STRINGSTRING
Rbpn-5 Rbpn-5 CG5334 CG5334 CG5347 CG5347 CG32581 CG32581 CG8974 CG8974 narya narya CG12477 CG12477 l(3)73Ah l(3)73Ah elgi elgi CG32847 CG32847 Pex2 Pex2 Cbl Cbl msl-2 msl-2 Mkrn1 Mkrn1 dgrn dgrn CG2926 CG2926 CG8419 CG8419 CG8141 CG8141 mdlc mdlc Sce Sce nenya nenya CG2218 CG2218 POSH POSH Mat1 Mat1 CG13605 CG13605 elfless elfless CG17048 CG17048 CG33144 CG33144 CG43058 CG43058 CG32369 CG32369 CG34289 CG34289 qin qin Su(z)2 Su(z)2 Hakai Hakai CG7376 CG7376 Rnf146 Rnf146 Topors Topors roq roq CG44271 CG44271 CG9014 CG9014 Bre1 Bre1 Psc Psc CG5071 CG5071 CG34308 CG34308 CG46383 CG46383 mei-P26 mei-P26 Pex10 Pex10 ari-2 ari-2 CG12099 CG12099 Traf6 Traf6 vilya vilya
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Rbpn-5Rabaptin-5 (Rbpn-5) encodes a Rab GTPase binding protein involved in regulation of endosome size. (647 aa)
CG5334Ubiquitin-protein transferase activity; zinc ion binding; metal ion binding; ubiquitin protein ligase activity. It is involved in the biological process described with: protein polyubiquitination. (210 aa)
CG5347LP05025p; Metal ion binding; ubiquitin protein ligase activity; zinc ion binding; ubiquitin-protein transferase activity. It is involved in the biological process described with: protein polyubiquitination. (285 aa)
CG32581RE35552p; Ubiquitin protein ligase activity; ubiquitin-protein transferase activity; zinc ion binding; ubiquitin-like protein conjugating enzyme binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; ER-associated misfolded protein catabolic process; protein ubiquitination. (283 aa)
CG8974GH14055p; Ubiquitin protein ligase activity; ubiquitin-like protein conjugating enzyme binding; zinc ion binding; ubiquitin-protein transferase activity. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; protein ubiquitination; ER-associated misfolded protein catabolic process. (277 aa)
naryaRING finger protein narya; Required for the formation of DNA double-strand breaks (DSBs) together with nenya and vilya during the meiotic recombination process. Plays a role in DSBs processing into crossovers. Plays a redundant role with nenya in chromosome segregation during female meiosis. (211 aa)
CG12477IP09428p; Metal ion binding; ubiquitin protein ligase activity; ubiquitin-protein transferase activity; zinc ion binding. It is involved in the biological process described with: protein polyubiquitination. (265 aa)
l(3)73AhLethal (3) 73Ah, isoform A; RNA polymerase II regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity; zinc ion binding. It is involved in the biological process described with: histone H2A-K119 monoubiquitination; inactivation of X chromosome by genetic imprinting. (222 aa)
elgiEarly girl (elgi) encodes a myosin binding protein involved in the regulation of meiosis and Fat signaling pathway. (315 aa)
CG32847GEO10296p1; Ubiquitin-like protein conjugating enzyme binding; ubiquitin-protein transferase activity; zinc ion binding; ubiquitin protein ligase activity. It is involved in the biological process described with: ER-associated misfolded protein catabolic process; protein ubiquitination; ubiquitin-dependent protein catabolic process. (164 aa)
Pex2Peroxin 2 (Pex2) encodes a peroxisome protein important for sperm development. (281 aa)
CblCbl proto-oncogene (Cbl) encodes an E3 protein-ubiquitin ligase for protein post-translational modification in RTK signaling (EGFR, VEGFR, FGF, and RET families) and non-RTK signaling (Src family). After the ubiquitination mediated by the product of Cbl, the substrates will be targeted to protein degradation for controlling cell growth, survival, migration and inflammation. (878 aa)
msl-2E3 ubiquitin-protein ligase msl-2; The Msl proteins are essential for elevating transcription of the single X chromosome in the male (X chromosome dosage compensation). Msl-2 is required for translation and/or stability of msl-1 in males. In complex with msl-1, acts as an E3 ubiquitin ligase that promotes ubiquitination of histone H2B. Belongs to the MSL2 family. (773 aa)
Mkrn1Makorin 1, isoform A; Ubiquitin protein ligase activity; metal ion binding; ubiquitin-protein transferase activity; zinc ion binding. It is involved in the biological process described with: protein polyubiquitination; positive regulation of insulin receptor signaling pathway; positive regulation of oogenesis. (386 aa)
dgrnDegringolade, isoform A; Degringolade (dgrn) encodes a SUMO-Targeted ubiquitin ligase. During development it is required for Notch signaling and patterning. It contributes to transcriptional regulation, DNA repair, and cytoskeleton dynamics. (319 aa)
CG2926Uncharacterized protein, isoform A; Zinc ion binding. It is involved in the biological process described with: regulation of alternative mRNA splicing, via spliceosome. (2296 aa)
CG8419FI06716p; Ubiquitin-protein transferase activity; zinc ion binding. It is involved in the biological process described with: positive regulation of transcription, DNA-templated; protein autoubiquitination. (921 aa)
CG8141RING-type domain-containing protein; Ubiquitin protein ligase activity; zinc ion binding; ubiquitin-like protein conjugating enzyme binding. It is involved in the biological process described with: ER-associated misfolded protein catabolic process; ubiquitin-dependent protein catabolic process. (239 aa)
mdlcCG4973 protein; Midlife crisis (mdlc) encodes a nuclear protein that is required for maintaining neuronal differentiation. (357 aa)
SceE3 ubiquitin-protein ligase RING1; E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-118' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-118' ubiquitination gives a specific tag for epigenetic transcriptional repression. Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. PcG [...] (435 aa)
nenyaRING finger protein nenya; Required for the formation of DNA double-strand breaks together with narya and vilya during the meiotic recombination process. Plays a redundant role with narya in chromosome segregation during female meiosis. (219 aa)
CG2218FI06144p; Ubiquitin-protein transferase activity; ubiquitin-ubiquitin ligase activity; ubiquitin protein ligase binding; ubiquitin protein ligase activity. It is involved in the biological process described with: protein ubiquitination; protein polyubiquitination. (486 aa)
POSHPlenty of SH3s (POSH) encodes a scaffold protein that regulates TNF-JNK signaling pathway. (838 aa)
Mat1CDK-activating kinase assembly factor MAT1; Menage a trois 1 (Mat1) encodes a RING finger protein involved in the activation of the kinase encoded by Cdk7. (320 aa)
CG13605LP20373p; Ubiquitin protein ligase activity; zinc ion binding. (669 aa)
elflessElfless, isoform B; Elfless (elfless) encodes a RING-finger E3 ubiquitin ligase expressed in the tail cyst cell nuclei of testes, although it is not required for male fertility. It interacts with the apoptosis pathway (with the products of Dronc, eff, Diap1) and may be involved in tail cyst cell degradation. (229 aa)
CG17048GEO12067p1; Zinc ion binding. (124 aa)
CG33144Ubiquitin-protein transferase activity; zinc ion binding; ubiquitin conjugating enzyme binding; ubiquitin protein ligase activity. It is involved in the biological process described with: protein polyubiquitination; ubiquitin-dependent protein catabolic process; positive regulation of proteasomal ubiquitin-dependent protein catabolic process. (1102 aa)
CG43058RING-type domain-containing protein; Transcription factor binding. It is involved in the biological process described with: positive regulation of transcription by RNA polymerase II. (100 aa)
CG32369Uncharacterized protein, isoform A; Zinc ion binding. (1066 aa)
CG34289Uncharacterized protein, isoform C; Zinc ion binding. (114 aa)
qinQin (qin) is a piRNA pathway gene that encodes a protein involved in posttranscriptional gene silencing. (1857 aa)
Su(z)2Suppressor of zeste 2 (Su(z)2) encodes a protein that regulates gene expression by modifying epigenetic marks. The gene is related to Psc and was orginally identified due to its ability to suppress transvection at z. (1396 aa)
HakaiE3 ubiquitin-protein ligase Hakai; E3 ubiquitin-protein ligase required during early development. E3 ubiquitin-protein ligases mediate ubiquitination of target proteins. Required for epithelial integrity and midgut morphogenesis. Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Its function in the WMM complex is unknown. Belongs to the Hakai family. (473 aa)
CG7376Uncharacterized protein, isoform A; ATP binding; zinc ion binding; ubiquitin-protein transferase activity; ubiquitin protein ligase activity. It is involved in the biological process described with: cellular response to DNA damage stimulus; protein polyubiquitination. (1270 aa)
Rnf146MIP02988p; Zinc ion binding; ubiquitin-protein transferase activity; poly-ADP-D-ribose binding; ubiquitin protein ligase activity. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; positive regulation of canonical Wnt signaling pathway; protein destabilization; positive regulation of proteasomal ubiquitin-dependent protein catabolic process. (448 aa)
ToporsE3 ubiquitin-protein ligase Topors; Functions as a ubiquitin-protein E3 ligase. Negatively regulates the transcriptional repressor h/hairy by promoting its ubiquitination and subsequent degradation. Also directs the nuclear organization of the gypsy chromatin insulator. Chromatin insulators are regulatory elements which establish independent domains of transcriptional activity within eukaryotic genomes. Insulators have two defining properties; they can block the communication between an enhancer and a promoter when placed between them, and can also buffer transgenes from position effec [...] (1038 aa)
roqRoquin, isoform A; Ubiquitin protein ligase activity; RNA binding; metal ion binding; zinc ion binding. It is involved in the biological process described with: protein polyubiquitination. (819 aa)
CG44271RING-type domain-containing protein. (106 aa)
CG9014LP07794p; Ubiquitin protein ligase activity; ubiquitin-protein transferase activity; zinc ion binding. It is involved in the biological process described with: protein polyubiquitination; protein ubiquitination. (328 aa)
Bre1E3 ubiquitin-protein ligase Bre1; E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-117' of histone H2B. H2B 'Lys-117' ubiquitination gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It thereby plays a central role in histone code and gene regulation. Required for the expression of Notch target genes in development by affecting the levels of Su(H) in imaginal disk cells and stimulating the Su(H)-mediated transcription of Notch-specific genes. Belongs to the BRE1 family. (1044 aa)
PscPolycomb group protein Psc; Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. Component of the PcG multiprotein PRC1 complex, a complex that acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-118', rendering chromatin heritably changed in its expressibility. Needed to maintain e [...] (1601 aa)
CG5071Uncharacterized protein, isoform B; Peptidyl-prolyl cis-trans isomerase activity; zinc ion binding; cyclosporin A binding. It is involved in the biological process described with: protein folding; protein peptidyl-prolyl isomerization. (680 aa)
CG34308RING-type domain-containing protein; Ubiquitin-like protein conjugating enzyme binding; ubiquitin protein ligase activity; metal ion binding. It is involved in the biological process described with: ER-associated misfolded protein catabolic process; ubiquitin-dependent protein catabolic process. (194 aa)
CG46383RING-type domain-containing protein. (65 aa)
mei-P26Meiotic P26, isoform F; Meiotic P26 (mei-P26) encodes a protein involved in meiosis, germline differentiation and spermatogenesis. (1310 aa)
Pex10Peroxin 10 (Pex10) encodes a peroxisome protein important for sperm development. (299 aa)
ari-2Potential E3 ubiquitin-protein ligase ariadne-2; Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates; Belongs to the RBR family. Ariadne subfamily. (509 aa)
CG12099LD09551p; Zinc ion binding; ubiquitin protein ligase activity; metal ion binding; transcription regulatory region sequence-specific DNA binding. It is involved in the biological process described with: positive regulation of transcription by RNA polymerase II; protein autoubiquitination. (708 aa)
Traf6TNF-receptor-associated factor 6 (Traf6) encodes a protein that belongs to a family of adaptor proteins involved in transducing downstream signaling by interacting with cell surface receptors. It mediates the pro-inflammatory effects of Toll and related receptor signaling, and the cell death induced by JNK activation via the product of egr. (475 aa)
vilyaVilya (vilya) encodes a meiosis-specific ring-domain-containing protein that is required for programmed meiotic double-strand break formation. It also functions as a component of the recombination nodule. (237 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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