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| | Vps11 | Vacuolar protein sorting 11 (Vps11) encodes a Class C Vps core subunit of HOPS, a heterohexameric tethering complex that consists of the products of car, dor, lt, Vps11, Vps16A and Vps39. HOPS tethers autophagosomes or late endosomes with lysosomes to facilitate fusion. The product of Vps11 roles include autophagosome-lysosome fusion, late endosome-lysosome fusion and biosynthetic trafficking to lysosomes. (830 aa) |
| | CG2681 | E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (626 aa) |
| | vilya | Vilya (vilya) encodes a meiosis-specific ring-domain-containing protein that is required for programmed meiotic double-strand break formation. It also functions as a component of the recombination nodule. (237 aa) |
| | dx | Protein deltex; Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it may also act as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch. May function as a ubiquitin ligase protein in the Notch pathway. Belongs to the Deltex family. (738 aa) |
| | Traf6 | TNF-receptor-associated factor 6 (Traf6) encodes a protein that belongs to a family of adaptor proteins involved in transducing downstream signaling by interacting with cell surface receptors. It mediates the pro-inflammatory effects of Toll and related receptor signaling, and the cell death induced by JNK activation via the product of egr. (475 aa) |
| | Rbpn-5 | Rabaptin-5 (Rbpn-5) encodes a Rab GTPase binding protein involved in regulation of endosome size. (647 aa) |
| | Plekhm1 | Pleckstrin homology and RUN domain containing M1; It is involved in the biological process described with: intracellular signal transduction. (720 aa) |
| | ari-2 | Potential E3 ubiquitin-protein ligase ariadne-2; Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates; Belongs to the RBR family. Ariadne subfamily. (509 aa) |
| | Lpt | Lost PHDs of trr (Lpt) encodes a core component of COMPASS-like nuclear receptor coactivator complexes. It is involved in histone methylation and dpp/BMP signaling regulation. (1482 aa) |
| | snama | Something that sticks like glue (snama) encodes a protein required for cell proliferation and survival in the developing eye. It is involved in apoptosis. (1231 aa) |
| | CG11414 | FI04483p; Zinc ion binding; ubiquitin protein ligase activity; RNA binding. It is involved in the biological process described with: mitotic cell cycle. (867 aa) |
| | Roc1b | RING-box protein 1B; Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate (By similarity). Belongs to the RING-box family. (122 aa) |
| | Pex10 | Peroxin 10 (Pex10) encodes a peroxisome protein important for sperm development. (299 aa) |
| | CG32486 | Cysteine and histidine-rich protein 1 homolog; Zinc ion binding; Belongs to the CYHR1 family. (412 aa) |
| | CG12099 | LD09551p; Zinc ion binding; ubiquitin protein ligase activity; metal ion binding; transcription regulatory region sequence-specific DNA binding. It is involved in the biological process described with: positive regulation of transcription by RNA polymerase II; protein autoubiquitination. (708 aa) |
| | CG14983 | GEO11537p1; Ubiquitin protein ligase activity; zinc ion binding; ubiquitin-protein transferase activity. It is involved in the biological process described with: interstrand cross-link repair; protein ubiquitination. (163 aa) |
| | CG9941 | LP12254p; Ubiquitin protein ligase activity; ubiquitin-protein transferase activity; zinc ion binding. It is involved in the biological process described with: protein ubiquitination. (789 aa) |
| | CG5334 | Ubiquitin-protein transferase activity; zinc ion binding; metal ion binding; ubiquitin protein ligase activity. It is involved in the biological process described with: protein polyubiquitination. (210 aa) |
| | CG5347 | LP05025p; Metal ion binding; ubiquitin protein ligase activity; zinc ion binding; ubiquitin-protein transferase activity. It is involved in the biological process described with: protein polyubiquitination. (285 aa) |
| | CG32581 | RE35552p; Ubiquitin protein ligase activity; ubiquitin-protein transferase activity; zinc ion binding; ubiquitin-like protein conjugating enzyme binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; ER-associated misfolded protein catabolic process; protein ubiquitination. (283 aa) |
| | CG8974 | GH14055p; Ubiquitin protein ligase activity; ubiquitin-like protein conjugating enzyme binding; zinc ion binding; ubiquitin-protein transferase activity. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; protein ubiquitination; ER-associated misfolded protein catabolic process. (277 aa) |
| | CG15814 | FI05221p; Ubiquitin protein ligase activity; metal ion binding; zinc ion binding. It is involved in the biological process described with: endoplasmic reticulum unfolded protein response; ubiquitin-dependent ERAD pathway. (321 aa) |
| | narya | RING finger protein narya; Required for the formation of DNA double-strand breaks (DSBs) together with nenya and vilya during the meiotic recombination process. Plays a role in DSBs processing into crossovers. Plays a redundant role with nenya in chromosome segregation during female meiosis. (211 aa) |
| | Ltn1 | E3 ubiquitin-protein ligase listerin; E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Ubiquitination leads to TER94/VCP recruitment for extraction and degradation of the incomplete translation product (By similarity). Belongs to the LTN1 family. (1747 aa) |
| | CG12477 | IP09428p; Metal ion binding; ubiquitin protein ligase activity; ubiquitin-protein transferase activity; zinc ion binding. It is involved in the biological process described with: protein polyubiquitination. (265 aa) |
| | l(3)73Ah | Lethal (3) 73Ah, isoform A; RNA polymerase II regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity; zinc ion binding. It is involved in the biological process described with: histone H2A-K119 monoubiquitination; inactivation of X chromosome by genetic imprinting. (222 aa) |
| | sina | E3 ubiquitin-protein ligase sina; E3 ubiquitin-protein ligase that is required for specification of R7 photoreceptor cell fate in the eye by mediating the ubiquitination and subsequent proteasomal degradation of Tramtrack (ttk). E3 Ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Acts via the formation of a complex with ebi and phyl that ubiquitinates the transcription repressor ttk, a general inhibitor of photoreceptor differentiation, in a subset of photoreceptor cel [...] (314 aa) |
| | mus302 | RE72625p; Ubiquitin protein ligase activity; ubiquitin-protein transferase activity; zinc ion binding. It is involved in the biological process described with: protein ubiquitination; interstrand cross-link repair. (608 aa) |
| | elgi | Early girl (elgi) encodes a myosin binding protein involved in the regulation of meiosis and Fat signaling pathway. (315 aa) |
| | mib1 | E3 ubiquitin-protein ligase mind-bomb; E3 ubiquitin-protein ligase that mediates ubiquitination of Delta (Dl) and Serrate (Ser) receptors, which act as ligands of Notch proteins. Positively regulates the Notch signaling by ubiquitinating the intracellular domain of Dl and Ser, leading to endocytosis of Dl and Ser receptors. Regulates a subset of Notch signaling events, including wing margin specification, leg segmentation and vein determination, that are distinct from those events requiring neuralize (neur) activity. Also modulates lateral inhibition, a neur- and Dl- dependent signalin [...] (1226 aa) |
| | CG32847 | GEO10296p1; Ubiquitin-like protein conjugating enzyme binding; ubiquitin-protein transferase activity; zinc ion binding; ubiquitin protein ligase activity. It is involved in the biological process described with: ER-associated misfolded protein catabolic process; protein ubiquitination; ubiquitin-dependent protein catabolic process. (164 aa) |
| | rols | Rolling pebbles (rols) encodes a protein required for myoblast fusion in founder cells. it interacts with the membrane spanning Immunoglobulin superfamily protein encoded by kirre and with the product of Mhcl. (1900 aa) |
| | CG12362 | RBR-type E3 ubiquitin transferase; Ubiquitin conjugating enzyme binding; ubiquitin protein ligase activity; zinc ion binding; ubiquitin-protein transferase activity. It is involved in the biological process described with: positive regulation of proteasomal ubiquitin-dependent protein catabolic process; ubiquitin-dependent protein catabolic process; protein polyubiquitination. (511 aa) |
| | Pex2 | Peroxin 2 (Pex2) encodes a peroxisome protein important for sperm development. (281 aa) |
| | Cbl | Cbl proto-oncogene (Cbl) encodes an E3 protein-ubiquitin ligase for protein post-translational modification in RTK signaling (EGFR, VEGFR, FGF, and RET families) and non-RTK signaling (Src family). After the ubiquitination mediated by the product of Cbl, the substrates will be targeted to protein degradation for controlling cell growth, survival, migration and inflammation. (878 aa) |
| | Vps8 | Vacuolar protein sorting-associated protein 8 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes probably as part of the class C core vacuole/endosome tethering (CORVET) complex. Specifically required for endocytic trafficking in a subset of cells, such as hemocytes and nephrocytes, which are highly active in endocytosis. (1229 aa) |
| | msl-2 | E3 ubiquitin-protein ligase msl-2; The Msl proteins are essential for elevating transcription of the single X chromosome in the male (X chromosome dosage compensation). Msl-2 is required for translation and/or stability of msl-1 in males. In complex with msl-1, acts as an E3 ubiquitin ligase that promotes ubiquitination of histone H2B. Belongs to the MSL2 family. (773 aa) |
| | CG17260 | LD44813p; Zinc ion binding. (364 aa) |
| | Mkrn1 | Makorin 1, isoform A; Ubiquitin protein ligase activity; metal ion binding; ubiquitin-protein transferase activity; zinc ion binding. It is involved in the biological process described with: protein polyubiquitination; positive regulation of insulin receptor signaling pathway; positive regulation of oogenesis. (386 aa) |
| | dgrn | Degringolade, isoform A; Degringolade (dgrn) encodes a SUMO-Targeted ubiquitin ligase. During development it is required for Notch signaling and patterning. It contributes to transcriptional regulation, DNA repair, and cytoskeleton dynamics. (319 aa) |
| | CG2926 | Uncharacterized protein, isoform A; Zinc ion binding. It is involved in the biological process described with: regulation of alternative mRNA splicing, via spliceosome. (2296 aa) |
| | Rchy1 | Ring finger and CHY zinc finger domain containing 1, isoform A; Ubiquitin protein ligase activity; zinc ion binding; ubiquitin-protein transferase activity. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; negative regulation of gliogenesis; protein ubiquitination. (433 aa) |
| | CG8419 | FI06716p; Ubiquitin-protein transferase activity; zinc ion binding. It is involved in the biological process described with: positive regulation of transcription, DNA-templated; protein autoubiquitination. (921 aa) |
| | stc | Protein shuttle craft; Plays an essential role during the late stages of embryonic neurogenesis. May either fine-tune the guidance or the spatial maintenance of the migrating SNB and in nerve roots, which are composed of axons originating from distinct groups of motor neurons and may be required to either guide or maintain the position of these nerves along a direct and straight path to their ultimate targets in particular muscle fields. May play a role in egg chamber development and/or may confer essential maternal contributions to the early embryo. (1106 aa) |
| | CG17329 | AT18988p; Ubiquitin protein ligase activity; ubiquitin-protein transferase activity; zinc ion binding. It is involved in the biological process described with: interstrand cross-link repair; protein ubiquitination. (162 aa) |
| | CG31807 | IP04788p; Ubiquitin-protein transferase activity; zinc ion binding; ubiquitin protein ligase activity. It is involved in the biological process described with: protein ubiquitination; interstrand cross-link repair. (155 aa) |
| | mib2 | Mind bomb 2 (mib2) encodes a protein required for regulating synaptic plasticity and memory formation and maintaining muscle integrity. (1049 aa) |
| | CG2617 | RE60872p; Ubiquitin protein ligase activity; zinc ion binding. It is involved in the biological process described with: protein ubiquitination. (274 aa) |
| | gzl | Godzilla E3 ubiquitin protein ligase (gzl) encodes a protein that ubiquitylates the SNARE protein encoded by Syb. It also promotes apico-basal transcytosis of the product of wg in the wing imaginal disc. (536 aa) |
| | Iru | E3 ubiquitin-protein ligase Iruka; E3 ubiquitin-protein ligase that mediates E2-dependent, 'Lys- 48'- and/or 'Lys-63'-linked polyubiquitination of substrates. Recognizes miRNA-empty Ago1 and triggers its degradation via polyubiquitination independently of the Bag6 complex. By targeting miRNA-empty Ago1, eliminates dysfunctional Ago1 not able to bind miRNA and thereby plays a role in the quality control of miRNA-mediated silencing. (380 aa) |
| | neur | Neuralized (neur) encodes an E3 ubiquitin ligase of the RING family. It is part of the Notch signaling pathway, where it is thought to contribute to the endocytosis-dependent activation of the ligand. It also has Notch-independent functions in epithelial morphogenesis. (754 aa) |
| | mura | Murashka, isoform C; Zinc ion binding; ubiquitin-protein transferase activity; ubiquitin protein ligase activity. It is involved in the biological process described with: long-term memory; protein ubiquitination; behavioral response to ethanol. (1173 aa) |
| | CG8141 | RING-type domain-containing protein; Ubiquitin protein ligase activity; zinc ion binding; ubiquitin-like protein conjugating enzyme binding. It is involved in the biological process described with: ER-associated misfolded protein catabolic process; ubiquitin-dependent protein catabolic process. (239 aa) |
| | trx | Histone-lysine N-methyltransferase trithorax; Histone methyltransferase that trimethylates 'Lys-9' of histone H3 (H3K9me3). H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional activation. Functions in segment determination through interaction with genes of bithorax (BX-C) and antennapedia (ANT-C) complexes. Acts as an activator of BX-C. Involved in the very early regulation of homeotic genes expressed only in the posterior region of the embryo. (3726 aa) |
| | CG6752 | AT01875p; Ubiquitin protein ligase activity; ubiquitin-protein transferase activity; zinc ion binding. It is involved in the biological process described with: proteolysis involved in cellular protein catabolic process. (1332 aa) |
| | CG7694 | E3 ubiquitin-protein ligase RNF181 homolog; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (147 aa) |
| | mdlc | CG4973 protein; Midlife crisis (mdlc) encodes a nuclear protein that is required for maintaining neuronal differentiation. (357 aa) |
| | CG5382 | Zinc finger protein-like 1 homolog; Zinc ion binding. It is involved in the biological process described with: dsRNA transport. (299 aa) |
| | CG4813 | LD46938p; Zinc ion binding; metal ion binding; ubiquitin protein ligase activity. It is involved in the biological process described with: protein ubiquitination. (398 aa) |
| | CG6688 | MIP11264p. (424 aa) |
| | Sce | E3 ubiquitin-protein ligase RING1; E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-118' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-118' ubiquitination gives a specific tag for epigenetic transcriptional repression. Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. PcG [...] (435 aa) |
| | nenya | RING finger protein nenya; Required for the formation of DNA double-strand breaks together with narya and vilya during the meiotic recombination process. Plays a redundant role with narya in chromosome segregation during female meiosis. (219 aa) |
| | nopo | No poles (nopo) encodes a RING domain-containing E3 ubiquitin ligase that is essential for early embryogenesis. It positively regulates caspase-dependent cell death. (435 aa) |
| | POSH | Plenty of SH3s (POSH) encodes a scaffold protein that regulates TNF-JNK signaling pathway. (838 aa) |
| | CG8910 | FI02064p; Ubiquitin-protein transferase activity; zinc ion binding. It is involved in the biological process described with: endocytosis; protein ubiquitination; Notch signaling pathway. (608 aa) |
| | Diap2 | Death-associated inhibitor of apoptosis 2; Required for activation of NF-kappaB transcription factors in the immune deficiency (Imd) signaling cascade which is essential for innate immune responses upon infection by Gram-negative bacteria. Promotes cytoplasmic cleavage of Rel and its translocation to the nucleus where it drives expression of antimicrobial peptides. Binds, polyubiquitinates and activates Dredd which is required for Rel- mediated induction of antimicrobial peptides. Anti- apoptotic protein which binds, ubiquitinates and inactivates the effector caspase Drice. Suppresses [...] (498 aa) |
| | CG13344 | Uncharacterized protein, isoform A; Zinc ion binding; ubiquitin-protein transferase activity; ubiquitin protein ligase activity. It is involved in the biological process described with: positive regulation of NF-kappaB transcription factor activity; protein ubiquitination. (374 aa) |
| | CG17019 | Uncharacterized protein, isoform A; Ubiquitin protein ligase activity; zinc ion binding. It is involved in the biological process described with: protein K48-linked ubiquitination; negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis; proteasome-mediated ubiquitin-dependent protein catabolic process; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors. (700 aa) |
| | Mat1 | CDK-activating kinase assembly factor MAT1; Menage a trois 1 (Mat1) encodes a RING finger protein involved in the activation of the kinase encoded by Cdk7. (320 aa) |
| | CG1909 | GH22690p; Protein-membrane adaptor activity; zinc ion binding; acetylcholine receptor binding. It is involved in the biological process described with: synaptic transmission, cholinergic. (606 aa) |
| | CG32850 | GEO07743p1; Zinc ion binding; ubiquitin-protein transferase activity; ubiquitin protein ligase activity. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; protein autoubiquitination. (147 aa) |
| | Trc8 | Protein TRC8 homolog; Plays a role in growth inhibition that is dependent upon COP9 signalosome subunits CSN5 and CSN6. May modulate signalosome levels or compartmentalization. Probably functions in the same or a related pathway to VHL during early midline development. (809 aa) |
| | mei-P26 | Meiotic P26, isoform F; Meiotic P26 (mei-P26) encodes a protein involved in meiosis, germline differentiation and spermatogenesis. (1310 aa) |
| | CG46383 | RING-type domain-containing protein. (65 aa) |
| | CG34308 | RING-type domain-containing protein; Ubiquitin-like protein conjugating enzyme binding; ubiquitin protein ligase activity; metal ion binding. It is involved in the biological process described with: ER-associated misfolded protein catabolic process; ubiquitin-dependent protein catabolic process. (194 aa) |
| | CG5071 | Uncharacterized protein, isoform B; Peptidyl-prolyl cis-trans isomerase activity; zinc ion binding; cyclosporin A binding. It is involved in the biological process described with: protein folding; protein peptidyl-prolyl isomerization. (680 aa) |
| | unk | Unkempt (unk) encodes a highly conserved protein with roles in mRNA binding and ubiquitination. Together with the product of hdc, it acts downstream of the product of Mtor to regulate photoreceptor differentiation during eye development. (673 aa) |
| | Mul1 | Mitochondrial E3 ubiquitin protein ligase 1; Exhibits weak E3 ubiquitin-protein ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Plays a role in the control of mitochondrial morphology by promoting mitochondrial fission. Negatively regulates the mitochondrial fusion protein marf by promoting its ubiquitination, acting in a pathway that is parallel to the park/pink1 regulatory pathway. (338 aa) |
| | hiw | E3 ubiquitin-protein ligase highwire; Atypical E3 ubiquitin-protein ligase which specifically mediates ubiquitination of threonine and serine residues on target proteins, instead of ubiquitinating lysine residues (By similarity). Shows esterification activity towards both threonine and serine, with a preference for threonine, and acts via two essential catalytic cysteine residues that relay ubiquitin to its substrate via thioester intermediates (By similarity). Required in the presynaptic motoneuron to down-regulate the levels of wnd and restrain synaptic terminal growth at the neuromu [...] (5233 aa) |
| | CG33552 | RING-type domain-containing protein; Ubiquitin protein ligase activity; zinc ion binding; ubiquitin-protein transferase activity. It is involved in the biological process described with: protein ubiquitination; interstrand cross-link repair. (157 aa) |
| | tn | Thin, isoform C; Thin (tn) encodes a TRIM/RBCC protein involved in myofibril assembly and stability. (1517 aa) |
| | gol | Goliath (gol) encodes an E3 ubiquitin ligase, whose cellular substrates are unknown. During embyrogenesis gol is expressed in fusion-competence myoblasts of the somatic and visceral mesoderm. (601 aa) |
| | CG13605 | LP20373p; Ubiquitin protein ligase activity; zinc ion binding. (669 aa) |
| | sinah | Probable E3 ubiquitin-protein ligase sinah; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. The adapter phyl is required to direct the degradation of the two isoforms of the transcriptional repressor Tramtrack (Ttk). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates. A phyl-independent mechanism of degradation exists for [...] (351 aa) |
| | elfless | Elfless, isoform B; Elfless (elfless) encodes a RING-finger E3 ubiquitin ligase expressed in the tail cyst cell nuclei of testes, although it is not required for male fertility. It interacts with the apoptosis pathway (with the products of Dronc, eff, Diap1) and may be involved in tail cyst cell degradation. (229 aa) |
| | Roc2 | Regulator of cullins 2 (Roc2) encodes a C2H2 type zinc finger protein that binds specifically to the product of Cul5 and recruits ubiquitin-charged E2 to the CRL5 E3 ubiquitin ligase complex, which functions during oogenesis. (113 aa) |
| | CG34375 | IP10571p; Ubiquitin protein ligase activity; zinc ion binding. (568 aa) |
| | CG17048 | GEO12067p1; Zinc ion binding. (124 aa) |
| | CG33144 | Ubiquitin-protein transferase activity; zinc ion binding; ubiquitin conjugating enzyme binding; ubiquitin protein ligase activity. It is involved in the biological process described with: protein polyubiquitination; ubiquitin-dependent protein catabolic process; positive regulation of proteasomal ubiquitin-dependent protein catabolic process. (1102 aa) |
| | Trim9 | E3 ubiquitin-protein ligase TRIM9; E3 ubiquitin-protein ligase activity (By similarity). During embryonic and larval development, regulates the pattern of axonal projections of class IV nociceptive sensory neurons (C4da) downstream of netrin receptor fra. Regulates fine-scale topography of C4da axon terminals upon neuronal activity. During eye development, consolidates the attachment of R8 photoreceptor growth cones to the target medulla layer, probably downstream of fra. Belongs to the TRIM/RBCC family. (740 aa) |
| | CG43058 | RING-type domain-containing protein; Transcription factor binding. It is involved in the biological process described with: positive regulation of transcription by RNA polymerase II. (100 aa) |
| | CG17721 | Uncharacterized protein, isoform C; Zinc ion binding. (149 aa) |
| | CG32369 | Uncharacterized protein, isoform A; Zinc ion binding. (1066 aa) |
| | ari-1 | E3 ubiquitin-protein ligase ariadne-1; Atypical E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 Ubc10. Controls the subcellular localization and morphology of muscle nuclei (myonuclei) by regulating the protein levels and distribution of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex. Functions by mediating the monoubiquitination of the LINC complex subunit koi leading to its subsequent proteasomal degradation. Appears to function, at least partially redundantly, with the RBR E3 ligase family mem [...] (503 aa) |
| | CG34289 | Uncharacterized protein, isoform C; Zinc ion binding. (114 aa) |
| | Roc1a | RING-box protein 1A; Core component of multiple SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Required for the specific SCF-dependent proteolysis of CI, but not that of ARM, suggesting that it also participates in the selection of substrates inside the SCF complex. During early metamorphosis, part of [...] (136 aa) |
| | CG4080 | LD02310p; Zinc ion binding; MHC protein binding; ubiquitin protein ligase activity. It is involved in the biological process described with: immune response; protein polyubiquitination; antigen processing and presentation of peptide antigen via MHC class II. (617 aa) |
| | CG4325 | Ubiquitin protein ligase activity; zinc ion binding. It is involved in the biological process described with: intracellular signal transduction; positive regulation of antibacterial peptide biosynthetic process; protein ubiquitination. (158 aa) |
| | CG11360 | LD09246p1; Ubiquitin protein ligase activity; RNA binding; zinc ion binding. It is involved in the biological process described with: regulation of alternative mRNA splicing, via spliceosome. (628 aa) |
| | qin | Qin (qin) is a piRNA pathway gene that encodes a protein involved in posttranscriptional gene silencing. (1857 aa) |
| | bon | Bonus, isoform C; Bonus (bon) encodes a nuclear receptor cofactor involved in axon guidance and chromatin organization. (1207 aa) |
| | sip3 | E3 ubiquitin-protein ligase HRD1; Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin- dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins. Protects cells from ER stress-induced apoptosis. Sequesters p53 in the cytoplasm and pro [...] (626 aa) |
| | CG6923 | Uncharacterized protein, isoform D; Ubiquitin protein ligase activity; zinc ion binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process. (1265 aa) |
| | dnr1 | Defense repressor 1, isoform B; Defense repressor 1 (dnr1) encodes a protein that interacts with the caspase encoded by Dredd. The product of dnr1 is involved in attenuation of innate immune response and neuro-inflammation. (696 aa) |
| | Su(z)2 | Suppressor of zeste 2 (Su(z)2) encodes a protein that regulates gene expression by modifying epigenetic marks. The gene is related to Psc and was orginally identified due to its ability to suppress transvection at z. (1396 aa) |
| | LUBEL | E3 ubiquitin-protein ligase lubel; E3 ubiquitin-protein ligase which conjugates linear 'Met- 1'- and 'Lys-63'-linked polyubiquitin chains to substrates and plays a crucial role in the NF-kappa-B intestinal inflammatory response to oral infection and in the heat stress response. Preferentially interacts with 'Lys-63'-linked, and to a lesser extent 'Lys-48'-linked, polyubiquitin chains. Upon oral infection with a Gram-negative bacterium E.carotovora subsp. carotovora 15, functions with the E2 ubiquitin- conjugating enzyme Ubc10 to mediate the conjugation of 'Lys-63'- and linear 'Met-1'-l [...] (2892 aa) |
| | Hakai | E3 ubiquitin-protein ligase Hakai; E3 ubiquitin-protein ligase required during early development. E3 ubiquitin-protein ligases mediate ubiquitination of target proteins. Required for epithelial integrity and midgut morphogenesis. Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Its function in the WMM complex is unknown. Belongs to the Hakai family. (473 aa) |
| | Cnot4 | CCR4-NOT transcription complex subunit 4 (Cnot4) encodes a positive regulator of the Jak/Stat pathway which acts by stabilizing the DNA binding of the product of Stat92E. (1062 aa) |
| | CG7376 | Uncharacterized protein, isoform A; ATP binding; zinc ion binding; ubiquitin-protein transferase activity; ubiquitin protein ligase activity. It is involved in the biological process described with: cellular response to DNA damage stimulus; protein polyubiquitination. (1270 aa) |
| | Rnf146 | MIP02988p; Zinc ion binding; ubiquitin-protein transferase activity; poly-ADP-D-ribose binding; ubiquitin protein ligase activity. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; positive regulation of canonical Wnt signaling pathway; protein destabilization; positive regulation of proteasomal ubiquitin-dependent protein catabolic process. (448 aa) |
| | Topors | E3 ubiquitin-protein ligase Topors; Functions as a ubiquitin-protein E3 ligase. Negatively regulates the transcriptional repressor h/hairy by promoting its ubiquitination and subsequent degradation. Also directs the nuclear organization of the gypsy chromatin insulator. Chromatin insulators are regulatory elements which establish independent domains of transcriptional activity within eukaryotic genomes. Insulators have two defining properties; they can block the communication between an enhancer and a promoter when placed between them, and can also buffer transgenes from position effec [...] (1038 aa) |
| | CG5555 | Uncharacterized protein, isoform B; Zinc ion binding; ubiquitin-protein transferase activity; ubiquitin protein ligase activity. It is involved in the biological process described with: protein ubiquitination. (558 aa) |
| | CG10916 | LD46221p; CG10916 encodes a zinc ion binding protein with ubiquitin-protein transferase activity. It is involved in intracellular signal transduction, determination of lifespan, protein ubiquitination and hypoxia. (263 aa) |
| | CG13481 | IP04153p; Zinc ion binding; ubiquitin-protein transferase activity; ubiquitin protein ligase activity. It is involved in the biological process described with: protein ubiquitination; interstrand cross-link repair. (176 aa) |
| | roq | Roquin, isoform A; Ubiquitin protein ligase activity; RNA binding; metal ion binding; zinc ion binding. It is involved in the biological process described with: protein polyubiquitination. (819 aa) |
| | lmgA | Putative APC11 anaphase-promoting complex subunit; Lemming A (lmgA) encodes the RING-finger containing Apc11 subunit of the APC/C ubiquitin ligase (E3). Together with the cullin subunit encoded by Apc2, it forms the minimal ubiquitin ligase module of the APC/C. (85 aa) |
| | Phf7 | PHD finger protein 7, isoform A; Histone binding. It is involved in the biological process described with: male germ-line cyst formation; positive regulation of gene expression; male germ-line sex determination. (520 aa) |
| | Diap1 | Death-associated inhibitor of apoptosis 1; Anti-apoptotic protein which functions as a caspase regulator, using its E3 ubiquitin-protein ligase activity to smother caspase activity. Binds, ubiquitinates and inactivates initiator caspase Dronc, and effector caspases Drice and Dcp-1. Acts as a Nedd8- E3 ubiquitin-protein ligase for Drice. Suppresses apoptosis by targeting the apoptosome for ubiquitination and inactivation. Plays an important role in cell motility. Overexpression suppresses rpr and hid- dependent cell death in the eye. Interaction of Diap1 with Dronc is required to suppre [...] (438 aa) |
| | CG44271 | RING-type domain-containing protein. (106 aa) |
| | CG14435 | Uncharacterized protein, isoform A; Ubiquitin protein ligase activity; zinc ion binding. It is involved in the biological process described with: protein ubiquitination. (303 aa) |
| | CG9014 | LP07794p; Ubiquitin protein ligase activity; ubiquitin-protein transferase activity; zinc ion binding. It is involved in the biological process described with: protein polyubiquitination; protein ubiquitination. (328 aa) |
| | lt | Vacuolar protein sorting-associated protein 41 homolog; Light (lt) encodes a cellular-protein trafficking protein that forms part of the homotypic fusion and vacuolar protein sorting (HOPS) and class C core vacuole/endosome tethering (CORVET) complexes. It is required for fusion of autophagosomes with lysosomes, endocytic down-regulation of Notch signaling, and eye pigment biogenesis; Belongs to the VPS41 family. (841 aa) |
| | Bre1 | E3 ubiquitin-protein ligase Bre1; E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-117' of histone H2B. H2B 'Lys-117' ubiquitination gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It thereby plays a central role in histone code and gene regulation. Required for the expression of Notch target genes in development by affecting the levels of Su(H) in imaginal disk cells and stimulating the Su(H)-mediated transcription of Notch-specific genes. Belongs to the BRE1 family. (1044 aa) |
| | Psc | Polycomb group protein Psc; Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. Component of the PcG multiprotein PRC1 complex, a complex that acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-118', rendering chromatin heritably changed in its expressibility. Needed to maintain e [...] (1601 aa) |
