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| | tutl | Turtle (tutl) encodes an Ig-superfamily transmembrane protein. Its roles include axonal tiling, dendrite self-avoidance, axonal pathfinding and coordinated motor control; Belongs to the immunoglobulin superfamily. Turtle family. (1536 aa) |
| | Ocrl | Oculocerebrorenal syndrome of Lowe (Ocrl) encodes an inositol polyphosphate 5-phosphatase that regulates PtdIns(4,5)P2 homeostasis by dephosphorylating PtdIns(4,5)P2 on endocytic compartments. In vitro experiments also suggest a role of the product of Ocrl during cytokinesis. (850 aa) |
| | CG9394 | RH02475p; Glycerophosphocholine phosphodiesterase activity; starch binding. It is involved in the biological process described with: glycerophospholipid catabolic process. (679 aa) |
| | wrapper | GH03113p; Wrapper (wrapper) encodes a protein involved in axon ensheathment and glial apoptosis. (500 aa) |
| | CG13532 | RE31221p. (263 aa) |
| | CG5597 | GH04238p. (260 aa) |
| | dpr20 | Defective proboscis extension response 20; It is involved in the biological process described with: synapse organization; sensory perception of chemical stimulus. (525 aa) |
| | ImpL2 | Neural/ectodermal development factor IMP-L2; Essential developmental role during embryogenesis, in particular the normal development of the nervous system. May be involved in some aspect of cell adhesion. (267 aa) |
| | sev | Protein sevenless; Receptor for an extracellular signal required to instruct a cell to differentiate into an R7 photoreceptor. The ligand for sev is the boss (bride of sevenless) protein on the surface of the neighboring R8 cell. (2554 aa) |
| | CG15744 | G protein-coupled receptor activity. It is involved in the biological process described with: G protein-coupled receptor signaling pathway; cell surface receptor signaling pathway. (1797 aa) |
| | dpr8 | Defective proboscis extension response 8, isoform A; It is involved in the biological process described with: synapse organization; sensory perception of chemical stimulus. (344 aa) |
| | dpr18 | Defective proboscis extension response 18; It is involved in the biological process described with: synapse organization; sensory perception of chemical stimulus. (519 aa) |
| | dome | Cytokine receptor; Critical for epithelial morphogenesis during oogenesis; border cell migration. Required in the germarium for the polarization of follicle cells during encapsulation of germline cells. Required for embryonic segmentation and trachea specification. Essential receptor molecule for upd and JAK/STAT signaling during oogenesis. (1282 aa) |
| | CG18135 | Uncharacterized protein, isoform D; Starch binding; glycerophosphocholine phosphodiesterase activity; myosin binding. It is involved in the biological process described with: glycerophospholipid catabolic process; multicellular organism reproduction. (770 aa) |
| | CG11619 | Uncharacterized protein; Glycerophosphocholine phosphodiesterase activity; starch binding. It is involved in the biological process described with: glycerophospholipid catabolic process. (699 aa) |
| | CG17839 | Uncharacterized protein, isoform B. (1656 aa) |
| | btl | Fibroblast growth factor receptor homolog 2; May be required for patterning of muscle precursor cells: generation of mesodermal and endodermal layers, invaginations of various types of cells, and CNS formation. Essential for the ability of the migrating tracheal and midline cells to recognize external guiding cues. (1052 aa) |
| | Ptp69D | Protein tyrosine phosphatase 69D (Ptp69D) encodes a transmembrane receptor tyrosine phosphatase (RPTP). It genetically interacts with the other RPTP genes and its mutants have embryonic motor axon guidance phenotypes. In particular, Ptp10D-Ptp69D double mutants have a strong phenotype in which embryonic CNS axons abnormally cross the ventral midline. The product of Ptp69D physically and genetically interacts with the product of Dscam1 to regulate arborization of mechanosensory neurons; Belongs to the protein-tyrosine phosphatase family. Receptor class subfamily. (1462 aa) |
| | CG7607 | Ig-like domain-containing protein. (167 aa) |
| | nkt | GEO08318p1. (162 aa) |
| | dpr10 | Defective proboscis extension response 10, isoform A; It is involved in the biological process described with: sensory perception of chemical stimulus; synapse organization. (408 aa) |
| | fan | Farinelli (fan) encodes an important protein for sperm development that interacts with the product of Osbp. (218 aa) |
| | CG7565 | FI19480p1. (1069 aa) |
| | vn | Vein (vn) encodes a secreted neuregulin-like EGFR ligand. It has weaker intrinsic activity, and a lower receptor affinity, than the TGFalpha-like ligand encoded by spi. It has roles in growth and patterning of tissues including muscle, midgut, ovary, trachea, glia, eye, leg, and wing. (623 aa) |
| | fipi | Factor of interpulse interval. (450 aa) |
| | bdl | Borderless (bdl) encodes a cell adhesion molecule that is required for glial extension and axon ensheathment. Its down-regulation by the products of tutl and Lar is required for photoreceptor axonal tiling and layer-specific target selection; Belongs to the immunoglobulin superfamily. (719 aa) |
| | Sec5 | Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family. (894 aa) |
| | CG2818 | LD22655p; Glycerophosphocholine phosphodiesterase activity; starch binding. It is involved in the biological process described with: glycerophospholipid catabolic process. (707 aa) |
| | Cont | Contactin; Required for organization of septate junctions and paracellular barrier functions. Septate junctions, which are the equivalent of vertebrates tight junctions, are characterized by regular arrays of transverse structures that span the intermembrane space and form a physical barrier to diffusion. (1390 aa) |
| | beta-Man | Beta-Mannosidase, isoform A; Beta-mannosidase activity. It is involved in the biological process described with: glycoprotein catabolic process. (908 aa) |
| | DIP-theta | Dpr-interacting protein theta; It is involved in the biological process described with: synapse organization. (606 aa) |
| | ihog | Interference hedgehog (ihog) encodes a type 1 membrane protein that acts as a co-receptor for the product of hh upstream or at the level of the receptor encoded by ptc. It interacts with the products of disp, dlp, dally and shf. It is involved in imaginal pattern formation and embryonic cuticle pattern formation. (886 aa) |
| | Tep3 | Thioester-containing protein 3 (Tep3) encodes a protein involved in the defense response to Gram-positive bacteria. (1469 aa) |
| | Tep2 | Thioester-containing protein 2 (Tep2) is a member of the Thioester-containing proteins (TEP) family of genes. The product of Tep2 has endopeptidase inhibitor activity and participates in the cellular immune response to certain Gram-negative bacteria. (1420 aa) |
| | Tg | Transglutaminase, isoform A; Transglutaminase (Tg) encodes an enzyme that catalyzes the isopeptide bond formation of epsilon-(gamma-glutamyl)lysine bonds in a Ca[2+]-dependent manner. It maintains the homeostasis of gut microbiota and promotes peritrophic matrix formation, as well as mediating cuticular morphogenesis and haemolymph coagulation. (776 aa) |
| | Mcr | Macroglobulin complement-related (Mcr) encodes a transmembrane protein of the conserved thioester-containing protein (TEP) superfamily including macroglobulins and complement proteins. It is a core component of septate junctions, which provide an essential paracellular barrier to epithelia. (1760 aa) |
| | Bsg | Basigin, isoform G; Basigin (Bsg) encodes an IgG family glycoprotein that promotes cytoskeletal rearrangements and lamellipodia formation in cultured insect cells. It contributes to photoreceptor cell morphogenesis, sarcomere organization and spermatid development. (648 aa) |
| | CG8419 | FI06716p; Ubiquitin-protein transferase activity; zinc ion binding. It is involved in the biological process described with: positive regulation of transcription, DNA-templated; protein autoubiquitination. (921 aa) |
| | DIP-zeta | Dpr-interacting protein zeta, isoform A; It is involved in the biological process described with: synapse organization. (532 aa) |
| | dpr19 | Defective proboscis extension response 19, isoform A; It is involved in the biological process described with: synapse organization; sensory perception of chemical stimulus. (385 aa) |
| | CG6201 | LD15174p; L-iduronidase activity; hydrolase activity, hydrolyzing O-glycosyl compounds. It is involved in the biological process described with: carbohydrate metabolic process. (636 aa) |
| | kek2 | Kekkon 2. (894 aa) |
| | DIP-kappa | Dpr-interacting protein kappa, isoform A. (672 aa) |
| | Su(H) | Suppressor of hairless protein; Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Binds directly the 5'-GTGRGAR-3' DNA consensus sequence, which is present in the regulatory region of several genes. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some Notch protein, it acts as a transcriptional activator that activates transcription of Notch target genes. Required for transcription of Sim. Spec [...] (594 aa) |
| | Tep1 | Thioester-containing protein 1; Endopeptidase inhibitor activity. It is involved in the biological process described with: innate immune response. (1354 aa) |
| | beat-IIIc | Beaten path IIIc, isoform A; It is involved in the biological process described with: motor neuron axon guidance; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; synaptic target inhibition. (383 aa) |
| | dl | Embryonic polarity protein dorsal; Embryonic developmental protein. The lateral or ventral identity of a cell depends upon the concentration of this protein in its nucleus during the blastoderm stage. A morphogenetic protein that specifically binds to the kappa B-related consensus sequence 5'- GRGAAAANCC-3', located in the enhancer region of zygotic genes such as Zen, Twist, Snail and Decapentaplegic. Mediates an immune response in larvae. Part of a signaling pathway involving NF- kappa-B and Toll-related receptors, that functions in the apoptosis of unfit cells during cell competition [...] (999 aa) |
| | Ama | Protein amalgam. (341 aa) |
| | dpr5 | Defective proboscis extension response 5, isoform A; It is involved in the biological process described with: synapse organization; sensory perception of chemical stimulus. (336 aa) |
| | dpr17 | Defective proboscis extension response 17, isoform A; It is involved in the biological process described with: sensory perception of chemical stimulus; synapse organization. (664 aa) |
| | dpr15 | Defective proboscis extension response 15, isoform A; It is involved in the biological process described with: sensory perception of chemical stimulus; synapse organization. (662 aa) |
| | CG3942 | FI16509p1; Glycerophosphocholine phosphodiesterase activity; starch binding. It is involved in the biological process described with: glycerophospholipid catabolic process. (739 aa) |
| | beat-Vb | Beaten path Vb, isoform A; It is involved in the biological process described with: motor neuron axon guidance; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. (328 aa) |
| | beat-IIb | Beaten path IIb, isoform A; It is involved in the biological process described with: motor neuron axon guidance; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. (407 aa) |
| | htl | Fibroblast growth factor receptor homolog 1; Heartless (htl) encodes a transmembrane tyrosine kinase receptor for secreted FGF ligands that utilizes the intracellular Ras-MAP kinase pathway. It contributes to embryonic mesoderm migration and the specification of several mature mesodermal cell derivatives; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily. (729 aa) |
| | InR | Insulin-like receptor subunit beta 1; Has a ligand-stimulated tyrosine-protein kinase activity. Required for cell survival. Regulates body size and organ size by altering cell number and cell size in a cell-autonomous manner. Involved in the development of the embryonic nervous system, and is necessary for axon guidance and targeting in the visual system. Also plays a role in life-span determination. (2144 aa) |
| | klg | LD10776p; Klingon (klg) encodes a homophilic cell adhesion molecule that is regulated by Notch signalling. It is involved in long term memory formation and photoreceptor cell commitment. (545 aa) |
| | Kal1 | Kallmann syndrome 1; Peptidase inhibitor activity. It is involved in the biological process described with: neuron differentiation. (525 aa) |
| | Wsck | Putative tyrosine-protein kinase Wsck; Putative receptor with tyrosine-protein kinase activity. (791 aa) |
| | CG5984 | Uncharacterized protein; Actin binding. It is involved in the biological process described with: actin cytoskeleton organization; cell differentiation. (271 aa) |
| | DIP-gamma | Dpr-interacting protein gamma (DIP-gamma) encodes a single-pass membrane protein expressed in the larval ventral nerve chord and pupal and adult optic lobe. It is required for synaptic development and survival, and interacts with the product of dpr11 to guide synaptic connectivity in the optic lobe. (413 aa) |
| | betaGlu | Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family. (686 aa) |
| | CG15117 | Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family. (670 aa) |
| | Sema2a | Semaphorin-2A; Semaphorin 2a (Sema2a) encodes a secreted member of the semaphorin protein family. It utilizes the receptor encoded by PlexB to mediate both repulsive and attractive axon guidance. It also utilizes the transmembrane semaphorin encoded by Sema1a as a receptor for dendrite process guidance. (724 aa) |
| | Tmem131 | Transmembrane protein 131 homolog. (1567 aa) |
| | CG17716 | Uncharacterized protein, isoform A; CG17716 encodes a predicted secreted immunoglobulin domain protein expressed in the embryonic central nervous system. (822 aa) |
| | AGBE | 1,4-Alpha-Glucan Branching Enzyme (AGBE) encodes a protein that is inferred to be a hydrolase involved in glycogen synthesis and hypoxia, based on the function of its orthologs. It contributes to the determination of lifespan. (685 aa) |
| | fra | Frazzled, isoform A; Frazzled (fra) encodes a DCC-like Netrin receptor that mediates axon guidance. It also contributes to dendrite guidance, development and morphogenesis. (1526 aa) |
| | Lac | Lachesin (Lac) encodes a cell surface protein that belongs to the Ig superfamily. It is required for the proper ultrastructural organisation of septate junctions. Lac is required for tracheal system morphogenesis and for muscle contractions associated with peristalsis. (359 aa) |
| | otk2 | Off-track2 (otk2) encodes a single-pass transmembrane protein with extracellular Ig-like repeats that functions as a coreceptor for the product of Wnt2. (433 aa) |
| | otk | Tyrosine-protein kinase-like otk; Acts as a calcium-dependent, homophilic cell adhesion molecule that regulates neural recognition during the development of the nervous system. Component of the repulsive Plexin signaling response to regulate motor axon guidance at the embryonic stage. Also component of a receptor complex that is required in the adult visual system to innervate the lamina layer; specific targeting of R1-R6 axons; Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. (1033 aa) |
| | CG1371 | Uncharacterized protein; Carbohydrate binding. (1199 aa) |
| | hig | Hikaru genki (hig) encodes a secretory matrix protein localized to the synaptic clefts of cholinergic synapses. It is required for the accumulation of acetylcholine receptor subunits on the postsynaptic membranes. (958 aa) |
| | alc | Alicorn, isoform A; Protein kinase binding. It is involved in the biological process described with: regulation of catalytic activity; maintenance of apical/basal cell polarity; neuron cellular homeostasis. (341 aa) |
| | Eph | Eph receptor tyrosine kinase (Eph) encodes an axon guidance molecule involved in the development of the nervous system. It also contributes to shaping the antero-posterior compartment boundary of the wing disc. (1096 aa) |
| | PlexA | Plexin A (PlexA) encodes a transmembrane receptor for Semaphorin ligands encoded by Sema1a and Sema1b. The intracellular region of this receptor has GTPase activating protein (GAP) activity on Ras/Rap small GTPases. The signaling by the product of PlexA alters actin, microtubules and cell adhesion in developmental processes such as axon guidance. (1945 aa) |
| | Rel | Nuclear factor NF-kappa-B p110 subunit; Plays a key role in the humoral immune response. Rel-p68 subunit translocates to the nucleus where it binds to the promoter of the Cecropin A1 gene and probably other antimicrobial peptide genes. I-kappa-B kinase complex (IKKbeta and key) and PGRP-LC are essential signaling components in transmitting the lipopolysaccharide (LPS) signal leading to cact degradation for NF-kappa-B (rel) activation. Part of a Toll-related receptor pathway that functions in the apoptosis of unfit cells during cell competition. May be part of a NF-kappa-B and Tollo sig [...] (971 aa) |
| | CG6867 | FI21454p1; It is involved in the biological process described with: motor neuron axon guidance; synaptic target inhibition. (949 aa) |
| | Pxn | Peroxidasin; Plays a role in extracellular matrix consolidation, phagocytosis and defense. (1527 aa) |
| | dpr1 | Defective proboscis extension response 1, isoform A; It is involved in the biological process described with: sensory perception of salty taste; synapse organization; salt aversion. (367 aa) |
| | side-III | Sidestep III, isoform O. (1689 aa) |
| | side-VI | Sidestep VI, isoform B. (1087 aa) |
| | sns | Sticks and stones (sns) encodes a single-pass transmembrane protein of the immunoglobulin superfamily, which mediates cell-cell recognition and adhesion. The product of sns marks the fusion competent population of myoblasts. It also contributes to formation and function of the nephrocyte diaphragm and cell sorting within the developing ommatidia. (1542 aa) |
| | side-VIII | Sidestep VIII, isoform B. (1201 aa) |
| | Fas3 | Fasciclin-3; Mediates cell adhesion in a Ca(2+)-independent manner. It plays a role in axon outgrowth, guidance and fasciculation of the developing nervous system. (577 aa) |
| | kn | Transcription factor collier; May act as a 'second-level regulator' of head patterning. Required for establishment of the PS(-1)/PS0 parasegmental border and formation of the intercalary segment. Required for expression of the segment polarity genes hedgehog, engrailed and wingless, and the segment-identity genes CAP and collar in the intercalary segment. Required at the onset of the gastrulation for the correct formation of the mandibular segment. (689 aa) |
| | NFAT | NFAT nuclear factor, isoform B; DNA-binding transcription factor activity; chromatin binding; transcription factor binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding. It is involved in the biological process described with: positive regulation of transcription by RNA polymerase II; negative regulation of synaptic vesicle exocytosis; response to salt stress. (1457 aa) |
| | DIP-iota | Dpr-interacting protein iota; It is involved in the biological process described with: synapse organization. (376 aa) |
| | Unc-89 | Obscurin; Structural component of the muscle M line which is involved in assembly and organization of sarcomere. Required for the development and organization of indirect flight muscle sarcomeres by regulating the formation of M line and H zone and the correct assembly of thick and thin filaments in the sarcomere. Likely to have serine/threonine-protein kinase activity as one of the two protein kinase domains appears to be functional (Probable). (4218 aa) |
| | Ptp52F | Protein tyrosine phosphatase 52F (Ptp52F) encodes a transmembrane receptor tyrosine phosphatase (RPTP). It genetically interacts with the other RPTP genes and its mutants have motor axon defects. It regulates Tartan signaling in embryonic SNa motor neurons. (1433 aa) |
| | beat-VII | Beaten path VII; It is involved in the biological process described with: heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. (517 aa) |
| | DIP-beta | Dpr-interacting protein beta, isoform C; It is involved in the biological process described with: synapse organization. (555 aa) |
| | DIP-epsilon | Dpr-interacting protein epsilon; It is involved in the biological process described with: synapse organization. (467 aa) |
| | mtgo | Miles to go, isoform E. (2064 aa) |
| | dpr13 | Defective proboscis extension response 13, isoform B; It is involved in the biological process described with: synapse organization; sensory perception of chemical stimulus. (419 aa) |
| | dpr4 | Defective proboscis extension response 4; It is involved in the biological process described with: synapse organization; sensory perception of chemical stimulus. (323 aa) |
| | Camta | Calmodulin-binding transcription activator (Camta) encodes a Ca[2+]-responsive transcription factor that either binds directly to DNA sequences containing a CGCG core motif or functions as a coactivator of NKX2 transcription factors. It mediates various physiological functions, including the regulation of visual signal transduction, memory formation and cell survival. (2044 aa) |
| | dpr12 | Defective proboscis extension response 12, isoform C; It is involved in the biological process described with: sensory perception of chemical stimulus; synaptic target recognition; synapse organization. (326 aa) |
| | beat-Ib | Beaten path Ib, isoform A; It is involved in the biological process described with: heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; motor neuron axon guidance. (327 aa) |
| | kek3 | Kekkon 3, isoform A. (1021 aa) |
| | mesh | Protein mesh; Required, together with Ssk and Tsp2A, for the proper organization of smooth septate junctions (sSJs), probably by mediating cell adhesion via its homophilic interaction. Also required for the correct subcellular localization of several sSJ components, such as Ssk, cora and l(2)gl, and for the barrier function of the midgut epithelium. Required for maintaining the three-layered structure of the proventriculus. (1454 aa) |
| | CG7166 | IP11255p; Axon guidance receptor activity. It is involved in the biological process described with: synapse organization; homophilic cell adhesion via plasma membrane adhesion molecules. (467 aa) |
| | bt | Bent, isoform F; Bent (bt) encodes the protein Projectin, a large protein associated with myosin thick filaments in insect muscles that contributes to the stiffness of flight muscle. (8933 aa) |
| | Dif | Dorsal-related immunity factor Dif; Mediates an immune response in larvae. DIF binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of the immunity gene CECA1. Involved in the melanization immune response to bacterial challenge, possibly by acting in a Toll signaling pathway that downregulates Spn27A in response to infection. Part of a signaling pathway involving NF-kappa-B (rel) and Toll-related receptors, that functions in the apoptosis of unfit cells during cell competition. May be part of a NF-kappa-B and Tollo signaling cascade that regulates dev [...] (987 aa) |
| | Ptp4E | Protein tyrosine phosphatase 4E (Ptp4E) encodes a transmembrane receptor tyrosine phosphatase closely related to the product of Ptp10D. Ptp4E single mutants have no known phenotypes. However, Ptp4E-Ptp10D double mutants have lethal respiratory defects. The product of Ptp4E regulates signaling through the receptor tyrosine kinases encoded by Egfr, btl and Pvr. (1767 aa) |
| | Ppn | Papilin; Essential extracellular matrix (ECM) protein that influences cell rearrangements. May act by modulating metalloproteinases action during organogenesis. Able to non-competitively inhibit procollagen N- proteinase, an ADAMTS metalloproteinase; Belongs to the papilin family. (2898 aa) |
| | lbk | Lambik. (1252 aa) |
| | Hasp | Hig-anchoring scaffold protein, isoform G; Peptidase inhibitor activity. (1677 aa) |
| | Pvr | Receptor protein-tyrosine kinase; PDGF- and VEGF-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (encoded by Pvf1, Pvf2 or Pvf3). It is involved in cell migration regulation and it has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1, Rho family small GTPases and the JNK cascade, in a context-dependent manner. (1577 aa) |
| | CG42658 | MSP domain-containing protein; FFAT motif binding. It is involved in the biological process described with: endoplasmic reticulum membrane organization; endoplasmic reticulum-plasma membrane tethering. (131 aa) |
| | DIP-eta | Dpr-interacting protein eta, isoform B; It is involved in the biological process described with: synapse organization. (450 aa) |
| | Ptp99A | Protein tyrosine phosphatase 99A (Ptp99A) encodes a transmembrane receptor tyrosine phosphatase. Its single mutants have no known phenotypes, but Ptp99A synergizes with Ptp69D to increase the penetrance of the Ptp69D motor axon defects. Ptp99A mutations also suppress the 'bypass' motor axon phenotype produced by Lar mutations; Belongs to the protein-tyrosine phosphatase family. Receptor class subfamily. (1397 aa) |
| | Trim9 | E3 ubiquitin-protein ligase TRIM9; E3 ubiquitin-protein ligase activity (By similarity). During embryonic and larval development, regulates the pattern of axonal projections of class IV nociceptive sensory neurons (C4da) downstream of netrin receptor fra. Regulates fine-scale topography of C4da axon terminals upon neuronal activity. During eye development, consolidates the attachment of R8 photoreceptor growth cones to the target medulla layer, probably downstream of fra. Belongs to the TRIM/RBCC family. (740 aa) |
| | Rbp | RIM-binding protein, isoform F; RIM-binding protein (Rbp) encodes an active zone protein involved in neuromuscular synaptic transmission and presynaptic active zone organization. (1844 aa) |
| | nrm | Neuromusculin, isoform E; Neuromusculin (nrm) encodes a protein involved in synaptic target recognition. (2192 aa) |
| | plum | Plum, isoform B; Plum (plum) encodes an Ig-superfamily transmembrane protein. It is required for developmental pruning of both mushroom body neurons and motor neurons via TGF-beta signaling. plum genetically interacts with myo and babo. (1298 aa) |
| | CG16974 | LD10349p. (1257 aa) |
| | Nrg | Neuroglian; The long isoform may play a role in neural and glial cell adhesion in the developing embryo. The short isoform may be a more general cell adhesion molecule involved in other tissues and imaginal disk morphogenesis. Vital for embryonic development. Essential for septate junctions. Septate junctions, which are the equivalent of vertebrates tight junctions, are characterized by regular arrays of transverse structures that span the intermembrane space and form a physical barrier to diffusion. Required for the blood-brain barrier formation. (1309 aa) |
| | Dg | Dystroglycan, isoform D; Dystroglycan (Dg) encodes a major non-integrin extracellular matrix (ECM) receptor that connects the ECM to the actin cytoskeleton. It regulates animal survival and temperature preference, muscle integrity, myotendinous and neuromuscular junction formation and function, nervous system development, axon pathfinding, rhabdomere differentiation, neuronal stem cell division and epithelial polarity. (1262 aa) |
| | Dscam1 | Down syndrome cell adhesion molecule 1, isoform BX; Identical protein binding; antigen binding; protein homodimerization activity; axon guidance receptor activity; cell-cell adhesion mediator activity. (2038 aa) |
| | CG14964 | Uncharacterized protein. (1443 aa) |
| | dpr14 | Defective proboscis extension response 14, isoform A; It is involved in the biological process described with: synapse organization; sensory perception of chemical stimulus. (340 aa) |
| | nolo | No long nerve cord (nolo) encodes a protein involved in ventral cord development. (1394 aa) |
| | fred | Friend of echinoid (fred) encodes a protein involved in cuticle biosynthesis and ommatidial rotation. (1447 aa) |
| | PlexB | Plexin-B; Involved in peripheral and central nervous system axon guidance. Acts as a receptor for Sema-2a and seems to transduce signal by suppressing Rac activity and enhancing Rho activity. Belongs to the plexin family. (2051 aa) |
| | CG31431 | MIP21433p. (361 aa) |
| | side-IV | Sidestep IV, isoform C. (1001 aa) |
| | side | Sidestep, isoform C; Sidestep (side) encodes a transmembrane protein of the immunoglobulin superfamily that is expressed in a defined spatiotemporal pattern in glial cells, sensory neurons and muscles. It functions as an attractive guidance cue to guide motor axons to their target regions. (986 aa) |
| | CG15312 | Uncharacterized protein, isoform D. (464 aa) |
| | kek5 | Kekkon 5 (kek5) encodes a transmembrane protein involved in BMP signaling regulation. (931 aa) |
| | CG33543 | Uncharacterized protein. (468 aa) |
| | kirre | Kin of irre (kirre) encodes a transmembrane protein of the Ig superfamily that is involved in heterotypic interactions with the product of sns. Interactions with intracellular adaptors regulate cytoskeleton dynamics. Its biological roles include myoblast aggregation and fusion, nephrocyte diaphragm formation, and cell sorting in the eye and wing imaginal discs. (956 aa) |
| | Scgalpha | Sarcoglycan alpha, isoform C; Structural constituent of muscle; calcium ion binding. (453 aa) |
| | beat-IIIb | Beaten path IIIb, isoform D; It is involved in the biological process described with: motor neuron axon guidance; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. (404 aa) |
| | robo2 | Roundabout 2 (robo2) encodes a member of the Robo receptor family that responds to the ligand encoded by sli as a repulsive cue in axons, dendrites, muscles, trachea and heart development. It can also inhibit robo1 signaling, likely explaining why the product of robo2 can appear to be an attractive receptor in certain contexts. (1519 aa) |
| | kek6 | Kekkon 6, isoform B; Neurotrophin binding; neurotrophin receptor activity. It is involved in the biological process described with: regulation of synaptic plasticity. (843 aa) |
| | CG33523 | Uncharacterized protein, isoform F. (654 aa) |
| | Dscam3 | Down syndrome cell adhesion molecule 3 (Dscam3) encodes a large transmembrane protein that functions in homophilic cell adhesion. It may also function as an axon guidance receptor. (2087 aa) |
| | jbug | Jitterbug, isoform N; Jitterbug (jbug) encodes a Filamin-type protein. Filamins are actin crosslinkers that organize actin filaments into networks and connect them to membrane receptors. The product of jbug is required in photoreceptor cells for axon targeting and in notum tendon cells to maintain its shape during muscle-tendon interaction. (2990 aa) |
| | side-V | Sidestep V, isoform B. (1174 aa) |
| | Dscam2 | Down syndrome cell adhesion molecule 2 (Dscam2) encodes a transmembrane protein. Its alternative splicing produces two biochemically distinct homophilic binding proteins expressed in different cells. It can mediate both repulsion and adhesion between neurons and contributes to boundary formation, neurite targeting and synapse formation in the brain. (2101 aa) |
| | Ptp10D | Protein tyrosine phosphatase 10D (Ptp10D) encodes a transmembrane receptor tyrosine phosphatase closely related to the product of Ptp4E. Ptp4E-Ptp10D double mutants have lethal respiratory defects. Ptp10D-Ptp69D double mutants have a strong phenotype in which embryonic CNS axons abnormally cross the ventral midline. The product of Ptp10D regulates signaling through the receptor tyrosine kinases encoded by Egfr, btl and Pvr. It also binds to the product of sas to regulate its signaling in glia. (1990 aa) |
| | Lar | Tyrosine-protein phosphatase Lar; Possible cell adhesion receptor (Probable). It possesses an intrinsic protein tyrosine phosphatase activity (PTPase). It controls motor axon guidance. In the developing eye, has a role in normal axonal targeting of the R7 photoreceptor, where it negatively regulates bdl. Inhibits bdl cell adhesion activity in vitro; this effect is independent of its PTPase function. (2032 aa) |
| | Tep4 | Thioester-containing protein 4 (Tep4) is a member of the Thioester-containing proteins (TEP) family of genes. The product of Tep4 has endopeptidase inhibitor activity and participates in the cellular immune response to certain Gram-negative bacteria. (1498 aa) |
| | side-VII | Sidestep VII, isoform A. (939 aa) |
| | zormin | Zormin, isoform J; Zormin (zormin) encodes a protein found in the Z-disc and the M-line of muscles. It probably has a structural function. (3664 aa) |
| | kek1 | Kekkon 1 (kek1) encodes a transmembrane protein that acts in a negative feedback loop to modulate the activity of the product of Egfr in a number of tissues, including follicle cells and imaginal discs. It also plays a role in axonal outgrowth in the central nervous system. (880 aa) |
| | beat-IV | Beaten path IV, isoform B; It is involved in the biological process described with: motor neuron axon guidance; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. (446 aa) |
| | sls | Titin; Key component in the assembly and functioning of adult and embryonic striated muscles and muscle tendons. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase. (18468 aa) |
| | CG42346 | Uncharacterized protein, isoform C. (1817 aa) |
| | beat-VI | Beaten path VI, isoform A; It is involved in the biological process described with: motor neuron axon guidance; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. (332 aa) |
| | Dscam4 | Down syndrome cell adhesion molecule 4 (Dscam4) one of four Dscam paralogs in the D. melanogaster genome. It encodes a homophilic cell adhesion molecule that regulates interactions between dendrites and axons in the visual system. (1935 aa) |
| | DIP-delta | Dpr-interacting protein delta, isoform D; It is involved in the biological process described with: synapse organization. (469 aa) |
| | DIP-alpha | Dpr-interacting protein alpha, isoform A; It is involved in the biological process described with: synapse organization. (554 aa) |
| | ed | Echinoid, isoform A; Echinoid (ed) encodes a cell adhesion molecule of adherens junctions that mediate cell adhesion/recognition. It participates in multiple signaling pathways including Egfr, Notch and Hippo during organogenesis. It is also required in multiple steps of dorsal closure during embryogenesis. (1332 aa) |
| | dpr7 | Defective proboscis extension response 7, isoform F; It is involved in the biological process described with: synapse organization; sensory perception of chemical stimulus. (312 aa) |
| | kek4 | Kekkon 4, isoform A. (649 aa) |
| | CG4238 | Uncharacterized protein, isoform D; Ubiquitin protein ligase activity; ubiquitin-protein transferase activity. (977 aa) |
| | dpr3 | Defective proboscis extension response 3, isoform B; It is involved in the biological process described with: sensory perception of chemical stimulus; synapse organization; store-operated calcium entry. (522 aa) |
| | boi | Brother of ihog (boi) encodes a transmembrane protein that binds to the product of hh. The products of boi and ihog promote Hh signaling in receiving cells by acting as a co-receptor for the effector protein encoded by ptc. The product of boi also can suppress Hh signaling through a sequestration and release mechanism in cells producing the product of hh. It regulates many hh-dependent processes including proliferation, cell fate specification, and patterning. (1105 aa) |
| | sas | Putative epidermal cell surface receptor; Stranded at second (sas) encodes a single-pass transmembrane protein that localizes to the apical cell surface in polarized epithelia, such as the embryonic/larval salivary gland (SG). Overexpression of sas in the developing SG leads to all membrane domains taking on apical membrane character, with the exception of the region where septate junctions form. (1693 aa) |
| | dpr21 | Defective proboscis extension response 21; It is involved in the biological process described with: synapse organization. (282 aa) |
| | robo3 | Roundabout 3, isoform A. (1342 aa) |
| | CG44153 | Uncharacterized protein, isoform A; G protein-coupled receptor activity; cell-cell adhesion mediator activity. It is involved in the biological process described with: axon guidance; dendrite self-avoidance; homophilic cell adhesion via plasma membrane adhesion molecules. (1946 aa) |
| | beat-Vc | Beaten path Vc; It is involved in the biological process described with: heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; motor neuron axon guidance. (297 aa) |
| | dpr11 | Defective proboscis extension response 11 (dpr11) encodes a protein involved in axon guidance and regulation of neuromuscular junction development. (360 aa) |
| | Strn-Mlck | Stretchin-Mlck, isoform U; Stretchin-Mlck (Strn-Mlck) encodes a complex locus producing many large protein isoforms, which likely regulate cytoskeletal dynamics in muscles. A shorter isoform is specifically expressed in indirect flight muscle, localizes to the thick filament and is required to prevent flight muscle hypercontraction. Strn-Mlck mutants cannot fly and show flight muscle atrophy. (8255 aa) |
| | beat-Va | Beaten path Va, isoform A; It is involved in the biological process described with: heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; motor neuron axon guidance. (300 aa) |
| | cher | Filamin-A; Cheerio (cher) encodes a dimeric F-actin crosslinking protein of the filamin protein family. It functions to organize the F-actin cytoskeleton in multiple contexts including ovarian germline ring canals, migrating somatic cells, and neuronal growth cones. (2429 aa) |
| | dpr16 | Defective proboscis extension response 16, isoform C; It is involved in the biological process described with: synapse organization; sensory perception of chemical stimulus. (488 aa) |
| | CG34353 | Uncharacterized protein, isoform C; Axon guidance receptor activity. It is involved in the biological process described with: gravitaxis; synapse organization; homophilic cell adhesion via plasma membrane adhesion molecules. (581 aa) |
| | CG6044 | RH13652p. (229 aa) |
| | babos | Babos, isoform A; Babos (babos) encodes a cell surface protein that belongs to the group of immunoglobulin superfamily cell adhesion molecules. If functions in learning and memory, as well as in developmental dendrite plasticity. (196 aa) |
| | CG5445 | MIP08896p; Ubiquitin binding. It is involved in the biological process described with: macroautophagy. (303 aa) |
| | unc-5 | Netrin receptor unc-5; Receptor for netrin required for motor axon guidance. Mediates both short- and long-range axon motor repulsion in the developing nervous system upon ligand binding. Also involved in glial migration. While short-range repulsion requires both fra and unc-5, long-range repulsion only requires unc-5. (1072 aa) |
| | beat-IIIa | Beaten path IIIa, isoform D; It is involved in the biological process described with: motor neuron axon guidance; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. (343 aa) |
| | sdk | Protein sidekick; Participates in homotypic or heterotypic interactions in the eye during pattern formation to prevent extra cells from joining the precluster and differentiating as photoreceptor cells. (2265 aa) |
| | dpr2 | Defective proboscis extension response 2, isoform F; It is involved in the biological process described with: synapse organization; sensory perception of chemical stimulus. (410 aa) |
| | Vap33 | VAMP-associated protein 33kDa, isoform B; VAMP-associated protein 33kDa (Vap33) encodes a protein that plays a conserved role in synaptic homeostasis. It controls a number of processes which depend on phosphoinositide levels, such as synaptic growth and axonal transport. It binds to the product of Sac1 to maintain normal levels of phosphoinositides and to the product of Dscam1 to affect its localization within axonal projections. (269 aa) |
| | trol | Terribly reduced optic lobes (trol) encodes the extracellular matrix component Perlecan, a secreted heparan sulfate proteoglycan. It regulates cell-signaling by multiple growth factors including those in the hedgehog, wingless/WNT, FGF, TGFbeta, EGF, and VEGF families, thus playing a role in many developmental patterning decisions. (4479 aa) |
| | CG13506 | FI23916p1; Axon guidance receptor activity. It is involved in the biological process described with: synapse organization; homophilic cell adhesion via plasma membrane adhesion molecules. (503 aa) |
| | CG33143 | Uncharacterized protein, isoform F. (757 aa) |
| | robo1 | Roundabout 1 (robo1) encodes a member of the Robo receptor family that uses the secreted glycoprotein encoded by sli as ligand and the products of Sdc and Dscam1 as co-receptors. It contributes to axon guidance and dendrite morphogenesis as well as regulating trachea and heart tube development. (1395 aa) |
| | Fas2 | Fasciclin-2; Neuronal recognition molecule for the MP1 axon pathway, pathway recognition for axons during the development of nerve fascicles. (885 aa) |
| | beat-Ic | Beaten path Ic (beat-Ic) encodes a protein involved in axon guidance. (534 aa) |
| | beat-Ia | Beaten path Ia (beat-Ia) encodes a transmembrane protein and the founding member of the beat family of proteins, which is part of the immunoglobulin superfamily. It is required for the selective defasciculation of motor axons. (437 aa) |
| | rst | Irregular chiasm C-roughest protein; Roughest (rst) encodes a multi-purpose transmembrane protein that is well studied in the fly eye and muscle during development. It interacts with the transmembrane ligand encoded by hbs to guide cell movement. (764 aa) |
| | wake | Wide awake, isoform G; Wide awake (wake) encodes a clock output molecule that regulates the timing of sleep onset. It upregulates the GABA receptor encoded by Rdl in the arousal-promoting large ventrolateral neurons, thus suppressing activity of the these cells at dusk and facilitating sleep onset at that time. (1648 aa) |
| | dpr6 | Defective proboscis extension response 6, isoform F; It is involved in the biological process described with: synapse organization; sensory perception of chemical stimulus. (396 aa) |
| | CG6527 | GEO13014p1; FFAT motif binding. It is involved in the biological process described with: endoplasmic reticulum membrane organization; endoplasmic reticulum-plasma membrane tethering. (166 aa) |
| | Hcf | HCF C-terminal chain; May be involved in control of the cell cycle. (1500 aa) |
| | hbs | Hibris, isoform B; Hibris (hbs) encodes a Ig repeat transmembrane protein with a fibronectin type III domain. It functions as a receptor involved in muscle cell fusion. (1235 aa) |
| | side-II | Sidestep II, isoform A. (1064 aa) |
| | CG45263 | Uncharacterized protein, isoform E. (1876 aa) |
| | CG15824 | Uncharacterized protein, isoform B. (1957 aa) |
| | hiw | E3 ubiquitin-protein ligase highwire; Atypical E3 ubiquitin-protein ligase which specifically mediates ubiquitination of threonine and serine residues on target proteins, instead of ubiquitinating lysine residues (By similarity). Shows esterification activity towards both threonine and serine, with a preference for threonine, and acts via two essential catalytic cysteine residues that relay ubiquitin to its substrate via thioester intermediates (By similarity). Required in the presynaptic motoneuron to down-regulate the levels of wnd and restrain synaptic terminal growth at the neuromu [...] (5233 aa) |
| | Sdr | Secreted decoy of InR (Sdr) encodes a secreted protein that shows extensive sequence similarity to the extracellular domain of the product of InR. It physically binds to insulin-like peptides and thereby modulates the insulin/IGF signaling pathway. (868 aa) |
| | dpr9 | Defective proboscis extension response 9, isoform A; It is involved in the biological process described with: behavioral response to ethanol; synapse organization; sensory perception of chemical stimulus. (602 aa) |
| | DIP-lambda | Dpr-interacting protein lambda. (548 aa) |
