STRINGSTRING
Usp5 Usp5 Ack Ack CG15047 CG15047 Tdrd3 Tdrd3 Cbl Cbl CG8209 CG8209 CG31528 CG31528 CG3223 CG3223 CG10435 CG10435 CG10694 CG10694 CG5111 CG5111 gw gw ref(2)P ref(2)P Vps13D Vps13D HERC2 HERC2 CG15445 CG15445 par-1 par-1 FBgn0028372 FBgn0028372 CG13604 CG13604 Rad23 Rad23 hyd hyd HUWE1 HUWE1 Ubqn Ubqn rngo rngo Ubc4 Ubc4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Usp5Ubiquitin carboxyl-terminal hydrolase; Ubiquitin specific protease 5 (Usp5) encodes an essential enzyme that cleaves unanchored lysine48-linked polyubiquitin chains. It is involved in photoreceptor differentiation, neuron pathfinding and apoptosis. (827 aa)
AckActivated Cdc42 kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1073 aa)
CG15047MIP23504p. (174 aa)
Tdrd3Tudor domain containing 3; RNA binding. It is involved in the biological process described with: mRNA processing. (836 aa)
CblCbl proto-oncogene (Cbl) encodes an E3 protein-ubiquitin ligase for protein post-translational modification in RTK signaling (EGFR, VEGFR, FGF, and RET families) and non-RTK signaling (Src family). After the ubiquitination mediated by the product of Cbl, the substrates will be targeted to protein degradation for controlling cell growth, survival, migration and inflammation. (878 aa)
CG8209GM09977p; Nucleic acid binding. (331 aa)
CG31528FI07626p; Polyubiquitin modification-dependent protein binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process. (344 aa)
CG3223GH08043p; Polyubiquitin modification-dependent protein binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process. (415 aa)
CG10435LD44032p; Ubiquitin binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. (495 aa)
CG10694AT15685p; Ubiquitin binding; polyubiquitin modification-dependent protein binding; damaged DNA binding; proteasome binding. It is involved in the biological process described with: nucleotide-excision repair; proteasome-mediated ubiquitin-dependent protein catabolic process. (290 aa)
CG5111FI08017p; It is involved in the biological process described with: protein ubiquitination; regulation of ubiquitin-dependent protein catabolic process. (614 aa)
gwProtein Gawky; Required for gene silencing mediated by micro-RNAs (miRNAs). Silences both polyadenylated and deadenylated mRNAs. Required for miRNA-mediated translational repression and mRNA decay. Not required for miRNA target recognition. Necessary to initiate but not to maintain silencing. Promotes mRNA deadenylation through the recruitment of the CCR4-NOT and PAN complexes and promotes decapping by the DCP1-DCP2 complex. Dissociates from silenced mRNAs after deadenylation. Required for completion of nuclear divisions during early embryonic development. Belongs to the GW182 family. (1384 aa)
ref(2)PProtein ref(2)P; Required for selective autophagy activation by ubiquitinated proteins. Implicated in sigma rhabdovirus multiplication and necessary for male fertility. Involved in activating transcription of Drs. (599 aa)
Vps13DVacuolar protein sorting-associated protein 13D; Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission. Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis. (3919 aa)
HERC2Probable E3 ubiquitin-protein ligase HERC2; Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (4912 aa)
CG15445LD38858p; It is involved in the biological process described with: regulation of ubiquitin-dependent protein catabolic process. (618 aa)
par-1Par-1 (par-1) encodes a protein kinase involved in multiple processes, including microtubule cytoskeleton organization, axis specification and cell polarity. It regulates hippo signaling and osk mRNA localization. (1170 aa)
FBgn0028372Isopeptidase-T-3, isoform C. (561 aa)
CG13604Protein UBASH3A homolog; Phosphatase activity. It is involved in the biological process described with: dephosphorylation. (763 aa)
Rad23DNA repair protein Rad23; Rad23 (Rad23) encodes an evolutionarily conserved member of the proteasome-associated proteins. It acts as a shuttle -or bridge- protein helping ubiquitinated proteins to interact with the proteasome, which in turn regulates their turnover. (414 aa)
hydE3 ubiquitin-protein ligase hyd; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity). Required for regulation of cell proliferation in imaginal disks and germ cells. Acts as a negative regulator of hh, ci and dpp expression in the anterior of the eye disk. (2887 aa)
HUWE1Uncharacterized protein, isoform H; Ubiquitin-protein transferase activity; ubiquitin protein ligase activity. It is involved in the biological process described with: protein ubiquitination; ubiquitin-dependent protein catabolic process; protein polyubiquitination; dsRNA transport. (5151 aa)
UbqnUbiquilin, isoform A; Ubiquilin (Ubqn) encodes a protein containing an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. It binds and delivers ubiquitinated, misfolded or no longer functionally required proteins to the ubiquitin-proteasome system and/or autophagy. (547 aa)
rngoRings lost (rngo) encodes a ubiquitin receptor that binds to ubiquitinated proteins via its ubiquitin-associated domain. It is an essential protein that is required for proper development of ring canals in the female germ line. (458 aa)
Ubc4Ubiquitin-conjugating enzyme E2-22 kDa; Catalyzes the covalent attachment of ubiquitin to other proteins. (199 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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