(8 nodes) PPM-type phosphatase, divalent cation binding network (Drosophila melanogaster)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

gene neighborhood

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co-expression

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Your Input:
	CG6036	Protein serine/threonine phosphatase activity; magnesium-dependent protein serine/threonine phosphatase activity; magnesium ion binding; manganese ion binding. It is involved in the biological process described with: protein dephosphorylation; negative regulation of stress-activated MAPK cascade. (371 aa)
	CG7115	Uncharacterized protein, isoform A; Cation binding; magnesium-dependent protein serine/threonine phosphatase activity; protein serine/threonine phosphatase activity. It is involved in the biological process described with: protein dephosphorylation. (524 aa)
	CG17598	GM14138p; Protein serine/threonine phosphatase activity; magnesium-dependent protein serine/threonine phosphatase activity; phosphoprotein phosphatase activity; cation binding; [pyruvate dehydrogenase (lipoamide)] phosphatase activity. It is involved in the biological process described with: positive regulation of pyruvate dehydrogenase activity; dephosphorylation; protein dephosphorylation. (651 aa)
	CG17746	LD28127p; Protein serine/threonine phosphatase activity; magnesium-dependent protein serine/threonine phosphatase activity; phosphoprotein phosphatase activity; cation binding. It is involved in the biological process described with: protein dephosphorylation. (371 aa)
	Ppm1	AT28366p; Cation binding; protein serine/threonine phosphatase activity; magnesium-dependent protein serine/threonine phosphatase activity; phosphoprotein phosphatase activity. It is involved in the biological process described with: protein dephosphorylation. (352 aa)
	Pp2C1	Protein phosphatase 2C, isoform A; Cation binding; mitogen-activated protein kinase binding; magnesium-dependent protein serine/threonine phosphatase activity; oxidoreductase activity; protein serine/threonine phosphatase activity. It is involved in the biological process described with: oxidation-reduction process; protein dephosphorylation. (1427 aa)
	CG10417	Cation binding; protein serine/threonine phosphatase activity; magnesium-dependent protein serine/threonine phosphatase activity. It is involved in the biological process described with: protein dephosphorylation. (662 aa)
	alph	Alphabet, isoform E; Alphabet (alph) encodes a Ser/Thr phosphatase that regulates RAS/MAPK signaling. (374 aa)

Your Current Organism:

Drosophila melanogaster

NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CG10417	CG17598	FBpp0085427	FBpp0305865	Cation binding; protein serine/threonine phosphatase activity; magnesium-dependent protein serine/threonine phosphatase activity. It is involved in the biological process described with: protein dephosphorylation.	GM14138p; Protein serine/threonine phosphatase activity; magnesium-dependent protein serine/threonine phosphatase activity; phosphoprotein phosphatase activity; cation binding; [pyruvate dehydrogenase (lipoamide)] phosphatase activity. It is involved in the biological process described with: positive regulation of pyruvate dehydrogenase activity; dephosphorylation; protein dephosphorylation.	0.521
CG17598	CG10417	FBpp0305865	FBpp0085427	GM14138p; Protein serine/threonine phosphatase activity; magnesium-dependent protein serine/threonine phosphatase activity; phosphoprotein phosphatase activity; cation binding; [pyruvate dehydrogenase (lipoamide)] phosphatase activity. It is involved in the biological process described with: positive regulation of pyruvate dehydrogenase activity; dephosphorylation; protein dephosphorylation.	Cation binding; protein serine/threonine phosphatase activity; magnesium-dependent protein serine/threonine phosphatase activity. It is involved in the biological process described with: protein dephosphorylation.	0.521
CG17598	CG6036	FBpp0305865	FBpp0084399	GM14138p; Protein serine/threonine phosphatase activity; magnesium-dependent protein serine/threonine phosphatase activity; phosphoprotein phosphatase activity; cation binding; [pyruvate dehydrogenase (lipoamide)] phosphatase activity. It is involved in the biological process described with: positive regulation of pyruvate dehydrogenase activity; dephosphorylation; protein dephosphorylation.	Protein serine/threonine phosphatase activity; magnesium-dependent protein serine/threonine phosphatase activity; magnesium ion binding; manganese ion binding. It is involved in the biological process described with: protein dephosphorylation; negative regulation of stress-activated MAPK cascade.	0.509
CG17598	CG7115	FBpp0305865	FBpp0079146	GM14138p; Protein serine/threonine phosphatase activity; magnesium-dependent protein serine/threonine phosphatase activity; phosphoprotein phosphatase activity; cation binding; [pyruvate dehydrogenase (lipoamide)] phosphatase activity. It is involved in the biological process described with: positive regulation of pyruvate dehydrogenase activity; dephosphorylation; protein dephosphorylation.	Uncharacterized protein, isoform A; Cation binding; magnesium-dependent protein serine/threonine phosphatase activity; protein serine/threonine phosphatase activity. It is involved in the biological process described with: protein dephosphorylation.	0.556
CG6036	CG17598	FBpp0084399	FBpp0305865	Protein serine/threonine phosphatase activity; magnesium-dependent protein serine/threonine phosphatase activity; magnesium ion binding; manganese ion binding. It is involved in the biological process described with: protein dephosphorylation; negative regulation of stress-activated MAPK cascade.	GM14138p; Protein serine/threonine phosphatase activity; magnesium-dependent protein serine/threonine phosphatase activity; phosphoprotein phosphatase activity; cation binding; [pyruvate dehydrogenase (lipoamide)] phosphatase activity. It is involved in the biological process described with: positive regulation of pyruvate dehydrogenase activity; dephosphorylation; protein dephosphorylation.	0.509
CG6036	alph	FBpp0084399	FBpp0084810	Protein serine/threonine phosphatase activity; magnesium-dependent protein serine/threonine phosphatase activity; magnesium ion binding; manganese ion binding. It is involved in the biological process described with: protein dephosphorylation; negative regulation of stress-activated MAPK cascade.	Alphabet, isoform E; Alphabet (alph) encodes a Ser/Thr phosphatase that regulates RAS/MAPK signaling.	0.904
CG7115	CG17598	FBpp0079146	FBpp0305865	Uncharacterized protein, isoform A; Cation binding; magnesium-dependent protein serine/threonine phosphatase activity; protein serine/threonine phosphatase activity. It is involved in the biological process described with: protein dephosphorylation.	GM14138p; Protein serine/threonine phosphatase activity; magnesium-dependent protein serine/threonine phosphatase activity; phosphoprotein phosphatase activity; cation binding; [pyruvate dehydrogenase (lipoamide)] phosphatase activity. It is involved in the biological process described with: positive regulation of pyruvate dehydrogenase activity; dephosphorylation; protein dephosphorylation.	0.556
alph	CG6036	FBpp0084810	FBpp0084399	Alphabet, isoform E; Alphabet (alph) encodes a Ser/Thr phosphatase that regulates RAS/MAPK signaling.	Protein serine/threonine phosphatase activity; magnesium-dependent protein serine/threonine phosphatase activity; magnesium ion binding; manganese ion binding. It is involved in the biological process described with: protein dephosphorylation; negative regulation of stress-activated MAPK cascade.	0.904