(21 nodes) DnaJ domain, conserved site network (Drosophila melanogaster)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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Your Input:
	l(3)80Fg	FI01132p; It is involved in the biological process described with: cell redox homeostasis. (780 aa)
	DnaJ-H	DnaJ homolog, isoform C; Unfolded protein binding; heat shock protein binding. It is involved in the biological process described with: protein folding. (440 aa)
	CG5001	FI02090p; Chaperone binding; unfolded protein binding. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; chaperone cofactor-dependent protein refolding. (350 aa)
	mrj	Mrj, isoform E; Unfolded protein binding; chaperone binding. It is involved in the biological process described with: chaperone-mediated protein folding; chaperone cofactor-dependent protein refolding; protein folding. (346 aa)
	CG5504	Protein tumorous imaginal discs, mitochondrial; May act as a tumor suppressor in larval imaginal disks. (520 aa)
	Droj2	DnaJ-like-2, isoform A; Unfolded protein binding; heat shock protein binding; ATP binding. It is involved in the biological process described with: response to heat; protein folding. (403 aa)
	CG6693	J domain-containing protein CG6693; Heat shock protein binding. (299 aa)
	Dph4	RE24848p; It is involved in the biological process described with: peptidyl-diphthamide biosynthetic process from peptidyl-histidine; tRNA wobble uridine modification. (183 aa)
	CG7130	GEO11142p1. (128 aa)
	shv	DnaJ homolog shv; Maintains stem cell niche architecture in the testes. Activates an extracellular integrin beta-PS pathway which regulates DE- cadherin (shg) levels in somatic hub cells, and is essential for maintaining the number of germline stem cells and the structure and localization of hub cells. (354 aa)
	DnaJ-1	DnaJ-like-1 (DnaJ-1) encodes a heat-shock protein co-factor that regulates and interacts with larger heat shock proteins providing client specificity. It regulates the folding of proteins whose misfolding leads to age-dependent neurodegeneration. (334 aa)
	Sec63	Secretory 63; Protein transmembrane transporter activity; RNA binding. It is involved in the biological process described with: SRP-dependent cotranslational protein targeting to membrane; posttranslational protein targeting to endoplasmic reticulum membrane; posttranslational protein targeting to membrane, translocation. (753 aa)
	CG7387	Unfolded protein binding; heat shock protein binding. It is involved in the biological process described with: regulation of apoptotic process; protein folding; mitochondrion organization. (449 aa)
	CG7872	DnaJ homolog subfamily C member 25 homolog; It is involved in the biological process described with: protein folding. (333 aa)
	CG32640	J domain-containing protein. (132 aa)
	CG2790	LD43587p; Nucleic acid binding; zinc ion binding. (540 aa)
	CG2887	AT19485p; Chaperone binding; unfolded protein binding. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; chaperone cofactor-dependent protein refolding. (342 aa)
	Csp	DnaJ homolog subfamily C member 5 homolog; Cysteine string protein (Csp) encodes a synaptic vesicle-associated co-chaperone of Hsc70 that is vital for presynaptic proteostasis and maintenance of synaptic function. The substartes of the product of Csp include SNARE proteins and the product of shi, which mediate synaptic vesicle exo- and endocytosis respectively. (249 aa)
	CG11035	LD38634p. (231 aa)
	CG7556	GH07340p; DNA binding. (522 aa)
	Tpr2	Tetratricopeptide repeat protein 2, isoform A; Heat shock protein binding. It is involved in the biological process described with: chaperone cofactor-dependent protein refolding. (508 aa)

Your Current Organism:

Drosophila melanogaster

NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CG11035	CG7130	FBpp0312540	FBpp0078137	LD38634p.	GEO11142p1.	0.821
CG2790	CG7556	FBpp0072315	FBpp0309972	LD43587p; Nucleic acid binding; zinc ion binding.	GH07340p; DNA binding.	0.607
CG2790	Csp	FBpp0072315	FBpp0311238	LD43587p; Nucleic acid binding; zinc ion binding.	DnaJ homolog subfamily C member 5 homolog; Cysteine string protein (Csp) encodes a synaptic vesicle-associated co-chaperone of Hsc70 that is vital for presynaptic proteostasis and maintenance of synaptic function. The substartes of the product of Csp include SNARE proteins and the product of shi, which mediate synaptic vesicle exo- and endocytosis respectively.	0.627
CG2887	CG5504	FBpp0071393	FBpp0088955	AT19485p; Chaperone binding; unfolded protein binding. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; chaperone cofactor-dependent protein refolding.	Protein tumorous imaginal discs, mitochondrial; May act as a tumor suppressor in larval imaginal disks.	0.461
CG2887	CG7387	FBpp0071393	FBpp0076446	AT19485p; Chaperone binding; unfolded protein binding. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; chaperone cofactor-dependent protein refolding.	Unfolded protein binding; heat shock protein binding. It is involved in the biological process described with: regulation of apoptotic process; protein folding; mitochondrion organization.	0.494
CG2887	DnaJ-H	FBpp0071393	FBpp0303024	AT19485p; Chaperone binding; unfolded protein binding. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; chaperone cofactor-dependent protein refolding.	DnaJ homolog, isoform C; Unfolded protein binding; heat shock protein binding. It is involved in the biological process described with: protein folding.	0.697
CG2887	Droj2	FBpp0071393	FBpp0082220	AT19485p; Chaperone binding; unfolded protein binding. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; chaperone cofactor-dependent protein refolding.	DnaJ-like-2, isoform A; Unfolded protein binding; heat shock protein binding; ATP binding. It is involved in the biological process described with: response to heat; protein folding.	0.694
CG5001	CG5504	FBpp0297899	FBpp0088955	FI02090p; Chaperone binding; unfolded protein binding. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; chaperone cofactor-dependent protein refolding.	Protein tumorous imaginal discs, mitochondrial; May act as a tumor suppressor in larval imaginal disks.	0.559
CG5001	CG7387	FBpp0297899	FBpp0076446	FI02090p; Chaperone binding; unfolded protein binding. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; chaperone cofactor-dependent protein refolding.	Unfolded protein binding; heat shock protein binding. It is involved in the biological process described with: regulation of apoptotic process; protein folding; mitochondrion organization.	0.479
CG5001	DnaJ-H	FBpp0297899	FBpp0303024	FI02090p; Chaperone binding; unfolded protein binding. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; chaperone cofactor-dependent protein refolding.	DnaJ homolog, isoform C; Unfolded protein binding; heat shock protein binding. It is involved in the biological process described with: protein folding.	0.756
CG5001	Droj2	FBpp0297899	FBpp0082220	FI02090p; Chaperone binding; unfolded protein binding. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; chaperone cofactor-dependent protein refolding.	DnaJ-like-2, isoform A; Unfolded protein binding; heat shock protein binding; ATP binding. It is involved in the biological process described with: response to heat; protein folding.	0.721
CG5504	CG2887	FBpp0088955	FBpp0071393	Protein tumorous imaginal discs, mitochondrial; May act as a tumor suppressor in larval imaginal disks.	AT19485p; Chaperone binding; unfolded protein binding. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; chaperone cofactor-dependent protein refolding.	0.461
CG5504	CG5001	FBpp0088955	FBpp0297899	Protein tumorous imaginal discs, mitochondrial; May act as a tumor suppressor in larval imaginal disks.	FI02090p; Chaperone binding; unfolded protein binding. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; chaperone cofactor-dependent protein refolding.	0.559
CG5504	CG7130	FBpp0088955	FBpp0078137	Protein tumorous imaginal discs, mitochondrial; May act as a tumor suppressor in larval imaginal disks.	GEO11142p1.	0.432
CG5504	DnaJ-1	FBpp0088955	FBpp0076830	Protein tumorous imaginal discs, mitochondrial; May act as a tumor suppressor in larval imaginal disks.	DnaJ-like-1 (DnaJ-1) encodes a heat-shock protein co-factor that regulates and interacts with larger heat shock proteins providing client specificity. It regulates the folding of proteins whose misfolding leads to age-dependent neurodegeneration.	0.452
CG5504	DnaJ-H	FBpp0088955	FBpp0303024	Protein tumorous imaginal discs, mitochondrial; May act as a tumor suppressor in larval imaginal disks.	DnaJ homolog, isoform C; Unfolded protein binding; heat shock protein binding. It is involved in the biological process described with: protein folding.	0.569
CG5504	Droj2	FBpp0088955	FBpp0082220	Protein tumorous imaginal discs, mitochondrial; May act as a tumor suppressor in larval imaginal disks.	DnaJ-like-2, isoform A; Unfolded protein binding; heat shock protein binding; ATP binding. It is involved in the biological process described with: response to heat; protein folding.	0.582
CG7130	CG11035	FBpp0078137	FBpp0312540	GEO11142p1.	LD38634p.	0.821
CG7130	CG5504	FBpp0078137	FBpp0088955	GEO11142p1.	Protein tumorous imaginal discs, mitochondrial; May act as a tumor suppressor in larval imaginal disks.	0.432
CG7130	CG7387	FBpp0078137	FBpp0076446	GEO11142p1.	Unfolded protein binding; heat shock protein binding. It is involved in the biological process described with: regulation of apoptotic process; protein folding; mitochondrion organization.	0.460