(6 nodes) Thiolase, acyl-enzyme intermediate active site network (Drosophila melanogaster)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	CG9149	Uncharacterized protein; acetyl-CoA C-acetyltransferase activity; acetyl-CoA C-acyltransferase activity. It is involved in the biological process described with: fatty acid beta-oxidation; Belongs to the thiolase-like superfamily. Thiolase family. (392 aa)
	CG17597	SD06839p; Transferase activity, transferring acyl groups other than amino-acyl groups. It is involved in the biological process described with: positive regulation of intracellular cholesterol transport; Belongs to the thiolase-like superfamily. Thiolase family. (407 aa)
	yip2	Yippee interacting protein 2; acetyl-CoA C-acyltransferase activity; acetyl-CoA C-acetyltransferase activity. It is involved in the biological process described with: fatty acid beta-oxidation; Belongs to the thiolase-like superfamily. Thiolase family. (398 aa)
	Mtpbeta	GH13256p; Mitochondrial trifunctional protein beta subunit (Mtpbeta) encodes a protein involved in fatty acid beta-oxidation; Belongs to the thiolase-like superfamily. Thiolase family. (469 aa)
	CG10932	LD24105p; acetyl-CoA C-acetyltransferase activity; acetyl-CoA C-acyltransferase activity. It is involved in the biological process described with: fatty acid beta-oxidation; fatty acid biosynthetic process; pyruvate metabolic process; Belongs to the thiolase-like superfamily. Thiolase family. (410 aa)
	ScpX	Sterol carrier protein X-related thiolase; Transferase activity, transferring acyl groups other than amino-acyl groups; phospholipid transporter activity. It is involved in the biological process described with: positive regulation of intracellular cholesterol transport; phospholipid transport; Belongs to the thiolase-like superfamily. Thiolase family. (544 aa)

Your Current Organism:

Drosophila melanogaster

NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CG10932	CG9149	FBpp0311869	FBpp0072560	LD24105p; acetyl-CoA C-acetyltransferase activity; acetyl-CoA C-acyltransferase activity. It is involved in the biological process described with: fatty acid beta-oxidation; fatty acid biosynthetic process; pyruvate metabolic process; Belongs to the thiolase-like superfamily. Thiolase family.	Uncharacterized protein; acetyl-CoA C-acetyltransferase activity; acetyl-CoA C-acyltransferase activity. It is involved in the biological process described with: fatty acid beta-oxidation; Belongs to the thiolase-like superfamily. Thiolase family.	0.915
CG10932	Mtpbeta	FBpp0311869	FBpp0072135	LD24105p; acetyl-CoA C-acetyltransferase activity; acetyl-CoA C-acyltransferase activity. It is involved in the biological process described with: fatty acid beta-oxidation; fatty acid biosynthetic process; pyruvate metabolic process; Belongs to the thiolase-like superfamily. Thiolase family.	GH13256p; Mitochondrial trifunctional protein beta subunit (Mtpbeta) encodes a protein involved in fatty acid beta-oxidation; Belongs to the thiolase-like superfamily. Thiolase family.	0.938
CG10932	ScpX	FBpp0311869	FBpp0080659	LD24105p; acetyl-CoA C-acetyltransferase activity; acetyl-CoA C-acyltransferase activity. It is involved in the biological process described with: fatty acid beta-oxidation; fatty acid biosynthetic process; pyruvate metabolic process; Belongs to the thiolase-like superfamily. Thiolase family.	Sterol carrier protein X-related thiolase; Transferase activity, transferring acyl groups other than amino-acyl groups; phospholipid transporter activity. It is involved in the biological process described with: positive regulation of intracellular cholesterol transport; phospholipid transport; Belongs to the thiolase-like superfamily. Thiolase family.	0.821
CG10932	yip2	FBpp0311869	FBpp0079472	LD24105p; acetyl-CoA C-acetyltransferase activity; acetyl-CoA C-acyltransferase activity. It is involved in the biological process described with: fatty acid beta-oxidation; fatty acid biosynthetic process; pyruvate metabolic process; Belongs to the thiolase-like superfamily. Thiolase family.	Yippee interacting protein 2; acetyl-CoA C-acyltransferase activity; acetyl-CoA C-acetyltransferase activity. It is involved in the biological process described with: fatty acid beta-oxidation; Belongs to the thiolase-like superfamily. Thiolase family.	0.931
CG17597	Mtpbeta	FBpp0311123	FBpp0072135	SD06839p; Transferase activity, transferring acyl groups other than amino-acyl groups. It is involved in the biological process described with: positive regulation of intracellular cholesterol transport; Belongs to the thiolase-like superfamily. Thiolase family.	GH13256p; Mitochondrial trifunctional protein beta subunit (Mtpbeta) encodes a protein involved in fatty acid beta-oxidation; Belongs to the thiolase-like superfamily. Thiolase family.	0.544
CG17597	ScpX	FBpp0311123	FBpp0080659	SD06839p; Transferase activity, transferring acyl groups other than amino-acyl groups. It is involved in the biological process described with: positive regulation of intracellular cholesterol transport; Belongs to the thiolase-like superfamily. Thiolase family.	Sterol carrier protein X-related thiolase; Transferase activity, transferring acyl groups other than amino-acyl groups; phospholipid transporter activity. It is involved in the biological process described with: positive regulation of intracellular cholesterol transport; phospholipid transport; Belongs to the thiolase-like superfamily. Thiolase family.	0.940
CG9149	CG10932	FBpp0072560	FBpp0311869	Uncharacterized protein; acetyl-CoA C-acetyltransferase activity; acetyl-CoA C-acyltransferase activity. It is involved in the biological process described with: fatty acid beta-oxidation; Belongs to the thiolase-like superfamily. Thiolase family.	LD24105p; acetyl-CoA C-acetyltransferase activity; acetyl-CoA C-acyltransferase activity. It is involved in the biological process described with: fatty acid beta-oxidation; fatty acid biosynthetic process; pyruvate metabolic process; Belongs to the thiolase-like superfamily. Thiolase family.	0.915
CG9149	Mtpbeta	FBpp0072560	FBpp0072135	Uncharacterized protein; acetyl-CoA C-acetyltransferase activity; acetyl-CoA C-acyltransferase activity. It is involved in the biological process described with: fatty acid beta-oxidation; Belongs to the thiolase-like superfamily. Thiolase family.	GH13256p; Mitochondrial trifunctional protein beta subunit (Mtpbeta) encodes a protein involved in fatty acid beta-oxidation; Belongs to the thiolase-like superfamily. Thiolase family.	0.925
CG9149	ScpX	FBpp0072560	FBpp0080659	Uncharacterized protein; acetyl-CoA C-acetyltransferase activity; acetyl-CoA C-acyltransferase activity. It is involved in the biological process described with: fatty acid beta-oxidation; Belongs to the thiolase-like superfamily. Thiolase family.	Sterol carrier protein X-related thiolase; Transferase activity, transferring acyl groups other than amino-acyl groups; phospholipid transporter activity. It is involved in the biological process described with: positive regulation of intracellular cholesterol transport; phospholipid transport; Belongs to the thiolase-like superfamily. Thiolase family.	0.806
CG9149	yip2	FBpp0072560	FBpp0079472	Uncharacterized protein; acetyl-CoA C-acetyltransferase activity; acetyl-CoA C-acyltransferase activity. It is involved in the biological process described with: fatty acid beta-oxidation; Belongs to the thiolase-like superfamily. Thiolase family.	Yippee interacting protein 2; acetyl-CoA C-acyltransferase activity; acetyl-CoA C-acetyltransferase activity. It is involved in the biological process described with: fatty acid beta-oxidation; Belongs to the thiolase-like superfamily. Thiolase family.	0.919
Mtpbeta	CG10932	FBpp0072135	FBpp0311869	GH13256p; Mitochondrial trifunctional protein beta subunit (Mtpbeta) encodes a protein involved in fatty acid beta-oxidation; Belongs to the thiolase-like superfamily. Thiolase family.	LD24105p; acetyl-CoA C-acetyltransferase activity; acetyl-CoA C-acyltransferase activity. It is involved in the biological process described with: fatty acid beta-oxidation; fatty acid biosynthetic process; pyruvate metabolic process; Belongs to the thiolase-like superfamily. Thiolase family.	0.938
Mtpbeta	CG17597	FBpp0072135	FBpp0311123	GH13256p; Mitochondrial trifunctional protein beta subunit (Mtpbeta) encodes a protein involved in fatty acid beta-oxidation; Belongs to the thiolase-like superfamily. Thiolase family.	SD06839p; Transferase activity, transferring acyl groups other than amino-acyl groups. It is involved in the biological process described with: positive regulation of intracellular cholesterol transport; Belongs to the thiolase-like superfamily. Thiolase family.	0.544
Mtpbeta	CG9149	FBpp0072135	FBpp0072560	GH13256p; Mitochondrial trifunctional protein beta subunit (Mtpbeta) encodes a protein involved in fatty acid beta-oxidation; Belongs to the thiolase-like superfamily. Thiolase family.	Uncharacterized protein; acetyl-CoA C-acetyltransferase activity; acetyl-CoA C-acyltransferase activity. It is involved in the biological process described with: fatty acid beta-oxidation; Belongs to the thiolase-like superfamily. Thiolase family.	0.925
Mtpbeta	ScpX	FBpp0072135	FBpp0080659	GH13256p; Mitochondrial trifunctional protein beta subunit (Mtpbeta) encodes a protein involved in fatty acid beta-oxidation; Belongs to the thiolase-like superfamily. Thiolase family.	Sterol carrier protein X-related thiolase; Transferase activity, transferring acyl groups other than amino-acyl groups; phospholipid transporter activity. It is involved in the biological process described with: positive regulation of intracellular cholesterol transport; phospholipid transport; Belongs to the thiolase-like superfamily. Thiolase family.	0.855
Mtpbeta	yip2	FBpp0072135	FBpp0079472	GH13256p; Mitochondrial trifunctional protein beta subunit (Mtpbeta) encodes a protein involved in fatty acid beta-oxidation; Belongs to the thiolase-like superfamily. Thiolase family.	Yippee interacting protein 2; acetyl-CoA C-acyltransferase activity; acetyl-CoA C-acetyltransferase activity. It is involved in the biological process described with: fatty acid beta-oxidation; Belongs to the thiolase-like superfamily. Thiolase family.	0.970
ScpX	CG10932	FBpp0080659	FBpp0311869	Sterol carrier protein X-related thiolase; Transferase activity, transferring acyl groups other than amino-acyl groups; phospholipid transporter activity. It is involved in the biological process described with: positive regulation of intracellular cholesterol transport; phospholipid transport; Belongs to the thiolase-like superfamily. Thiolase family.	LD24105p; acetyl-CoA C-acetyltransferase activity; acetyl-CoA C-acyltransferase activity. It is involved in the biological process described with: fatty acid beta-oxidation; fatty acid biosynthetic process; pyruvate metabolic process; Belongs to the thiolase-like superfamily. Thiolase family.	0.821
ScpX	CG17597	FBpp0080659	FBpp0311123	Sterol carrier protein X-related thiolase; Transferase activity, transferring acyl groups other than amino-acyl groups; phospholipid transporter activity. It is involved in the biological process described with: positive regulation of intracellular cholesterol transport; phospholipid transport; Belongs to the thiolase-like superfamily. Thiolase family.	SD06839p; Transferase activity, transferring acyl groups other than amino-acyl groups. It is involved in the biological process described with: positive regulation of intracellular cholesterol transport; Belongs to the thiolase-like superfamily. Thiolase family.	0.940
ScpX	CG9149	FBpp0080659	FBpp0072560	Sterol carrier protein X-related thiolase; Transferase activity, transferring acyl groups other than amino-acyl groups; phospholipid transporter activity. It is involved in the biological process described with: positive regulation of intracellular cholesterol transport; phospholipid transport; Belongs to the thiolase-like superfamily. Thiolase family.	Uncharacterized protein; acetyl-CoA C-acetyltransferase activity; acetyl-CoA C-acyltransferase activity. It is involved in the biological process described with: fatty acid beta-oxidation; Belongs to the thiolase-like superfamily. Thiolase family.	0.806
ScpX	Mtpbeta	FBpp0080659	FBpp0072135	Sterol carrier protein X-related thiolase; Transferase activity, transferring acyl groups other than amino-acyl groups; phospholipid transporter activity. It is involved in the biological process described with: positive regulation of intracellular cholesterol transport; phospholipid transport; Belongs to the thiolase-like superfamily. Thiolase family.	GH13256p; Mitochondrial trifunctional protein beta subunit (Mtpbeta) encodes a protein involved in fatty acid beta-oxidation; Belongs to the thiolase-like superfamily. Thiolase family.	0.855
ScpX	yip2	FBpp0080659	FBpp0079472	Sterol carrier protein X-related thiolase; Transferase activity, transferring acyl groups other than amino-acyl groups; phospholipid transporter activity. It is involved in the biological process described with: positive regulation of intracellular cholesterol transport; phospholipid transport; Belongs to the thiolase-like superfamily. Thiolase family.	Yippee interacting protein 2; acetyl-CoA C-acyltransferase activity; acetyl-CoA C-acetyltransferase activity. It is involved in the biological process described with: fatty acid beta-oxidation; Belongs to the thiolase-like superfamily. Thiolase family.	0.732