of the product of His2B at active promoters. The product of Atxn7 anchors the non-stop containing deubiquitinase module to the remainder of SAGA. Atxn7 is an essential gene for larval survival, neural development, and maintenance of neural tissues. (971 aa)
Sf3b3Splicing factor 3B subunit 3; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (By similarity). May also be involved in the assembly of the 'E' complex (By similarity). Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing [...] (1227 aa)
e(y)2Enhancer of yellow 2 transcription factor; Involved in mRNA export coupled transcription activation by association with both the AMEX and the SAGA complexes. The SAGA complex is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Involved in t [...] (101 aa)
e(y)1Transcription initiation factor TFIID subunit 9; Enhancer of yellow 1 (e(y)1) encodes a TAF9 protein and a main component of the Transcription factor II D (TFIID) complex. TFIID is involved in recruiting the transcription machinery to core promoters and organizing specific enhancer-promoter interactions. (278 aa)
Spt7LD38742p; Spt7 (Spt7) encodes a subunit of the SAGA chromatin modifying complex. (359 aa)
Taf6TBP-associated factor 6 (Taf6) encodes a protein that forms part of the multisubunit basal transcription factor TFIID, and it might be important for its stability. It forms a histone-like pair with the product of e(y)1. It is required during all stages of development, but particularly during imaginal disc development and gametogenesis. (606 aa)
Ada2aTranscriptional adapter 2A; GCN5-independent Rpb4 complexes are highly enriched in decondensed chromosome puffs so may play a role in RNA polymerase II- dependent transcription. (562 aa)
Sgf29SAGA-associated factor 29kDa (Sgf29) encodes a encodes subunit of some chromatin modifying complexes. (289 aa)
Ada3Transcriptional Adaptor 3 (Ada3) encodes subunit of some chromatin modifying complexes. (588 aa)
notUbiquitin carboxyl-terminal hydrolase nonstop; Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of histone H2B, thereby acting as a coactivator in a large subset of genes. Required to counteract heterochromatin silencing. Controls the development of neuronal connectivity in visual system by being required for accurate axon targeting in the optic lobe. Required for expression of ecdysone-induced genes such as br/broad. Belongs to the peptidase C19 family. UBP8 subfamily. (496 aa)
HcfHCF C-terminal chain; May be involved in control of the cell cycle. (1500 aa)
Spt20Spt20, isoform A; Transcription coregulator activity. It is involved in the biological process described with: regulation of transcription by RNA polymerase II; histone acetylation. (1873 aa)
Gcn5Gcn5 acetyltransferase (Gcn5) encodes a lysine acetyltransferase subunit of several chromatin modifying complexes. It contributes to oogenesis and metamorphosis. (813 aa)
Spt3FI01013p; Spt3 (Spt3) encodes a encodes a subunit of the SAGA chromatin modifying complex. (384 aa)
wdaWill decrease acetylation (wda) encodes a component of the highly conserved Spt-Ada-Gcn5 Acetyltransferase (SAGA) chromatin modifying complex. This complex is responsible for acetylation of histones and deubiquitination of the product of His2B at active promoters. The product of wda is a component of the histone-acetyltransferase (HAT) module, and is essential for full HAT activity of the the product of Gcn5. (743 aa)
Mocs2BMolybdopterin synthase catalytic subunit; Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated Mocs2A into precursor Z to generate a dithiolene group; Belongs to the MoaE family. MOCS2B subfamily. (367 aa)
Chrac-14DNA polymerase epsilon subunit 3; Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity). Histone-like protein which promotes nucleosome sliding of ATP-dependent nucleosome remodeling complexes. Part of the chromatin-accessibility complex (CHRAC) which uses energy/ATP to increase the general accessibility of DNA in chromatin. As an heterodimer with Chrac-16, binds DNA and facilitates nucleosome sliding by Acf. Has a role in DNA damage response by preventing cid mislocalization to chromatin [...] (128 aa)
Taf10Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. (167 aa)
Taf10bTranscription initiation factor TFIID subunit 10b; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. (146 aa)
Saf6SAGA factor-like TAF6 (Saf6) encodes a component of the Spt-Ada-Gcn5 Acetyltransferase (SAGA) chromatin modifying complex. This complex is responsible for acetylation of histones and deubiquitination of the product of His2B at active promoters. The product of Saf6 replaces the product of mia within SAGA when the product of mia is restricted to the TFIID transcription complex. Notably, the product of Saf6 is essential for SAGA's co-activator function but does not impact either of its enzymatic activities. (717 aa)
Atac1Ada2a-containing complex component 1 (Atac1) encodes a protein involved in chromatin remodeling and histone acetylation. (356 aa)
D12D12 (D12) encodes a protein involved in chromatin remodeling and histone acetylation. (969 aa)
Ada1-2Transcriptional Adaptor 1-2 (Ada1-2) encodes a subunit of the SAGA chromatin modifying complex. (308 aa)
Ada1-1Transcriptional Adaptor 1-1 (Ada1-1) encodes a subunit of the SAGA chromatin modifying complex. (308 aa)
NC2betaProtein Dr1; Bifunctional basic transcription factor. Activates transcription of DPE (Downstream Promoter Element) containing promoters while repressing transcription of promoters which contain TATA elements. Together with Chrac-14, promotes nucleosome sliding of ATP-dependent nucelosome remodeling complexes. Belongs to the NC2 beta/DR1 family. (183 aa)
Atac2Ada2a-containing complex component 2 (Atac2) encodes a protein involved in chromatin organization, intestinal stem cell homeostasis, and histone acetylation. (774 aa)
Sf3b5Splicing factor 3B subunit 5; Involved in pre-mRNA splicing as component of spliceosome. As part of the spliceosome complex, plays a role in the regulation of spermatogonial differentiation. When associated with the SAGA transcription regulatory histone acetylation (HAT) complex, might be involved in the transcriptional activation of a subset of SAGA-regulated genes ; Belongs to the SF3B5 family. (85 aa)
Taf12TBP-associated factor 12 (Taf12) encodes a protein that forms part of the multisubunit basal transcription factor TFIID, and it is important for its stability. It forms a histone-like pair with Taf4. Taf12 is also an integral component of the Drosophila SAGA histone acetyltransferase complex. (196 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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