STRINGSTRING
Tdrd3 Tdrd3 CG2701 CG2701 CG12024 CG12024 Usp5 Usp5 sbr sbr CG15047 CG15047 Cbl Cbl CG8209 CG8209 CG31528 CG31528 mEFTs mEFTs CG3223 CG3223 CG9636 CG9636 CG10435 CG10435 CG10694 CG10694 CG5111 CG5111 dmrt99B dmrt99B p47 p47 gw gw nxf2 nxf2 ref(2)P ref(2)P CG42383 CG42383 HERC2 HERC2 SCCRO SCCRO CG10508 CG10508 CG15445 CG15445 FBgn0028372 FBgn0028372 CG13604 CG13604 lig lig CG8892 CG8892 Rad23 Rad23 CG5445 CG5445 HUWE1 HUWE1 Ubqn Ubqn rngo rngo Ubc4 Ubc4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Tdrd3Tudor domain containing 3; RNA binding. It is involved in the biological process described with: mRNA processing. (836 aa)
CG2701EG:95B7.9 protein; Ubiquitin binding. It is involved in the biological process described with: regulation of transcription, DNA-templated. (735 aa)
CG12024GH08896p. (292 aa)
Usp5Ubiquitin carboxyl-terminal hydrolase; Ubiquitin specific protease 5 (Usp5) encodes an essential enzyme that cleaves unanchored lysine48-linked polyubiquitin chains. It is involved in photoreceptor differentiation, neuron pathfinding and apoptosis. (827 aa)
sbrNuclear RNA export factor 1; Mediates the export of the majority of mRNAs from the nucleus to the cytoplasm. (672 aa)
CG15047MIP23504p. (174 aa)
CblCbl proto-oncogene (Cbl) encodes an E3 protein-ubiquitin ligase for protein post-translational modification in RTK signaling (EGFR, VEGFR, FGF, and RET families) and non-RTK signaling (Src family). After the ubiquitination mediated by the product of Cbl, the substrates will be targeted to protein degradation for controlling cell growth, survival, migration and inflammation. (878 aa)
CG8209GM09977p; Nucleic acid binding. (331 aa)
CG31528FI07626p; Polyubiquitin modification-dependent protein binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process. (344 aa)
mEFTsMitochondrial translation elongation factor Ts (mEFTs) encodes a protein predicted to function within mitochondria to recharge the products of mEFTu1 and mEFTu2 with GTP during the elongation phase of mRNA translation; Belongs to the EF-Ts family. (318 aa)
CG3223GH08043p; Polyubiquitin modification-dependent protein binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process. (415 aa)
CG9636LD29354p; It is involved in the biological process described with: negative regulation of macrophage cytokine production. (304 aa)
CG10435LD44032p; Ubiquitin binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. (495 aa)
CG10694AT15685p; Ubiquitin binding; polyubiquitin modification-dependent protein binding; damaged DNA binding; proteasome binding. It is involved in the biological process described with: nucleotide-excision repair; proteasome-mediated ubiquitin-dependent protein catabolic process. (290 aa)
CG5111FI08017p; It is involved in the biological process described with: protein ubiquitination; regulation of ubiquitin-dependent protein catabolic process. (614 aa)
dmrt99BDoublesex-Mab related 99B; DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II regulatory region sequence-specific DNA binding. It is involved in the biological process described with: regulation of transcription by RNA polymerase II. (510 aa)
p47GH01724p; P47 (p47) encodes a protein involved in nuclear envelope reassembly and rhabdomere development. (407 aa)
gwProtein Gawky; Required for gene silencing mediated by micro-RNAs (miRNAs). Silences both polyadenylated and deadenylated mRNAs. Required for miRNA-mediated translational repression and mRNA decay. Not required for miRNA target recognition. Necessary to initiate but not to maintain silencing. Promotes mRNA deadenylation through the recruitment of the CCR4-NOT and PAN complexes and promotes decapping by the DCP1-DCP2 complex. Dissociates from silenced mRNAs after deadenylation. Required for completion of nuclear divisions during early embryonic development. Belongs to the GW182 family. (1384 aa)
nxf2Nuclear RNA export factor 2; May be involved in the export of mRNA from the nucleus to the cytoplasm. In the ovaries, forms a complex with nxf2, piwi and Nxt1 which acts as effectors of cotranscriptional transposon silencing. On recruitment to a target transcript, interacts with single stranded RNA, thereby anchoring the complex via the nascent target transcript to chromatin and allowing Panx to recruit silencing effectors to establishing repressive heterochromatin at transposon loci. Does not affect piRNA biogenesis. The interaction with Panx stabilizes the nuclear protein complex. Do [...] (841 aa)
ref(2)PProtein ref(2)P; Required for selective autophagy activation by ubiquitinated proteins. Implicated in sigma rhabdovirus multiplication and necessary for male fertility. Involved in activating transcription of Drs. (599 aa)
CG42383Uncharacterized protein; Ubiquitin binding. It is involved in the biological process described with: proteasome-mediated ubiquitin-dependent protein catabolic process; nuclear envelope reassembly; autophagosome assembly; membrane fusion; Golgi organization. (353 aa)
HERC2Probable E3 ubiquitin-protein ligase HERC2; Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (4912 aa)
SCCRODCN1-like protein; May contribute to neddylation of cullin components of SCF- type E3 ubiquitin ligase complexes. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity (By similarity). (297 aa)
CG10508Uncharacterized protein, isoform K. (733 aa)
CG15445LD38858p; It is involved in the biological process described with: regulation of ubiquitin-dependent protein catabolic process. (618 aa)
FBgn0028372Isopeptidase-T-3, isoform C. (561 aa)
CG13604Protein UBASH3A homolog; Phosphatase activity. It is involved in the biological process described with: dephosphorylation. (763 aa)
ligLingerer (lig) encodes a putative RNA binding protein that forms a complex with the products of orb and orb2. Loss of lig results in defects in copulation and short-term memory. (1417 aa)
CG8892UBX domain-containing protein 7. (496 aa)
Rad23DNA repair protein Rad23; Rad23 (Rad23) encodes an evolutionarily conserved member of the proteasome-associated proteins. It acts as a shuttle -or bridge- protein helping ubiquitinated proteins to interact with the proteasome, which in turn regulates their turnover. (414 aa)
CG5445MIP08896p; Ubiquitin binding. It is involved in the biological process described with: macroautophagy. (303 aa)
HUWE1Uncharacterized protein, isoform H; Ubiquitin-protein transferase activity; ubiquitin protein ligase activity. It is involved in the biological process described with: protein ubiquitination; ubiquitin-dependent protein catabolic process; protein polyubiquitination; dsRNA transport. (5151 aa)
UbqnUbiquilin, isoform A; Ubiquilin (Ubqn) encodes a protein containing an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. It binds and delivers ubiquitinated, misfolded or no longer functionally required proteins to the ubiquitin-proteasome system and/or autophagy. (547 aa)
rngoRings lost (rngo) encodes a ubiquitin receptor that binds to ubiquitinated proteins via its ubiquitin-associated domain. It is an essential protein that is required for proper development of ring canals in the female germ line. (458 aa)
Ubc4Ubiquitin-conjugating enzyme E2-22 kDa; Catalyzes the covalent attachment of ubiquitin to other proteins. (199 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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