(22 nodes) Cyclic nucleotide-binding domain network (Drosophila melanogaster)

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	for	cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B; Foraging (for) encodes a serine/threonine kinase and a member of the protein kinase G family. For roles include feeding, locomotion, metabolism, development, olfactory habituation, learning and memory, stress, social behavior, as well as Malpighian tubule, heart, muscle and synaptic function. (1088 aa)
	Ih	I[[h]] channel (Ih) encodes a low-threshold, voltage-gated ion channel. It may influence excitatory postsynaptic potential kinetics and integration. (1327 aa)
	eag	Potassium voltage-gated channel protein eag; Structural component of a potassium channel. Mediates the potassium permeability of membranes; potassium current is regulated by CaMKII and CASK. Has a role in growth of the perineurial glial layer of the larval peripheral nerve. (1270 aa)
	uex	Unextended, isoform E; Transmembrane transporter activity. It is involved in the biological process described with: cellular ion homeostasis. (834 aa)
	Pka-R1	Protein kinase, cAMP-dependent, regulatory subunit type 1 (Pka-R1) encodes a cAMP-dependent protein kinase regulator that contributes to actin filament and microtubule organization. It is involved in neuromuscular synaptic transmission, molting and response to ethanol. (464 aa)
	CngA	Cyclic nucleotide-gated ion channel subunit A (CngA) encodes a non-selective cation channel related to the superfamily of voltage-gated ion channels. It is involved in both excitation and adaptation of sensory cells, as well as in Ca[2+] response in the mushroom bodies. (840 aa)
	Epac	Exchange protein directly activated by cAMP (Epac) encodes a guanine nucleotide exchange factor for the Ras-like small GTPases encoded by Rap1 and Rap2l. It is involved in transducing cAMP effects during synaptic potentiation, neuronal differentiation and renal secretion. (1006 aa)
	Cngl	Intracellular cyclic nucleotide activated cation channel activity. It is involved in the biological process described with: cyclic-nucleotide-mediated signaling; transmembrane transport; cation transport. (1970 aa)
	CG14693	Uncharacterized protein, isoform E. (586 aa)
	sei	Putative potassium channel subunit homolog; Seizure (sei) encodes a protein involved in sound perception. (855 aa)
	CG42260	Uncharacterized protein, isoform E; CG42260 encodes a protein predicted to form the beta subunit of a cyclic nucleotide-gated ion channel. It could form a functional channel as a heterodimer with either the products of CngA or Cngl. (1269 aa)
	sws	Neuropathy target esterase sws; Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain. Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain; Belongs to the NTE family. (1425 aa)
	CngB	Cyclic nucleotide-gated ion channel subunit B, isoform A; cGMP binding; intracellular cAMP-activated cation channel activity; intracellular cGMP-activated cation channel activity; intracellular cyclic nucleotide activated cation channel activity. It is involved in the biological process described with: cation transport; cation transmembrane transport; cyclic-nucleotide-mediated signaling. (1040 aa)
	CG12698	Cyclic nucleotide-binding domain-containing protein. (580 aa)
	CG8958	Cyclic nucleotide-binding domain-containing protein. (621 aa)
	Pkg21D	Protein kinase, cGMP-dependent at 21D (Pkg21D) encodes a Mg[+] dependent-kinase that is activated by cGMP. It contributes to somatic muscle development, salivary gland morphogenesis and epithelial fluid transport. (768 aa)
	PDZ-GEF	PDZ domain-containing guanine nucleotide exchange factor (PDZ-GEF) encodes a guanine nucleotide exchange factor for the product of Rap1. The product of PDZ-GEF contributes to ventral furrow formation, border cell migration, macrophage migration, epithelial migration and morphogenesis, eye development, ovary development, spermathecae formation, germline stem cell maintenance in the testis, adherens junction formation, and anchorage of stem cells to niche. (1573 aa)
	CG4839	LP05330p; ATP binding; cGMP-dependent protein kinase activity. It is involved in the biological process described with: protein phosphorylation. (1003 aa)
	Lrch	Leucine-rich-repeats and calponin homology domain protein (Lrch) encodes a scaffold protein well conserved across animals that associates with actin-rich structures during cell division. Lack of Lrch results in a reduction of fertility and fitness. (1135 aa)
	Elk	Eag-like K[+] channel, isoform A; Voltage-gated potassium channel activity; voltage-gated cation channel activity. It is involved in the biological process described with: regulation of membrane potential; potassium ion transmembrane transport; potassium ion transport. (1284 aa)
	Pka-R2	cAMP-dependent protein kinase type II regulatory subunit; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Mediates membrane association by binding to anchoring proteins, such as Akap200. Might play an essential role in the regulation of neuronal activity in the brain. (377 aa)
	CG33965	RT07682p; Phosphatidylinositol bisphosphate binding. (317 aa)

Your Current Organism:

Drosophila melanogaster

NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CG12698	CG8958	FBpp0073944	FBpp0073987	Cyclic nucleotide-binding domain-containing protein.	Cyclic nucleotide-binding domain-containing protein.	0.635
CG42260	CngA	FBpp0423144	FBpp0292051	Uncharacterized protein, isoform E; CG42260 encodes a protein predicted to form the beta subunit of a cyclic nucleotide-gated ion channel. It could form a functional channel as a heterodimer with either the products of CngA or Cngl.	Cyclic nucleotide-gated ion channel subunit A (CngA) encodes a non-selective cation channel related to the superfamily of voltage-gated ion channels. It is involved in both excitation and adaptation of sensory cells, as well as in Ca[2+] response in the mushroom bodies.	0.737
CG42260	CngB	FBpp0423144	FBpp0071592	Uncharacterized protein, isoform E; CG42260 encodes a protein predicted to form the beta subunit of a cyclic nucleotide-gated ion channel. It could form a functional channel as a heterodimer with either the products of CngA or Cngl.	Cyclic nucleotide-gated ion channel subunit B, isoform A; cGMP binding; intracellular cAMP-activated cation channel activity; intracellular cGMP-activated cation channel activity; intracellular cyclic nucleotide activated cation channel activity. It is involved in the biological process described with: cation transport; cation transmembrane transport; cyclic-nucleotide-mediated signaling.	0.970
CG42260	Cngl	FBpp0423144	FBpp0300628	Uncharacterized protein, isoform E; CG42260 encodes a protein predicted to form the beta subunit of a cyclic nucleotide-gated ion channel. It could form a functional channel as a heterodimer with either the products of CngA or Cngl.	Intracellular cyclic nucleotide activated cation channel activity. It is involved in the biological process described with: cyclic-nucleotide-mediated signaling; transmembrane transport; cation transport.	0.785
CG4839	CngA	FBpp0079534	FBpp0292051	LP05330p; ATP binding; cGMP-dependent protein kinase activity. It is involved in the biological process described with: protein phosphorylation.	Cyclic nucleotide-gated ion channel subunit A (CngA) encodes a non-selective cation channel related to the superfamily of voltage-gated ion channels. It is involved in both excitation and adaptation of sensory cells, as well as in Ca[2+] response in the mushroom bodies.	0.513
CG8958	CG12698	FBpp0073987	FBpp0073944	Cyclic nucleotide-binding domain-containing protein.	Cyclic nucleotide-binding domain-containing protein.	0.635
CngA	CG42260	FBpp0292051	FBpp0423144	Cyclic nucleotide-gated ion channel subunit A (CngA) encodes a non-selective cation channel related to the superfamily of voltage-gated ion channels. It is involved in both excitation and adaptation of sensory cells, as well as in Ca[2+] response in the mushroom bodies.	Uncharacterized protein, isoform E; CG42260 encodes a protein predicted to form the beta subunit of a cyclic nucleotide-gated ion channel. It could form a functional channel as a heterodimer with either the products of CngA or Cngl.	0.737
CngA	CG4839	FBpp0292051	FBpp0079534	Cyclic nucleotide-gated ion channel subunit A (CngA) encodes a non-selective cation channel related to the superfamily of voltage-gated ion channels. It is involved in both excitation and adaptation of sensory cells, as well as in Ca[2+] response in the mushroom bodies.	LP05330p; ATP binding; cGMP-dependent protein kinase activity. It is involved in the biological process described with: protein phosphorylation.	0.513
CngA	CngB	FBpp0292051	FBpp0071592	Cyclic nucleotide-gated ion channel subunit A (CngA) encodes a non-selective cation channel related to the superfamily of voltage-gated ion channels. It is involved in both excitation and adaptation of sensory cells, as well as in Ca[2+] response in the mushroom bodies.	Cyclic nucleotide-gated ion channel subunit B, isoform A; cGMP binding; intracellular cAMP-activated cation channel activity; intracellular cGMP-activated cation channel activity; intracellular cyclic nucleotide activated cation channel activity. It is involved in the biological process described with: cation transport; cation transmembrane transport; cyclic-nucleotide-mediated signaling.	0.993
CngA	Cngl	FBpp0292051	FBpp0300628	Cyclic nucleotide-gated ion channel subunit A (CngA) encodes a non-selective cation channel related to the superfamily of voltage-gated ion channels. It is involved in both excitation and adaptation of sensory cells, as well as in Ca[2+] response in the mushroom bodies.	Intracellular cyclic nucleotide activated cation channel activity. It is involved in the biological process described with: cyclic-nucleotide-mediated signaling; transmembrane transport; cation transport.	0.770
CngA	Pkg21D	FBpp0292051	FBpp0077706	Cyclic nucleotide-gated ion channel subunit A (CngA) encodes a non-selective cation channel related to the superfamily of voltage-gated ion channels. It is involved in both excitation and adaptation of sensory cells, as well as in Ca[2+] response in the mushroom bodies.	Protein kinase, cGMP-dependent at 21D (Pkg21D) encodes a Mg[+] dependent-kinase that is activated by cGMP. It contributes to somatic muscle development, salivary gland morphogenesis and epithelial fluid transport.	0.405
CngB	CG42260	FBpp0071592	FBpp0423144	Cyclic nucleotide-gated ion channel subunit B, isoform A; cGMP binding; intracellular cAMP-activated cation channel activity; intracellular cGMP-activated cation channel activity; intracellular cyclic nucleotide activated cation channel activity. It is involved in the biological process described with: cation transport; cation transmembrane transport; cyclic-nucleotide-mediated signaling.	Uncharacterized protein, isoform E; CG42260 encodes a protein predicted to form the beta subunit of a cyclic nucleotide-gated ion channel. It could form a functional channel as a heterodimer with either the products of CngA or Cngl.	0.970
CngB	CngA	FBpp0071592	FBpp0292051	Cyclic nucleotide-gated ion channel subunit B, isoform A; cGMP binding; intracellular cAMP-activated cation channel activity; intracellular cGMP-activated cation channel activity; intracellular cyclic nucleotide activated cation channel activity. It is involved in the biological process described with: cation transport; cation transmembrane transport; cyclic-nucleotide-mediated signaling.	Cyclic nucleotide-gated ion channel subunit A (CngA) encodes a non-selective cation channel related to the superfamily of voltage-gated ion channels. It is involved in both excitation and adaptation of sensory cells, as well as in Ca[2+] response in the mushroom bodies.	0.993
CngB	Cngl	FBpp0071592	FBpp0300628	Cyclic nucleotide-gated ion channel subunit B, isoform A; cGMP binding; intracellular cAMP-activated cation channel activity; intracellular cGMP-activated cation channel activity; intracellular cyclic nucleotide activated cation channel activity. It is involved in the biological process described with: cation transport; cation transmembrane transport; cyclic-nucleotide-mediated signaling.	Intracellular cyclic nucleotide activated cation channel activity. It is involved in the biological process described with: cyclic-nucleotide-mediated signaling; transmembrane transport; cation transport.	0.956
Cngl	CG42260	FBpp0300628	FBpp0423144	Intracellular cyclic nucleotide activated cation channel activity. It is involved in the biological process described with: cyclic-nucleotide-mediated signaling; transmembrane transport; cation transport.	Uncharacterized protein, isoform E; CG42260 encodes a protein predicted to form the beta subunit of a cyclic nucleotide-gated ion channel. It could form a functional channel as a heterodimer with either the products of CngA or Cngl.	0.785
Cngl	CngA	FBpp0300628	FBpp0292051	Intracellular cyclic nucleotide activated cation channel activity. It is involved in the biological process described with: cyclic-nucleotide-mediated signaling; transmembrane transport; cation transport.	Cyclic nucleotide-gated ion channel subunit A (CngA) encodes a non-selective cation channel related to the superfamily of voltage-gated ion channels. It is involved in both excitation and adaptation of sensory cells, as well as in Ca[2+] response in the mushroom bodies.	0.770
Cngl	CngB	FBpp0300628	FBpp0071592	Intracellular cyclic nucleotide activated cation channel activity. It is involved in the biological process described with: cyclic-nucleotide-mediated signaling; transmembrane transport; cation transport.	Cyclic nucleotide-gated ion channel subunit B, isoform A; cGMP binding; intracellular cAMP-activated cation channel activity; intracellular cGMP-activated cation channel activity; intracellular cyclic nucleotide activated cation channel activity. It is involved in the biological process described with: cation transport; cation transmembrane transport; cyclic-nucleotide-mediated signaling.	0.956
Elk	eag	FBpp0085981	FBpp0110308	Eag-like K[+] channel, isoform A; Voltage-gated potassium channel activity; voltage-gated cation channel activity. It is involved in the biological process described with: regulation of membrane potential; potassium ion transmembrane transport; potassium ion transport.	Potassium voltage-gated channel protein eag; Structural component of a potassium channel. Mediates the potassium permeability of membranes; potassium current is regulated by CaMKII and CASK. Has a role in growth of the perineurial glial layer of the larval peripheral nerve.	0.472
Elk	sei	FBpp0085981	FBpp0310000	Eag-like K[+] channel, isoform A; Voltage-gated potassium channel activity; voltage-gated cation channel activity. It is involved in the biological process described with: regulation of membrane potential; potassium ion transmembrane transport; potassium ion transport.	Putative potassium channel subunit homolog; Seizure (sei) encodes a protein involved in sound perception.	0.445
Pka-R1	Pka-R2	FBpp0291777	FBpp0087524	Protein kinase, cAMP-dependent, regulatory subunit type 1 (Pka-R1) encodes a cAMP-dependent protein kinase regulator that contributes to actin filament and microtubule organization. It is involved in neuromuscular synaptic transmission, molting and response to ethanol.	cAMP-dependent protein kinase type II regulatory subunit; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Mediates membrane association by binding to anchoring proteins, such as Akap200. Might play an essential role in the regulation of neuronal activity in the brain.	0.752