(9 nodes) HSP40/DnaJ peptide-binding network (Drosophila melanogaster)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DnaJ-1	DnaJ-like-1 (DnaJ-1) encodes a heat-shock protein co-factor that regulates and interacts with larger heat shock proteins providing client specificity. It regulates the folding of proteins whose misfolding leads to age-dependent neurodegeneration. (334 aa)
	shv	DnaJ homolog shv; Maintains stem cell niche architecture in the testes. Activates an extracellular integrin beta-PS pathway which regulates DE- cadherin (shg) levels in somatic hub cells, and is essential for maintaining the number of germline stem cells and the structure and localization of hub cells. (354 aa)
	Droj2	DnaJ-like-2, isoform A; Unfolded protein binding; heat shock protein binding; ATP binding. It is involved in the biological process described with: response to heat; protein folding. (403 aa)
	CG5504	Protein tumorous imaginal discs, mitochondrial; May act as a tumor suppressor in larval imaginal disks. (520 aa)
	CG5001	FI02090p; Chaperone binding; unfolded protein binding. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; chaperone cofactor-dependent protein refolding. (350 aa)
	DnaJ-H	DnaJ homolog, isoform C; Unfolded protein binding; heat shock protein binding. It is involved in the biological process described with: protein folding. (440 aa)
	CG2887	AT19485p; Chaperone binding; unfolded protein binding. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; chaperone cofactor-dependent protein refolding. (342 aa)
	CG12020	J domain-containing protein; Chaperone binding; unfolded protein binding. It is involved in the biological process described with: chaperone cofactor-dependent protein refolding. (366 aa)
	CG7387	Unfolded protein binding; heat shock protein binding. It is involved in the biological process described with: regulation of apoptotic process; protein folding; mitochondrion organization. (449 aa)

Your Current Organism:

Drosophila melanogaster

NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CG12020	CG7387	FBpp0072661	FBpp0076446	J domain-containing protein; Chaperone binding; unfolded protein binding. It is involved in the biological process described with: chaperone cofactor-dependent protein refolding.	Unfolded protein binding; heat shock protein binding. It is involved in the biological process described with: regulation of apoptotic process; protein folding; mitochondrion organization.	0.473
CG12020	DnaJ-H	FBpp0072661	FBpp0303024	J domain-containing protein; Chaperone binding; unfolded protein binding. It is involved in the biological process described with: chaperone cofactor-dependent protein refolding.	DnaJ homolog, isoform C; Unfolded protein binding; heat shock protein binding. It is involved in the biological process described with: protein folding.	0.640
CG12020	Droj2	FBpp0072661	FBpp0082220	J domain-containing protein; Chaperone binding; unfolded protein binding. It is involved in the biological process described with: chaperone cofactor-dependent protein refolding.	DnaJ-like-2, isoform A; Unfolded protein binding; heat shock protein binding; ATP binding. It is involved in the biological process described with: response to heat; protein folding.	0.640
CG2887	CG5504	FBpp0071393	FBpp0088955	AT19485p; Chaperone binding; unfolded protein binding. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; chaperone cofactor-dependent protein refolding.	Protein tumorous imaginal discs, mitochondrial; May act as a tumor suppressor in larval imaginal disks.	0.461
CG2887	CG7387	FBpp0071393	FBpp0076446	AT19485p; Chaperone binding; unfolded protein binding. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; chaperone cofactor-dependent protein refolding.	Unfolded protein binding; heat shock protein binding. It is involved in the biological process described with: regulation of apoptotic process; protein folding; mitochondrion organization.	0.494
CG2887	DnaJ-H	FBpp0071393	FBpp0303024	AT19485p; Chaperone binding; unfolded protein binding. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; chaperone cofactor-dependent protein refolding.	DnaJ homolog, isoform C; Unfolded protein binding; heat shock protein binding. It is involved in the biological process described with: protein folding.	0.697
CG2887	Droj2	FBpp0071393	FBpp0082220	AT19485p; Chaperone binding; unfolded protein binding. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; chaperone cofactor-dependent protein refolding.	DnaJ-like-2, isoform A; Unfolded protein binding; heat shock protein binding; ATP binding. It is involved in the biological process described with: response to heat; protein folding.	0.694
CG5001	CG5504	FBpp0297899	FBpp0088955	FI02090p; Chaperone binding; unfolded protein binding. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; chaperone cofactor-dependent protein refolding.	Protein tumorous imaginal discs, mitochondrial; May act as a tumor suppressor in larval imaginal disks.	0.559
CG5001	CG7387	FBpp0297899	FBpp0076446	FI02090p; Chaperone binding; unfolded protein binding. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; chaperone cofactor-dependent protein refolding.	Unfolded protein binding; heat shock protein binding. It is involved in the biological process described with: regulation of apoptotic process; protein folding; mitochondrion organization.	0.479
CG5001	DnaJ-H	FBpp0297899	FBpp0303024	FI02090p; Chaperone binding; unfolded protein binding. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; chaperone cofactor-dependent protein refolding.	DnaJ homolog, isoform C; Unfolded protein binding; heat shock protein binding. It is involved in the biological process described with: protein folding.	0.756
CG5001	Droj2	FBpp0297899	FBpp0082220	FI02090p; Chaperone binding; unfolded protein binding. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; chaperone cofactor-dependent protein refolding.	DnaJ-like-2, isoform A; Unfolded protein binding; heat shock protein binding; ATP binding. It is involved in the biological process described with: response to heat; protein folding.	0.721
CG5504	CG2887	FBpp0088955	FBpp0071393	Protein tumorous imaginal discs, mitochondrial; May act as a tumor suppressor in larval imaginal disks.	AT19485p; Chaperone binding; unfolded protein binding. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; chaperone cofactor-dependent protein refolding.	0.461
CG5504	CG5001	FBpp0088955	FBpp0297899	Protein tumorous imaginal discs, mitochondrial; May act as a tumor suppressor in larval imaginal disks.	FI02090p; Chaperone binding; unfolded protein binding. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; chaperone cofactor-dependent protein refolding.	0.559
CG5504	DnaJ-1	FBpp0088955	FBpp0076830	Protein tumorous imaginal discs, mitochondrial; May act as a tumor suppressor in larval imaginal disks.	DnaJ-like-1 (DnaJ-1) encodes a heat-shock protein co-factor that regulates and interacts with larger heat shock proteins providing client specificity. It regulates the folding of proteins whose misfolding leads to age-dependent neurodegeneration.	0.452
CG5504	DnaJ-H	FBpp0088955	FBpp0303024	Protein tumorous imaginal discs, mitochondrial; May act as a tumor suppressor in larval imaginal disks.	DnaJ homolog, isoform C; Unfolded protein binding; heat shock protein binding. It is involved in the biological process described with: protein folding.	0.569
CG5504	Droj2	FBpp0088955	FBpp0082220	Protein tumorous imaginal discs, mitochondrial; May act as a tumor suppressor in larval imaginal disks.	DnaJ-like-2, isoform A; Unfolded protein binding; heat shock protein binding; ATP binding. It is involved in the biological process described with: response to heat; protein folding.	0.582
CG7387	CG12020	FBpp0076446	FBpp0072661	Unfolded protein binding; heat shock protein binding. It is involved in the biological process described with: regulation of apoptotic process; protein folding; mitochondrion organization.	J domain-containing protein; Chaperone binding; unfolded protein binding. It is involved in the biological process described with: chaperone cofactor-dependent protein refolding.	0.473
CG7387	CG2887	FBpp0076446	FBpp0071393	Unfolded protein binding; heat shock protein binding. It is involved in the biological process described with: regulation of apoptotic process; protein folding; mitochondrion organization.	AT19485p; Chaperone binding; unfolded protein binding. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; chaperone cofactor-dependent protein refolding.	0.494
CG7387	CG5001	FBpp0076446	FBpp0297899	Unfolded protein binding; heat shock protein binding. It is involved in the biological process described with: regulation of apoptotic process; protein folding; mitochondrion organization.	FI02090p; Chaperone binding; unfolded protein binding. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; chaperone cofactor-dependent protein refolding.	0.479
CG7387	DnaJ-1	FBpp0076446	FBpp0076830	Unfolded protein binding; heat shock protein binding. It is involved in the biological process described with: regulation of apoptotic process; protein folding; mitochondrion organization.	DnaJ-like-1 (DnaJ-1) encodes a heat-shock protein co-factor that regulates and interacts with larger heat shock proteins providing client specificity. It regulates the folding of proteins whose misfolding leads to age-dependent neurodegeneration.	0.479