STRINGSTRING
Stam Stam Gga Gga Hrs Hrs CG3529 CG3529
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
StamSignal transducing adaptor molecule (Stam) encodes a component of the ESCRT-0 complex, which mediates multivesicular body formation. It is involved in RTK signaling regulation, tracheal cell migration and endosomal trafficking. (689 aa)
GgaGolgi-localized, gamma-adaptin ear containing, ARF binding protein (Gga) encodes a clathrin binding protein involved in post-Golgi vesicle-mediated transport. (660 aa)
HrsHepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded. (760 aa)
CG3529GH05942p; It is involved in the biological process described with: intracellular protein transport. (543 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: low (28%) [HD]